Abstract:
BACKGROUND/AIMS:Stent thrombosis is a serious complication after percutaneous coronary intervention and femoropopliteal endovascular intervention. The aim of this study was to determine the antithrombotic effects of a direct factor Xa inhibitor edoxaban alone or in combination with antiplatelet agents in a rat model of stent thrombosis. METHODS:Stainless steel stents (4 stents per rat) were placed in an extracorporeal arteriovenous shunt. The shunt was inserted into the carotid artery and the jugular vein in each rat to circulate blood. Stent thrombosis was induced by exposing the stents to arterial blood for 30 min. Protein content of the thrombus was measured. Edoxaban and antiplatelet agents (aspirin, clopidogrel, and ticagrelor) were orally administered before the thrombus induction. RESULTS:Edoxaban (0.3-3 mg/kg), clopidogrel (1-10 mg/kg), aspirin (10-100 mg/kg), and ticagrelor (0.3-3 mg/kg) exerted significant and dose-dependent antithrombotic effects in a rat stent thrombosis model. The effect of edoxaban was comparable to that of antiplatelet agents. The combination of submaximal doses of edoxaban and clopidogrel or aspirin significantly potentiated the antithrombotic effects compared with antiplatelet agents alone. CONCLUSION:These results suggest that edoxaban alone and in combination with clopidogrel or aspirin are promising antithrombotic therapies for the prevention of stent thrombosis.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Morishima Y,Honda Y,Kamisato Cdoi
10.1159/000494059subject
Has Abstractpub_date
2019-01-01 00:00:00pages
17-22issue
1-2eissn
0031-7012issn
1423-0313pii
000494059journal_volume
103pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::The absorption into the systemic circulation of compounds administered intraperitoneally in large volumes was investigated in the rat. The influence on absorption of molecular weight, lipid-water partition coefficient (K), and dissociation constant (pKa) was studied. Nine neutral compounds ranging in molecular weight ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136874
更新日期:1978-01-01 00:00:00
abstract::We studied the anti-inflammatory activity of meloxicam on rat carrageenin-induced pleurisy and its toxicity for rat gastric mucosa, relative to its in vitro inhibitory potency against partially purified cyclooxygenase (COX)-1 and COX-2 preparations in order to clarify the pharmacological profile of the compound as an ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139511
更新日期:1997-07-01 00:00:00
abstract::The effect of sucralfate treatment (3 g daily for 6 weeks) on gastric HCO3- secretion was investigated in 15 duodenal ulcer patients. After treatment a highly significant (p less than 0.01) increase in gastric bicarbonate output was found. It is suggested that the mode of action of sucralfate includes stimulation of g...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138136
更新日期:1985-01-01 00:00:00
abstract::This study examined effects of intracerebroventricularly (i.c.v.) administered somatostatin (SRIH-14 and SRIH-28) on growth and function of pituitary somatotropes (GH cells) and lactotropes (PRL cells). Male rats received three i.c.v. injections (1 microgram/5 microliters) of SRIH-14 or SRIH-28 every second day. Blood...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028223
更新日期:1998-07-01 00:00:00
abstract::The effect of atropine sulfate, trihexyphenidyl HCl, benztropine mesylate, diphenhydramine HCl and ethopropazine HCl on gastric emptying and intestinal transit of a phenol red solution in the rat was examined. Intraperitoneal administration of 0.3 mg/kg atropine, 1.2 mg/kg benztropine and trihexyphenidyl results in a ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136728
更新日期:1977-01-01 00:00:00
abstract::Several experiments suggested that vaccines might inhibit liver drug-metabolizing enzymes, an assumption in agreement with other findings obtained with most immuno-enhancing agents. A direct, non-specific activation of macrophages with subsequent release of interleukin 1 may account for this inhibition. The purpose of...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138370
更新日期:1988-01-01 00:00:00
abstract::The observations that people infected with HIV suffer not only from an inflammatory stress but also from depleted glutathione levels have led to a general hypothesis that these two are causally related, and that treatment of AIDS should include thiol-replenishment therapy. In particular, inflammatory stimulations are ...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000139037
更新日期:1993-01-01 00:00:00
