Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice.

abstract：BACKGROUND:Aspirin and ibuprofen are the most frequently prescribed non-steroidal anti-inflammatory drugs in the world. However, both are associated with a variety of toxicities. We applied serum metabonomics and Fisher discrimination for the early diagnosis of its toxic reaction in order to help diagnose these toxicit...

journal_title：Pharmacology

authors： Zhang J,Song H,Jiang S,Chen Z,Tong S,Lin F,Wen C,Zhang X,Hu L

更新日期：2017-01-01 00:00:00

abstract：:The possible role of carbonic anhydrase in bone resorption induced by prostaglandin E2 (PGE2) was studied using an in vitro neonatal mouse calvarial culture system. PGE2 (10(-6) M) was effective in stimulating resorption, as assessed by calcium release into culture media. This enhanced resorption was accompanied by si...

journal_title：Pharmacology

authors： Hall GE,Kenny AD

更新日期：1985-01-01 00:00:00

abstract：:The signaling of seven transmembrane receptors/G-protein- coupled receptors (GPCRs) is regulated by a number of receptor interacting proteins, including βarrestins (βarrs) and GPCR kinases (GRKs). In the present report, we have analyzed the interaction pattern between the glucagon-like peptide-1 (GLP-1) receptor (GLP-...

journal_title：Pharmacology

authors： Jorgensen R,Norklit Roed S,Heding A,Elling CE

更新日期：2011-01-01 00:00:00

abstract：:Induction of endogenous superoxide anion stress by the use of the superoxide dismutase inhibitor diethylthiocarbamate (DETCA; 10 mmol/l) produced a potent inhibition of the ATP (0.3-10 mmol/l) and diadenosine tetraphosphate (AP(4)A) contractile activity in the isolated vas deferens by 29-92 and 24-90%, respectively. P...

journal_title：Pharmacology

authors： Al-Rawi MB,Aleisa AM,Khattab MM

更新日期：2008-01-01 00:00:00

abstract：:Artemether, highly effective in multi-drug-resistant malaria is not routinely available for use in pregnancy due to the lack of adequate research data in animals and man. This study was therefore aimed at investigating some pregnancy-related effects of artemether. Artemether (1.5, 7.5 and 15 mg/kg i.p. daily for 7 day...

journal_title：Pharmacology

authors： Ejiofor JI,Kwanashie HO,Anuka JA

更新日期：2006-01-01 00:00:00

abstract：:The H2-antagonist tiotidine inhibited the H2-receptor-mediated, histamine-induced increase in cyclic AMP in dispersed mucosal cells from guinea pig stomach (Ki, 4 X 10(-8) M). The radiolabeled [3H]-tiotidine bound specifically and reversibly to the same cells with a half-maximal binding occurring at 5 X 10(-7) M tioti...

journal_title：Pharmacology

authors： Batzri S,Harmon JW

更新日期：1986-01-01 00:00:00

abstract：:The vascular relaxant effect of salbutamol and its dependence on the endothelium were studied in the isolated dog coronary artery, precontracted with prostaglandin F2 alpha. Salbutamol induced a concentration-dependent relaxation which was partially inhibited by removal of endothelial cells. Atenolol 10(-6) mol/l, a b...

journal_title：Pharmacology

authors： Bernard F,Jouquey S,Hamon G

更新日期：1991-01-01 00:00:00

abstract：:We compared detailed efficacy of efonidipine and nifedipine, dihydropyridine analogues, and mibefradil using recombinant T- and L-type Ca2+ channels expressed separately in mammalian cells. All these Ca2+ channel antagonists blocked T-type Ca2+ channel currents (I(Ca(T))) with distinct blocking manners: I(Ca(T)) was b...

journal_title：Pharmacology

authors： Lee TS,Kaku T,Takebayashi S,Uchino T,Miyamoto S,Hadama T,Perez-Reyes E,Ono K

更新日期：2006-01-01 00:00:00

abstract：:We investigated the vascular effects of glucagon-like peptide-1 (GLP-1) and Exendin-4 in type 2 diabetic rat aortae. Studies were performed in a normal control group (NC) (0.2 ml i.p. saline, n = 10), streptozotocin (STZ)/nicotinamide diabetic control group (DC) (a single dose of 80 mg/kg STZ i.p. injection 15 min aft...

journal_title：Pharmacology

authors： Ozyazgan S,Kutluata N,Afşar S,Ozdaş SB,Akkan AG

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND/AIMS:Isoniazid (ISO) has been reported to inhibit the hepatic aldehyde dehydrogenase (ALDH) and to cause a disulfiram (DIS)-like reaction, albeit there are no reports demonstrating increased blood acetaldehyde levels after co-administration of ISO with alcohol. The aim of our study was to clarify whether the...

