Abstract:
:Cinnamedrine is an active ingredient in preparations used to relieve dysmenorrhea. It has been reported to have local anesthetic properties in nerve. This property prompted us to evaluate the effects of cinnamedrine on the cardiac action potential. Cinnamedrine (10-35 microM) significantly reduced the overshoot and maximum rate of rise, and also prolonged the duration of action potentials recorded from rat and guinea pig ventricular tissues. The action of cinnamedrine to depress upstroke velocity in guinea pig papillary muscle was dependent on the rate of stimulation. In addition, the refractory period of rat ventricular muscle was prolonged markedly. Finally, cinnamedrine (10 microM) significantly reduced, or totally abolished, epinephrine-induced automatic activity in both dog and rat myocardium in vitro. Prolongation of action potential duration and refractory period, and depression of upstroke velocity are characteristics which cinnamedrine shares with antiarrhythmic drugs.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Arena JP,McArdle JJ,Argentieri TMdoi
10.1159/000138281subject
Has Abstractpub_date
1987-01-01 00:00:00pages
286-95issue
5eissn
0031-7012issn
1423-0313journal_volume
34pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::We report that the loop diuretic drugs bumetanide and furosemide used in the treatment of hypertension are GPR35 agonists. We utilized calcium flux, inositol phosphate accumulation, and dynamic redistribution assays to examine the pharmacology of these compounds on the human, mouse and rat GPR35. While potent on human...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000335127
更新日期:2012-01-01 00:00:00
abstract::Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and function. Reported prevalence of this geriatric syndrome, differs depending on the definition, the population and the method used to identify sarcopenia. The causes of sarcopenia are multifactorial, and can...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000448247
更新日期:2017-01-01 00:00:00
abstract::It has previously been demonstrated in several species that the secretory granules of pancreatic beta-cells have the ability to store substantial amounts of calcium and bioactive amines, such as dopamine and serotonin. Furthermore, evidence for a similar topographical localization for amine and calcium within the peri...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138053
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:To study the myocardial benefit effect and mechanism of paeoniflorin on myocardial ischemia reperfusion injury (MIRI) in rats. METHODS:Hundred SD rats were randomly divided into 5 groups: sham group, model group, Paeoniflorin (15 mg/kg) group, Paeoniflorin (30 mg/kg) group, and Paeoniflorin (60 mg/kg) group....
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000503583
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Bronchial asthma continues to be a big challenge to therapy. Mast cells play an important role in allergic asthma. Histamine and leukotrienes are established mast cell mediators, but antihistamines currently play no role in asthma therapy. METHODS:Human bronchial strips were exposed to the mast cell ac...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000440769
更新日期:2015-01-01 00:00:00
abstract::Bilateral stopping of plantar perspiration in the mouse was obtained by application of a cotton-wool swab soaked in a 3% solution of BRL 556 in 60% ethanol for 1--2 min to the plantar surface of its right hind paw. For humans, aerosols which are at present on the market produce a sensible reduction in palmar sweating....
