Abstract:
:The effects of alpha-tocopherol, ascorbic acid and rutin on peroxidative processes were studied in xanthine-xanthine oxidase system, linoleic acid ufasomes and human erythrocyte membranes. In these three systems, tested compounds scavenge superoxide anion radicals or inhibit lipid peroxidation in a concentration-dependent manner, and it was shown that rutin was the most potent radical scavenger, followed by ascorbic acid and alpha-tocopherol. An important antilipoperoxidant activity was observed when these compounds were tested in combination, demonstrating that a dose-dependent interaction occurs. Water-soluble (rutin and ascorbic acid) as well as lipid-soluble (tocopherol) antioxidants are involved in the protection of polyunsaturated fatty acids constituting the ufasome or erythrocyte ghosts. When these compounds are used in combination, an additive effect is observed with alpha-tocopherol and ascorbic acid or rutin, while a supra-additive effect (synergism) is noted with ascorbic acid and rutin. Results obtained with the triple combination alpha-tocopherol-ascorbic acid-rutin show that an increase in superoxide radical scavenging activities or in lipid peroxidation inhibition is possible after the addition of a third antioxidant, as compared with the protective effects produced by the double combination of these compounds. This interaction takes place not only in homogeneous aqueous solutions, but also in ufasome or erythrocyte ghost preparations. It is suggested that ascorbic acid and rutin interacts with tocopherol at the surface of or the interface with the membrane, and that rutin simultaneously interacts with ascorbic acid.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Nègre-Salvayre A,Affany A,Hariton C,Salvayre Rdoi
10.1159/000138807subject
Has Abstractpub_date
1991-01-01 00:00:00pages
262-72issue
5eissn
0031-7012issn
1423-0313journal_volume
42pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::Four monoclonal antibodies (MAbs) to phenobarbital-induced cytochrome P-450 (PB-P-450) show different patterns of inhibition of PB-P-450 catalyzed aryl hydrocarbon hydroxylase (AHH), 7-ethoxycoumarin deethylase, benzphetamine demethylase and ethylmorphine demethylase. The inhibition constants vary depending on the ind...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138677
更新日期:1990-01-01 00:00:00
abstract::Renal lithium clearance, tissue lithium levels, serum lithium concentration, and body temperature were determined in rats given lithium alone or combined with haloperidol (0.5-1 mg/kg). A slight increase in serum lithium concentration occurred in one of the three groups given lithium plus haloperidol. Haloperidol fail...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136708
更新日期:1977-01-01 00:00:00
abstract::Lesopitron acts as a ligand for central serotonin 5-HT1A receptors. Ki obtained from [3H]8-OH-DPAT competition studies was 104.8 +/- 10.6 nmol/l. As lesopitron did not affect the binding of [3H]paroxetine, involvement of the serotonin reuptake system in the effects of lesopitron is rejected. Lesopitron inhibits halope...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000079133
更新日期:2004-10-01 00:00:00
abstract:INTRODUCTION:The accumulation of amyloid-β (Aβ) plaque in the brain is a characteristic feature of Alzheimer's disease (AD) and the cause of fatal oxidative damage to neuronal cells. Korean red ginseng (RG) is used extensively in traditional medicine and is known to have anti-oxidative and anti-inflammatory properties....
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000505592
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Homeostasis of cholesterol is crucial for cellular function, and dysregulated cholesterol biosynthesis is a metabolic event that can lead to hepatic and cardiovascular abnormalities. OBJECTIVE:The aim of this study was to investigate the effects and mechanisms of domain-associated protein (Daxx) and andro...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000506488
更新日期:2020-07-21 00:00:00
abstract::Chronic administration of epinephrine to adult male rats resulted in a significant increase in the rate of ethanol elimination, when given alone or together with the beta-adrenergic blocker alprenolol. This effect was observed concomitantly with an increased hepatic oxygen utilization and no changes in mitochondrial r...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137228
更新日期:1979-01-01 00:00:00
abstract:AIMS:Basal insulin administered to type-2 diabetic patients with poor glycaemic control when managed with oral anti-diabetics (OADs) alone can lead to an increased risk of weight gain and hypoglycaemia. In the absence of head-to-head trials, an indirect comparison of the once-daily insulin detemir with insulin glargine...
