Lack of effect of intravenous hypertonic glucose on the intensity of alcohol intoxication induced experimentally and observed in patients of an emergency room.

abstract：:The vascular relaxant effect of salbutamol and its dependence on the endothelium were studied in the isolated dog coronary artery, precontracted with prostaglandin F2 alpha. Salbutamol induced a concentration-dependent relaxation which was partially inhibited by removal of endothelial cells. Atenolol 10(-6) mol/l, a b...

journal_title：Pharmacology

authors： Bernard F,Jouquey S,Hamon G

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND/AIM:Perception of risk of adverse drug events (ADEs) is different between health and nonhealth professionals, but these differences have not been investigated sufficiently in the general population. Women are more affected by ADEs. With the aim to investigate ADE risk perception in a sample of nonhealth prof...

journal_title：Pharmacology

authors： Salvo F,Miroddi M,Alibrandi A,Calapai F,Cafeo V,Mancari F,Gangemi S,Caputi AP,Calapai G

更新日期：2013-01-01 00:00:00

abstract：:Angiotensin II (ANG II) is a potent vasoconstrictor in most vascular beds. We studied the role of cyclooxygenase products and/or endothelium-derived relaxing factor (EDRF) in modulating the pressor response to ANG II in the isolated, blood perfused dog lung. ANG II was given as a bolus dose of 2, 4 and 8 micrograms be...

journal_title：Pharmacology

authors： el-Kashef HA,Ehrhart IC,Hofman WF

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Cassia angustifolia L. (senna) is traditionally used as a laxative. Its major components are sennosides that are responsible for the laxative effect. Senna is recommended for the short-term treatment of acute constipation. Nevertheless people use its preparations as self-medication, often for long periods, t...

journal_title：Pharmacology

authors： Vitalone A,Di Giacomo S,Di Sotto A,Franchitto A,Mammola CL,Mariani P,Mastrangelo S,Mazzanti G

更新日期：2011-01-01 00:00:00

abstract：:Esculentoside A, a kind of saponin isolated from the root of the Chinese herb Phytolaca esculenta, is reported to possess potent anti-inflammatory effects in acute and chronic experimental models. In the present study, we investigated the effects of esculentoside A on the production of tumor necrosis factor (TNF), int...

journal_title：Pharmacology

authors： Ju DW,Zheng QY,Cao X,Fang J,Wang HB

更新日期：1998-04-01 00:00:00

abstract：:We report that the loop diuretic drugs bumetanide and furosemide used in the treatment of hypertension are GPR35 agonists. We utilized calcium flux, inositol phosphate accumulation, and dynamic redistribution assays to examine the pharmacology of these compounds on the human, mouse and rat GPR35. While potent on human...

journal_title：Pharmacology

authors： Yang Y,Fu A,Wu X,Reagan JD

更新日期：2012-01-01 00:00:00

abstract：:The ovariectomized (OVX) rat, as an established animal model of human osteoporosis, was adopted in the present experiment to study the protective effects of sodium daidzein sulfonate (SDS) on trabecular bone. Six-month-old Sprague-Dawley rats were sham-operated or ovariectomized. Five days later, the OVX rats were ran...

journal_title：Pharmacology

authors： Ren P,Ji H,Shao Q,Chen X,Han J,Sun Y

更新日期：2007-01-01 00:00:00

abstract：:The effect of age on the clearance (CL) of therapeutic proteins has not been explored extensively in pediatric subjects. Recently, resting energy expenditure (REE) has been proposed to link age-dependent CL with developmental changes. Allometric relationship was explored to assess the impact of REE on the CL of therap...

journal_title：Pharmacology

authors： Lee SK

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Functional linkages between the cannabinoid CB(1) and the dopaminergic systems have been reported although the observations and the mechanisms hypothesizing their interactions at the G protein-coupled receptor (GPCR) functionality level are conflicting. METHODS:Administration of a potent cannabinoid ag...

journal_title：Pharmacology

authors： Nguyen VH,Wang H,Verdurand M,Zavitsanou K

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Centhaquin is a centrally acting hypotensive drug like clonidine. Clonidine also produces analgesia and hypothermia in mice and potentiates morphine analgesia. Clonidine analgesia is blocked by idazoxan and naloxone while it is potentiated by BQ123 and sulfisoxazole. This study was conducted to determine the...

