Abstract:
:TRK-530 is a novel synthetic bisphosphonate compound which exhibits inhibitory activity in the rat adjuvant arthritis (AA) model. We found that, during AA development, the concentrations of cytokine-induced neutrophil chemoattractant-1 (CINC-1) and tumor necrosis factor alpha (TNF-alpha) in the bone marrow increased, and that administration of TRK-530 decreased the concentrations of these cytokines. The suppression of these concentration increases paralleled the inhibition of paw edema. Paw edema inhibition by TRK-530 in rat AA may be the result of decreasing CINC-1 and TNF-alpha concentrations.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Tanahashi M,Koike J,Kawabe N,Nakadate-Matsushita Tdoi
10.1159/000028203subject
Has Abstractpub_date
1998-05-01 00:00:00pages
237-41issue
5eissn
0031-7012issn
1423-0313pii
pha56237journal_volume
56pub_type
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