Abstract:
:The affinity of amitriptyline for muscarine M1 receptors was studied in the rat cerebral cortex and rabbit vas deferens utilizing binding studies as well as inhibition of carbachol-induced phosphoinositide hydrolysis in the cerebral cortex and blockade of the muscarinic prejunctional inhibition of sympathetic nerve stimulation in the rabbit vas deferens. The inhibition constants (KI) or dissociation constants (KB) obtained were approximately 6- to 20-fold lower than those obtained at muscarine M2 receptors in rat atria (binding and negative inotropic response) indicating that amitriptyline exhibits a degree of muscarine M1 receptor selectivity.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Choi A,Mitchelson Fdoi
10.1159/000139192subject
Has Abstractpub_date
1994-05-01 00:00:00pages
293-300issue
5eissn
0031-7012issn
1423-0313journal_volume
48pub_type
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