Effect of nitrofurans on duodenal ulceration induced by cysteamine or indometacin.

Abstract:

:The present experiments examined the protective effect of the nitrofuran drugs, furazolidone (FZ) and nitrofurazone (NF), on duodenal ulceration induced by cysteamine or indometacin in rats. FZ at oral doses of 25, 50 or 100 mg/kg for 2 consecutive days signficantly reduced, in a dose-dependent manner, the incidence and extent of cysteamine-induced ulceration. However, oral NF (100 mg/kg) given for 2 consecutive days had no significant effect on duodenal ulceration. The duodenal mucus content of rats was not significantly affected by either FZ or cysteamine treatments. FZ at an oral dose of 100 mg/kg for 2 consecutive days significantly reduced the incidence and extent of indometacin-induced ulceration. Smaller doses of 25 or 50 mg/kg had no significant effects.

journal_name

Pharmacology

journal_title

Pharmacology

authors

Ali BH

doi

10.1159/000138767

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

49-53

issue

1

eissn

0031-7012

issn

1423-0313

journal_volume

42

pub_type

杂志文章
  • Evidence for a mitochondrial impact of trimetazidine during cold ischemia and reperfusion.

    abstract::In organ transplantation, ischemia-reperfusion injury (IRI) has been implicated in delayed graft function (DGF) as well as in short- and long-term complications. Using an autotransplant pig kidney model, changes in renal function and morphology were determined after different periods of cold ischemia in kidneys preser...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000076259

    authors: Baumert H,Faure JP,Zhang K,Petit I,Goujon JM,Dutheil D,Favreau F,Barrière M,Tillement JP,Mauco G,Papadopoulos V,Hauet T

    更新日期:2004-05-01 00:00:00

  • Ganoderic Acid A Inhibits Bleomycin-Induced Lung Fibrosis in Mice.

    abstract:BACKGROUND:To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. METHODS:ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0. Then the mice were orally given GAA (25, 50 mg/kg) or dexamethasone (2 mg/kg). After treatment for 21 days,...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000505297

    authors: Wen G,Li T,He H,Zhou X,Zhu J

    更新日期:2020-01-01 00:00:00

  • N-tosyl-L-phenylalanyl-chloromethyl ketone eliminates the increase in caspase-3 and bcl-2 caused by brain injury in the newborn rat.

    abstract::N-Tosyl-L-phenylalanyl-chloromethyl ketone (TPCK) is neuroprotective in rat pups. We measured bcl-2, Bax and caspase-3 to determine the mechanisms. Seven-day-old rats had the right carotid artery ligated and were subjected to 2.5 h of 8% oxygen. Ten mg/kg of PTCK or vehicle was given intraperitoneally 15 min prior to ...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000063793

    authors: Feng Y,LeBlanc MH

    更新日期:2002-11-01 00:00:00

  • Naloxone pretreatment blocks the hypotensive effects of atenolol in SHR and WKY rats.

    abstract::The present study examined the interaction of opioidergic systems in the hypotensive action of atenolol. Anesthetized, adult spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats were instrumented to monitor blood pressure and heart rate. Atenolol (100 micrograms/kg, i.v.) produced a decrease in blood pressure ...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000138585

    authors: Laskey RE,Jones LF,Tackett RL

    更新日期:1989-01-01 00:00:00

  • Clinical significance of M1 receptor antagonists.

    abstract::The M1-selective antimuscarinic drugs pirenzepine and telenzepine moderately reduce gastric acid secretion without inhibiting smooth-muscle activity as much as nonselective antimuscarinics, e.g. atropine and 1-hyoscyamine. They hasten peptic ulcer healing and improve the symptoms of reflux oesophagitis. In combination...

    journal_title:Pharmacology

    pub_type: 杂志文章,评审

    doi:10.1159/000138507

    authors: Stockbrügger RW

    更新日期:1988-01-01 00:00:00

  • Effect of ergot alkaloids on sulfonylurea-stimulated insulin secretion in dogs.

    abstract::The insulinogenic response to a standard i.v. dose of a sulfonylurea can be markedly augmented in normal, conscious dogs if they are given 30 min earlier a single i.v. dose of dihydroergotamine (DHE). Since the parent substance ergotamine posssed no such amplifying properties, further experiments were conducted to cla...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000136697

    authors: Sirek A,Sirek OV,Policova Z,Kerekes A

    更新日期:1977-01-01 00:00:00

  • Effects of magnesium on human umbilical arteries: role of intracellular calcium stores.