journal_title：Pharmacology

authors： Karamanakos PN,Pappas P,Boumba V,Vougiouklakis T,Marselos M

更新日期：2016-01-01 00:00:00

abstract：:The purpose of the study was to test the hypothesis that the postischemic neuronal damage is accompanied by changes of the electrocorticogram (ECoG) of freely moving rats during long-term recovery after forebrain ischemia. Ten minutes forebrain ischemia was induced in male Wistar rats. ECoG was recorded 1 day before a...

journal_title：Pharmacology

authors： Peruche B,Klaassens H,Krieglstein J

更新日期：1995-04-01 00:00:00

abstract：:The aim of this study was to compare the effects of a new thromboxane synthase inhibitor, camonagrel, on platelet aggregation and platelet-subendothelium interaction under flow conditions, in comparison with a standard thromboxane synthase inhibitor (dazoxiben) and a cyclooxygenase inhibitor (acetylsalicylic acid). Wi...

journal_title：Pharmacology

authors： Villalobos MA,De La Cruz JP,Escalante R,Arrebola MM,Guerrero A,Sánchez de la Cuesta F

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Targeting inflammation in patients with coronary artery disease and/or acute myocardial infarction (AMI) is a matter of debate. Methotrexate (MTX) is one of the most widely used immunosuppressants. Cardiovascular Inflammation Reduction Trial (CIRT) recently failed to demonstrate reduced cardiovascular events...

journal_title：Pharmacology

authors： Dannenberg L,Trojovsky K,Ayhan A,Helten C,Zako S,M'Pembele R,Mourikis P,Benkhoff M,Ignatov D,Sarabhai T,Petzold T,Huhn-Wientgen R,Zeus T,Kelm M,Levkau B,Polzin A

更新日期：2020-11-20 00:00:00

abstract：:We investigated the contribution of the sympathetic nervous system (SNS) in maintaining the blood pressure and in regulating the cardiac function during and after carvedilol administration in rats with heart failure (group F). Left ventricular end-diastolic pressure, percent functional shortening, and rates of intrave...

journal_title：Pharmacology

authors： Abe Y,Watanabe K,Sato S,Nagai Y,Kamal FA,Wahed MI,Wen J,Narasimman G,Ma M,Suresh P,Takahashi T,Tachikawa H,Kashimura T,Tanabe N,Kodama M,Aizawa Y,Yamaguchi K,Miyazaki M,Kakemi M

更新日期：2004-12-01 00:00:00

abstract：:There is an ongoing debate about possible advantages of the coadministration of caffeine with cyclooxygenase (COX) inhibitors in the treatment of pain. There are results suggesting interference by caffeine with COX expression and activity in rat immune cells. In the present study, we have used, therefore, human endoto...

journal_title：Pharmacology

authors： Ulcar R,Schuligoi R,Heinemann A,Santner B,Amann R

更新日期：2003-02-01 00:00:00

abstract：:Chronic administration of epinephrine to adult male rats resulted in a significant increase in the rate of ethanol elimination, when given alone or together with the beta-adrenergic blocker alprenolol. This effect was observed concomitantly with an increased hepatic oxygen utilization and no changes in mitochondrial r...

journal_title：Pharmacology

authors： Petermann M,Bravo M,Videla L,Ugarte G

更新日期：1979-01-01 00:00:00

abstract：:Elastase, a serine proteinase released by activated human neutrophils, can degrade a wide variety of biomacromolecules including elastin, and is considered a marker of inflammatory diseases. As the logical strategy to protect tissue is to inhibit excessive elastase activity, experimental and clinical researches have c...

journal_title：Pharmacology

authors： Braga PC,Dal Sasso M,Culici M,Bianchi T,Bordoni L,Marabini L

更新日期：2006-01-01 00:00:00

abstract：:In the isolated guinea pig vas deferens, 10(-4) M cocaine shifts to the left (13.5-fold at the EC50 level) the concentration-effect curve and increases the maximum response to noradrenaline, whilst supersensitivity to phenylephrine, an amine with a low affinity for the neuronal uptake, was smaller (4.1-fold) and the m...

journal_title：Pharmacology

authors： DeMoraes S,Capaz FR

更新日期：1977-01-01 00:00:00

abstract：:Prior studies revealed an apparent bimodal distribution of adrenal xenobiotic-metabolizing activities in outbred guinea pigs. High activities were characteristic of most animals but a minority had very low rates of metabolism. The present studies were done to determine the basis for this distribution. Among the enzyma...

journal_title：Pharmacology

authors： Colby HD,Huang Y,Jiang Q,Voigt JM

更新日期：2000-08-01 00:00:00

abstract：:The effects of aspirin and suprofen on gastrointestinal blood loss were compared in a double-blind, crossover study of 20 healthy male subjects. Fecal blood loss was measured by 51Cr-labeled red cells. Subjects treated with aspirin (2,600 mg/day) experienced a mean fecal blood loss of 4.2 ml/day, compared with subject...

