Abstract:
:Chronic administration of epinephrine to adult male rats resulted in a significant increase in the rate of ethanol elimination, when given alone or together with the beta-adrenergic blocker alprenolol. This effect was observed concomitantly with an increased hepatic oxygen utilization and no changes in mitochondrial respiratory functions. Epinephrine given acutely did not modify the rate of ethanol metabolism. Blood glucose levels were enhanced in these conditions, but were unaffected in rats treated with epinephrine plus alprenolol. These results suggest that chronic epinephrine treatment induces an increased oxidative capacity in the liver characterized by enhanced rates of oxygen uptake and ethanol metabolism, which is not related to its beta-adrenergic actions.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Petermann M,Bravo M,Videla L,Ugarte Gdoi
10.1159/000137228subject
Has Abstractpub_date
1979-01-01 00:00:00pages
42-7issue
1eissn
0031-7012issn
1423-0313journal_volume
18pub_type
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