Abstract:
:The depression of evoked cortical potentials caused by brief periods of cerebral ischemia is attenuated by prior intracarotid injection of cytidoline (2, 4 or 8 mg/kg). Studies performed in hypercapnic cats suggest that the protection afforded by cytidoline is of metabolic rather than hemodynamic origin. The participation of the central dopaminergic structures by the drug is suggested according to the previous data.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Boismare F,Le Poncin M,Lefrançois J,Lecordier JCdoi
10.1159/000136830subject
Has Abstractpub_date
1978-01-01 00:00:00pages
15-20issue
1eissn
0031-7012issn
1423-0313journal_volume
17pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::The effects of the calcium channel antagonist nifedipine and the protein kinase C (PKC) inhibitor, staurosporine were examined on the pressor actions of a full, cirazoline, and a partial, St587, alpha 1-adrenoceptor agonist as well as the alpha 2-adrenoceptor agonist B-HT 920 in the pithed rat preparation. Administrat...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138838
更新日期:1991-01-01 00:00:00
abstract::Glutathione S-transferases (GSTs) detoxify diverse electrophilic chemicals, including anticancer drugs. Containing at least 100 microM total GST, the adult rat liver has abundant alpha and mu class GST isoenzymes. We utilized primary cultured rat hepatocytes, maintained in chemically defined medium, to examine direct ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139312
更新日期:1995-06-01 00:00:00
abstract::The observations that people infected with HIV suffer not only from an inflammatory stress but also from depleted glutathione levels have led to a general hypothesis that these two are causally related, and that treatment of AIDS should include thiol-replenishment therapy. In particular, inflammatory stimulations are ...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000139037
更新日期:1993-01-01 00:00:00
abstract::Renal lithium clearance, tissue lithium levels, serum lithium concentration, and body temperature were determined in rats given lithium alone or combined with haloperidol (0.5-1 mg/kg). A slight increase in serum lithium concentration occurred in one of the three groups given lithium plus haloperidol. Haloperidol fail...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136708
更新日期:1977-01-01 00:00:00
abstract::Anoxia has been shown to potentiate the constrictor effects of 5-hydroxytryptamine (5HT) in isolated vascular tissue. In the present study, canine coronary arterial rings were incubated with various treatments and exposed to 5HT (4 X 10(-7) M) and anoxia (95% N2 and 5% CO2). Developed tension was increased by 250 +/- ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138211
更新日期:1986-01-01 00:00:00
abstract::Desferrioxamine (DFO) metabolism and its pharmacokinetics were studied in a swine model using high-performance liquid chromatography. DFO and three iron-binding metabolites occurred in plasma. Interindividual differences in pharmacokinetics and metabolism were observed. Urine analysis in 4 pigs showed three iron-bindi...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138730
更新日期:1990-01-01 00:00:00
abstract::The intracerebroventricular injection of the cholecystokinin-A receptor antagonist L-364,718, at the doses of 0.5, 5, 10 or 20 micrograms/mouse, while having no effect on pain threshold (hot plate, 51 degrees C), antagonized the analgesic activity of morphine (10 mg/kg i.p.). This effect was obtained with a dose of 10...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138798
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Chemotherapy-induced neuropathic pain (CINP) is a serious side effect of chemotherapy. Korean Red Ginseng (KRG) is a popular herbal medicine in Asian countries. We examined the therapeutic potential of intrathecally administered KRG for CINP and clarified the mechanisms of action with regard to 5-hydroxytryp...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000503259
更新日期:2020-01-01 00:00:00
abstract:UNLABELLED:We have reported that intermediate conductance Ca(2+)-activated K(+) channels (ImK) showed augmented expression in angiotensin II (AII) type 1 receptor-dependent manner in post-ischemic rat heart. ImK has tyrosine phosphorylation sequence in the C-terminus and motifs for NFkappaB and AP1 in the promoter. Whi...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000070455
更新日期:2003-08-01 00:00:00
abstract::The present study aims at investigating the effects of mannitol and dimethylthiourea, known hydroxyl radical scavengers, on lipid peroxidation as an indicative of oxidative damage, NF-kappa B activation and IL-8 production by Helicobacter pylori in gastric epithelial cells. A human gastric epithelial cell line, AGS, t...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028321
更新日期:1999-10-01 00:00:00
abstract::Artemether, highly effective in multi-drug-resistant malaria is not routinely available for use in pregnancy due to the lack of adequate research data in animals and man. This study was therefore aimed at investigating some pregnancy-related effects of artemether. Artemether (1.5, 7.5 and 15 mg/kg i.p. daily for 7 day...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000094521
更新日期:2006-01-01 00:00:00
abstract::The effects of alpha-tocopherol, ascorbic acid and rutin on peroxidative processes were studied in xanthine-xanthine oxidase system, linoleic acid ufasomes and human erythrocyte membranes. In these three systems, tested compounds scavenge superoxide anion radicals or inhibit lipid peroxidation in a concentration-depen...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138807
更新日期:1991-01-01 00:00:00
abstract::Nitric oxide has been shown to decrease myocardial contractility and O2 consumption. This study was designed to evaluate the hypothesis that nitric oxide-mediated increases in cyclic GMP require elevated cyclic AMP to produce cardiac depression. Using isolated, Langendorff-perfused rat hearts, we determined the effect...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139529
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND/AIMS:The knowledge of molecular mechanisms determining drug pharmacokinetics in pathological states is relevant for the development of new therapeutic approaches. This study was undertaken to evaluate the cortical renal blood flow (cRBF) and the renal protein expression of the organic anion transporters (OAT...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000110555
更新日期:2008-01-01 00:00:00
abstract::34 experienced marijuana users were divided into four equated groups of eight subjects each based on recognition memory test performance. One week later each group was retested following administration of marijuana containing 0, 5, 10 or 15 mg delta9-tetrahydrocannabinol. A dose-related effect of marijuana on pulse ra...