journal_title:Pharmacology
pub_type: 杂志文章,meta分析
doi:10.1159/000149569
更新日期:2008-01-01 00:00:00
abstract::TRK-530 is a novel synthetic bisphosphonate compound which exhibits inhibitory activity in the rat adjuvant arthritis (AA) model. We found that, during AA development, the concentrations of cytokine-induced neutrophil chemoattractant-1 (CINC-1) and tumor necrosis factor alpha (TNF-alpha) in the bone marrow increased, ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028203
更新日期:1998-05-01 00:00:00
abstract::Various stressful stimuli cause mast cell degranulation. Hemorrhagic shock is one such stressful stimulus which may cause mast cell degranulation and histamine release. Histamine may be involved in the pathophysiology of hemorrhage. It was reported that there are large amounts of histamine in the anterior and posterio...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138826
更新日期:1991-01-01 00:00:00
abstract::Danthron infused intravenously in rats shows a complex dose-dependent pattern of metabolism and excretion. The metabolites, particularly the more polar ones, are in general excreted predominantly in bile, to a lesser extent in urine. They can be separated as metabolite groups according to polarity and molecular size o...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139852
更新日期:1993-10-01 00:00:00
abstract::Combination therapy with antiretroviral drugs is used for the treatment of patients infected with the human immunodeficiency virus. To achieve optimal drug concentrations for viral suppression and avoidance of drug toxicity, monitoring of drug levels has been considered essential. We set up an analytical procedure for...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000073664
更新日期:2003-12-01 00:00:00
abstract::The first step in the conversion of spironolactone (SP) to its biologically active metabolites is deacetylation to 7 alpha-thiospirolactone (7 alpha-thio-SL). Studies were done to evaluate the effects of reduced glutathione (GSH) on SP deacetylation by adrenal microsomal preparations. In the absence of GSH, adrenal mi...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139358
更新日期:1996-01-01 00:00:00
abstract::A double-blind crossover trial was conducted in 42 outpatients of either sex in order to obtain information on the properties of 7.5 mg of zopiclone in a general practice setting compared with 2 mg of flunitrazepam. Each patient went through two periods of treatment, each period lasting 10 days. A comparison of the ef...
journal_title:Pharmacology
pub_type: 临床试验,杂志文章
doi:10.1159/000137923
更新日期:1983-01-01 00:00:00
abstract::Papers published over 100 years since the beginning of the scientific study of drug metabolism in birds were reviewed. Birds were found to be able to accomplish more than 20 general biotransformation reactions in both functionalization and conjugation. Chickens were the primary subject of study but over 30 species of ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137327
更新日期:1979-01-01 00:00:00
abstract::The electrophysiological and mechanical effects of HNS-32, a novel azulene-1-carboxamidine derivative with antiarrhythmic activity, were studied in isolated guinea-pig myocardial preparations. HNS-32 (10(-6)-10(-4) mol/l) concentration-dependently decreased the maximum rate of rise (V(max)) of action potential in isol...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056148
更新日期:2002-01-01 00:00:00
abstract::The type-1 cannabinoid receptor (CB1R) was initially identified as the neuronal target of Δ(9)-tetrahydrocannabinol (THC), the major psychoactive substance of marijuana. This receptor is one of the most abundant G-protein-coupled receptors in the adult brain, the target of endocannabinoid ligands and a well-characteri...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000339075
更新日期:2012-01-01 00:00:00
abstract::The oral bioavailability of two investigational formulations of bicalutamide was compared with the current clinical formulation. The first formulation was amorphous R-/S-bicalutamide in solid dispersion with a polymeric matrix of hydroxypropyl methylcellulose phthalate (HP55S) (R-/S-bicalutamide/HP55S); the second was...
