Harmine action in rats with lymphostatic encephalopathy.

abstract：:Based on their anabolic properties in skeletal muscles, beta-adrenergic agonists are of interest as potential countermeasures to microgravity-induced skeletal muscle atrophy. The levels of clenbuterol (Cb), a beta(2)-adrenergic agonist, in both plasma and skeletal muscle were higher in hindlimb-suspended rats than in ...

journal_title：Pharmacology

authors： von Deutsch DA,Abukhalaf IK,Wineski LE,Roper RR,Aboul-Enein HY,Paulsen DF,Potter DE

更新日期：2002-05-01 00:00:00

abstract：:We studied the anti-inflammatory activity of meloxicam on rat carrageenin-induced pleurisy and its toxicity for rat gastric mucosa, relative to its in vitro inhibitory potency against partially purified cyclooxygenase (COX)-1 and COX-2 preparations in order to clarify the pharmacological profile of the compound as an ...

journal_title：Pharmacology

authors： Ogino K,Hatanaka K,Kawamura M,Katori M,Harada Y

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND/AIMS:morphine is known to inhibit cholinergic contractions of the guinea pig small intestine. This has been compared to the human small intestinal innervated longitudinal muscle in the current study. METHODS:cholinergic primary contractions of human small intestinal longitudinal strips were evoked by electr...

journal_title：Pharmacology

authors： Benko R,Molnár Z,Nemes D,Dékány A,Kelemen D,Illényi L,Cseke L,Papp A,Varga G,Bartho L

更新日期：2010-01-01 00:00:00

abstract：:A controlled, double-blind study was made of the efficacy and safety of a new hypnotic, zopiclone, on the preoperative night's sleep by a Joint Study Unit Group of the anesthesiology departments in 6 national hospitals. The following results were found: (1) zopiclone 7.5 and 10 mg and nitrazepam 10 mg were significant...

journal_title：Pharmacology

authors： Momose T

更新日期：1983-01-01 00:00:00

abstract：:This study examined the inhibitory effects of papaverine on twitches directly elicited by electrical stimulation of the mouse diaphragm. Papaverine (3-100 μM) inhibited twitches in a dose-dependent manner. Papaverine increased the cyclic adenosine monophosphate (cAMP) but not cyclic guanosine monophosphate (cGMP) cont...

journal_title：Pharmacology

authors： Kaneda T,Hayasaka R,Nagai Y,Tajima T,Urakawa N,Nakajyo S,Shimizu K

更新日期：2010-01-01 00:00:00

abstract：:The cardiovascular effects of SKP-450, a newly synthesized potassium channel activator, and its two major metabolites SKP-818 and SKP-310 were evaluated on isolated rat aorta and in freely moving rats and anesthetized beagle dogs. The rank order of potency in relaxing rat aorta precontracted with norepinephrine was SK...

journal_title：Pharmacology

authors： Shin HS,Seo HW,Yoo SE,Lee BH

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND/AIMS:Macitentan is a novel dual endothelin receptor antagonist with sustained receptor binding in clinical development for pulmonary arterial hypertension. The present study compared the pharmacokinetics and safety of macitentan in healthy Caucasian and Japanese subjects and explored the potential sex differ...

journal_title：Pharmacology

authors： Bruderer S,Marjason J,Sidharta PN,Dingemanse J

更新日期：2013-01-01 00:00:00

abstract：:Previously published data from this laboratory on the urinary excretion of 3-hydroxymethyl antipyrine (one of the major metabolites of antipyrine in man) have to be reconsidered, because of use of an impure reference substance in the high-pressure liquid chromatographic assay method. Comparison with newly synthesized,...

journal_title：Pharmacology

authors： Danhof M,Teunissen MW,Breimer DD

更新日期：1982-01-01 00:00:00

abstract：:The effects of some ergot derivatives on the electroencephalogram and behavior of laboratory animals (mice, rats, rabbits) have been surveyed. The interference of bromocriptine on the dopaminergic central systems has been studied using behavioral (interference with the effects induced by L-dopa, 5HT, TRF or neurolepti...

journal_title：Pharmacology

authors： Longo VG,Loizzo A

更新日期：1978-01-01 00:00:00

abstract：:The vascular relaxant effect of salbutamol and its dependence on the endothelium were studied in the isolated dog coronary artery, precontracted with prostaglandin F2 alpha. Salbutamol induced a concentration-dependent relaxation which was partially inhibited by removal of endothelial cells. Atenolol 10(-6) mol/l, a b...

