Regional cerebral glucose utilization during vasopressin-induced barrel rotations or bicuculline-induced seizures in rats.


:Regional cerebral metabolic rates of glucose (rCMRglu) were measured in conscious rats grouped according to three treatments: control, bicuculline (5.5 mg/kg s.c.), and intracerebroventricular arginine vasopressin (0.5 micrograms/5 microliter). Rats in the latter group were pre-exposed to the peptide 48 h earlier to render them 100% susceptible to a motor output termed barrel rotation (BR). Marked increases in rCMRglu occurred in all brain areas investigated after bicuculline. Increases after intracerebroventricular arginine vasopressin were smaller and occurred in fewer brain areas. Opposite to bicuculline, arginine vasopressin reduced rCMRglu in hippocampus and auditory cortex. The data confirm marked stimulation of rCMRglu during bicuculline-induced seizures and provide initial data for an endogenous peptide that causes BR. Generalized seizures and BR may share some neural substrates, but they produce distinct changes in rCMRglu. The rCMRglu changes are compatible with the interpretation that BR is initiated by brainstem/cerebellar areas that process visual-vestibular information, with subsequent involvement of higher brain structures.






Wurpel JN,Dundore RL,Bryan RM Jr,Keil LC,Severs WB




Has Abstract


1988-01-01 00:00:00












  • Antihypertensive and Renoprotective Effects of Dietary Flaxseed and its Mechanism of Action in Deoxycorticosterone Acetate-Salt Hypertensive Rats.

    abstract:BACKGROUND/AIMS:Flaxseed contains alpha-linolenic acid (ALA), lignans, and dietary fiber, and its intake lowers blood pressure in hypertensive patients. Here, we examined the effects of flaxseed powder, which includes all flaxseed components, flaxseed oil, composed mainly of ALA, flaxseed lignan, and flaxseed fiber, on...


    pub_type: 杂志文章


    authors: Watanabe Y,Ohata K,Fukanoki A,Fujimoto N,Matsumoto M,Nessa N,Toba H,Kobara M,Nakata T

    更新日期:2020-01-01 00:00:00

  • Anoxia and glucose-sensitive 86Rb outflow from rat portal vein.

    abstract::Exposure of rat portal veins to an N2-gassed buffer markedly increased 86Rb outflow. Moreover, glucose caused a pronounced reduction in 86Rb outflow from portal veins perfused with an N2-gassed buffer. Pinacidil, cromakalim and diazoxide provoked a sustained increase in 86Rb outflow. The stimulatory effect of pinacidi...


    pub_type: 杂志文章


    authors: Antoine MH,Herchuelz A,Lebrun P

    更新日期:1992-01-01 00:00:00

  • Superoxide anion stress attenuates the contractile response of the Guinea pig vas deferens to ATP and diadenosine tetraphosphate. Possible effect on calcium dysregulation.

    abstract::Induction of endogenous superoxide anion stress by the use of the superoxide dismutase inhibitor diethylthiocarbamate (DETCA; 10 mmol/l) produced a potent inhibition of the ATP (0.3-10 mmol/l) and diadenosine tetraphosphate (AP(4)A) contractile activity in the isolated vas deferens by 29-92 and 24-90%, respectively. P...


    pub_type: 杂志文章


    authors: Al-Rawi MB,Aleisa AM,Khattab MM

    更新日期:2008-01-01 00:00:00

  • Physiologic responses to chronic dietary tyrosine supplementation in DOCA-salt-treated rats.

    abstract::The antihypertensive effect of chronic administration of L-tyrosine (Tyr) was investigated in a two-part study. In the first experiment, adult male Sprague-Dawley rats were assigned to 1 of 4 treatment groups: control diet plus unilateral nephrectomy (Nphx) and 0.15 M NaCl (Sal) as the sole drinking solution (C-CTRL);...


    pub_type: 杂志文章


    authors: Henley WN,Fregly MJ,Wilson KM,Hathaway S

    更新日期:1986-01-01 00:00:00

  • Protection by zinc sulphate against reserpine-induced ulceration and other gastric effects in the rat.

    abstract::The effects of intraperitoneal pretreatment, 48 h beforehand, with zinc sulphate (22, 44 or 88 mg/kg) were studied on gastric ulceration, gastric secretion and changes in stomach wall mast cell counts induced after 4 h by reserpine (5 mg/kg) given intraperitoneally to intact (unoperated for pylorus occlusion) or pylor...


    pub_type: 杂志文章


    authors: Ogle CW,Cho CH

    更新日期:1978-01-01 00:00:00

  • Prolonged analgesia induced by cathinone. The role of stress and opioid and nonopioid mechanisms.

