Influence of epithelium and isoprenaline incubation on responsiveness of guinea-pig trachea to methacholine.

abstract：:When rat mast cells were cultured for a short period in plastic dishes and adhering cells were permeabilized with beta-escin and exposed to Ca2+ at concentrations higher than 10(-7) mol/l, histamine release was induced dose-dependently. Protein kinase C (PKC) activity in the crude extracts obtained from adhering mast ...

journal_title：Pharmacology

authors： Izushi K,Tasaka K

更新日期：1992-01-01 00:00:00

abstract：:Human endothelial cells were cultivated on microporous membranes mimicking the luminal and basal spaces of blood vessels. When fluorescence-labeled lipid microspheres (LM) were added to the upper chambers of the model cultures, confluent monolayers of endothelial cells transported considerable levels of fluorescence t...

journal_title：Pharmacology

authors： Takahashi K,Suzuki K,Ichiki Y,Fukushima T,Nakamura H,Sawasaki Y

更新日期：1996-07-01 00:00:00

abstract：:The effect and mechanism of action of serotonin (5-HT) were studied in the pulmonary circulation of normal and diabetic rabbits. 5-HT (10, 50 and 100 nmol/l) produced a concentration-dependent increase in rabbit pulmonary arterial tension. Pulmonary arterial rings from diabetic rabbits were more responsive to 5-HT com...

journal_title：Pharmacology

authors： el-Kashef H

更新日期：1996-09-01 00:00:00

abstract：:We examined the effects of cannabinoid receptor agonists on (45)Ca(2+) uptake in rat brain synaptosomes. A cannabinoid receptor agonist, (R)-(+)-[2,3-dihydro-5-methyl-3-[(4-merpholino)methyl]pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl](1-naphthyl)methanone (WIN 55212-2) dose-dependently inhibited (45)Ca(2+) uptake in rat s...

journal_title：Pharmacology

authors： Yoshihara S,Morimoto H,Ohori M,Yamada Y,Abe T,Arisaka O

更新日期：2006-01-01 00:00:00

abstract：:We investigated the total urinary kallikrein levels, left-ventricular wall thickness and mean arterial blood pressure of nontreated and captopril-treated diabetic and nondiabetic spontaneously hypertensive rats. The mean arterial blood pressure was significantly elevated in diabetic spontaneously hypertensive rats as ...

journal_title：Pharmacology

authors： Sharma JN,Kesavarao U

更新日期：2002-04-01 00:00:00

abstract：:This study was designed to document possible changes in the binding of bupivacaine (BV), lidocaine (LC) and their main metabolites desbutylbupivacaine (PPX) and monoethylglycinexylydide (MEGX), respectively, to plasma proteins and erythrocytes in mice after acute treatment with the calcium antagonists diltiazem (DZ), ...

journal_title：Pharmacology

authors： Jacob D,Grignon S,Attolini L,Gantenbein M,Bruguerolle B

更新日期：1996-10-01 00:00:00

abstract：:In isolated perfused rat hearts with coronary occlusion and reperfusion, the effect of adenosine antagonists on the release of adenosine and its degradation products inosine, hypoxanthine, xanthine and uric acid was investigated. An antagonist with high selectivity for the A1 receptor, 8-phenyltheophylline, was applie...

journal_title：Pharmacology

authors： Bernauer W

更新日期：1996-11-01 00:00:00

abstract：:The systemic and coronary hemodynamic effects of the nitrovasodilator, pirsidomine, were compared with SIN-1, nitroprusside, and nitroglycerin. Four groups consisting of 32 experiments were performed in 17 conscious dogs chronically instrumented for measurement of aortic and left ventricular pressure, left ventricular...

journal_title：Pharmacology

authors： Arkonac BM,Kersten JR,Wynsen JC,Nijhawan N,Warltier DC

更新日期：1996-02-01 00:00:00

abstract：:Cimetidine infused intravenously into 6 healthy volunteers did not induce significant changes in plasma levels of prolactin (hPRL), thyreotropin (hTSH), gonadotropin (hLH and hFSH) and growth hormone (hGH). Conversely it caused a significant increase in prolactin response to TRH without modifying the hTSH response to ...

journal_title：Pharmacology

authors： Scarpignato C,Valenti G,Ceda GP,Bertaccini G

更新日期：1979-01-01 00:00:00

abstract：:Chronic administration of triazolam (0.25 mg/kg/day, i.p.) on days 1-8 and its withdrawal produced an anxiogenic reaction in mice as assessed in the mirrored-chamber test. Daily administration of bupropion (2 or 5 mg/kg, i.p.) prior to triazolam for 8 days prevented withdrawal-induced anxiety in mice. Triazolam withdr...