journal_title：Pharmacology

authors： Bernard F,Jouquey S,Hamon G

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To study the myocardial benefit effect and mechanism of paeoniflorin on myocardial ischemia reperfusion injury (MIRI) in rats. METHODS:Hundred SD rats were randomly divided into 5 groups: sham group, model group, Paeoniflorin (15 mg/kg) group, Paeoniflorin (30 mg/kg) group, and Paeoniflorin (60 mg/kg) group....

journal_title：Pharmacology

authors： Wu F,Ye B,Wu X,Lin X,Li Y,Wu Y,Tong L

更新日期：2020-01-01 00:00:00

abstract：:Increased concentrations of immunoreactive methionine-enkephalin but not leucine-enkephalin were measured in fractions of cerebrospinal fluid perfusate collected from ventricular-cisternally perfused, urethane-anesthetized rats exposed to a mixture of 75% nitrous oxide/25% oxygen for 60 min. These findings suggest tha...

journal_title：Pharmacology

authors： Quock RM,Kouchich FJ,Tseng LF

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the efficacy, tolerability, and safety of once-a day trazodone tablets (Trittico Prolong® 300 mg) in patients with moderate to severe depression in routine clinical practice. METHODS:Men and women ≥18 years old with Montgomery-Åsberg Depression Rating Scale (MADRS) scores...

journal_title：Pharmacology

authors： Češková E,Šedová M,Kellnerová R,Starobová O

更新日期：2018-01-01 00:00:00

abstract：:The effects of alpha-tocopherol, ascorbic acid and rutin on peroxidative processes were studied in xanthine-xanthine oxidase system, linoleic acid ufasomes and human erythrocyte membranes. In these three systems, tested compounds scavenge superoxide anion radicals or inhibit lipid peroxidation in a concentration-depen...

journal_title：Pharmacology

authors： Nègre-Salvayre A,Affany A,Hariton C,Salvayre R

更新日期：1991-01-01 00:00:00

abstract：:Several compounds with the backbone of 1,4-naphthoquinone chemical structure have been reported to display antiplatelet and antithrombotic activities, indicating that this congener compound may be a new source in the antithrombotic drug development. In the present study, the possible antiplatelet activity and antithro...

journal_title：Pharmacology

authors： Jin YR,Ryu CK,Moon CK,Cho MR,Yun YP

更新日期：2004-04-01 00:00:00

abstract：:CC chemokine receptor 4 (CCR4) is expressed on Th2 cells, found in inflamed tissues of allergic diseases, and is therefore suspected to be involved in the pathogenesis of allergic diseases by controlling Th2 cell migration into inflamed tissues. The aim of the present study was to investigate the inhibitory effect of ...

journal_title：Pharmacology

authors： Sato T,Komai M,Iwase M,Kobayashi K,Tahara H,Ohshima E,Arai H,Miki I

更新日期：2009-01-01 00:00:00

abstract：:The histamine levels in rat plasma treated with various new trypanocidal diamidines and diimidazolines were evaluated by HPLC and fluorometric detection. Equimolar doses (10 mumol/kg) of the new compounds raised the plasma histamine level to a much smaller degree than pentamidine or diminazene. ...

journal_title：Pharmacology

authors： Steinmann U,Estler CJ,Dann O

更新日期：1988-01-01 00:00:00

abstract：:Metabotropic G protein-coupled receptors have recently been recognized as targets for anesthetics and analgesics. In particular, G(q)-coupled receptors such as muscarinic M(1) receptors (M(1)R) and 5-hydroxytryptamine (5-HT) type 2A receptors have been reported to be targets for anesthetics. Much less is known, howeve...

journal_title：Pharmacology

authors： Minami K,Uezono Y,Shiraishi M,Okamoto T,Ogata J,Horishita T,Taniyama K,Shigematsu A

更新日期：2004-11-01 00:00:00

abstract：:Serum protein binding and serum levels of antipyrine, phenytoin and phenylbutazone were measured in rabbits with acute renal failure induced by uranyl nitrate. The kinetics of antipyrine are not altered in the uraemic rabbit. Serum protein binding of phenytoin and phenylbutazone is decreased and the volume of distribu...

journal_title：Pharmacology

authors： Van Peer A,Belpaire F,Bogaert M

更新日期：1978-01-01 00:00:00

abstract：:We examined the effects of cannabinoid receptor agonists on (45)Ca(2+) uptake in rat brain synaptosomes. A cannabinoid receptor agonist, (R)-(+)-[2,3-dihydro-5-methyl-3-[(4-merpholino)methyl]pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl](1-naphthyl)methanone (WIN 55212-2) dose-dependently inhibited (45)Ca(2+) uptake in rat s...

