Combination of Sitagliptin and Insulin against Type 2 Diabetes Mellitus with Neuropathy in Rats: Neuroprotection and Role of Oxidative and Inflammation Stress.

abstract：:The effects of sennosides on uterine motility were evaluated by electromyography in healthy adult ewes between day 70 and 120 of pregnancy to assess possible disturbances of the physiological pattern of contractility and eventual risks in pregnancy maintenance. At this stage of pregnancy, the ovine genital tract prese...

journal_title：Pharmacology

authors： Garcia-Villar R

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Angiogenesis is usually driven by inflammation. Matrix metalloproteinases MMP-3 and MMP-9 and tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 are implicated in vascular remodeling. TIMP-2 exhibits antiangiogenic properties. Statins show benefits that are additional to lipid lowering including pro- ...

journal_title：Pharmacology

authors： Siddiqui AJ,Gustafsson T,Sylven C,Crisby M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Serotonin (5-hydroxytryptamine, 5-HT)-induced contraction and the involvement of RhoA/Rho-kinase pathway in the 5-HT-induced contraction was investigated isometrically in vitro in both diabetic and nondiabetic human corpus cavernosum (HCC) tissues. METHODS:HCC tissues were obtained from 12 patients. Th...

journal_title：Pharmacology

authors： Murat N,Soner BC,Demir O,Esen A,Gidener S

更新日期：2009-01-01 00:00:00

abstract：:The effects of hypothermia (4 degrees C) on the components of the cholinergic system of the ileal longitudinal muscle and the adherent Auerbach's plexus of the guinea pig ileum have been investigated. Acetylcholine (ACh) content of the muscle was determined by pyrolysis-gas chromatography. It decreased from 119 to a f...

journal_title：Pharmacology

authors： Ochillo R,Rowell PP,Sastry BV

更新日期：1978-01-01 00:00:00

abstract：:Effects of bepridil on the low voltage-activated T-type Ca2+ channel (CaV3.2) current stably expressed in human embryonic kidney (HEK)-293 cells were examined using patch-clamp techniques. Bepridil potently inhibited ICa,T with a markedly voltage-dependent manner; the IC50 of bepridil was 0.4 micromol/l at the holding...

journal_title：Pharmacology

authors： Uchino T,Lee TS,Kaku T,Yamashita N,Noguchi T,Ono K

更新日期：2005-07-01 00:00:00

abstract：:The haemodynamic changes during epidural anaesthesia and following the administration of dihydroergotamine (DHE; 10 micrograms/kg i.v.) were studied in 7 dogs (epidural group). Epidural anaesthesia was associated with reductions in mean arterial, mean pulmonary arterial and mean right atrial pressures. Femoral flow wa...

journal_title：Pharmacology

authors： Zimpfer M,Schwarz M,Stanek B,Raberger G

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Historical evidence has verified the multifaceted antiviral efficacy of polyoxometalates (PMs). METHODS:We carried out a study to investigate the antimicrobial effects of each of the 5 substances comprising virus block (VB): 3 PMs that have antibacterial and antiviral activity, an antibiotic agent, and an a...

journal_title：Pharmacology

authors： Dan K,Katoh N,Matsuoka T,Fujinami K

更新日期：2019-06-06 00:00:00

abstract：:Cimetidine infused intravenously into 6 healthy volunteers did not induce significant changes in plasma levels of prolactin (hPRL), thyreotropin (hTSH), gonadotropin (hLH and hFSH) and growth hormone (hGH). Conversely it caused a significant increase in prolactin response to TRH without modifying the hTSH response to ...

journal_title：Pharmacology

authors： Scarpignato C,Valenti G,Ceda GP,Bertaccini G

更新日期：1979-01-01 00:00:00

abstract：:Three synthetic peptides, urotensin I, sauvagine and ovine CRF, have less than 50% sequence homology. In the dog, all three produce selective mesenteric dilation, which appears to be solely responsible for a decrease in peripheral resistance and systemic arterial blood pressure. Urotensin I and sauvagine were found to...

journal_title：Pharmacology

authors： MacCannell KL,Lederis K,Hamilton PL,Rivier J

更新日期：1982-01-01 00:00:00

abstract：:Hepatic lipid accumulation and apoptosis is elevated in patients with non-alcoholic steatohepatitis and is closely associated with severity. Saturated fatty acid palmitate stimulates lipid accumulation and apoptosis in hepatocytes. In the present study, we examined bee-bee tree oil (BO)-mediated protective effects on ...