journal_title：Pharmacology

authors： Arnold JD,Berger AE

更新日期：1983-01-01 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants. PBDEs have been widely used in textiles, flexible polyurethane foams, electronic components, electrical components, and plastics. 11β-Hydroxysteroid dehydrogenases, isoform 1 (HSD11B1) and isoform 2 (HSD11B2), have been demonstrated to ...

journal_title：Pharmacology

authors： Chen X,Dong Y,Cao S,Li X,Wang Z,Chen R,Ge RS

更新日期：2016-01-01 00:00:00

abstract：:We investigated the effects of vinconate and pentobarbital against the alterations in spirodecanone binding in the gerbil striatum and hippocampus 5 h and 7 days after 10 min of cerebral ischemia, using receptor autoradiography. Vinconate and pentobarbital were given intraperitoneally 10 and 30 min prior to ischemic i...

journal_title：Pharmacology

authors： Murakami F,Araki T,Kanai Y,Kato H,Fujiwara T,Kogure K

更新日期：1994-11-01 00:00:00

abstract：:The distribution of primaquine was measured in seven rat tissues at 15-180 min after the intraperitoneal injection of the antimalarial 8-aminoquinoline. The half-life of unmetabolized primaquine was 4.0 h in lung, 1.7-1.9 h in blood, spleen, kidney and heart, and 1.2 h in liver. At each interval, the concentrations of...

journal_title：Pharmacology

authors： Holbrook DJ Jr,Griffin JB,Fowler L,Gibson BR

更新日期：1981-01-01 00:00:00

abstract：:The intracerebroventricular injection of the cholecystokinin-A receptor antagonist L-364,718, at the doses of 0.5, 5, 10 or 20 micrograms/mouse, while having no effect on pain threshold (hot plate, 51 degrees C), antagonized the analgesic activity of morphine (10 mg/kg i.p.). This effect was obtained with a dose of 10...

journal_title：Pharmacology

authors： Poggioli R,Vergoni AV,Sandrini M,Barbafiera L,Marrama D,Bertolini A

更新日期：1991-01-01 00:00:00

abstract：:The effects of 3 alpha 2-adrenergic receptor agonists on renal function in vasopressin (AVP)-deficient Brattleboro (DI) rats were evaluated. The aim of this study was to determine the relative contribution of central versus peripheral alpha 2-adrenoceptors in mediating diuresis and natriuresis, as well as the role of ...

journal_title：Pharmacology

authors： Dawson R Jr,Wallace DR

更新日期：1989-01-01 00:00:00

abstract：:Chronic exposure to cold increases the growth of brown adipose tissue and the resistance to more severe cold, thus improving thermogenesis. The present study examined the possibility that dietary compounds can modify cold acclimation. Adenosine (ADO) or adenine (ADE) were administered in drinking water (0.05%, w/v) fo...

journal_title：Pharmacology

authors： Nishimura M,Moriya M,Saitoh M,Murakoshi N,Shimizu Y

更新日期：1999-09-01 00:00:00

abstract：:Human endothelial cells were cultivated on microporous membranes mimicking the luminal and basal spaces of blood vessels. When fluorescence-labeled lipid microspheres (LM) were added to the upper chambers of the model cultures, confluent monolayers of endothelial cells transported considerable levels of fluorescence t...

journal_title：Pharmacology

authors： Takahashi K,Suzuki K,Ichiki Y,Fukushima T,Nakamura H,Sawasaki Y

更新日期：1996-07-01 00:00:00

abstract：:The first step in the conversion of spironolactone (SP) to its biologically active metabolites is deacetylation to 7 alpha-thiospirolactone (7 alpha-thio-SL). Studies were done to evaluate the effects of reduced glutathione (GSH) on SP deacetylation by adrenal microsomal preparations. In the absence of GSH, adrenal mi...

journal_title：Pharmacology

authors： Colby HD,LaCagnin LB,Los LE

更新日期：1996-01-01 00:00:00

abstract：:The protective effect of cimetidine, ranitidine and a newer H2-receptor antagonist, mifentidine (proposed INN), on models of gastric and duodenal damage, caused by activation of H2 receptors, was studied. Gastric erosions were induced in rats by intravenous dimaprit (100 mg/kg) while duodenal damage was investigated i...

journal_title：Pharmacology

authors： Del Soldato P,Ghiorzi A,Cereda E,Donetti A

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND/AIMS:Vaginismus is characterized by recurrent or persistent involuntary contraction of the perineal muscles surrounding the outer third of the vagina when penile, finger, tampon, or speculum penetration is attempted. Recent results have suggested the use of botulinum toxin for the treatment of vaginismus. He...

journal_title：Pharmacology

authors： Ferreira JR,Souza RP

更新日期：2012-01-01 00:00:00