journal_title:Pharmacology
pub_type: 临床试验,杂志文章
doi:10.1159/000136698
更新日期:1977-01-01 00:00:00
abstract::The protective effect of cimetidine, ranitidine and a newer H2-receptor antagonist, mifentidine (proposed INN), on models of gastric and duodenal damage, caused by activation of H2 receptors, was studied. Gastric erosions were induced in rats by intravenous dimaprit (100 mg/kg) while duodenal damage was investigated i...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138049
更新日期:1985-01-01 00:00:00
abstract::The effects of some ergot derivatives on the electroencephalogram and behavior of laboratory animals (mice, rats, rabbits) have been surveyed. The interference of bromocriptine on the dopaminergic central systems has been studied using behavioral (interference with the effects induced by L-dopa, 5HT, TRF or neurolepti...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136819
更新日期:1978-01-01 00:00:00
abstract::We investigated the effects of S-777469 (1-[[6-Ethyl-1-[4-fluorobenzyl]-5-methyl-2-oxo-1, 2-dihydropyridine-3-carbonyl]amino]-cyclohexanecarboxylic acid), a novel cannabinoid type 2 receptor (CB2) agonist, on 1-fluoro-2,4-dinitrobenzene (DNFB)-induced ear inflammation and mite antigen-induced dermatitis in mice. The o...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000455916
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Serotonin (5-hydroxytryptamine, 5-HT)-induced contraction and the involvement of RhoA/Rho-kinase pathway in the 5-HT-induced contraction was investigated isometrically in vitro in both diabetic and nondiabetic human corpus cavernosum (HCC) tissues. METHODS:HCC tissues were obtained from 12 patients. Th...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000221380
更新日期:2009-01-01 00:00:00
abstract::Chronic exposure to cold increases the growth of brown adipose tissue and the resistance to more severe cold, thus improving thermogenesis. The present study examined the possibility that dietary compounds can modify cold acclimation. Adenosine (ADO) or adenine (ADE) were administered in drinking water (0.05%, w/v) fo...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028315
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND/AIMS:The in vivo metabolic profile of a benzopyridooxathiazepine (BPT) derivative, a potent tubulin polymerization inhibitor with a promising in vitro activity, was investigated. METHODS:The quantification of the BPT derivative and the identification of metabolites in the plasma of Wistar rats after i.p. an...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000368084
更新日期:2014-01-01 00:00:00
abstract::The effects of two synthetic heme analogues, zinc mesoporphyrin (ZnMP) and tin mesoporphyrin (SnMP), on in vivo hematopoietic progenitor cell mobilization and in vitro hematopoiesis were examined in rabbit bone marrow. Rabbits received granulocyte colony-stimulating factor (rhG-CSF) for 7 days in order to mobilize inc...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028267
更新日期:1999-01-01 00:00:00
abstract::Stimulants (histamine, acetylcholine and substance P) and relaxants (isoprenaline and bradykinin) of the guinea pig trachea were tested in the absence and presence of mepacrine, eicosatetraynoic acid, BW 755C and indomethacin in order to evaluate the involvement of prostaglandins and congeners in the effects of amines...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137758
更新日期:1982-01-01 00:00:00
abstract::The effects of intravenous administration of adrenoceptor agonists and antagonists on electrocardiographic or blood pressure (BP) functional parameters were assessed in urethane-anesthetized rats. The responses of cardiovascular functional parameters produced by these drugs included: (1) isoproterenol decreased the du...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138922
更新日期:1992-01-01 00:00:00
abstract::The H2-antagonist tiotidine inhibited the H2-receptor-mediated, histamine-induced increase in cyclic AMP in dispersed mucosal cells from guinea pig stomach (Ki, 4 X 10(-8) M). The radiolabeled [3H]-tiotidine bound specifically and reversibly to the same cells with a half-maximal binding occurring at 5 X 10(-7) M tioti...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138176
更新日期:1986-01-01 00:00:00
abstract::Under the specific conditions reported for the separate tests delta9-tetrahydrocannabinol (THC) did not elicit a mutagenic response in microbial and eukaryotic in vitro test systems. THC treatment to histidine auxotrophs of Salmonella typhimurium strains TA 98 (susceptible to frame shift mutation) and TA 100 (suscepti...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136789
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND/AIMS:Putative in vitro-in vivo correlations of pharmacokinetic (PK) parameters are regarded as a prerequisite to filter hits derived from high-throughput screening (HTS) approaches for subsequent murine in vivo PK studies. METHODS:In this study, we assessed stabilities in rat and human microsomes of 121 com...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000343241
更新日期:2012-01-01 00:00:00
abstract::There are reports regarding harmful effect of long-term use of beta2-agonist drugs on asthma severity and airway responsiveness. In the present study, the responses of guinea pig trachea with intact and denuded epithelium (groups 1 and 2, n = 10) to methacholine as EC50 were measured in tissues nonincubated or incubat...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000088739
更新日期:2006-01-01 00:00:00
abstract::Regional cerebral metabolic rates of glucose (rCMRglu) were measured in conscious rats grouped according to three treatments: control, bicuculline (5.5 mg/kg s.c.), and intracerebroventricular arginine vasopressin (0.5 micrograms/5 microliter). Rats in the latter group were pre-exposed to the peptide 48 h earlier to r...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138340
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:Advanced glycation end products (AGEs) play a pivotal role in the initiation and progression of osteoarthritis (OA). Peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to exhibit anti-inflammatory and anticatabolic properties and to be protective in animal models of OA. This study was aimed t...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000369074
更新日期:2014-01-01 00:00:00