Abstract:
:The distribution of primaquine was measured in seven rat tissues at 15-180 min after the intraperitoneal injection of the antimalarial 8-aminoquinoline. The half-life of unmetabolized primaquine was 4.0 h in lung, 1.7-1.9 h in blood, spleen, kidney and heart, and 1.2 h in liver. At each interval, the concentrations of unmetabolized primaquine were (in order): lung greater than liver, kidney, spleen greater than heart greater than brain greater than or equal to blood. At 3 h after the injection of [6-O-methyl-3H]primaquine, unmetabolized primaquine constituted 10% of the total 3H in blood and 40-60% of the total 3H in liver, brain, heart and kidney.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Holbrook DJ Jr,Griffin JB,Fowler L,Gibson BRdoi
10.1159/000137508subject
Has Abstractpub_date
1981-01-01 00:00:00pages
330-6issue
5eissn
0031-7012issn
1423-0313journal_volume
22pub_type
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