journal_title:Pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000094599
更新日期:2006-01-01 00:00:00
abstract::The effect of morphine, fentanyl, pethidine and pentazocine was studied in gerbils against air blast-induced seizures. Major, generalized seizures were suppressed by morphine (ED50 = 4.0 mg/kg s.c.), fentanyl (ED50 = 64 micrograms/kg s.c.), and pethidine (ED50 = 2.4 mg/kg s.c.), but not by pentazocine. The anticonvuls...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138189
更新日期:1986-01-01 00:00:00
abstract::The present study was aimed at investigating the effects of diabetes on the cavernosal smooth muscle relaxations mediated by adenosine and adenosine triphosphate (ATP) in tissues obtained from men and rats. Adenosine- and ATP-induced relaxant responses showed an enhanced sensitivity with an unaltered effectiveness in ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028354
更新日期:2000-02-01 00:00:00
abstract::The effect of atropine sulfate, trihexyphenidyl HCl, benztropine mesylate, diphenhydramine HCl and ethopropazine HCl on gastric emptying and intestinal transit of a phenol red solution in the rat was examined. Intraperitoneal administration of 0.3 mg/kg atropine, 1.2 mg/kg benztropine and trihexyphenidyl results in a ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136728
更新日期:1977-01-01 00:00:00
abstract::Hepatic lipid accumulation and apoptosis is elevated in patients with non-alcoholic steatohepatitis and is closely associated with severity. Saturated fatty acid palmitate stimulates lipid accumulation and apoptosis in hepatocytes. In the present study, we examined bee-bee tree oil (BO)-mediated protective effects on ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000487892
更新日期:2018-01-01 00:00:00
abstract::The vasodepressor responses to intravenous injections of arachidonic acid, and the formation of its metabolites, were studied in rats made diabetic 1 or 2 weeks after a 1-dose alloxan treatment. Arachidonic acid dose-dependently decreased the diastolic blood pressure in normal animals, but this hypotensive effect was ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138612
更新日期:1989-01-01 00:00:00
abstract::Congestive heart failure (CHF) is associated with exercise intolerance that cannot be entirely explained by hypoperfusion of the skeletal muscles. We studied the contractile properties of fast-twitch (extensor digitorum longus; EDL) and slow-twitch (soleus; SOL) skeletal muscles in doxorubicin-induced CHF in rats, and...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000241723
更新日期:2009-01-01 00:00:00
abstract::This study tests the hypothesis that contractile responses in aortae of hypertensive rats are more dependent on gap junctional communication compared to those from normotensive rats. The experimental approach was pharmacological, using inhibitors of gap junctional activity (heptanol and octanol). Two models of experim...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056069
更新日期:2001-01-01 00:00:00
abstract::The endocrine (plasma renin activity, insulin and ADH) and hemodynamic responses (heart rate and mean arterial pressure) to isoprenaline infusion were examined in conscious deoxycorticosterone-salt hypertensive rats (DS) and compared with uninephrectomized-salt control rats (US). A dose-related rise in plasma renin ac...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138522
更新日期:1989-01-01 00:00:00
abstract::Human endothelial cells were cultivated on microporous membranes mimicking the luminal and basal spaces of blood vessels. When fluorescence-labeled lipid microspheres (LM) were added to the upper chambers of the model cultures, confluent monolayers of endothelial cells transported considerable levels of fluorescence t...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139413
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stepwise propofol target-controlled infusion (TCI) can achieve a less disturbed condition of hemodynamics and respiration. Its combination with dexmedetomidine may have some advantages for patients. We studied the effects of different loading doses of dexmedetomidine on the bispectral index (BIS)...
journal_title:Pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000343634
更新日期:2013-01-01 00:00:00
abstract::Previous studies have demonstrated that calcium storage and release from IP3-dependent sites in the sarcoplasmic reticulum play an important role in the contractile response of the rabbit urinary bladder to both field stimulation (mediated via neurotransmitter release) and bethanechol (direct muscarinic stimulation). ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139543
更新日期:1997-12-01 00:00:00
abstract::The vascular relaxant effect of salbutamol and its dependence on the endothelium were studied in the isolated dog coronary artery, precontracted with prostaglandin F2 alpha. Salbutamol induced a concentration-dependent relaxation which was partially inhibited by removal of endothelial cells. Atenolol 10(-6) mol/l, a b...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138804
更新日期:1991-01-01 00:00:00
abstract::Ketotifen is an antiallergic drug and may have direct inhibitory effects on eosinophils. To investigate the anti-eosinophilic effect of ketotifen, we examined the effect of ketotifen on the production of reactive oxygen species (ROS) from eotaxin-primed human eosinophils. Ketotifen at 10(-10)-10(-6) mol/l significantl...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000072666
更新日期:2003-11-01 00:00:00