journal_title：Pharmacology

authors： Jung TW,Kim SY,Kim DS,Shin EC,Park YB,Lee KT

更新日期：2018-01-01 00:00:00

abstract：:Nitric oxide has been shown to decrease myocardial contractility and O2 consumption. This study was designed to evaluate the hypothesis that nitric oxide-mediated increases in cyclic GMP require elevated cyclic AMP to produce cardiac depression. Using isolated, Langendorff-perfused rat hearts, we determined the effect...

journal_title：Pharmacology

authors： Weiss HR,Sadoff JD,Scholz PM,Klabunde RE

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND/AIM:The effect of isocaloric diets and sibutramine on dietary behaviour and TNF-alpha is poorly understood. The aim of the study was to investigate the effects of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-alpha in free-feeding rats. METHODS:Three groups of male Wista...

journal_title：Pharmacology

authors： Trapali M,Liapi C,Perelas A,Perrea D,Stroubini T,Dontas I,Couvari E,Mavri M,Galanopoulou P

更新日期：2008-01-01 00:00:00

abstract：:The signaling of seven transmembrane receptors/G-protein- coupled receptors (GPCRs) is regulated by a number of receptor interacting proteins, including βarrestins (βarrs) and GPCR kinases (GRKs). In the present report, we have analyzed the interaction pattern between the glucagon-like peptide-1 (GLP-1) receptor (GLP-...

journal_title：Pharmacology

authors： Jorgensen R,Norklit Roed S,Heding A,Elling CE

更新日期：2011-01-01 00:00:00

abstract：:There are reports regarding harmful effect of long-term use of beta2-agonist drugs on asthma severity and airway responsiveness. In the present study, the responses of guinea pig trachea with intact and denuded epithelium (groups 1 and 2, n = 10) to methacholine as EC50 were measured in tissues nonincubated or incubat...

journal_title：Pharmacology

authors： Boskabady MH,Aslani MR,Tabatabaei A

更新日期：2006-01-01 00:00:00

abstract：:The histamine levels in rat plasma treated with various new trypanocidal diamidines and diimidazolines were evaluated by HPLC and fluorometric detection. Equimolar doses (10 mumol/kg) of the new compounds raised the plasma histamine level to a much smaller degree than pentamidine or diminazene. ...

journal_title：Pharmacology

authors： Steinmann U,Estler CJ,Dann O

更新日期：1988-01-01 00:00:00

abstract：:The present study was designed to investigate the involvement of the nitric oxide (NO)/cyclic guanylate monophosphate pathway in pilocarpine-induced seizures in mice. Male Swiss mice (26-32 g) were used as the in vivo model. The following pharmacological tools were utilized: the non-selective NO synthase (NOS) inhibit...

journal_title：Pharmacology

authors： Vasconcelos Rios ER,Moura Rocha NF,Rodrigues Carvalho AM,Freire Vasconcelos L,Leite Dias M,de Carvalho Lima CN,Soares Lopes K,Cavalcante Melo FH,de França Fonteles MM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIMS:morphine is known to inhibit cholinergic contractions of the guinea pig small intestine. This has been compared to the human small intestinal innervated longitudinal muscle in the current study. METHODS:cholinergic primary contractions of human small intestinal longitudinal strips were evoked by electr...

journal_title：Pharmacology

authors： Benko R,Molnár Z,Nemes D,Dékány A,Kelemen D,Illényi L,Cseke L,Papp A,Varga G,Bartho L

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:The primary aim of the present investigation was to determine and compare the pharmacokinetic (PK) profiles of inorganic phosphate in serum and urine after intravenous administration of sodium glycerophosphate and inorganic sodium phosphate. Additionally, study product safety profiles were evaluated. SUBJECT...

journal_title：Pharmacology

authors： Topp H,Hochfeld O,Bark S,Grossmann M,Joukhadar C,Westphal M,Straatsma H,Rothenburger M

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the efficacy, tolerability, and safety of once-a day trazodone tablets (Trittico Prolong® 300 mg) in patients with moderate to severe depression in routine clinical practice. METHODS:Men and women ≥18 years old with Montgomery-Åsberg Depression Rating Scale (MADRS) scores...

journal_title：Pharmacology

authors： Češková E,Šedová M,Kellnerová R,Starobová O

更新日期：2018-01-01 00:00:00

abstract：:Stimulants (histamine, acetylcholine and substance P) and relaxants (isoprenaline and bradykinin) of the guinea pig trachea were tested in the absence and presence of mepacrine, eicosatetraynoic acid, BW 755C and indomethacin in order to evaluate the involvement of prostaglandins and congeners in the effects of amines...