abstract::Self-administration of either nicotine (NIC) or ethanol (ETH) has been extensively studied. This study addressed for the first time the self-administration of both substances when offered together. Male and female rats of different ages were offered NIC and ETH using the two- or three-bottle free-choice method. When N...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000067801
更新日期:2003-03-01 00:00:00
abstract::Induction of endogenous superoxide anion stress by the use of the superoxide dismutase inhibitor diethylthiocarbamate (DETCA; 10 mmol/l) produced a potent inhibition of the ATP (0.3-10 mmol/l) and diadenosine tetraphosphate (AP(4)A) contractile activity in the isolated vas deferens by 29-92 and 24-90%, respectively. P...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000148260
更新日期:2008-01-01 00:00:00
abstract::The effect of sodium rhein on contractile activity and fluid flow in the rat complete large intestine was studied in vitro. Contractile activity was recorded using serosal strain gauges and volume transducers recorded distal fluid flow from the segment. Luminal sodium rhein (1 mM) produced a protracted increase in cae...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139840
更新日期:1993-10-01 00:00:00
abstract::The effect of age on the clearance (CL) of therapeutic proteins has not been explored extensively in pediatric subjects. Recently, resting energy expenditure (REE) has been proposed to link age-dependent CL with developmental changes. Allometric relationship was explored to assess the impact of REE on the CL of therap...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000362562
更新日期:2014-01-01 00:00:00
abstract::delta9-Tetrahydrocannabinol (THC) inhibited ulcer formation in the pylorus-ligated rat (Shay rat test). However, this antiulcer activity of THC was substantially less than for the anticholinergic substance tridihexethyl chloride both in terms of degree of activity and potency. In addition, the results of the present s...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136851
更新日期:1978-01-01 00:00:00
abstract::The effects of dietary taurine on lipid secretion and ketone body production were examined in the livers of Wistar and Sprague-Dawley rats fed high-cholesterol diets. The weight gain of the Sprague-Dawley rats tended to be higher than that of the Wistar rats, although food intake was comparable between the strains. Th...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028343
更新日期:2000-01-01 00:00:00
abstract::The duration of action of melatonin may be important for improvements in sleep efficiency in insomniacs. Ramelteon, a selective melatonin agonist, is primarily metabolized to the active metabolite M-II, which has a longer half-life and greater systemic exposure than ramelteon. Hence, M-II may contribute significantly ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000362459
更新日期:2014-01-01 00:00:00
abstract::The distribution of primaquine was measured in seven rat tissues at 15-180 min after the intraperitoneal injection of the antimalarial 8-aminoquinoline. The half-life of unmetabolized primaquine was 4.0 h in lung, 1.7-1.9 h in blood, spleen, kidney and heart, and 1.2 h in liver. At each interval, the concentrations of...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137508
更新日期:1981-01-01 00:00:00
abstract::Erythropoietin (EPO) has been used for the management of renal anemia. Recent studies suggest the pleiotropic properties of EPO in various tissues such as brain, kidney and vasculature. Diabetes mellitus is a major risk for development of vascular impairment. The aim of the present study was to investigate the hypothe...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000343963
更新日期:2013-01-01 00:00:00
abstract::The vasodepressor responses to intravenous injections of arachidonic acid, and the formation of its metabolites, were studied in rats made diabetic 1 or 2 weeks after a 1-dose alloxan treatment. Arachidonic acid dose-dependently decreased the diastolic blood pressure in normal animals, but this hypotensive effect was ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138612
更新日期:1989-01-01 00:00:00
abstract::We examined the effects of cannabinoid receptor agonists on (45)Ca(2+) uptake in rat brain synaptosomes. A cannabinoid receptor agonist, (R)-(+)-[2,3-dihydro-5-methyl-3-[(4-merpholino)methyl]pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl](1-naphthyl)methanone (WIN 55212-2) dose-dependently inhibited (45)Ca(2+) uptake in rat s...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000091228
更新日期:2006-01-01 00:00:00
abstract::The involvement of AT1 and AT2 receptor subtypes in the response of the isolated rat uterus to angiotensin II (AngII) was studied throughout the estrous cycle. The AngII potency varied during the different estrous cycle phases, as indicated by significantly different pD2 values. No significant differences were observe...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000058043
