Abstract:
:The observations that people infected with HIV suffer not only from an inflammatory stress but also from depleted glutathione levels have led to a general hypothesis that these two are causally related, and that treatment of AIDS should include thiol-replenishment therapy. In particular, inflammatory stimulations are dependent on intracellular thiol levels, as they are potentiated at low glutathione levels (oxidative stress) and inhibited at high glutathione levels. Inflammatory stress may itself lead to decreased levels of glutathione. HIV has taken advantage of inflammatory signals to regulate its own replication; thus, the HIV infection is exacerbated by low levels of glutathione. We have shown that N-acetylcysteine can inhibit inflammatory stimulations, including that of HIV replication. Since N-acetylcysteine can replenish depleted glutathione levels in vivo, we suggest that it be used as an adjunct in the treatment of AIDS.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Roederer M,Staal FJ,Ela SW,Herzenberg LA,Herzenberg LAdoi
10.1159/000139037subject
Has Abstractpub_date
1993-01-01 00:00:00pages
121-9issue
3eissn
0031-7012issn
1423-0313journal_volume
46pub_type
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