    abstract::Cathinone, the active principle of Catha edulis (khat), shows long-lasting analgesic effects when the tail-flick test is used in rats. The involvement of monoamines, endogenous opioids and stress in this analgesic effect was tested. Both early (30 min) and late (24 h) analgesic effects of cathinone were prevented by r...


    pub_type: 杂志文章


    authors: Nencini P,Ahmed AM,Anania MC,Moscucci M,Paroli E

    更新日期:1984-01-01 00:00:00

  • Inhibition of prostaglandin biosynthesis in human endotoxin-stimulated peripheral blood monocytes: effects of caffeine.

    abstract::There is an ongoing debate about possible advantages of the coadministration of caffeine with cyclooxygenase (COX) inhibitors in the treatment of pain. There are results suggesting interference by caffeine with COX expression and activity in rat immune cells. In the present study, we have used, therefore, human endoto...


    pub_type: 杂志文章


    authors: Ulcar R,Schuligoi R,Heinemann A,Santner B,Amann R

    更新日期:2003-02-01 00:00:00

  • Clinical significance of M1 receptor antagonists.

    abstract::The M1-selective antimuscarinic drugs pirenzepine and telenzepine moderately reduce gastric acid secretion without inhibiting smooth-muscle activity as much as nonselective antimuscarinics, e.g. atropine and 1-hyoscyamine. They hasten peptic ulcer healing and improve the symptoms of reflux oesophagitis. In combination...


    pub_type: 杂志文章,评审


    authors: Stockbrügger RW

    更新日期:1988-01-01 00:00:00

  • Harmine action in rats with lymphostatic encephalopathy.

    abstract::In rats with lymphostatic encephalopathy the duration of harmine tremor was lengthened, and the brain concentrations of harmine decreased more slowly than in sham-operated controls. The tremor began simultaneously in both rat groups at coinciding brain concentrations of harmine. In rats with lymphostatic encephalopath...


    pub_type: 杂志文章


    authors: Back G,Seidel G

    更新日期:1977-01-01 00:00:00

  • Mechanisms for the inhibition of vasopressin-stimulated water flow by captopril in the toad bladder.

    abstract::The mechanisms by which captopril inhibits vasopressin-stimulated osmotic water flow in the toad bladder have been investigated in vitro. Captopril has two possible mechanisms for the inhibitory action on the water flow, one is its stimulative effect on prostaglandin E2 (PGE2) biosynthesis by inhibition of kininase II...


    pub_type: 杂志文章


    authors: Marumo F,Nara Y

    更新日期:1987-01-01 00:00:00

  • Effects of different loading doses of dexmedetomidine on bispectral index under stepwise propofol target-controlled infusion.

    abstract:BACKGROUND AND PURPOSE:Stepwise propofol target-controlled infusion (TCI) can achieve a less disturbed condition of hemodynamics and respiration. Its combination with dexmedetomidine may have some advantages for patients. We studied the effects of different loading doses of dexmedetomidine on the bispectral index (BIS)...


    pub_type: 杂志文章,随机对照试验


    authors: Wang T,Ge S,Xiong W,Zhou P,Cang J,Xue Z

    更新日期:2013-01-01 00:00:00

  • beta-adrenergic reactivity in conscious DOCA-salt hypertensive rats.

    abstract::The endocrine (plasma renin activity, insulin and ADH) and hemodynamic responses (heart rate and mean arterial pressure) to isoprenaline infusion were examined in conscious deoxycorticosterone-salt hypertensive rats (DS) and compared with uninephrectomized-salt control rats (US). A dose-related rise in plasma renin ac...


    pub_type: 杂志文章


    authors: Vargas F,Haro JM,Garcia-Torres L,Soler A,Garcia del Rio C

    更新日期:1989-01-01 00:00:00

  • Reversion of multidrug resistance in a chemoresistant human breast cancer cell line by β-elemene.

    abstract:BACKGROUND:Multidrug resistance (MDR) presents a problem in cancer chemotherapy, and developing new agents to overcome MDR is important. This study intends to investigate the reversal effect of -elemene on MDR in human breast carcinoma MCF-7 and doxorubicin-resistant MCF-7 cells. METHODS:MTT cytotoxicity assays, flow ...


    pub_type: 杂志文章


    authors: Xu HB,Li L,Fu J,Mao XP,Xu LZ

    更新日期:2012-01-01 00:00:00

  • Subcellular distribution of SERCA and calcium-activated ATPase in rabbit and human urinary bladder smooth muscle.