journal_title：Pharmacology

authors： Mizrahi J,D'Orléans-Juste P,Caranikas S,Regoli D

更新日期：1982-01-01 00:00:00

abstract：:There is an ongoing debate about possible advantages of the coadministration of caffeine with cyclooxygenase (COX) inhibitors in the treatment of pain. There are results suggesting interference by caffeine with COX expression and activity in rat immune cells. In the present study, we have used, therefore, human endoto...

journal_title：Pharmacology

authors： Ulcar R,Schuligoi R,Heinemann A,Santner B,Amann R

更新日期：2003-02-01 00:00:00

abstract：:In anesthetized rats the glucose release of the kidneys was estimated from the glucose concentrations in the arterial and renal venous plasma, urinary glucose excretion and the total renal plasma flow. Net renal glucose release was found in control experiments. The glucose release of the kidneys decreased with rising ...

journal_title：Pharmacology

authors： Greven J,van Eys B,Jacobs W

更新日期：1975-01-01 00:00:00

abstract：:Verapamil-induced cardiovascular depression has been examined in dial-urethane-anesthetized open chest dogs. Verapamil was administered slowly intravenously until the mean arterial pressure was decreased by approximately 45 mm Hg. The dose of verapamil required to reach the hemodynamic endpoint was 1,495 +/- (SE) 165 ...

journal_title：Pharmacology

authors： Jolly SR,Kipnis JN,Lucchesi BR

更新日期：1987-01-01 00:00:00

abstract：:The effect of sucralfate treatment (3 g daily for 6 weeks) on gastric HCO3- secretion was investigated in 15 duodenal ulcer patients. After treatment a highly significant (p less than 0.01) increase in gastric bicarbonate output was found. It is suggested that the mode of action of sucralfate includes stimulation of g...

journal_title：Pharmacology

authors： Guslandi M

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the effects of trichostatin A (TSA) on cervical cancer and the related mechanisms. METHODS:The HeLa and Caski cervical cancer cell lines were treated with different concentrations of TSA. Cell viability was measured by MTT assays. Cell apoptosis was analysed using flo...

journal_title：Pharmacology

authors： Liu JH,Cao YM,Rong ZP,Ding J,Pan X

更新日期：2020-11-03 00:00:00

abstract：:Black Swiss (BS) mice were shown to be an advantageous strain to model behavioral domains of mania, but to date only male mice were tested, whereas bipolar disorder (BPD) is equally prevalent in women and men. This study was therefore designed to examine the possibility of using both male and female BS mice in future ...

journal_title：Pharmacology

authors： Ene HM,Kara NZ,Einat H

更新日期：2015-01-01 00:00:00

abstract：:The antagonism of carbachol-induced contractions of guinea pig gallbladder smooth muscle strips via selective antagonists, methoctramine, HHSiD, pf-HHSiD and DABDMA has been investigated in order to find out the m-cholinoceptor subtype(s) of gallbladder smooth muscle. All m-cholinoceptor antagonists examined, displace...

journal_title：Pharmacology

authors： Ozkutlu U,Alican I,Karahan F,Onat F,Yegen BC,Ulusoy NB,Oktay S

更新日期：1993-06-01 00:00:00

abstract：:Honokiol and magnolol have been identified as modulators of the GABAA receptors in vitro. Our previous study suggested a possible selectivity of honokiol and magnolol on GABAA receptor subtypes. This possibility was examined in the current study by 3H-muscimol and 3H-flunitrazepam binding assays on various rat brain m...

journal_title：Pharmacology

authors： Ai J,Wang X,Nielsen M

更新日期：2001-07-01 00:00:00

abstract：:In organ transplantation, ischemia-reperfusion injury (IRI) has been implicated in delayed graft function (DGF) as well as in short- and long-term complications. Using an autotransplant pig kidney model, changes in renal function and morphology were determined after different periods of cold ischemia in kidneys preser...

journal_title：Pharmacology

authors： Baumert H,Faure JP,Zhang K,Petit I,Goujon JM,Dutheil D,Favreau F,Barrière M,Tillement JP,Mauco G,Papadopoulos V,Hauet T

更新日期：2004-05-01 00:00:00

abstract：:Zinc acexamate (NAS-501), an anti-ulcer agent, has been reported to prevent various acute experimental gastric mucosal lesions and duodenal ulcers in rats. In order to clarify the mechanisms by which NAS-501 exhibits the anti-ulcer effects, we investigated the anti-oxidative effects of NAS-501 in vitro and in vivo. NA...

journal_title：Pharmacology

authors： Tsutsui Y,Nakamura Y,Yamaguchi S,Kawanaka N,Sato M

更新日期：1999-04-01 00:00:00