journal_title：Pharmacology

authors： Andurkar SV,Gulati A

更新日期：2011-01-01 00:00:00

abstract：AIM:Our study aimed to investigate the effect of amlodipine on bone metabolism in orchidectomized rats. METHODS:Eight-week-old rats were divided into three groups. The sham-operated control group (SHAM) and the control group after orchidectomy (ORX) received the standard laboratory diet (SLD). The experimental group a...

journal_title：Pharmacology

authors： Gradosova I,Zivna H,Palicka V,Hubena S,Svejkovska K,Zivny P

更新日期：2012-01-01 00:00:00

abstract：:The effect of cimetidine and two new histamine H2-receptor antagonists, oxmetidine and SKF 93479, on histamine-stimulated adenylate cyclase activity was studied in guinea pig gastric mucosal cells. Histamine stimulated the enzyme activity in concentration-dependent fashion. The concentration-response curve of histamin...

journal_title：Pharmacology

authors： Cheret AM,Scarpignato C,Lewin MJ,Bertaccini G

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND/AIMS:Isoniazid (ISO) has been reported to inhibit the hepatic aldehyde dehydrogenase (ALDH) and to cause a disulfiram (DIS)-like reaction, albeit there are no reports demonstrating increased blood acetaldehyde levels after co-administration of ISO with alcohol. The aim of our study was to clarify whether the...

journal_title：Pharmacology

authors： Karamanakos PN,Pappas P,Boumba V,Vougiouklakis T,Marselos M

更新日期：2016-01-01 00:00:00

abstract：AIMS:To compare the bioavailability of a new oromucosal formulation of flurbiprofen 8.75-mg lozenges, developed by Alfa Wassermann S.p.A. (test drug) to that of marketed flurbiprofen 8.75-mg lozenges (Benactiv Gola®, reference drug). METHODS:This was an open, randomised, two-period, crossover, pharmacokinetic (PK) stu...

journal_title：Pharmacology

authors： Matzneller P,Burian A,Martin W,Annoni O,Lauro V,Tacchi R,Brunner M,Zeitlinger M

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:The accumulation of amyloid-β (Aβ) plaque in the brain is a characteristic feature of Alzheimer's disease (AD) and the cause of fatal oxidative damage to neuronal cells. Korean red ginseng (RG) is used extensively in traditional medicine and is known to have anti-oxidative and anti-inflammatory properties....

journal_title：Pharmacology

authors： Choi S,Lim JW,Kim H

更新日期：2020-01-01 00:00:00

abstract：:The possible role of carbonic anhydrase in bone resorption induced by prostaglandin E2 (PGE2) was studied using an in vitro neonatal mouse calvarial culture system. PGE2 (10(-6) M) was effective in stimulating resorption, as assessed by calcium release into culture media. This enhanced resorption was accompanied by si...

journal_title：Pharmacology

authors： Hall GE,Kenny AD

更新日期：1985-01-01 00:00:00

abstract：:A comparative study of four natural eugenol compounds found in the volatile oil fraction of Myristica fragans, namely eugenol (E), methyleugenol (ME), isoeugenol and methylisoeugenol, was carried out in mice. Using a mixture of saline + tween-80 to suspend the compounds and the intraperitoneal route, ME revealed to be...

journal_title：Pharmacology

authors： Sell AB,Carlini EA

更新日期：1976-01-01 00:00:00

abstract：:The pathogenesis of aplastic anemia from chloramphenicol (CAP) remains uncertain. Recent observations suggest that metabolites of CAP generated by intestinal bacteria may play an important role in mediating hematotoxicity from the drug. Thus, it is possible that once in circulation and after passage through the liver,...

journal_title：Pharmacology

authors： Abou-Khalil WH,Yunis AA,Abou-Khalil S

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Poncirus fructus (PF), also known as the dried immature fruit of Poncirus trifoliata (L.) Raf., has long been used as a cure for the treatment of various gastrointestinal disorders in eastern Asia. Recently, it was reported that naringin, a flavonoid constituent of the PF extract, causes the acti...

journal_title：Pharmacology

authors： Jang Y,Kim TK,Shim WS

更新日期：2013-01-01 00:00:00

abstract：:There is an ongoing debate about possible advantages of the coadministration of caffeine with cyclooxygenase (COX) inhibitors in the treatment of pain. There are results suggesting interference by caffeine with COX expression and activity in rat immune cells. In the present study, we have used, therefore, human endoto...

journal_title：Pharmacology

authors： Ulcar R,Schuligoi R,Heinemann A,Santner B,Amann R

更新日期：2003-02-01 00:00:00

abstract：:The effects of mitemcinal (GM-611) on the gastrointestinal contractile activity were investigated using chronically implanted force transducers in conscious dogs and were compared with the effects of porcine motilin (pMTL), EM-523 and EM-574. In the interdigestive state, intravenous and oral administration of mitemcin...