journal_title：Pharmacology

authors： Joshi D,Naidu PS,Singh A,Kulkarni SK

更新日期：2005-10-01 00:00:00

abstract：:Previous studies have indicated that structurally dissimilar serotonin2 (5HT2) antagonists can protect globally ischemic/reperfused reperfused rat hearts. We therefore determined if the 5HT2 antagonist cinanserin can protect the ischemic myocardium in two models of pacing-induced ischemia in anesthetized dogs. In one ...

journal_title：Pharmacology

authors： Grover GJ,Parham CS,Youssef S,Ogletree ML

更新日期：1995-05-01 00:00:00

abstract：:A potential cytokine-drug interaction between interleukin 6 (IL-6) and itraconazole (ITZ) was studied using human hepatocytes in primary culture. Cultures from 5 adult males (mean age 42 +/- 15 years) who had not received any medicines known to interact with CYP3A4 were studied. Cultures were exposed to ITZ 500 ng/ml,...

journal_title：Pharmacology

authors： Gubbins PO,Melchert RB,McConnell SA,Franks AM,Penzak SR,Gurley BJ

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Centhaquin is a centrally acting hypotensive drug like clonidine. Clonidine also produces analgesia and hypothermia in mice and potentiates morphine analgesia. Clonidine analgesia is blocked by idazoxan and naloxone while it is potentiated by BQ123 and sulfisoxazole. This study was conducted to determine the...

journal_title：Pharmacology

authors： Andurkar SV,Gulati A

更新日期：2011-01-01 00:00:00

abstract：:Black Swiss (BS) mice were shown to be an advantageous strain to model behavioral domains of mania, but to date only male mice were tested, whereas bipolar disorder (BPD) is equally prevalent in women and men. This study was therefore designed to examine the possibility of using both male and female BS mice in future ...

journal_title：Pharmacology

authors： Ene HM,Kara NZ,Einat H

更新日期：2015-01-01 00:00:00

abstract：:Several compounds with the backbone of 1,4-naphthoquinone chemical structure have been reported to display antiplatelet and antithrombotic activities, indicating that this congener compound may be a new source in the antithrombotic drug development. In the present study, the possible antiplatelet activity and antithro...

journal_title：Pharmacology

authors： Jin YR,Ryu CK,Moon CK,Cho MR,Yun YP

更新日期：2004-04-01 00:00:00

abstract：AIM:Our study aimed to investigate the effect of amlodipine on bone metabolism in orchidectomized rats. METHODS:Eight-week-old rats were divided into three groups. The sham-operated control group (SHAM) and the control group after orchidectomy (ORX) received the standard laboratory diet (SLD). The experimental group a...

journal_title：Pharmacology

authors： Gradosova I,Zivna H,Palicka V,Hubena S,Svejkovska K,Zivny P

更新日期：2012-01-01 00:00:00

abstract：:Amphetamine is a sympathomimetic and psychotropic drug which is extensively metabolized in liver and in brain. One of its major metabolites, p-hydroxyamphetamine, is accumulated by cortical and striatal synaptosomes. In order to learn whether p-hydroxyamphetamine can be further metabolized to a catecholamine, a sensit...

journal_title：Pharmacology

authors： Hoffman AR,Sastry BV,Axelrod J

更新日期：1979-01-01 00:00:00

abstract：:The present study was designed to investigate the involvement of the nitric oxide (NO)/cyclic guanylate monophosphate pathway in pilocarpine-induced seizures in mice. Male Swiss mice (26-32 g) were used as the in vivo model. The following pharmacological tools were utilized: the non-selective NO synthase (NOS) inhibit...

journal_title：Pharmacology

authors： Vasconcelos Rios ER,Moura Rocha NF,Rodrigues Carvalho AM,Freire Vasconcelos L,Leite Dias M,de Carvalho Lima CN,Soares Lopes K,Cavalcante Melo FH,de França Fonteles MM

更新日期：2013-01-01 00:00:00

abstract：:The antihypertensive effect of chronic administration of L-tyrosine (Tyr) was investigated in a two-part study. In the first experiment, adult male Sprague-Dawley rats were assigned to 1 of 4 treatment groups: control diet plus unilateral nephrectomy (Nphx) and 0.15 M NaCl (Sal) as the sole drinking solution (C-CTRL);...

journal_title：Pharmacology

authors： Henley WN,Fregly MJ,Wilson KM,Hathaway S

更新日期：1986-01-01 00:00:00

abstract：:The depression of evoked cortical potentials caused by brief periods of cerebral ischemia is attenuated by prior intracarotid injection of cytidoline (2, 4 or 8 mg/kg). Studies performed in hypercapnic cats suggest that the protection afforded by cytidoline is of metabolic rather than hemodynamic origin. The participa...

