Abstract:
:This study was performed to investigate the effect of muscimol on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice. A single administration of morphine induced hyperactivity as measured in mice, and the morphine-induced hyperactivity was inhibited dose-dependently by the administration of the GABA(A) agonist, muscimol (0.3, 0.5 and 1.0 mg kg(-1) i.p.). However, daily repeated administration of morphine caused the development of reverse tolerance against morphine hyperactivity (10 mg kg(-1) s.c.). The administration of muscimol inhibited the development of reverse tolerance against morphine hyperactivity (10 mg kg(-1) s.c.) in mice that had received chronic administration of morphine. Postsynaptic dopamine receptor supersensitivity, as shown by the enhanced ambulatory activity after administration of apomorphine (2 mg kg(-1) s.c.), also developed in reverse-tolerant mice. Muscimol also inhibited the development of postsynaptic dopamine receptor supersensitivity induced by the chronic administration of morphine. These results suggest that the hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity induced by morphine can be inhibited via the activation of GABA(A) receptors.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Yoon IS,Kim HS,Hong JT,Lee MK,Oh KWdoi
10.1159/000064345subject
Has Abstractpub_date
2002-08-01 00:00:00pages
204-9issue
4eissn
0031-7012issn
1423-0313pii
64345journal_volume
65pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::The effects of two synthetic heme analogues, zinc mesoporphyrin (ZnMP) and tin mesoporphyrin (SnMP), on in vivo hematopoietic progenitor cell mobilization and in vitro hematopoiesis were examined in rabbit bone marrow. Rabbits received granulocyte colony-stimulating factor (rhG-CSF) for 7 days in order to mobilize inc...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028267
更新日期:1999-01-01 00:00:00
abstract::The objective of this study was to determine the effects of hypercholesterolemia on basal vascular tone and vascular responses to pharmacologic agents in hindquarter resistance vessels. Blood pressure and hindquarter blood flow were measured in conscious rabbits fed a high cholesterol diet (1%) for 17 weeks (HC) compa...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056137
更新日期:2001-01-01 00:00:00
abstract:INTRODUCTION:Homeostasis of cholesterol is crucial for cellular function, and dysregulated cholesterol biosynthesis is a metabolic event that can lead to hepatic and cardiovascular abnormalities. OBJECTIVE:The aim of this study was to investigate the effects and mechanisms of domain-associated protein (Daxx) and andro...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000506488
更新日期:2020-07-21 00:00:00
abstract::86Rb efflux assay was used to investigate the effect of cromakalim, pinacidil and P1075 in guinea pig urinary bladder strips. The type of K channel opened by cromakalim and pinacidil was determined using specific K channel blockers through 86Rb efflux assay in detrusor strips. Cromakalim, pinacidil and P1075 all three...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139230
更新日期:1994-09-01 00:00:00
abstract::The hypoxia-inducible factor 1alpha (HIF-1alpha), a member of the PAS superfamily, is a global regulator of cellular and systemic O(2) homeostasis as well as embryonic development. As the activity of HIF-1alpha is increased by a lowered oxygen tension in vivo and in vitro, we established a cell line producing high amo...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000072359
更新日期:2003-10-01 00:00:00
abstract::Zinc acexamate (NAS-501), an anti-ulcer agent, has been reported to prevent various acute experimental gastric mucosal lesions and duodenal ulcers in rats. In order to clarify the mechanisms by which NAS-501 exhibits the anti-ulcer effects, we investigated the anti-oxidative effects of NAS-501 in vitro and in vivo. NA...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028283
更新日期:1999-04-01 00:00:00
abstract::The purpose of the study was to test the hypothesis that the postischemic neuronal damage is accompanied by changes of the electrocorticogram (ECoG) of freely moving rats during long-term recovery after forebrain ischemia. Ten minutes forebrain ischemia was induced in male Wistar rats. ECoG was recorded 1 day before a...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139287
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:Cassia angustifolia L. (senna) is traditionally used as a laxative. Its major components are sennosides that are responsible for the laxative effect. Senna is recommended for the short-term treatment of acute constipation. Nevertheless people use its preparations as self-medication, often for long periods, t...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000331858
更新日期:2011-01-01 00:00:00
abstract::Human endothelial cells were cultivated on microporous membranes mimicking the luminal and basal spaces of blood vessels. When fluorescence-labeled lipid microspheres (LM) were added to the upper chambers of the model cultures, confluent monolayers of endothelial cells transported considerable levels of fluorescence t...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139413
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Aspirin and ibuprofen are the most frequently prescribed non-steroidal anti-inflammatory drugs in the world. However, both are associated with a variety of toxicities. We applied serum metabonomics and Fisher discrimination for the early diagnosis of its toxic reaction in order to help diagnose these toxicit...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000477971
更新日期:2017-01-01 00:00:00
abstract:AIM:Our study aimed to investigate the effect of amlodipine on bone metabolism in orchidectomized rats. METHODS:Eight-week-old rats were divided into three groups. The sham-operated control group (SHAM) and the control group after orchidectomy (ORX) received the standard laboratory diet (SLD). The experimental group a...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000335491
更新日期:2012-01-01 00:00:00
