Does nitrous oxide induce release of brain opioid peptides?

abstract：:The insulinogenic response to a standard i.v. dose of a sulfonylurea can be markedly augmented in normal, conscious dogs if they are given 30 min earlier a single i.v. dose of dihydroergotamine (DHE). Since the parent substance ergotamine posssed no such amplifying properties, further experiments were conducted to cla...

journal_title：Pharmacology

authors： Sirek A,Sirek OV,Policova Z,Kerekes A

更新日期：1977-01-01 00:00:00

abstract：:Effects of schisandrin B enantiomer ((+)Sch B and (-)Sch B) treatment on the reduced cellular glutathione (GSH) level and susceptibility to menadione-induced toxicity were investigated and compared in AML12 hepatocytes. (+)Sch B or (-)Sch B treatment at 6.25 micromol/l produced a time-dependent change in cellular GSH ...

journal_title：Pharmacology

authors： Chiu PY,Leung HY,Poon MK,Mak DH,Ko KM

更新日期：2006-01-01 00:00:00

abstract：:The in vitro addition of (-)-delta9-tetrahydrocannabinol (delta9-THC) resulted in a dose-responsive inhibition of the high-affinity specific synaptosomal uptake of both 3H-tryptophan and 3H-choline in mouse forebrain crude synaptosomal preparations. The approximate concentrations of delta9-THC required to cause a 50% ...

journal_title：Pharmacology

authors： Johnson KM,Dewey WL

更新日期：1978-01-01 00:00:00

abstract：:Congestive heart failure (CHF) is associated with exercise intolerance that cannot be entirely explained by hypoperfusion of the skeletal muscles. We studied the contractile properties of fast-twitch (extensor digitorum longus; EDL) and slow-twitch (soleus; SOL) skeletal muscles in doxorubicin-induced CHF in rats, and...

journal_title：Pharmacology

authors： Ertunc M,Sara Y,Korkusuz P,Onur R

更新日期：2009-01-01 00:00:00

abstract：:A comparison was made of the anti-ischemic effects of dihydropyridine calcium antagonists in isolated globally ischemic rat hearts. Pretreatment with amlodipine, nifedipine, nitredipine, or nisoldipine reduced reperfusion enzyme (lactate dehydrogenase) release and contracture after 25 min of global ischemia and 30 min...

journal_title：Pharmacology

authors： Grover GJ,Dzwonczyk S,Sleph PG

更新日期：1990-01-01 00:00:00

abstract：:Previous studies have demonstrated that calcium storage and release from IP3-dependent sites in the sarcoplasmic reticulum play an important role in the contractile response of the rabbit urinary bladder to both field stimulation (mediated via neurotransmitter release) and bethanechol (direct muscarinic stimulation). ...

journal_title：Pharmacology

authors： Levin RM,Nicholas TJ,Snitkoff GG,Mandell J,Russell D,Wilbur HJ,Mogavero LJ

更新日期：1997-12-01 00:00:00

abstract：:The observations that people infected with HIV suffer not only from an inflammatory stress but also from depleted glutathione levels have led to a general hypothesis that these two are causally related, and that treatment of AIDS should include thiol-replenishment therapy. In particular, inflammatory stimulations are ...

journal_title：Pharmacology

authors： Roederer M,Staal FJ,Ela SW,Herzenberg LA,Herzenberg LA

更新日期：1993-01-01 00:00:00

abstract：:Phencyclidine (PCP; 10 mg/kg, s.c.) produced a marked diuresis which occurred without significant changes in solute excretion. This diuresis occurred predominantly within 2 h of PCP injection, and was blocked by pretreatment with vasopressin. The maximum diuresis corresponded temporally to a significant fall in plasma...

journal_title：Pharmacology

authors： Zerbe RL,Bayorh MA,Quirion R,Kopin IJ

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Periplaneta americana is one of the ancient insect groups with the strongest vitality. Periplaneta americana extract (PAE) has been explored as an alternative remedy for many diseases. Although much progress has been made in the study about PAE, the role of the drug in renal disease is rarely reported, espec...

journal_title：Pharmacology

authors： Liu J,Zhou L,He L,Zhong Y,Zhang X,Xiao B,Liu G

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Poncirus fructus (PF), also known as the dried immature fruit of Poncirus trifoliata (L.) Raf., has long been used as a cure for the treatment of various gastrointestinal disorders in eastern Asia. Recently, it was reported that naringin, a flavonoid constituent of the PF extract, causes the acti...

