Abstract:
:In organ transplantation, ischemia-reperfusion injury (IRI) has been implicated in delayed graft function (DGF) as well as in short- and long-term complications. Using an autotransplant pig kidney model, changes in renal function and morphology were determined after different periods of cold ischemia in kidneys preserved in the University of Wisconsin solution (UW), high-Na(+) version of UW (HEH) or Celsior (CEL) a newly developed high-Na(+) solution, with or without trimetazidine (TMZ). Kidney function was better preserved in CEL, UW and particularly HEH in combination with TMZ, particularly after 48 and 72 h. Mitochondria integrity was improved in TMZ-preserved groups. This study indicates that TMZ is efficiently protective against IRI even after prolonged preservation and in different preservation solutions.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Baumert H,Faure JP,Zhang K,Petit I,Goujon JM,Dutheil D,Favreau F,Barrière M,Tillement JP,Mauco G,Papadopoulos V,Hauet Tdoi
10.1159/000076259subject
Has Abstractpub_date
2004-05-01 00:00:00pages
25-37issue
1eissn
0031-7012issn
1423-0313pii
76259journal_volume
71pub_type
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