Abstract:
:This study tests the hypothesis that contractile responses in aortae of hypertensive rats are more dependent on gap junctional communication compared to those from normotensive rats. The experimental approach was pharmacological, using inhibitors of gap junctional activity (heptanol and octanol). Two models of experimental hypertension were characterized: (1) mineralocorticoid (DOCA)-hypertensive rats and (2) stroke-prone spontaneous hypertensive rats (SHRSP). Vessels from DOCA-hypertensive rats showed a greater relaxation to heptanol and octanol, particularly when precontracted with phenylephrine, compared to sham-operated animals. Octanol-induced relaxation in aortic segments from SHRSP did not differ from normotensive values regardless of the agonist used to cause contraction. These results suggest that in DOCA hypertension, gap junctional communication and voltage-operated calcium channels are differentially regulated, which could explain in part the changes in vascular reactivity observed in mineralocorticoid hypertension.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Leite R,Webb RCdoi
10.1159/000056069subject
Has Abstractpub_date
2001-01-01 00:00:00pages
29-35issue
1eissn
0031-7012issn
1423-0313pii
56069journal_volume
62pub_type
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