    abstract::Previous studies have demonstrated that calcium storage and release from IP3-dependent sites in the sarcoplasmic reticulum play an important role in the contractile response of the rabbit urinary bladder to both field stimulation (mediated via neurotransmitter release) and bethanechol (direct muscarinic stimulation). ...


    pub_type: 杂志文章


    authors: Levin RM,Nicholas TJ,Snitkoff GG,Mandell J,Russell D,Wilbur HJ,Mogavero LJ

    更新日期:1997-12-01 00:00:00

  • Effect of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on ischemia-reperfusion injury in rats.

    abstract::Two groups of rats were used to examine the effect of pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, on rat hearts using an in vivo model of ischemia-reperfusion (I/R) to elucidate potential mechanisms. One group was the 30-min reperfusion group, which was further subdivided into...


    pub_type: 杂志文章


    authors: Cao Z,Ye P,Long C,Chen K,Li X,Wang H

    更新日期:2007-01-01 00:00:00

  • Mechanism of heme oxygenase-1 gene induction by quercetin in rat aortic smooth muscle cells.

    abstract::We previously reported that adenovirus-mediated gene transfer of heme oxygenase-1 (HO-1) inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. This finding implies that HO-1 induction is beneficial for protecting blood vessels. We also found that quercetin, a common polyphenolic compound in f...


    pub_type: 杂志文章


    authors: Lin HC,Cheng TH,Chen YC,Juan SH

    更新日期:2004-06-01 00:00:00

  • Effect of nitrofurans on duodenal ulceration induced by cysteamine or indometacin.

    abstract::The present experiments examined the protective effect of the nitrofuran drugs, furazolidone (FZ) and nitrofurazone (NF), on duodenal ulceration induced by cysteamine or indometacin in rats. FZ at oral doses of 25, 50 or 100 mg/kg for 2 consecutive days signficantly reduced, in a dose-dependent manner, the incidence a...


    pub_type: 杂志文章


    authors: Ali BH

    更新日期:1991-01-01 00:00:00

  • Effects of delta9-THC on the synaptosomal uptake of 3H-tryptophan and 3H-choline.

    abstract::The in vitro addition of (-)-delta9-tetrahydrocannabinol (delta9-THC) resulted in a dose-responsive inhibition of the high-affinity specific synaptosomal uptake of both 3H-tryptophan and 3H-choline in mouse forebrain crude synaptosomal preparations. The approximate concentrations of delta9-THC required to cause a 50% ...


    pub_type: 杂志文章


    authors: Johnson KM,Dewey WL

    更新日期:1978-01-01 00:00:00

  • Intraspecific aggressiveness after lesions of midbrain raphe nuclei in rats.

    abstract::Serotonin-depleting lesions of midbrain raphe (extensive lesions located within dorsal and partly median raphe muclei) induced intraspecific agressiveness in grouped Wistar male rats but failed to increase mouse-killing behaviour. Rats which had lesions in the lateral midbrain did not display intraspecific aggression ...


    pub_type: 杂志文章


    authors: Kostowski W,Cxlonkowski A,Markowdka L,Markiewicz L

    更新日期:1975-01-01 00:00:00

  • Effect of synthetic retinoid, TAC-101, on experimental autoimmune disease.

    abstract::The effect of 4-[3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101), one of the synthetic retinoids, on collagen-induced arthritis (CIA) in mice and experimental autoimmune encephalomyelitis (EAE) in rats was studied. TAC-101 at doses of 5 and 20 mg/kg clearly inhibited the development of CIA in terms of the swe...


    pub_type: 杂志文章


    authors: Miyagawa N,Homma T,Kagechika H,Shudo K,Nagai H

    更新日期:2003-01-01 00:00:00

  • In vitro enantioselective glucuronidation of fenoprofen.

    abstract::The diastereomeric glucuronic acid conjugates are major metabolites of the nonsteroidal anti-inflammatory drug fenoprofen (FEN). Glucuronidation of FEN enantiomers was investigated with liver microsomal preparations from different species (sheep, rabbit, rat and human). The formed R- and S-FEN conjugates can be separa...


    pub_type: 杂志文章


    authors: Volland C,Benet LZ

    更新日期:1991-01-01 00:00:00

  • Electrophysiological studies of 6-(N,N-diethylamino)-Hexyl-3,4,5,-Trimethoxybenzoate on ventricular muscle and conduction system.

    abstract::The agent, 6-(N,N-diethylamino)-hexyl- 3, 4, 5,-Trimethoxybenzoate (TMB-6) which relaxes smooth and skeletal muscle by interfering with intracellular Ca ++ availability was tested for its electrophysiological effects on canine cardiac Purkinje fibres and feline papillary muscles. In both tissues the drug causes a decr...