journal_title：Pharmacology

authors： Ozaki K,Yogo K,Sudo H,Onoma M,Kamei K,Akima M,Koga H,Itoh Z,Omura S,Takanashi H

更新日期：2007-01-01 00:00:00

abstract：:In a model of dimethylhydrazine-induced colorectal tumors in male mice aloin- or sennoside-enriched diets (0.03%) did not promote incidence and growth of adenomas and carcinomas after 20 weeks. Furthermore, in anthranoid-fed mice no significant changes in serum electrolytes as well as parameters of hepato- and nephrot...

journal_title：Pharmacology

authors： Siegers CP,Siemers J,Baretton G

更新日期：1993-10-01 00:00:00

abstract：:The effects of dietary taurine on lipid secretion and ketone body production were examined in the livers of Wistar and Sprague-Dawley rats fed high-cholesterol diets. The weight gain of the Sprague-Dawley rats tended to be higher than that of the Wistar rats, although food intake was comparable between the strains. Th...

journal_title：Pharmacology

authors： Yamamoto K,Yoshitama A,Sakono M,Nasu T,Murakami S,Fukuda N

更新日期：2000-01-01 00:00:00

abstract：:Metformin is a widely used antidiabetic agent that is generally considered safe. However, metformin-associated lactic acidosis (MALA), though not common, occurs from time to time and results in significantly high mortality. A series of 23 MALA cases in a local major hospital in Hong Kong is reported in this article to...

journal_title：Pharmacology

authors： Yeung CW,Chung HY,Fong BM,Tsai NW,Chan WM,Siu TS,Tam S,Tsui SH

更新日期：2011-01-01 00:00:00

abstract：:Hypothyroidism is a common disorder that is associated with psychological disturbances such as dementia, depression, and psychomotor disorders. We recently found that chronic treatment with the T-type calcium channel enhancer SAK3 prevents the cholinergic neurodegeneration induced by a single intraperitoneal (i.p.) in...

journal_title：Pharmacology

authors： Husain N,Yabuki Y,Shinoda Y,Fukunaga K

更新日期：2018-01-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) detoxify diverse electrophilic chemicals, including anticancer drugs. Containing at least 100 microM total GST, the adult rat liver has abundant alpha and mu class GST isoenzymes. We utilized primary cultured rat hepatocytes, maintained in chemically defined medium, to examine direct ...

journal_title：Pharmacology

authors： Grgurevich S,Greene FE

更新日期：1995-06-01 00:00:00

abstract：:Rat intestinal transit was determined 30, 60, 150 and 270 min after morphine sulfate or saline given either subcutaneously (s.c.), intraduodenally (i.d.) or intracerebroventricularly (i.c.v.). In addition, two popular methods of quantifying the progression of a radioactive marker along the bowel, the intercept and geo...

journal_title：Pharmacology

authors： Stewart JJ

更新日期：1984-01-01 00:00:00

abstract：:The influence of changes in the sodium balance on angiotensin II-induced pressor responses were studied in the pithed rat preparation, which is characterized by a highly activated renin-angiotensin-aldosterone system (RAAS) with high plasma renin and angiotensin II concentrations. The pressor response to angiotensin I...

journal_title：Pharmacology

authors： Knape JT,van Zwieten PA

更新日期：1988-01-01 00:00:00

abstract：INTRODUCTION:Homeostasis of cholesterol is crucial for cellular function, and dysregulated cholesterol biosynthesis is a metabolic event that can lead to hepatic and cardiovascular abnormalities. OBJECTIVE:The aim of this study was to investigate the effects and mechanisms of domain-associated protein (Daxx) and andro...

journal_title：Pharmacology

authors： Li TP,Sun SW,Xiong GZ,Qiu F,Yang DM,Sun SY,Xie XJ,Liao DF,Chen JX,Tuo QH

更新日期：2020-07-21 00:00:00

abstract：:The effects of alpha-adrenergic agonists on 45Ca efflux from slices of rat liver were studied and the results compared to earlier studies on the rabbit aorta. Norepinephrine and phenylephrine (PE) cause a stimulation of 45Ca efflux which was due to alpha 1-receptor activation. The mitochondrial uncoupler dinitrophenol...

journal_title：Pharmacology

authors： Lynch CJ,Deth RC

更新日期：1984-01-01 00:00:00