journal_title：Pharmacology

authors： Jang Y,Kim TK,Shim WS

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the effects of trichostatin A (TSA) on cervical cancer and the related mechanisms. METHODS:The HeLa and Caski cervical cancer cell lines were treated with different concentrations of TSA. Cell viability was measured by MTT assays. Cell apoptosis was analysed using flo...

journal_title：Pharmacology

authors： Liu JH,Cao YM,Rong ZP,Ding J,Pan X

更新日期：2020-11-03 00:00:00

abstract：:The signaling of seven transmembrane receptors/G-protein- coupled receptors (GPCRs) is regulated by a number of receptor interacting proteins, including βarrestins (βarrs) and GPCR kinases (GRKs). In the present report, we have analyzed the interaction pattern between the glucagon-like peptide-1 (GLP-1) receptor (GLP-...

journal_title：Pharmacology

authors： Jorgensen R,Norklit Roed S,Heding A,Elling CE

更新日期：2011-01-01 00:00:00

abstract：AIM:An increase in carotid intima-media thickness (CIMT) represents an early phase of the atherosclerotic process. The aim of our study was to evaluate whether a reduction in CIMT could be seen with 1-year treatment with rosuvastatin (10 mg/day). METHODS AND RESULTS:Forty-five patients with hypercholesterolemia and as...

journal_title：Pharmacology

authors： Riccioni G,Vitulano N,Mancini B,Zanasi A,D'Orazio N

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the efficacy, tolerability, and safety of once-a day trazodone tablets (Trittico Prolong® 300 mg) in patients with moderate to severe depression in routine clinical practice. METHODS:Men and women ≥18 years old with Montgomery-Åsberg Depression Rating Scale (MADRS) scores...

journal_title：Pharmacology

authors： Češková E,Šedová M,Kellnerová R,Starobová O

更新日期：2018-01-01 00:00:00

abstract：:The aim of this study was to compare the effects of a new thromboxane synthase inhibitor, camonagrel, on platelet aggregation and platelet-subendothelium interaction under flow conditions, in comparison with a standard thromboxane synthase inhibitor (dazoxiben) and a cyclooxygenase inhibitor (acetylsalicylic acid). Wi...

journal_title：Pharmacology

authors： Villalobos MA,De La Cruz JP,Escalante R,Arrebola MM,Guerrero A,Sánchez de la Cuesta F

更新日期：2003-09-01 00:00:00

abstract：:In an experimental model of haemorrhagic shock that causes 100% mortality in rats within 30 min, the intravenous bolus injection (20 micrograms/kg) of sulfated cholecystokinin octapeptide (CCK-8) induces a prompt and sustained rise in blood pressure and pulse amplitude, all treated animals still surviving at the end o...

journal_title：Pharmacology

authors： Guarini S,Vergoni AV,Bertolini A

更新日期：1988-01-01 00:00:00

abstract：:Both in vivo and in vitro exposure to morphine have been reported to produce a number of immunomodulatory effects in both laboratory animals and humans. The current study was performed to assess the direct in vitro effect of exposure to morphine or morphine metabolites on immune response parameters. Murine B6C3F1 sple...

journal_title：Pharmacology

authors： Thomas PT,Bhargava HN,House RV

更新日期：1995-01-01 00:00:00

abstract：:We investigated the effects of calcium ions (Ca2+) on the adenylyl cyclase activity in purified turkey erythrocyte membranes. Results showed the following: (i) Ca2+ inhibits cAMP accumulation stimulated by isoproterenol (1 micromol/l), NaF + AlCl3 (10 mmol/l + 20 micromol/l) or forskolin (10 micromol/l) in EGTA-washed...

journal_title：Pharmacology

authors： Demirel E,Ugur O,Onaran HO

更新日期：1998-10-01 00:00:00

abstract：:The aim of this study was to assess whether moderate hypoxia affects the disposition of diltiazem. Six male beagle dogs received diltiazem (0.6 mg/kg) on three occasions: (1) while breathing air, i.e. during normoxia; (2) 1 h after initiating exposure to a FiO2 of 0.08, a FiCO2 of 0.035 and a FiN2 of 0.885, i.e. durin...

journal_title：Pharmacology

authors： du Souich P,Hartemann D,Saunier C

更新日期：1993-12-01 00:00:00

abstract：:The relationship between alpha(1)-adrenoceptor binding in rat tissues and pharmacodynamic effects of continuous infusion of KMD-3213 was examined. In vivo specific binding of [(3)H]KMD-3213 after continuous intravenous infusion of the ligand (100 pmol/kg/min for 10 min, followed by 30 pmol/kg/min for 60 or 90 min) dif...

journal_title：Pharmacology

authors： Akiyama K,Tatemichi S,Katayama S,Nakajima M,Oki T,Okura T,Yamada S,Kimura R