    pub_type: 杂志文章


    authors: Posner P,Chiou CY

    更新日期:1976-01-01 00:00:00

  • Dependence potential of zopiclone studied in monkeys.

    abstract::In gross behavioral observation the minimum effective dose of zopiclone was intravenously 0.06-0.25 mg/kg and intragastrically 1-4 mg/kg in rhesus monkeys. Zopiclone suppressed barbital withdrawal signs of rhesus monkeys at a single dose of 16 mg/kg or more. The suppressing effect of zopiclone 32 mg/kg i.g. was compar...


    pub_type: 杂志文章


    authors: Yanagita T

    更新日期:1983-01-01 00:00:00

  • Increase of adenosine release by adenosine antagonists in hearts with coronary occlusion and reperfusion.

    abstract::In isolated perfused rat hearts with coronary occlusion and reperfusion, the effect of adenosine antagonists on the release of adenosine and its degradation products inosine, hypoxanthine, xanthine and uric acid was investigated. An antagonist with high selectivity for the A1 receptor, 8-phenyltheophylline, was applie...


    pub_type: 杂志文章


    authors: Bernauer W

    更新日期:1996-11-01 00:00:00

  • Positive inotropic action of veratridine in rat atria: possible involvement of prostanoids.

    abstract::Veratridine caused a positive inotropic action in the electrically driven left atria of rats. Quinacrine (a phospholipase A2 inhibitor), indomethacin (a cyclooxygenase inhibitor) and aspirin (a cyclooxygenase inhibitor), but not nordihydroguaiaretic acid (a lipoxygenase inhibitor), inhibited the response to veratridin...


    pub_type: 杂志文章


    authors: Morikawa M,Satake N,Shibata S,Shibata T

    更新日期:1991-01-01 00:00:00

  • Effects of HNS-32, a novel antiarrhythmic agent, on guinea-pig myocardium.

    abstract::The electrophysiological and mechanical effects of HNS-32, a novel azulene-1-carboxamidine derivative with antiarrhythmic activity, were studied in isolated guinea-pig myocardial preparations. HNS-32 (10(-6)-10(-4) mol/l) concentration-dependently decreased the maximum rate of rise (V(max)) of action potential in isol...


    pub_type: 杂志文章


    authors: Noguchi K,Kase J,Saitoh M,Masumiya H,Saitoh M,Nakazawa T,Tanaka Y,Tanaka H,Hashimoto K,Shigenobu K

    更新日期:2002-01-01 00:00:00

  • Stability of chloramphenicol metabolites in human blood and liver as determined by high-performance liquid chromatography.

    abstract::The pathogenesis of aplastic anemia from chloramphenicol (CAP) remains uncertain. Recent observations suggest that metabolites of CAP generated by intestinal bacteria may play an important role in mediating hematotoxicity from the drug. Thus, it is possible that once in circulation and after passage through the liver,...


    pub_type: 杂志文章


    authors: Abou-Khalil WH,Yunis AA,Abou-Khalil S

    更新日期:1988-01-01 00:00:00

  • Dietary taurine decreases hepatic secretion of cholesterol ester in rats fed a high-cholesterol diet.

    abstract::The effects of dietary taurine on lipid secretion and ketone body production were examined in the livers of Wistar and Sprague-Dawley rats fed high-cholesterol diets. The weight gain of the Sprague-Dawley rats tended to be higher than that of the Wistar rats, although food intake was comparable between the strains. Th...


    pub_type: 杂志文章


    authors: Yamamoto K,Yoshitama A,Sakono M,Nasu T,Murakami S,Fukuda N

    更新日期:2000-01-01 00:00:00

  • Changes in arachidonic acid metabolite patterns in alloxan-induced diabetic rats.

    abstract::The vasodepressor responses to intravenous injections of arachidonic acid, and the formation of its metabolites, were studied in rats made diabetic 1 or 2 weeks after a 1-dose alloxan treatment. Arachidonic acid dose-dependently decreased the diastolic blood pressure in normal animals, but this hypotensive effect was ...


    pub_type: 杂志文章


    authors: Hui SC,Ogle CW,Wang Z,An Y,Hu YH

    更新日期:1989-01-01 00:00:00

  • Plasma histamine levels in rats treated with trypanocidal diamidines.

    abstract::The histamine levels in rat plasma treated with various new trypanocidal diamidines and diimidazolines were evaluated by HPLC and fluorometric detection. Equimolar doses (10 mumol/kg) of the new compounds raised the plasma histamine level to a much smaller degree than pentamidine or diminazene. ...


    pub_type: 杂志文章


    authors: Steinmann U,Estler CJ,Dann O

    更新日期:1988-01-01 00:00:00