journal_title:Pharmacology
pub_type: 临床试验,杂志文章
doi:10.1159/000136769
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Periplaneta americana is one of the ancient insect groups with the strongest vitality. Periplaneta americana extract (PAE) has been explored as an alternative remedy for many diseases. Although much progress has been made in the study about PAE, the role of the drug in renal disease is rarely reported, espec...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000488535
更新日期:2018-01-01 00:00:00
abstract::Double-stranded, RNA-dependent protein kinase R (PKR) is a serine/threonine protein kinase activated by various stress signals. It plays an important role in inflammation, insulin sensitivity and glucose homeostasis. Increased PKR activity has been observed in obese humans as well as in obese diabetic mice. Indirubin-...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000441727
更新日期:2016-01-01 00:00:00
abstract::The radioligand binding profiles and in vivo pharmacological characteristics of YM-44781, YM-44778 and YM-49598, novel non-peptide tachykinin receptor antagonists, were examined and compared to those of FK-888 and GR-159897. Since no functional NK(3) receptors were found in the rat bladder, the emphasis will be on the...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056193
更新日期:2002-05-01 00:00:00
abstract::Binding of cefpiramide (CPM) and other beta-lactam antimicrobial agents to 2(3)-tert-butyl-4-hydroxyanisole (BHA)-induced liver glutathione (GSH) S-transferases (EC 2.5.1.18) from CD-1 mice was studied. A marked induction of hepatic GSH S-transferase from mice fed BHA was observed. Gel chromatography of liver cytosol ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138600
更新日期:1989-01-01 00:00:00
abstract::The use of angiotensin converting enzyme (ACE) inhibitors in combination with diuretics is a common strategy used for the treatment of patients affected by heart failure. An infant affected by initial congestive cardiac failure, after starting the treatment with enalapril in association with furosemide, developed acut...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000441950
更新日期:2016-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor that regulates lipid metabolism. Recently, PPARgamma was reported to be a negative regulator in the immune system. Eosinophils also express PPARgamma, however, the role of PPARgamma in eosinophil functions is not well understood. Surfac...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000085034
更新日期:2005-07-01 00:00:00
abstract::Four monoclonal antibodies (MAbs) to phenobarbital-induced cytochrome P-450 (PB-P-450) show different patterns of inhibition of PB-P-450 catalyzed aryl hydrocarbon hydroxylase (AHH), 7-ethoxycoumarin deethylase, benzphetamine demethylase and ethylmorphine demethylase. The inhibition constants vary depending on the ind...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138677
更新日期:1990-01-01 00:00:00
abstract::Rat intestinal transit was determined 30, 60, 150 and 270 min after morphine sulfate or saline given either subcutaneously (s.c.), intraduodenally (i.d.) or intracerebroventricularly (i.c.v.). In addition, two popular methods of quantifying the progression of a radioactive marker along the bowel, the intercept and geo...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137991
更新日期:1984-01-01 00:00:00
abstract::Maternal smoking during pregnancy causes reduction of fetal breathing movements, an effect attributed to nicotine in fetal blood. Nicotine is metabolized to cotinine which has a long plasma half-life and exhibits slow clearance across membrane barriers. It is also known to activate placental phospholipase-A2-like enzy...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028231
更新日期:1998-08-01 00:00:00
abstract::In a three-phase study, single oral doses of placebo, followed in 1 week by pyrazinoylguanidine (PZG; 900 mg), followed in 3 weeks by pyrazinoic acid (PZA; 300 mg) were given to 8 normal male subjects. Blood analyses performed 0, 2 and 4 h after administration of placebo or drug revealed that compared to mean 0 h valu...
journal_title:Pharmacology
pub_type: 临床试验,杂志文章
doi:10.1159/000028276
更新日期:1999-03-01 00:00:00
abstract::Increased concentrations of immunoreactive methionine-enkephalin but not leucine-enkephalin were measured in fractions of cerebrospinal fluid perfusate collected from ventricular-cisternally perfused, urethane-anesthetized rats exposed to a mixture of 75% nitrous oxide/25% oxygen for 60 min. These findings suggest tha...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138056
更新日期:1985-01-01 00:00:00
abstract::Honokiol and magnolol have been identified as modulators of the GABAA receptors in vitro. Our previous study suggested a possible selectivity of honokiol and magnolol on GABAA receptor subtypes. This possibility was examined in the current study by 3H-muscimol and 3H-flunitrazepam binding assays on various rat brain m...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056110
更新日期:2001-07-01 00:00:00
