Abstract:
:The agent, 6-(N,N-diethylamino)-hexyl- 3, 4, 5,-Trimethoxybenzoate (TMB-6) which relaxes smooth and skeletal muscle by interfering with intracellular Ca ++ availability was tested for its electrophysiological effects on canine cardiac Purkinje fibres and feline papillary muscles. In both tissues the drug causes a decrease in resting membrane potential and action potential amplitude as well as spontaneous rate in Purkinje fibres, and an increase in stimulus needed to reach threshold. The minimum effective dose for both tissues was similar at 7.32 x 10-5 M. The drug effects were reversible in both tissues upon removal of the TMB-6. The Ca++ -dependent action potentials of canine cardiac Purkinje fibres were also inhibited by TMB-6 at dose range of 7.32 x 10-5 -24.4 x 10-5 M. Because of its electro physiological effects of threshold, automaticity and "slow response" action potentials and its reversibility, TMB-6 could become a useful antiarrhythmic drug.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Posner P,Chiou CYdoi
10.1159/000136585subject
Has Abstractpub_date
1976-01-01 00:00:00pages
97-103issue
2eissn
0031-7012issn
1423-0313journal_volume
14pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::Amphetamine is a sympathomimetic and psychotropic drug which is extensively metabolized in liver and in brain. One of its major metabolites, p-hydroxyamphetamine, is accumulated by cortical and striatal synaptosomes. In order to learn whether p-hydroxyamphetamine can be further metabolized to a catecholamine, a sensit...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137320
更新日期:1979-01-01 00:00:00
abstract::Chronic exposure to cold increases the growth of brown adipose tissue and the resistance to more severe cold, thus improving thermogenesis. The present study examined the possibility that dietary compounds can modify cold acclimation. Adenosine (ADO) or adenine (ADE) were administered in drinking water (0.05%, w/v) fo...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028315
更新日期:1999-09-01 00:00:00
abstract::Verapamil-induced cardiovascular depression has been examined in dial-urethane-anesthetized open chest dogs. Verapamil was administered slowly intravenously until the mean arterial pressure was decreased by approximately 45 mm Hg. The dose of verapamil required to reach the hemodynamic endpoint was 1,495 +/- (SE) 165 ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138317
更新日期:1987-01-01 00:00:00
abstract::The effect of promethazine on the metabolic responsiveness of human polymorphonuclear leukocytes to opsonized zymosan was evaluated by chemiluminescence (CL) assay under the following situations: (1) preincubation of granulocytes with promethazine; (2) simultaneous addition of zymosan and promethazine, and (3) additio...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136787
更新日期:1978-01-01 00:00:00
abstract::The isolated whole stomach of the mouse has been used to study the effect of atropine on gastic acid secretion stimulated by acetylcholine, bethanechol and histamine. Atropine inhibited acid secretory response to acetylcholine and bethanechol in a competitive manner. The following pA2 values for atropine were calculat...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137441
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Periplaneta americana is one of the ancient insect groups with the strongest vitality. Periplaneta americana extract (PAE) has been explored as an alternative remedy for many diseases. Although much progress has been made in the study about PAE, the role of the drug in renal disease is rarely reported, espec...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000488535
更新日期:2018-01-01 00:00:00
abstract::A comparative study of four natural eugenol compounds found in the volatile oil fraction of Myristica fragans, namely eugenol (E), methyleugenol (ME), isoeugenol and methylisoeugenol, was carried out in mice. Using a mixture of saline + tween-80 to suspend the compounds and the intraperitoneal route, ME revealed to be...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136617
更新日期:1976-01-01 00:00:00
abstract::GPR61 is an orphan receptor that belongs to Class A of G-protein-coupled receptors. It has been reported that GPR61 has a constitutive activity and couples to Gαs. In the present study, we characterized GPR61 function and ligand binding by experimental and molecular docking studies. We demonstrated that heterologous e...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000501926
更新日期:2019-01-01 00:00:00
abstract::A variety of prostaglandin synthetase inhibitors are cooxygenated during arachidonic acid peroxidation catalyzed by rat renal medulla prostaglandin synthetase or soybean lipoxygenase. Phenylbutazone, aminopyrine, 1,3-diphenylisobenzofuran, paracetamol, p-aminophenol, p-phenetidine and other o- and m-substituted aminop...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137880
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Lipopolysaccharide (LPS) induces intestinal dysmotility by alteration of smooth muscle and enteric neuronal activities. However, there is no report on the modulatory effects of LPS on the interstitial cells of Cajal (ICCs). We investigated the effect of LPS and its signal transduction in ICCs. M...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000340018
