Anesthetic action of methyleugenol and other eugenol derivatives.

abstract：:Hepatic lipid accumulation and apoptosis is elevated in patients with non-alcoholic steatohepatitis and is closely associated with severity. Saturated fatty acid palmitate stimulates lipid accumulation and apoptosis in hepatocytes. In the present study, we examined bee-bee tree oil (BO)-mediated protective effects on ...

journal_title：Pharmacology

authors： Jung TW,Kim SY,Kim DS,Shin EC,Park YB,Lee KT

更新日期：2018-01-01 00:00:00

abstract：:Protective influence of verapamil upon ouabain-induced cardiac arrhythmias was investigated in anesthetized (alpha-chloralose 60 mg/kg and urethane 500 mg/kg) open-chest guinea pigs. Verapamil in doses between 100 and 150 micrograms/kg significantly increased (80-90%) the dose of ouabain, necessary to cause ventricula...

journal_title：Pharmacology

authors： Khatter JC,Navaratnam S,Hoeschen RJ

更新日期：1988-01-01 00:00:00

abstract：:It can be readily shown in vitro that various compounds inhibit platelet aggregation but it has been difficult to demonstrate in vivo. A method is suggested here to enable in vivo testing of these compounds; the method utilizes relatively low doses of sodium arachidonate, made possible by the ligation of the pterygopa...

journal_title：Pharmacology

authors： Schwartzmiller D

更新日期：1980-01-01 00:00:00

abstract：:We evaluated the effects of sodium alginate (AL-Na) on dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. DSS was added to the drinking water for 7 days. In another experiment, DSS was added to the drinking water for 5 days and DSS-free water was provided thereafter. ...

journal_title：Pharmacology

authors： Yamamoto A,Itoh T,Nasu R,Nishida R

更新日期：2013-01-01 00:00:00

abstract：AIM:Our study aimed to investigate the effect of amlodipine on bone metabolism in orchidectomized rats. METHODS:Eight-week-old rats were divided into three groups. The sham-operated control group (SHAM) and the control group after orchidectomy (ORX) received the standard laboratory diet (SLD). The experimental group a...

journal_title：Pharmacology

authors： Gradosova I,Zivna H,Palicka V,Hubena S,Svejkovska K,Zivny P

更新日期：2012-01-01 00:00:00

abstract：:The present study was aimed at investigating the effects of diabetes on the cavernosal smooth muscle relaxations mediated by adenosine and adenosine triphosphate (ATP) in tissues obtained from men and rats. Adenosine- and ATP-induced relaxant responses showed an enhanced sensitivity with an unaltered effectiveness in ...

journal_title：Pharmacology

authors： Gür S,Oztürk B

更新日期：2000-02-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) detoxify diverse electrophilic chemicals, including anticancer drugs. Containing at least 100 microM total GST, the adult rat liver has abundant alpha and mu class GST isoenzymes. We utilized primary cultured rat hepatocytes, maintained in chemically defined medium, to examine direct ...

journal_title：Pharmacology

authors： Grgurevich S,Greene FE

更新日期：1995-06-01 00:00:00

abstract：:The endocrine (plasma renin activity, insulin and ADH) and hemodynamic responses (heart rate and mean arterial pressure) to isoprenaline infusion were examined in conscious deoxycorticosterone-salt hypertensive rats (DS) and compared with uninephrectomized-salt control rats (US). A dose-related rise in plasma renin ac...

journal_title：Pharmacology

authors： Vargas F,Haro JM,Garcia-Torres L,Soler A,Garcia del Rio C

更新日期：1989-01-01 00:00:00

abstract：:The affinity of amitriptyline for muscarine M1 receptors was studied in the rat cerebral cortex and rabbit vas deferens utilizing binding studies as well as inhibition of carbachol-induced phosphoinositide hydrolysis in the cerebral cortex and blockade of the muscarinic prejunctional inhibition of sympathetic nerve st...

journal_title：Pharmacology

authors： Choi A,Mitchelson F

更新日期：1994-05-01 00:00:00

abstract：:43 patients with osteoarthritis of the knee and/or hip(s) were treated with suprofen 800 mg/day or ibuprofen 1,600 mg/day for 14 days. Both drugs produced an improvement in subjective symptoms by day 7, although the most rapid analgesic effect was obtained with suprofen. Patients receiving suprofen experienced a signi...