journal_title：Pharmacology

authors： Boismare F,Le Poncin M,Lefrançois J,Lecordier JC

更新日期：1978-01-01 00:00:00

abstract：:The effects of sammarium (Sm3+) on drug responsiveness of the isolated guinea pig ileum were studied. The lanthanid at the concentration of 2x10(-4) M reduced responsiveness to acetylcholine, histamine and submaximal concentrations of potassium. The maximum response to potassium and the responsiveness to barium remain...

journal_title：Pharmacology

authors： Turrin MA,De Moraes S

更新日期：1977-01-01 00:00:00

abstract：:The effect of promethazine on the metabolic responsiveness of human polymorphonuclear leukocytes to opsonized zymosan was evaluated by chemiluminescence (CL) assay under the following situations: (1) preincubation of granulocytes with promethazine; (2) simultaneous addition of zymosan and promethazine, and (3) additio...

journal_title：Pharmacology

authors： Trush MA,Van Dyke K

更新日期：1978-01-01 00:00:00

abstract：AIMS:The present study evaluated the effects of sitagliptin-insulin against type 2 diabetes mellitus with neuropathy in rats and possible neuroprotective mechanisms. METHODS:Diabetes was induced in 32 adult male albino rats by 6-week high-fat high-sugar diet followed by streptozotocin 30 mg/kg intraperitoneal injectio...

journal_title：Pharmacology

authors： Kelany ME,Hakami TM,Omar AH,Abdallah MA

更新日期：2016-01-01 00:00:00

abstract：:Elastase, a serine proteinase released by activated human neutrophils, can degrade a wide variety of biomacromolecules including elastin, and is considered a marker of inflammatory diseases. As the logical strategy to protect tissue is to inhibit excessive elastase activity, experimental and clinical researches have c...

journal_title：Pharmacology

authors： Braga PC,Dal Sasso M,Culici M,Bianchi T,Bordoni L,Marabini L

更新日期：2006-01-01 00:00:00

abstract：:This study examined the inhibitory effects of papaverine on twitches directly elicited by electrical stimulation of the mouse diaphragm. Papaverine (3-100 μM) inhibited twitches in a dose-dependent manner. Papaverine increased the cyclic adenosine monophosphate (cAMP) but not cyclic guanosine monophosphate (cGMP) cont...

journal_title：Pharmacology

authors： Kaneda T,Hayasaka R,Nagai Y,Tajima T,Urakawa N,Nakajyo S,Shimizu K

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stepwise propofol target-controlled infusion (TCI) can achieve a less disturbed condition of hemodynamics and respiration. Its combination with dexmedetomidine may have some advantages for patients. We studied the effects of different loading doses of dexmedetomidine on the bispectral index (BIS)...

journal_title：Pharmacology

authors： Wang T,Ge S,Xiong W,Zhou P,Cang J,Xue Z

更新日期：2013-01-01 00:00:00

abstract：:The effects of dietary taurine on lipid secretion and ketone body production were examined in the livers of Wistar and Sprague-Dawley rats fed high-cholesterol diets. The weight gain of the Sprague-Dawley rats tended to be higher than that of the Wistar rats, although food intake was comparable between the strains. Th...

journal_title：Pharmacology

authors： Yamamoto K,Yoshitama A,Sakono M,Nasu T,Murakami S,Fukuda N

更新日期：2000-01-01 00:00:00

abstract：:DL-o-, and p-octopamine were tested for beta- and alpha-adrenergic activity in rats. When compared to DL-isoproterenol, a beta-adrenergic agonist, all three isomers failed to show significant beta-adrenergic activity as assessed by intiation of thirst and by increase in tail skin temperature. All three isomers increas...

journal_title：Pharmacology

authors： Fregly MJ,Kelleher DL,Williams CM

更新日期：1979-01-01 00:00:00

abstract：:We investigated the vascular effects of glucagon-like peptide-1 (GLP-1) and Exendin-4 in type 2 diabetic rat aortae. Studies were performed in a normal control group (NC) (0.2 ml i.p. saline, n = 10), streptozotocin (STZ)/nicotinamide diabetic control group (DC) (a single dose of 80 mg/kg STZ i.p. injection 15 min aft...

journal_title：Pharmacology

authors： Ozyazgan S,Kutluata N,Afşar S,Ozdaş SB,Akkan AG

更新日期：2005-06-01 00:00:00

abstract：AIMS:This study analyzed the role of the amiloride-sensitive component and the participation of the Na(+)/H(+) exchanger in renal responsiveness to vasoconstrictors in the isolated perfused rat kidney. METHODS:The renal responses to vasoconstrictors (angiotensin II, phenylephrine, vasopressin and KCl) were studied und...

journal_title：Pharmacology

authors： Vargas P,Wangensteen R,Rodríguez-Gómez I,Perez-Abud R,Osuna A,Quesada A,Vargas F

更新日期：2011-01-01 00:00:00