Abstract:
:Phencyclidine (PCP; 10 mg/kg, s.c.) produced a marked diuresis which occurred without significant changes in solute excretion. This diuresis occurred predominantly within 2 h of PCP injection, and was blocked by pretreatment with vasopressin. The maximum diuresis corresponded temporally to a significant fall in plasma vasopressin and rise in mean arterial pressure. Thus, PCP-induced diuresis is due, at least in part, to suppression of plasma vasopressin. This suppression is probably related to the rise in blood pressure, though direct effects of PCP on the neurohypophysis cannot be excluded.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Zerbe RL,Bayorh MA,Quirion R,Kopin IJdoi
10.1159/000137786subject
Has Abstractpub_date
1983-01-01 00:00:00pages
73-8issue
2eissn
0031-7012issn
1423-0313journal_volume
26pub_type
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