The Small Molecule Indirubin-3'-Oxime Inhibits Protein Kinase R: Antiapoptotic and Antioxidant Effect in Rat Cardiac Myocytes.

abstract：:The present experiments examined the protective effect of the nitrofuran drugs, furazolidone (FZ) and nitrofurazone (NF), on duodenal ulceration induced by cysteamine or indometacin in rats. FZ at oral doses of 25, 50 or 100 mg/kg for 2 consecutive days signficantly reduced, in a dose-dependent manner, the incidence a...

journal_title：Pharmacology

authors： Ali BH

更新日期：1991-01-01 00:00:00

abstract：:The present study was aimed at investigating the effects of diabetes on the cavernosal smooth muscle relaxations mediated by adenosine and adenosine triphosphate (ATP) in tissues obtained from men and rats. Adenosine- and ATP-induced relaxant responses showed an enhanced sensitivity with an unaltered effectiveness in ...

journal_title：Pharmacology

authors： Gür S,Oztürk B

更新日期：2000-02-01 00:00:00

abstract：:The systemic and coronary hemodynamic effects of the nitrovasodilator, pirsidomine, were compared with SIN-1, nitroprusside, and nitroglycerin. Four groups consisting of 32 experiments were performed in 17 conscious dogs chronically instrumented for measurement of aortic and left ventricular pressure, left ventricular...

journal_title：Pharmacology

authors： Arkonac BM,Kersten JR,Wynsen JC,Nijhawan N,Warltier DC

更新日期：1996-02-01 00:00:00

abstract：:Pain and mental status were assessed in a series of 35 consecutive hospitalized patients with metastatic cancer receiving narcotics for pain that was difficult to control. Forty-five episodes of mental status impairment were detected in 27 of these patients. Fifteen patients had dose-related oversedation or organic br...

journal_title：Pharmacology

authors： Leipzig RM,Goodman H,Gray G,Erle H,Reidenberg MM

更新日期：1987-01-01 00:00:00

abstract：:Sedum telephium ssp. maximum is a medicinal plant that possesses anti-inflammatory, analgesic and keratolytic properties. We investigated the anti-inflammatory activity of its methanolic extract (STME) in rat peritoneal macrophages (MPhis) stimulated with lipopolysaccharide from Salmonella enteritidis. After stimulati...

journal_title：Pharmacology

authors： Altavilla D,Polito F,Bitto A,Minutoli L,Miraldi E,Fiumara T,Biagi M,Marini H,Giachetti D,Vaccaro M,Squadrito F

更新日期：2008-01-01 00:00:00

abstract：:The cardioprotective effects of (2S,3R,4S)-N'-benzyl- N"-cyano-N-(3,4-dihydro-2-dimethoxymethyl-3-hydro- xy-2-methyl-6-nitro-2H-benzopyran-4-yl)-guanidine (KR-31372) were evaluated against ischemic/reperfusion injury in isolated rat hearts in vitro and in anesthetized rats and dogs in vivo. In isolated perfused rat he...

journal_title：Pharmacology

authors： Lee BH,Seo HW,Yoo SE

更新日期：2004-02-01 00:00:00

abstract：:The influence of changes in the sodium balance on angiotensin II-induced pressor responses were studied in the pithed rat preparation, which is characterized by a highly activated renin-angiotensin-aldosterone system (RAAS) with high plasma renin and angiotensin II concentrations. The pressor response to angiotensin I...

journal_title：Pharmacology

authors： Knape JT,van Zwieten PA

更新日期：1988-01-01 00:00:00

abstract：:We studied the anti-inflammatory activity of meloxicam on rat carrageenin-induced pleurisy and its toxicity for rat gastric mucosa, relative to its in vitro inhibitory potency against partially purified cyclooxygenase (COX)-1 and COX-2 preparations in order to clarify the pharmacological profile of the compound as an ...

journal_title：Pharmacology

authors： Ogino K,Hatanaka K,Kawamura M,Katori M,Harada Y

更新日期：1997-07-01 00:00:00

abstract：:We investigated the vascular effects of glucagon-like peptide-1 (GLP-1) and Exendin-4 in type 2 diabetic rat aortae. Studies were performed in a normal control group (NC) (0.2 ml i.p. saline, n = 10), streptozotocin (STZ)/nicotinamide diabetic control group (DC) (a single dose of 80 mg/kg STZ i.p. injection 15 min aft...