更新日期：2002-01-01 00:00:00

abstract：:We established an Ascaris-induced biphasic skin allergic reaction in mice. In the early-phase reaction (EPR), mast cell degranulation was observed, and tranilast inhibited ear edema. In mast-cell-deficient mice (WBB6F(1)-W/W(V) mice), ear edema in the EPR disappeared, whereas that in the late-phase reaction (LPR) rema...

journal_title：Pharmacology

authors： Sengoku T,Sato S,Sakuma S,Ogawa T,Ohkubo Y,Goto T

更新日期：2001-01-01 00:00:00

abstract：:In gross behavioral observation the minimum effective dose of zopiclone was intravenously 0.06-0.25 mg/kg and intragastrically 1-4 mg/kg in rhesus monkeys. Zopiclone suppressed barbital withdrawal signs of rhesus monkeys at a single dose of 16 mg/kg or more. The suppressing effect of zopiclone 32 mg/kg i.g. was compar...

journal_title：Pharmacology

authors： Yanagita T

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Angiogenesis is usually driven by inflammation. Matrix metalloproteinases MMP-3 and MMP-9 and tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 are implicated in vascular remodeling. TIMP-2 exhibits antiangiogenic properties. Statins show benefits that are additional to lipid lowering including pro- ...

journal_title：Pharmacology

authors： Siddiqui AJ,Gustafsson T,Sylven C,Crisby M

更新日期：2014-01-01 00:00:00

abstract：:The effect of morphine, fentanyl, pethidine and pentazocine was studied in gerbils against air blast-induced seizures. Major, generalized seizures were suppressed by morphine (ED50 = 4.0 mg/kg s.c.), fentanyl (ED50 = 64 micrograms/kg s.c.), and pethidine (ED50 = 2.4 mg/kg s.c.), but not by pentazocine. The anticonvuls...

journal_title：Pharmacology

authors： Frey HH

更新日期：1986-01-01 00:00:00

abstract：:Pain and mental status were assessed in a series of 35 consecutive hospitalized patients with metastatic cancer receiving narcotics for pain that was difficult to control. Forty-five episodes of mental status impairment were detected in 27 of these patients. Fifteen patients had dose-related oversedation or organic br...

journal_title：Pharmacology

authors： Leipzig RM,Goodman H,Gray G,Erle H,Reidenberg MM

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND/AIMS:Since beta-adrenoceptors have been shown to affect cardiac gap junction channels, we wanted to elucidate the possible effect of metoprolol on the gap junction protein connexin-43, using racemic RS-metoprolol or the isomer R-metoprolol (no beta-adrenoceptor blockade) or S-metoprolol (beta(1)-adrenoceptor...

journal_title：Pharmacology

authors： Salameh A,Blanke K,Dhein S,Janousek J

更新日期：2010-01-01 00:00:00

abstract：:Esculentoside A, a kind of saponin isolated from the root of the Chinese herb Phytolaca esculenta, is reported to possess potent anti-inflammatory effects in acute and chronic experimental models. In the present study, we investigated the effects of esculentoside A on the production of tumor necrosis factor (TNF), int...

journal_title：Pharmacology

authors： Ju DW,Zheng QY,Cao X,Fang J,Wang HB

更新日期：1998-04-01 00:00:00

abstract：:The effects of mitemcinal (GM-611) on the gastrointestinal contractile activity were investigated using chronically implanted force transducers in conscious dogs and were compared with the effects of porcine motilin (pMTL), EM-523 and EM-574. In the interdigestive state, intravenous and oral administration of mitemcin...

journal_title：Pharmacology

authors： Ozaki K,Yogo K,Sudo H,Onoma M,Kamei K,Akima M,Koga H,Itoh Z,Omura S,Takanashi H

更新日期：2007-01-01 00:00:00

abstract：:When rat mast cells were cultured for a short period in plastic dishes and adhering cells were permeabilized with beta-escin and exposed to Ca2+ at concentrations higher than 10(-7) mol/l, histamine release was induced dose-dependently. Protein kinase C (PKC) activity in the crude extracts obtained from adhering mast ...

journal_title：Pharmacology

authors： Izushi K,Tasaka K

更新日期：1992-01-01 00:00:00

abstract：:The isolated whole stomach of the mouse has been used to study the effect of atropine on gastic acid secretion stimulated by acetylcholine, bethanechol and histamine. Atropine inhibited acid secretory response to acetylcholine and bethanechol in a competitive manner. The following pA2 values for atropine were calculat...

journal_title：Pharmacology

authors： Szelenyi I,Vergin H

更新日期：1980-01-01 00:00:00