abstract::The temporal effects of vitamin A deficiency on hepatic cytochrome P-450-dependent and conjugation reactions were studied in the rat. Cytochrome P-450 levels and N-methyl-p-chloroaniline N-demethylase activity were significantly reduced in the deficient animals. No other changes in parameters dependent on cytochrome P...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137457
更新日期:1980-01-01 00:00:00
abstract::In the isolated guinea pig vas deferens, 10(-4) M cocaine shifts to the left (13.5-fold at the EC50 level) the concentration-effect curve and increases the maximum response to noradrenaline, whilst supersensitivity to phenylephrine, an amine with a low affinity for the neuronal uptake, was smaller (4.1-fold) and the m...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136722
更新日期:1977-01-01 00:00:00
abstract::The signaling of seven transmembrane receptors/G-protein- coupled receptors (GPCRs) is regulated by a number of receptor interacting proteins, including βarrestins (βarrs) and GPCR kinases (GRKs). In the present report, we have analyzed the interaction pattern between the glucagon-like peptide-1 (GLP-1) receptor (GLP-...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000330742
更新日期:2011-01-01 00:00:00
abstract::In anesthetized rats intravenously infused, norepinephrine (NE) was accumulated by the heart, the spleen and the lung in a dose-related manner. With the lower dose of NE (2.5 mg/kg) the organ/blood ratios were more than unity and were generally greater than with higher doses (5 and 10 mg/kg), indicating that accumulat...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136926
更新日期:1975-01-01 00:00:00
abstract::Veratridine caused a positive inotropic action in the electrically driven left atria of rats. Quinacrine (a phospholipase A2 inhibitor), indomethacin (a cyclooxygenase inhibitor) and aspirin (a cyclooxygenase inhibitor), but not nordihydroguaiaretic acid (a lipoxygenase inhibitor), inhibited the response to veratridin...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138774
更新日期:1991-01-01 00:00:00
abstract::The isolated whole stomach of the mouse has been used to study the effect of atropine on gastic acid secretion stimulated by acetylcholine, bethanechol and histamine. Atropine inhibited acid secretory response to acetylcholine and bethanechol in a competitive manner. The following pA2 values for atropine were calculat...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137441
更新日期:1980-01-01 00:00:00
abstract::Black Swiss (BS) mice were shown to be an advantageous strain to model behavioral domains of mania, but to date only male mice were tested, whereas bipolar disorder (BPD) is equally prevalent in women and men. This study was therefore designed to examine the possibility of using both male and female BS mice in future ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000381785
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carvedilol is used clinically as a β-adrenoceptor antagonist for the treatment of chronic heart failure and is primarily metabolized into glucuronides by UDP-glucuronosyltransferase (UGT). In this study, the stereoselective glucuronidation of carvedilol by the human liver and intestinal microsome...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000340020
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:Macitentan is a novel dual endothelin receptor antagonist with sustained receptor binding in clinical development for pulmonary arterial hypertension. The present study compared the pharmacokinetics and safety of macitentan in healthy Caucasian and Japanese subjects and explored the potential sex differ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000351704
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To investigate the efficacy, safety, and clinical benefit of prolonged-release trazodone (Trittico) in the treatment of major depressive disorder (MDD). METHODS:In this study, 363 Chinese patients with MDD were randomized 1:1 to receive either prolonged-release trazodone (150-450 mg) or placebo treatment for...
journal_title:Pharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000368559
更新日期:2014-01-01 00:00:00
abstract::We examined the effects of cannabinoid receptor agonists on (45)Ca(2+) uptake in rat brain synaptosomes. A cannabinoid receptor agonist, (R)-(+)-[2,3-dihydro-5-methyl-3-[(4-merpholino)methyl]pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl](1-naphthyl)methanone (WIN 55212-2) dose-dependently inhibited (45)Ca(2+) uptake in rat s...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000091228
更新日期:2006-01-01 00:00:00
abstract::The insulinogenic response to a standard i.v. dose of a sulfonylurea can be markedly augmented in normal, conscious dogs if they are given 30 min earlier a single i.v. dose of dihydroergotamine (DHE). Since the parent substance ergotamine posssed no such amplifying properties, further experiments were conducted to cla...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136697
更新日期:1977-01-01 00:00:00