journal_title：Pharmacology

authors： Schuermans Y

更新日期：1983-01-01 00:00:00

abstract：:The effect of repeated administration of U-50,488H, a kappa-opioid receptor agonist, on the development of tolerance to its analgesic effect and on the 5-HT1 and 5-HT2 receptors in the cerebral cortex and spinal cord of the rat were determined. Male Sprague-Dawley rats were injected twice daily with U-50,488H, (25 mg/...

journal_title：Pharmacology

authors： Gulati A,Ramarao P,Bhargava HN

更新日期：1989-01-01 00:00:00

abstract：:Several attempts have been made in order to classify the gastrointestinal motility disorders; they are mainly based upon the type of disorder in transit and the region of the gastrointestinal tract affected. Many digestive motor disturbances do not constitute entities, but are pathophysiologic mechanisms that may cont...

journal_title：Pharmacology

authors： Buéno L,Frexinos J,Fioramonti J

更新日期：1988-01-01 00:00:00

abstract：:Under the specific conditions reported for the separate tests delta9-tetrahydrocannabinol (THC) did not elicit a mutagenic response in microbial and eukaryotic in vitro test systems. THC treatment to histidine auxotrophs of Salmonella typhimurium strains TA 98 (susceptible to frame shift mutation) and TA 100 (suscepti...

journal_title：Pharmacology

authors： Zimmerman AM,Stich H,San R

更新日期：1978-01-01 00:00:00

abstract：:The effect of sodium rhein on contractile activity and fluid flow in the rat complete large intestine was studied in vitro. Contractile activity was recorded using serosal strain gauges and volume transducers recorded distal fluid flow from the segment. Luminal sodium rhein (1 mM) produced a protracted increase in cae...

journal_title：Pharmacology

authors： Rumsey RD,Squires PE,Read NW

更新日期：1993-10-01 00:00:00

abstract：:Erythrocytes can take up amino acids from the blood by using a variety of transport systems. GLYT is a key transport protein in the plasma membrane responsible for the Na(2+)-dependent uptake of glycine needed for glutathione biosynthesis. Certain cysteine-specific compounds, particularly mercuric chloride and 5,5'-di...

journal_title：Pharmacology

authors： McCormick SJ,Tunnicliff G

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Lipopolysaccharide (LPS) induces intestinal dysmotility by alteration of smooth muscle and enteric neuronal activities. However, there is no report on the modulatory effects of LPS on the interstitial cells of Cajal (ICCs). We investigated the effect of LPS and its signal transduction in ICCs. M...

journal_title：Pharmacology

authors： Zuo DC,Choi S,Shahi PK,Kim MY,Park CG,Kim YD,Lee J,Chang IY,Lee HS,Yeom SC,Moon HJ,Seong SY,So I,Jun JY

更新日期：2012-01-01 00:00:00

abstract：:Two diazepam derivatives, the N-desmethyl and the 2'-chlor-N-desmethyldiazepam, were compared in rats using behavioral and EEG techniques. Both drugs had depressant effects upon locomotor activity, facilitated behavior suppressed by punishment, increased the number of shocks received by rats in a Sidman avoidance proc...

journal_title：Pharmacology

authors： Babbini M,Gaiardi M,Bartoletti M

更新日期：1978-01-01 00:00:00

abstract：:In the present study, the effects of ghrelin against the gastric damage induced by intragastric administration of 0.6 N HCl and the involvement of histamine H₃ receptors (H₃Rs) were investigated in conscious rats with selective H₃R ligands. Intraperitoneal (i.p.) injection of ghrelin (40 μg/kg) significantly reduced (...

journal_title：Pharmacology

authors： Adami M,Pozzoli C,Leurs R,Stark H,Coruzzi G

更新日期：2010-01-01 00:00:00

abstract：:Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and function. Reported prevalence of this geriatric syndrome, differs depending on the definition, the population and the method used to identify sarcopenia. The causes of sarcopenia are multifactorial, and can...

journal_title：Pharmacology

authors： Campins L,Camps M,Riera A,Pleguezuelos E,Yebenes JC,Serra-Prat M

更新日期：2017-01-01 00:00:00

abstract：:Noradrenergic neurotransmission in the electrically stimulated isolated splenic strip of the cat was found to be modulated via opiate receptor. Pharmacodynamic parameters of morphine, methionine-enkephalin, azidomorphine, naloxone and N-cyclopropylmethyl-norazidomorphine (CAM) were determined. As CAM proved to be more...