更新日期:2002-07-01 00:00:00
abstract::Rat intestinal transit was determined 30, 60, 150 and 270 min after morphine sulfate or saline given either subcutaneously (s.c.), intraduodenally (i.d.) or intracerebroventricularly (i.c.v.). In addition, two popular methods of quantifying the progression of a radioactive marker along the bowel, the intercept and geo...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137991
更新日期:1984-01-01 00:00:00
abstract::The intracerebroventricular injection of the cholecystokinin-A receptor antagonist L-364,718, at the doses of 0.5, 5, 10 or 20 micrograms/mouse, while having no effect on pain threshold (hot plate, 51 degrees C), antagonized the analgesic activity of morphine (10 mg/kg i.p.). This effect was obtained with a dose of 10...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138798
更新日期:1991-01-01 00:00:00
abstract::The hypoxia-inducible factor 1alpha (HIF-1alpha), a member of the PAS superfamily, is a global regulator of cellular and systemic O(2) homeostasis as well as embryonic development. As the activity of HIF-1alpha is increased by a lowered oxygen tension in vivo and in vitro, we established a cell line producing high amo...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000072359
更新日期:2003-10-01 00:00:00
abstract::Five healthy subjects performed submaximal physical exercise approximately 20 h after a single oral dose of phenytoin (5 mg/kg of the sodium salt). The plasma levels of free fatty acids (FFA) increased 2- to 3-fold in the post-exercise period. In spite of this, the degree of plasma binding of phenytoin and its total c...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136744
更新日期:1978-01-01 00:00:00
abstract::Desferrioxamine (DFO) metabolism and its pharmacokinetics were studied in a swine model using high-performance liquid chromatography. DFO and three iron-binding metabolites occurred in plasma. Interindividual differences in pharmacokinetics and metabolism were observed. Urine analysis in 4 pigs showed three iron-bindi...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138730
更新日期:1990-01-01 00:00:00
abstract::Both acute and chronic oral administration (1-20 mg/kg) of FCE 22716, a new ergoline derivative, resulted in a dose-related fall of arterial blood pressure lasting for more than 6 h. Tachycardia was observed only at high dosages. Yohimbine, propranolol and indometacin did not modify its antihypertensive effect; on the...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138523
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND/AIMS:In the present study, we tested whether or not acute antioxidant treatment with vitamin C is able to protect the heart during myocardial infarction. The effects of vitamin C on the autonomic balancing of the heart and on the histopathological and immunohistochemical changes in response to isoproterenol ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000222245
更新日期:2009-01-01 00:00:00
abstract::We report that the loop diuretic drugs bumetanide and furosemide used in the treatment of hypertension are GPR35 agonists. We utilized calcium flux, inositol phosphate accumulation, and dynamic redistribution assays to examine the pharmacology of these compounds on the human, mouse and rat GPR35. While potent on human...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000335127
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Aspirin and ibuprofen are the most frequently prescribed non-steroidal anti-inflammatory drugs in the world. However, both are associated with a variety of toxicities. We applied serum metabonomics and Fisher discrimination for the early diagnosis of its toxic reaction in order to help diagnose these toxicit...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000477971
更新日期:2017-01-01 00:00:00
abstract::The effects of alpha-tocopherol, ascorbic acid and rutin on peroxidative processes were studied in xanthine-xanthine oxidase system, linoleic acid ufasomes and human erythrocyte membranes. In these three systems, tested compounds scavenge superoxide anion radicals or inhibit lipid peroxidation in a concentration-depen...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138807
更新日期:1991-01-01 00:00:00
abstract::The insulinogenic response to a standard i.v. dose of a sulfonylurea can be markedly augmented in normal, conscious dogs if they are given 30 min earlier a single i.v. dose of dihydroergotamine (DHE). Since the parent substance ergotamine posssed no such amplifying properties, further experiments were conducted to cla...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136697
更新日期:1977-01-01 00:00:00