Abstract:
:Five healthy subjects performed submaximal physical exercise approximately 20 h after a single oral dose of phenytoin (5 mg/kg of the sodium salt). The plasma levels of free fatty acids (FFA) increased 2- to 3-fold in the post-exercise period. In spite of this, the degree of plasma binding of phenytoin and its total concentration in plasma were unaffected. Thus FFA at the levels reached (1.5-2.9 mEq/l), did not displace phenytoin from its binding sites on albumin. Furthermore, during the FFA peak the plasma protein binding of warfarin, as measured in vitro, did not decrease as compared to the pre-exercise period. These findings contrast to previous observations in rats and dogs, where FFA caused a considerable displacement of warfarin and phenytoin at relatively low FFA/albumin molar ratios.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Borgå O,Juhlin-Dannfeldt A,Dahlqvist Rdoi
10.1159/000136744subject
Has Abstractpub_date
1978-01-01 00:00:00pages
37-43issue
1eissn
0031-7012issn
1423-0313journal_volume
16pub_type
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