    abstract::The purpose of this investigation on human umbilical arteries was: (1) to analyze the effects of magnesium (Mg2+) in the prevention of contractions induced by 5-hydroxytryptamine (5-HT), KCl, Bay K 8644 and BaCl2; (2) to determine whether the presence of Mg2+ could modulate the response to caffeine in Ca2+-free medium...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000028255

    authors: Tiritilli A

    更新日期:1998-12-01 00:00:00

  • Dexamethasone upregulates Nox1 expression in vascular smooth muscle cells.

    abstract:BACKGROUND/AIM:It has been demonstrated that dexamethasone-induced hypertension can be prevented by the NADPH oxidase inhibitor apocynin. The effect of dexamethasone on NADPH oxidase, however, is unknown. The present study was conducted to investigate the effect of dexamethasone on the gene expression of Nox1, the majo...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000365932

    authors: Siuda D,Tobias S,Rus A,Xia N,Förstermann U,Li H

    更新日期:2014-01-01 00:00:00

  • Studies on the mechanism of monoclonal antibody inhibition of enzyme activity of phenobarbital-induced cytochrome P-450.

    abstract::Four monoclonal antibodies (MAbs) to phenobarbital-induced cytochrome P-450 (PB-P-450) show different patterns of inhibition of PB-P-450 catalyzed aryl hydrocarbon hydroxylase (AHH), 7-ethoxycoumarin deethylase, benzphetamine demethylase and ethylmorphine demethylase. The inhibition constants vary depending on the ind...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000138677

    authors: Fujino T,West D,Park SS,Gelboin HV

    更新日期:1990-01-01 00:00:00

  • Pharmacological characterization of M-II, the major human metabolite of ramelteon.

    abstract::The duration of action of melatonin may be important for improvements in sleep efficiency in insomniacs. Ramelteon, a selective melatonin agonist, is primarily metabolized to the active metabolite M-II, which has a longer half-life and greater systemic exposure than ramelteon. Hence, M-II may contribute significantly ...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000362459

    authors: Nishiyama K,Nishikawa H,Kato K,Miyamoto M,Tsukamoto T,Hirai K

    更新日期:2014-01-01 00:00:00

  • Influence of the 2'-chloro substitution on central activity of desmethyldiazepam.

    abstract::Two diazepam derivatives, the N-desmethyl and the 2'-chlor-N-desmethyldiazepam, were compared in rats using behavioral and EEG techniques. Both drugs had depressant effects upon locomotor activity, facilitated behavior suppressed by punishment, increased the number of shocks received by rats in a Sidman avoidance proc...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000136845

    authors: Babbini M,Gaiardi M,Bartoletti M

    更新日期:1978-01-01 00:00:00

  • Antihypertensive and Renoprotective Effects of Dietary Flaxseed and its Mechanism of Action in Deoxycorticosterone Acetate-Salt Hypertensive Rats.

    abstract:BACKGROUND/AIMS:Flaxseed contains alpha-linolenic acid (ALA), lignans, and dietary fiber, and its intake lowers blood pressure in hypertensive patients. Here, we examined the effects of flaxseed powder, which includes all flaxseed components, flaxseed oil, composed mainly of ALA, flaxseed lignan, and flaxseed fiber, on...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000502789

    authors: Watanabe Y,Ohata K,Fukanoki A,Fujimoto N,Matsumoto M,Nessa N,Toba H,Kobara M,Nakata T

    更新日期:2020-01-01 00:00:00

  • Relationship between prostatic alpha(1)-adrenoceptor binding and reduction in intraurethral pressure following continuous infusion of KMD-3213 in rats.

    abstract::The relationship between alpha(1)-adrenoceptor binding in rat tissues and pharmacodynamic effects of continuous infusion of KMD-3213 was examined. In vivo specific binding of [(3)H]KMD-3213 after continuous intravenous infusion of the ligand (100 pmol/kg/min for 10 min, followed by 30 pmol/kg/min for 60 or 90 min) dif...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000056163

    authors: Akiyama K,Tatemichi S,Katayama S,Nakajima M,Oki T,Okura T,Yamada S,Kimura R

    更新日期:2002-01-01 00:00:00

  • Increased dilator response to heptanol and octanol in aorta from DOCA-salt-hypertensive rats.

    abstract::This study tests the hypothesis that contractile responses in aortae of hypertensive rats are more dependent on gap junctional communication compared to those from normotensive rats. The experimental approach was pharmacological, using inhibitors of gap junctional activity (heptanol and octanol). Two models of experim...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000056069

    authors: Leite R,Webb RC

    更新日期:2001-01-01 00:00:00

  • Effect of Angiotensin-(1-7) on Aortic Response, TNF-α, IL-1β and Receptor for Advanced Glycation Endproduct in Rat's Adjuvant-Induced Arthritis.

