Abstract:
:It can be readily shown in vitro that various compounds inhibit platelet aggregation but it has been difficult to demonstrate in vivo. A method is suggested here to enable in vivo testing of these compounds; the method utilizes relatively low doses of sodium arachidonate, made possible by the ligation of the pterygopalatine artery. Adenosine, ATP and sulfinpyrazone, agents known to inhibit platelet aggregation in vitro, were effective in varying degrees in inhibiting in vivo platelet aggregating response as suggested by their ability to antagonize arachidonate-induced EEG depression.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Schwartzmiller Ddoi
10.1159/000137350subject
Has Abstractpub_date
1980-01-01 00:00:00pages
101-5issue
2eissn
0031-7012issn
1423-0313journal_volume
20pub_type
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