journal_title：Pharmacology

authors： Ozyazgan S,Kutluata N,Afşar S,Ozdaş SB,Akkan AG

更新日期：2005-06-01 00:00:00

abstract：:The activity of myocardial adenylate cyclase from two age groups (10-11 and 18-19 weeks old, respectively) of male spontaneously hypertensive rats (SHR) and their age-matched normotensive Wistar-Kyoto rats (WKY) was examined. Stimulation of the enzyme by isoproterenol and 5'-guanylyl-imidodiphosphate (GMP-PNP) was dec...

journal_title：Pharmacology

authors： Chiu TH

更新日期：1981-01-01 00:00:00

abstract：:There is an ongoing debate about possible advantages of the coadministration of caffeine with cyclooxygenase (COX) inhibitors in the treatment of pain. There are results suggesting interference by caffeine with COX expression and activity in rat immune cells. In the present study, we have used, therefore, human endoto...

journal_title：Pharmacology

authors： Ulcar R,Schuligoi R,Heinemann A,Santner B,Amann R

更新日期：2003-02-01 00:00:00

abstract：:The effect of promethazine on the metabolic responsiveness of human polymorphonuclear leukocytes to opsonized zymosan was evaluated by chemiluminescence (CL) assay under the following situations: (1) preincubation of granulocytes with promethazine; (2) simultaneous addition of zymosan and promethazine, and (3) additio...

journal_title：Pharmacology

authors： Trush MA,Van Dyke K

更新日期：1978-01-01 00:00:00

abstract：:The present study examined the interaction of opioidergic systems in the hypotensive action of atenolol. Anesthetized, adult spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats were instrumented to monitor blood pressure and heart rate. Atenolol (100 micrograms/kg, i.v.) produced a decrease in blood pressure ...

journal_title：Pharmacology

authors： Laskey RE,Jones LF,Tackett RL

更新日期：1989-01-01 00:00:00

abstract：:The depression of evoked cortical potentials caused by brief periods of cerebral ischemia is attenuated by prior intracarotid injection of cytidoline (2, 4 or 8 mg/kg). Studies performed in hypercapnic cats suggest that the protection afforded by cytidoline is of metabolic rather than hemodynamic origin. The participa...

journal_title：Pharmacology

authors： Boismare F,Le Poncin M,Lefrançois J,Lecordier JC

更新日期：1978-01-01 00:00:00

abstract：:We evaluated the effects of sodium alginate (AL-Na) on dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. DSS was added to the drinking water for 7 days. In another experiment, DSS was added to the drinking water for 5 days and DSS-free water was provided thereafter. ...

journal_title：Pharmacology

authors： Yamamoto A,Itoh T,Nasu R,Nishida R

更新日期：2013-01-01 00:00:00

abstract：:Cinnamedrine is an active ingredient in preparations used to relieve dysmenorrhea. It has been reported to have local anesthetic properties in nerve. This property prompted us to evaluate the effects of cinnamedrine on the cardiac action potential. Cinnamedrine (10-35 microM) significantly reduced the overshoot and ma...

journal_title：Pharmacology

authors： Arena JP,McArdle JJ,Argentieri TM

更新日期：1987-01-01 00:00:00

abstract：:34 experienced marijuana users were divided into four equated groups of eight subjects each based on recognition memory test performance. One week later each group was retested following administration of marijuana containing 0, 5, 10 or 15 mg delta9-tetrahydrocannabinol. A dose-related effect of marijuana on pulse ra...

journal_title：Pharmacology

authors： Miller L,Cornett T,Drew W,McFarland D,Brightwell D,Wikler A

更新日期：1977-01-01 00:00:00

abstract：:Nitric oxide has been shown to decrease myocardial contractility and O2 consumption. This study was designed to evaluate the hypothesis that nitric oxide-mediated increases in cyclic GMP require elevated cyclic AMP to produce cardiac depression. Using isolated, Langendorff-perfused rat hearts, we determined the effect...

journal_title：Pharmacology

authors： Weiss HR,Sadoff JD,Scholz PM,Klabunde RE

更新日期：1997-10-01 00:00:00

abstract：:The agent, 6-(N,N-diethylamino)-hexyl- 3, 4, 5,-Trimethoxybenzoate (TMB-6) which relaxes smooth and skeletal muscle by interfering with intracellular Ca ++ availability was tested for its electrophysiological effects on canine cardiac Purkinje fibres and feline papillary muscles. In both tissues the drug causes a decr...

journal_title：Pharmacology

authors： Posner P,Chiou CY

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the effects of trichostatin A (TSA) on cervical cancer and the related mechanisms. METHODS:The HeLa and Caski cervical cancer cell lines were treated with different concentrations of TSA. Cell viability was measured by MTT assays. Cell apoptosis was analysed using flo...