    abstract::Altered vascular reactivity due to endothelial dysfunction, consequent to vascular damage, is observed in rheumatoid arthritis. We investigated the effect of angiotensin (Ang)-(1-7) on vasculature changes in arthritis induced by complete Freund's adjuvant in male Wistar rats. Arthritis decreased soluble receptor for a...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000444188

    authors: Açikalin Ö,Bölükbaşi Hatip FF,Tan RF,Hatip-Al-Khatib I

    更新日期:2016-01-01 00:00:00

  • Effect of vasoactive intestinal peptide and naloxone combination on urinary N-acetyl-beta-D-glucosaminidase level and kidney histology of rats exposed to severe hemorrhage.

    abstract::Renal hypoperfusion which occurs in hemorrhagic shock creates an environment in which cellular injury and organ dysfunction can occur during the episode of shock as well as reoxygenation and reperfusion. At the same time, mast cell degranulation which is observed during hemorrhage may have an additional deleterious ef...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000139097

    authors: Akin MZ,Tunçel N,Gürer F,Kural N,Uslu S

    更新日期:1993-09-01 00:00:00

  • Tetanic Facilitation of Neuromuscular Transmission by Adenosine A2A and Muscarinic M1 Receptors is Dependent on the Uptake of Choline via High-Affinity Transporters.

    abstract:BACKGROUND/AIMS:In this study, we evaluated the functional impact of facilitatory presynaptic adenosine A2A and muscarinic M1 receptors in the recovery of neuromuscular tetanic depression caused by the blockage of high-affinity choline transporter (HChT) by hemicholinium-3 (HC-3), a condition that mimics a myasthenia-l...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000494058

    authors: Castellão-Santana LM,Yumi Abiko P,Ambiel CR,Peixoto AR,Noronha-Matos JB,Correia-de-Sá P,Alves-Do-Prado W

    更新日期:2019-01-01 00:00:00

  • Effects of adrenoceptor agonists and antagonists on cardiovascular functional parameters in rats.

    abstract::The effects of intravenous administration of adrenoceptor agonists and antagonists on electrocardiographic or blood pressure (BP) functional parameters were assessed in urethane-anesthetized rats. The responses of cardiovascular functional parameters produced by these drugs included: (1) isoproterenol decreased the du...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000138922

    authors: Young MS,Lin KW,Lin MT

    更新日期:1992-01-01 00:00:00

  • Efficacy and safety of prolonged-release trazodone in major depressive disorder: a multicenter, randomized, double-blind, flexible-dose trial.

    abstract:OBJECTIVE:To investigate the efficacy, safety, and clinical benefit of prolonged-release trazodone (Trittico) in the treatment of major depressive disorder (MDD). METHODS:In this study, 363 Chinese patients with MDD were randomized 1:1 to receive either prolonged-release trazodone (150-450 mg) or placebo treatment for...

    journal_title:Pharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1159/000368559

    authors: Zhang L,Xie WW,Li LH,Zhang HG,Wang G,Chen DC,Cao Y,Cui LJ,Zhang KR,Shi JG,Tan QR,Zheng HB,Xu XF,Cheng ZH,Zhao JP

    更新日期:2014-01-01 00:00:00

  • Selective suppression of glutathione S-transferase activities in rat primary hepatocytes by growth hormone.

    abstract::Glutathione S-transferases (GSTs) detoxify diverse electrophilic chemicals, including anticancer drugs. Containing at least 100 microM total GST, the adult rat liver has abundant alpha and mu class GST isoenzymes. We utilized primary cultured rat hepatocytes, maintained in chemically defined medium, to examine direct ...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000139312

    authors: Grgurevich S,Greene FE

    更新日期:1995-06-01 00:00:00

  • Increased nitric oxide accounts for decreased basal vascular tone and responsiveness in the resistance vessels of high-cholesterol-fed rabbits.

    abstract::The objective of this study was to determine the effects of hypercholesterolemia on basal vascular tone and vascular responses to pharmacologic agents in hindquarter resistance vessels. Blood pressure and hindquarter blood flow were measured in conscious rabbits fed a high cholesterol diet (1%) for 17 weeks (HC) compa...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000056137

    authors: Fitch R,Da Cunha V,Kauser K,Dole W,Parkinson J,Vergona R,Sullivan ME,Wang YX

    更新日期:2001-01-01 00:00:00

  • In vitro effect of carvedilol on professional phagocytes.

    abstract:AIM:Superfluous reactive nitrogen and oxygen species generation is implicated in the damage of tissues at sites of inflammation where activated neutrophils and macrophages are involved. This study was conducted to investigate whether the beneficial effects of carvedilol involve modulation of respiratory burst, degranul...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000097818

    authors: Pecivová J,Macicková T,Lojek A,Gallova L,Cíz M,Nosál' R,Holománová D

    更新日期:2007-01-01 00:00:00

  • The Efficacy of Rituximab Combined with 131I for Ophthalmic Outcomes of Graves' Ophthalmopathy Patients.