journal_title：Pharmacology

authors： Kerecsen L,Knoll J

更新日期：1981-01-01 00:00:00

abstract：:The marijuana plant Cannabis sp. and its derivatives and analogues, known as cannabinoids (CBs), induce many effects throughout the whole body. Herein we briefly review the gastrointestinal (GI) pharmacology of CBs, with special focus on motor function. Some drugs are available to treat nausea and emesis, and evidence...

journal_title：Pharmacology

authors： Abalo R,Vera G,López-Pérez AE,Martínez-Villaluenga M,Martín-Fontelles MI

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:The in vivo metabolic profile of a benzopyridooxathiazepine (BPT) derivative, a potent tubulin polymerization inhibitor with a promising in vitro activity, was investigated. METHODS:The quantification of the BPT derivative and the identification of metabolites in the plasma of Wistar rats after i.p. an...

journal_title：Pharmacology

authors： Bourdon F,Lecoeur M,Lebègue N,Gressier B,Luyckx M,Odou P,Dine T,Goossens JF,Kambia N

更新日期：2014-01-01 00:00:00

abstract：:Mast cells from different locations are shown to vary in their histochemical, ultrastructural, cytochemical and functional properties. The clinical consequences of this heterogeneity and possible reasons for its origin are discussed. ...

journal_title：Pharmacology

authors： Pearce FL

更新日期：1986-01-01 00:00:00

abstract：:Self-administration of either nicotine (NIC) or ethanol (ETH) has been extensively studied. This study addressed for the first time the self-administration of both substances when offered together. Male and female rats of different ages were offered NIC and ETH using the two- or three-bottle free-choice method. When N...

journal_title：Pharmacology

authors： Marshall CE,Dadmarz M,Hofford JM,Gottheil E,Vogel WH

更新日期：2003-03-01 00:00:00

abstract：:The oral bioavailability of two investigational formulations of bicalutamide was compared with the current clinical formulation. The first formulation was amorphous R-/S-bicalutamide in solid dispersion with a polymeric matrix of hydroxypropyl methylcellulose phthalate (HP55S) (R-/S-bicalutamide/HP55S); the second was...

journal_title：Pharmacology

authors： Cantarini M,Fuhr R,Morris T

更新日期：2006-01-01 00:00:00

abstract：:DL-o-, and p-octopamine were tested for beta- and alpha-adrenergic activity in rats. When compared to DL-isoproterenol, a beta-adrenergic agonist, all three isomers failed to show significant beta-adrenergic activity as assessed by intiation of thirst and by increase in tail skin temperature. All three isomers increas...

journal_title：Pharmacology

authors： Fregly MJ,Kelleher DL,Williams CM

更新日期：1979-01-01 00:00:00

abstract：:Using a discrete-trial avoidance-escape schedule in rats the interactions of morphine (M), chlorpromazine (C) and Haloperidol (H) were studied. All three drugs given alone or in combination disrupted operant behavior. At low doses C and H potentiated each other's effect, while at high doses antagonism could be observe...

journal_title：Pharmacology

authors： Tarnawa I,Székely JI

更新日期：1980-01-01 00:00:00

abstract：:Tetraethylammonium chloride (TEA) at concentrations over 10(-3) mol/l produced a concentration-dependent contraction in the isolated canine coronary artery. We investigated mechanisms of the contractile response and the effects of various vasodilators on the contraction. While phentolamine, propranolol, guanethidine, ...

journal_title：Pharmacology

authors： Nishio M,Kigoshi S,Muramatsu I

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:In the present study, we tested whether or not acute antioxidant treatment with vitamin C is able to protect the heart during myocardial infarction. The effects of vitamin C on the autonomic balancing of the heart and on the histopathological and immunohistochemical changes in response to isoproterenol ...

journal_title：Pharmacology

authors： Buttros JB,Bergamaschi CT,Ribeiro DA,Fracalossi AC,Campos RR

更新日期：2009-01-01 00:00:00

abstract：AIM:To study whether rosiglitazone prevents the development of diabetic nephropathy through reduction of reactive oxygen species and its downstream signal transduction pathways. METHODS:The rats were intraperitoneally injected with streptozotocin to induce diabetes, meanwhile the rats in the therapeutic groups were gi...

journal_title：Pharmacology

authors： Bao Y,Jia RH,Yuan J,Li J

更新日期：2007-01-01 00:00:00