journal_title：Pharmacology

authors： Liu JH,Cao YM,Rong ZP,Ding J,Pan X

更新日期：2020-11-03 00:00:00

abstract：:A double-blind crossover trial was conducted in 42 outpatients of either sex in order to obtain information on the properties of 7.5 mg of zopiclone in a general practice setting compared with 2 mg of flunitrazepam. Each patient went through two periods of treatment, each period lasting 10 days. A comparison of the ef...

journal_title：Pharmacology

authors： Wickstrøm E,Barbo SE,Dreyfus JF,Jerkø D,Kleiven R,Slåttbrekk R,Stray Tønnesen JN

更新日期：1983-01-01 00:00:00

abstract：:Angiotensin had a dual action on the epididymal half of rat vas deferens. It potentiated electrical stimulated contraction and exerted a direct contractile effect on the muscle. The potentiation of electrically stimulated response may be mediated by presynaptic facilitation of neurotransmitter release. Muscular contra...

journal_title：Pharmacology

authors： Sum CS,Cheung WT

更新日期：1995-08-01 00:00:00

abstract：:Ulcerative colitis is characterized by dysfunctional motility. Our main objective in this investigation was to study the effect of an acetic acid-induced ulcerative colitis on the expression and function of beta(3)-adrenoceptors in the rat colon. Inflammation was induced by administering acetic acid intrarectally into...

journal_title：Pharmacology

authors： Khan I,Hussein SM,Oriowo M

更新日期：2002-02-01 00:00:00

abstract：:The distribution pattern of (-)-3H-dihydroalprenolol (3H-DHA) binding sites within the thoracic and abdominal aorta was studied using a histoautoradiographic technique. Frozen sections of rabbit aorta were incubated with 3H-DHA in the presence or absence of 1 mumol/l (-)-propranolol and of increasing concentrations of...

journal_title：Pharmacology

authors： Amenta F,Cavallotti C,De Rossi M

更新日期：1985-01-01 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants. PBDEs have been widely used in textiles, flexible polyurethane foams, electronic components, electrical components, and plastics. 11β-Hydroxysteroid dehydrogenases, isoform 1 (HSD11B1) and isoform 2 (HSD11B2), have been demonstrated to ...

journal_title：Pharmacology

authors： Chen X,Dong Y,Cao S,Li X,Wang Z,Chen R,Ge RS

更新日期：2016-01-01 00:00:00

abstract：:Two groups of rats were used to examine the effect of pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, on rat hearts using an in vivo model of ischemia-reperfusion (I/R) to elucidate potential mechanisms. One group was the 30-min reperfusion group, which was further subdivided into...

journal_title：Pharmacology

authors： Cao Z,Ye P,Long C,Chen K,Li X,Wang H

更新日期：2007-01-01 00:00:00

abstract：:Hypothyroidism is a common disorder that is associated with psychological disturbances such as dementia, depression, and psychomotor disorders. We recently found that chronic treatment with the T-type calcium channel enhancer SAK3 prevents the cholinergic neurodegeneration induced by a single intraperitoneal (i.p.) in...

journal_title：Pharmacology

authors： Husain N,Yabuki Y,Shinoda Y,Fukunaga K

更新日期：2018-01-01 00:00:00

abstract：:Previously published data from this laboratory on the urinary excretion of 3-hydroxymethyl antipyrine (one of the major metabolites of antipyrine in man) have to be reconsidered, because of use of an impure reference substance in the high-pressure liquid chromatographic assay method. Comparison with newly synthesized,...

journal_title：Pharmacology

authors： Danhof M,Teunissen MW,Breimer DD

更新日期：1982-01-01 00:00:00

abstract：INTRODUCTION:Homeostasis of cholesterol is crucial for cellular function, and dysregulated cholesterol biosynthesis is a metabolic event that can lead to hepatic and cardiovascular abnormalities. OBJECTIVE:The aim of this study was to investigate the effects and mechanisms of domain-associated protein (Daxx) and andro...

journal_title：Pharmacology

authors： Li TP,Sun SW,Xiong GZ,Qiu F,Yang DM,Sun SY,Xie XJ,Liao DF,Chen JX,Tuo QH

更新日期：2020-07-21 00:00:00

abstract：:Three synthetic peptides, urotensin I, sauvagine and ovine CRF, have less than 50% sequence homology. In the dog, all three produce selective mesenteric dilation, which appears to be solely responsible for a decrease in peripheral resistance and systemic arterial blood pressure. Urotensin I and sauvagine were found to...

journal_title：Pharmacology

authors： MacCannell KL,Lederis K,Hamilton PL,Rivier J

更新日期：1982-01-01 00:00:00