更新日期:2012-01-01 00:00:00
abstract::We investigated the vascular effects of glucagon-like peptide-1 (GLP-1) and Exendin-4 in type 2 diabetic rat aortae. Studies were performed in a normal control group (NC) (0.2 ml i.p. saline, n = 10), streptozotocin (STZ)/nicotinamide diabetic control group (DC) (a single dose of 80 mg/kg STZ i.p. injection 15 min aft...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000084277
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND/AIM:The effect of isocaloric diets and sibutramine on dietary behaviour and TNF-alpha is poorly understood. The aim of the study was to investigate the effects of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-alpha in free-feeding rats. METHODS:Three groups of male Wista...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000127363
更新日期:2008-01-01 00:00:00
abstract::34 experienced marijuana users were divided into four equated groups of eight subjects each based on recognition memory test performance. One week later each group was retested following administration of marijuana containing 0, 5, 10 or 15 mg delta9-tetrahydrocannabinol. A dose-related effect of marijuana on pulse ra...
journal_title:Pharmacology
pub_type: 临床试验,杂志文章
doi:10.1159/000136698
更新日期:1977-01-01 00:00:00
abstract::The mechanisms underlying the fade of the tetanic contraction induced by pancuronium were studied in vitro by means of myographical and electrophysiological techniques in the extensor digitorum longus muscle of the rat. Pancuronium (0.5 mumol/l) induced a complete fade of the tetanic contraction while leaving the twit...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139242
更新日期:1994-10-01 00:00:00
abstract::We investigated the effects of calcium ions (Ca2+) on the adenylyl cyclase activity in purified turkey erythrocyte membranes. Results showed the following: (i) Ca2+ inhibits cAMP accumulation stimulated by isoproterenol (1 micromol/l), NaF + AlCl3 (10 mmol/l + 20 micromol/l) or forskolin (10 micromol/l) in EGTA-washed...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028245
更新日期:1998-10-01 00:00:00
abstract::There are reports regarding harmful effect of long-term use of beta2-agonist drugs on asthma severity and airway responsiveness. In the present study, the responses of guinea pig trachea with intact and denuded epithelium (groups 1 and 2, n = 10) to methacholine as EC50 were measured in tissues nonincubated or incubat...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000088739
更新日期:2006-01-01 00:00:00
abstract::DL-o-, and p-octopamine were tested for beta- and alpha-adrenergic activity in rats. When compared to DL-isoproterenol, a beta-adrenergic agonist, all three isomers failed to show significant beta-adrenergic activity as assessed by intiation of thirst and by increase in tail skin temperature. All three isomers increas...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137250
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND/AIMS:Since beta-adrenoceptors have been shown to affect cardiac gap junction channels, we wanted to elucidate the possible effect of metoprolol on the gap junction protein connexin-43, using racemic RS-metoprolol or the isomer R-metoprolol (no beta-adrenoceptor blockade) or S-metoprolol (beta(1)-adrenoceptor...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000276982
更新日期:2010-01-01 00:00:00
abstract::Congestive heart failure (CHF) is associated with exercise intolerance that cannot be entirely explained by hypoperfusion of the skeletal muscles. We studied the contractile properties of fast-twitch (extensor digitorum longus; EDL) and slow-twitch (soleus; SOL) skeletal muscles in doxorubicin-induced CHF in rats, and...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000241723
更新日期:2009-01-01 00:00:00
abstract::A controlled, double-blind study was made of the efficacy and safety of a new hypnotic, zopiclone, on the preoperative night's sleep by a Joint Study Unit Group of the anesthesiology departments in 6 national hospitals. The following results were found: (1) zopiclone 7.5 and 10 mg and nitrazepam 10 mg were significant...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137927
更新日期:1983-01-01 00:00:00
abstract:AIM:The purpose of the present study was to examine the effects of acetaldehyde on the contractile force and membrane potentials and currents in the bullfrog heart. METHODS:Contractile force was recorded using right atrial tissues, and membrane potentials and currents were measured by using whole cell patch clamp meth...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000342388
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:The primary aim of the present investigation was to determine and compare the pharmacokinetic (PK) profiles of inorganic phosphate in serum and urine after intravenous administration of sodium glycerophosphate and inorganic sodium phosphate. Additionally, study product safety profiles were evaluated. SUBJECT...