journal_title：Pharmacology

authors： Yoshihara S,Morimoto H,Ohori M,Yamada Y,Abe T,Arisaka O

更新日期：2006-01-01 00:00:00

abstract：:We investigated the effects of vinconate and pentobarbital against the alterations in spirodecanone binding in the gerbil striatum and hippocampus 5 h and 7 days after 10 min of cerebral ischemia, using receptor autoradiography. Vinconate and pentobarbital were given intraperitoneally 10 and 30 min prior to ischemic i...

journal_title：Pharmacology

authors： Murakami F,Araki T,Kanai Y,Kato H,Fujiwara T,Kogure K

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this study was to evaluate the effect and mechanisms of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on immune responses in murine colitis. METHODS:Mice with dextran sulfate sodium (DSS)-induced colitis were injected intraperitoneally with hUC-MSCs or human bone marrow-deri...

journal_title：Pharmacology

authors： Li L,Liu S,Xu Y,Zhang A,Jiang J,Tan W,Xing J,Feng G,Liu H,Huo F,Tang Q,Gu Z

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIM:Perception of risk of adverse drug events (ADEs) is different between health and nonhealth professionals, but these differences have not been investigated sufficiently in the general population. Women are more affected by ADEs. With the aim to investigate ADE risk perception in a sample of nonhealth prof...

journal_title：Pharmacology

authors： Salvo F,Miroddi M,Alibrandi A,Calapai F,Cafeo V,Mancari F,Gangemi S,Caputi AP,Calapai G

更新日期：2013-01-01 00:00:00

abstract：:The present study was aimed at investigating the effects of diabetes on the cavernosal smooth muscle relaxations mediated by adenosine and adenosine triphosphate (ATP) in tissues obtained from men and rats. Adenosine- and ATP-induced relaxant responses showed an enhanced sensitivity with an unaltered effectiveness in ...

journal_title：Pharmacology

authors： Gür S,Oztürk B

更新日期：2000-02-01 00:00:00

abstract：:As a major Ca(2+) source for muscle contraction, the sarcoplasmic reticulum (SR) of skeletal muscle maintains its Ca(2+) content by uptake of myoplasmic Ca(2+) and by replenishment with extracellular Ca(2+). Since transection of motor nerve alters the functions of SR Ca(2+) pump and sarcolemma ion channels, this study...

journal_title：Pharmacology

authors： Hong SJ,Liang HC,Shen CJ

更新日期：2005-03-01 00:00:00

abstract：:We investigated a possible alteration in the ability of leukocytes to produce reactive oxygen species by stobadine, a pyridoindole antioxidant, in streptozotocin-diabetic rats. The production of free radicals from whole blood was assessed by luminol-enhanced chemiluminescence after stimulation by phorbol myristate ace...

journal_title：Pharmacology

authors： Demiryürek AT,Karasu C,Stefek M,Stolc S

更新日期：2004-01-01 00:00:00

abstract：:To investigate the effects of beraprost sodium on the proliferation and oxidative stress of glomerular mesangial cells under high glucose conditions, a rat mesangial cell line (rat mesangial cells; RMCs) was treated with beraprost sodium in the presence of high glucose concentrations. Proliferation rates of mesangial ...

journal_title：Pharmacology

authors： Zhang LY,Zou JJ,Liu ZM

更新日期：2011-01-01 00:00:00

abstract：:This study examined effects of intracerebroventricularly (i.c.v.) administered somatostatin (SRIH-14 and SRIH-28) on growth and function of pituitary somatotropes (GH cells) and lactotropes (PRL cells). Male rats received three i.c.v. injections (1 microgram/5 microliters) of SRIH-14 or SRIH-28 every second day. Blood...

journal_title：Pharmacology

authors： Milosević V,Brkić B,Velkovski SD,Sekulić M,Lovren M,Starcević V,Severs WB

更新日期：1998-07-01 00:00:00

abstract：:Artemether, highly effective in multi-drug-resistant malaria is not routinely available for use in pregnancy due to the lack of adequate research data in animals and man. This study was therefore aimed at investigating some pregnancy-related effects of artemether. Artemether (1.5, 7.5 and 15 mg/kg i.p. daily for 7 day...

journal_title：Pharmacology

authors： Ejiofor JI,Kwanashie HO,Anuka JA

更新日期：2006-01-01 00:00:00

abstract：:Bilateral stopping of plantar perspiration in the mouse was obtained by application of a cotton-wool swab soaked in a 3% solution of BRL 556 in 60% ethanol for 1--2 min to the plantar surface of its right hind paw. For humans, aerosols which are at present on the market produce a sensible reduction in palmar sweating....

journal_title：Pharmacology

authors： Sivadjian J

更新日期：1978-01-01 00:00:00