    abstract:PURPOSE:The purpose of this study is to examine the effectiveness of introducing both rituximab (RTX) and 131I for active Graves' ophthalmopathy (GO) with hyperthyroidism. METHODS:In total, 217 patients suffering from active GO with hyperthyroidism were included in this research. All subjects were randomly assigned to...

    journal_title:Pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000453618

    authors: Li J,Xiao Z,Hu X,Li Y,Zhang X,Zhang S,Gong W,Zhao J,Ye X

    更新日期:2017-01-01 00:00:00

  • On the heterogeneity of mast cells.

    abstract::Mast cells from different locations are shown to vary in their histochemical, ultrastructural, cytochemical and functional properties. The clinical consequences of this heterogeneity and possible reasons for its origin are discussed. ...

    journal_title:Pharmacology

    pub_type: 杂志文章,评审

    doi:10.1159/000138153

    authors: Pearce FL

    更新日期:1986-01-01 00:00:00

  • Effects of HNS-32, a novel antiarrhythmic agent, on guinea-pig myocardium.

    abstract::The electrophysiological and mechanical effects of HNS-32, a novel azulene-1-carboxamidine derivative with antiarrhythmic activity, were studied in isolated guinea-pig myocardial preparations. HNS-32 (10(-6)-10(-4) mol/l) concentration-dependently decreased the maximum rate of rise (V(max)) of action potential in isol...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000056148

    authors: Noguchi K,Kase J,Saitoh M,Masumiya H,Saitoh M,Nakazawa T,Tanaka Y,Tanaka H,Hashimoto K,Shigenobu K

    更新日期:2002-01-01 00:00:00

  • Protective effect of amlodipine on rat bone tissue after orchidectomy.

    abstract:AIM:Our study aimed to investigate the effect of amlodipine on bone metabolism in orchidectomized rats. METHODS:Eight-week-old rats were divided into three groups. The sham-operated control group (SHAM) and the control group after orchidectomy (ORX) received the standard laboratory diet (SLD). The experimental group a...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000335491

    authors: Gradosova I,Zivna H,Palicka V,Hubena S,Svejkovska K,Zivny P

    更新日期:2012-01-01 00:00:00

  • Nonmutagenic action of cannabinoids in vitro.

    abstract::Under the specific conditions reported for the separate tests delta9-tetrahydrocannabinol (THC) did not elicit a mutagenic response in microbial and eukaryotic in vitro test systems. THC treatment to histidine auxotrophs of Salmonella typhimurium strains TA 98 (susceptible to frame shift mutation) and TA 100 (suscepti...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000136789

    authors: Zimmerman AM,Stich H,San R

    更新日期:1978-01-01 00:00:00

  • Superoxide anion stress attenuates the contractile response of the Guinea pig vas deferens to ATP and diadenosine tetraphosphate. Possible effect on calcium dysregulation.

    abstract::Induction of endogenous superoxide anion stress by the use of the superoxide dismutase inhibitor diethylthiocarbamate (DETCA; 10 mmol/l) produced a potent inhibition of the ATP (0.3-10 mmol/l) and diadenosine tetraphosphate (AP(4)A) contractile activity in the isolated vas deferens by 29-92 and 24-90%, respectively. P...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000148260

    authors: Al-Rawi MB,Aleisa AM,Khattab MM

    更新日期:2008-01-01 00:00:00

  • Effects of papaverine on twitches in mouse diaphragm.

    abstract::This study examined the inhibitory effects of papaverine on twitches directly elicited by electrical stimulation of the mouse diaphragm. Papaverine (3-100 μM) inhibited twitches in a dose-dependent manner. Papaverine increased the cyclic adenosine monophosphate (cAMP) but not cyclic guanosine monophosphate (cGMP) cont...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000320769

    authors: Kaneda T,Hayasaka R,Nagai Y,Tajima T,Urakawa N,Nakajyo S,Shimizu K

    更新日期:2010-01-01 00:00:00

  • Effect of carvedilol on renal hemodynamics and renal excretory function in spontaneously hypertensive rats.

    abstract::The effects of the novel antihypertensive agent, carvedilol, on renal hemodynamics and excretory function have been investigated and compared with the effects of labetalol in conscious, spontaneously hypertensive rats. Sustained intravenous infusion of carvedilol or labetalol at a rate of 10 micrograms/kg/min resulted...

    journal_title:Pharmacology

    pub_type: 杂志文章

    doi:10.1159/000138719

    authors: Gellai M,DeWolf R,Ruffolo RR Jr

    更新日期:1990-01-01 00:00:00