journal_title:Pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000331341
更新日期:2011-01-01 00:00:00
abstract::The effects of the calcium channel antagonist nifedipine and the protein kinase C (PKC) inhibitor, staurosporine were examined on the pressor actions of a full, cirazoline, and a partial, St587, alpha 1-adrenoceptor agonist as well as the alpha 2-adrenoceptor agonist B-HT 920 in the pithed rat preparation. Administrat...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138838
更新日期:1991-01-01 00:00:00
abstract::The aim of this study was to assess whether moderate hypoxia affects the disposition of diltiazem. Six male beagle dogs received diltiazem (0.6 mg/kg) on three occasions: (1) while breathing air, i.e. during normoxia; (2) 1 h after initiating exposure to a FiO2 of 0.08, a FiCO2 of 0.035 and a FiN2 of 0.885, i.e. durin...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139121
更新日期:1993-12-01 00:00:00
abstract::The effects of sammarium (Sm3+) on drug responsiveness of the isolated guinea pig ileum were studied. The lanthanid at the concentration of 2x10(-4) M reduced responsiveness to acetylcholine, histamine and submaximal concentrations of potassium. The maximum response to potassium and the responsiveness to barium remain...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136693
更新日期:1977-01-01 00:00:00
abstract::Three doses (0.31, 3.1 and 31 mg/kg) of methotrexate (MTX) were given intravenously to rats. The resulting concentration-time curves in plasma (normalized by dividing the plasma concentration by a multiple of the dose) were not superimposable, indicating nonlinear plasma pharmacokinetics. In liver, kidney, bone marrow...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137723
更新日期:1982-01-01 00:00:00
abstract:OBJECTIVE:To investigate the efficacy, safety, and clinical benefit of prolonged-release trazodone (Trittico) in the treatment of major depressive disorder (MDD). METHODS:In this study, 363 Chinese patients with MDD were randomized 1:1 to receive either prolonged-release trazodone (150-450 mg) or placebo treatment for...
journal_title:Pharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000368559
更新日期:2014-01-01 00:00:00
abstract::Black Swiss (BS) mice were shown to be an advantageous strain to model behavioral domains of mania, but to date only male mice were tested, whereas bipolar disorder (BPD) is equally prevalent in women and men. This study was therefore designed to examine the possibility of using both male and female BS mice in future ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000381785
更新日期:2015-01-01 00:00:00
abstract::The effect of morphine, fentanyl, pethidine and pentazocine was studied in gerbils against air blast-induced seizures. Major, generalized seizures were suppressed by morphine (ED50 = 4.0 mg/kg s.c.), fentanyl (ED50 = 64 micrograms/kg s.c.), and pethidine (ED50 = 2.4 mg/kg s.c.), but not by pentazocine. The anticonvuls...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138189
更新日期:1986-01-01 00:00:00
abstract::The effects of a purine precursor, AICAriboside (5-aminoimidazole-4-carboxamide riboside), on postischemic recovery of myocardial function and adenine nucleotides have been studied in the isolated blood-perfused cat heart. The isolated hearts received either AICAriboside or saline prior to 60 min of global ischemia an...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138107
更新日期:1985-01-01 00:00:00