Abstract:
:The effect of probenecid on the plasma protein binding of methotrexate (MTX) has been examined in vitro. At concentrations greater than or equal to 5 x 10(-4) M, probenecid caused a significant reduction (greater than 30%) in the plasma binding of MTX. It is suggested that in vivo this would lead to a greater dispersion into the tissues and a larger volume of distribution, and may be partly responsible for the longer MTX elimination half-life observed with concurrent administration of probenecid.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Paxton JWdoi
10.1159/000137947subject
Has Abstractpub_date
1984-01-01 00:00:00pages
86-9issue
2eissn
0031-7012issn
1423-0313journal_volume
28pub_type
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