abstract::The effect and mechanism of action of serotonin (5-HT) were studied in the pulmonary circulation of normal and diabetic rabbits. 5-HT (10, 50 and 100 nmol/l) produced a concentration-dependent increase in rabbit pulmonary arterial tension. Pulmonary arterial rings from diabetic rabbits were more responsive to 5-HT com...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139426
更新日期:1996-09-01 00:00:00
abstract::The in vitro addition of (-)-delta9-tetrahydrocannabinol (delta9-THC) resulted in a dose-responsive inhibition of the high-affinity specific synaptosomal uptake of both 3H-tryptophan and 3H-choline in mouse forebrain crude synaptosomal preparations. The approximate concentrations of delta9-THC required to cause a 50% ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136839
更新日期:1978-01-01 00:00:00
abstract::Various new butyridenyl-2-hydroxybenzylidenyl-1,3-thiazolidinones were synthesized and characterized by elemental analyses, IR and PMR spectral data. The compounds were evaluated for their ability to afford protection against inflammation by carrageenin-induced oedema and cotton pellet implantation in albino rats of e...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138130
更新日期:1985-01-01 00:00:00
abstract::The purpose of this investigation on human umbilical arteries was: (1) to analyze the effects of magnesium (Mg2+) in the prevention of contractions induced by 5-hydroxytryptamine (5-HT), KCl, Bay K 8644 and BaCl2; (2) to determine whether the presence of Mg2+ could modulate the response to caffeine in Ca2+-free medium...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028255
更新日期:1998-12-01 00:00:00
abstract::This study was designed to document possible changes in the binding of bupivacaine (BV), lidocaine (LC) and their main metabolites desbutylbupivacaine (PPX) and monoethylglycinexylydide (MEGX), respectively, to plasma proteins and erythrocytes in mice after acute treatment with the calcium antagonists diltiazem (DZ), ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139433
更新日期:1996-10-01 00:00:00
abstract::In a model of dimethylhydrazine-induced colorectal tumors in male mice aloin- or sennoside-enriched diets (0.03%) did not promote incidence and growth of adenomas and carcinomas after 20 weeks. Furthermore, in anthranoid-fed mice no significant changes in serum electrolytes as well as parameters of hepato- and nephrot...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139859
更新日期:1993-10-01 00:00:00
abstract::The systemic and coronary hemodynamic effects of the nitrovasodilator, pirsidomine, were compared with SIN-1, nitroprusside, and nitroglycerin. Four groups consisting of 32 experiments were performed in 17 conscious dogs chronically instrumented for measurement of aortic and left ventricular pressure, left ventricular...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139372
更新日期:1996-02-01 00:00:00
abstract::Prior studies revealed an apparent bimodal distribution of adrenal xenobiotic-metabolizing activities in outbred guinea pigs. High activities were characteristic of most animals but a minority had very low rates of metabolism. The present studies were done to determine the basis for this distribution. Among the enzyma...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028384
更新日期:2000-08-01 00:00:00
abstract::Metabotropic G protein-coupled receptors have recently been recognized as targets for anesthetics and analgesics. In particular, G(q)-coupled receptors such as muscarinic M(1) receptors (M(1)R) and 5-hydroxytryptamine (5-HT) type 2A receptors have been reported to be targets for anesthetics. Much less is known, howeve...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000080106
更新日期:2004-11-01 00:00:00
abstract::The temporal effects of vitamin A deficiency on hepatic cytochrome P-450-dependent and conjugation reactions were studied in the rat. Cytochrome P-450 levels and N-methyl-p-chloroaniline N-demethylase activity were significantly reduced in the deficient animals. No other changes in parameters dependent on cytochrome P...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137457
更新日期:1980-01-01 00:00:00
abstract::Although proton pump inhibitors (PPI) are generally well tolerated, with most adverse effects being minor and self-limiting, there are singular reports on hypersensitivity immune reactions triggered by a PPI or its metabolites. Here we report a case of acute drug-induced fever with leukocytosis and a transient increas...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000364781
更新日期:2014-01-01 00:00:00
abstract::The effect of probenecid on the plasma protein binding of methotrexate (MTX) has been examined in vitro. At concentrations greater than or equal to 5 x 10(-4) M, probenecid caused a significant reduction (greater than 30%) in the plasma binding of MTX. It is suggested that in vivo this would lead to a greater dispersi...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137947
更新日期:1984-01-01 00:00:00
abstract::Previously it was demonstrated that intravenously administered morphine produced greater analgesic but lower hyperthermic responses to morphine in 24-week-old rats in comparison to 8-week-old rats. The differential pharmacological responses to morphine could not solely be attributed to the pharmacokinetic parameters, ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139073
更新日期:1993-07-01 00:00:00
abstract::The present study was designed to examine the reaction pathway of colloidal bismuth subcitrate (CBS) with thiols. Studies were performed using the monothiol glutathione (GSH), the dithiol dithiothreitol (DTT) and the thiol enzymes papain and H+/K(+)-ATPase. UV-vis spectra showed that CBS forms complexes with GSH and D...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139088
更新日期:1993-08-01 00:00:00
abstract::Effects of bepridil on the low voltage-activated T-type Ca2+ channel (CaV3.2) current stably expressed in human embryonic kidney (HEK)-293 cells were examined using patch-clamp techniques. Bepridil potently inhibited ICa,T with a markedly voltage-dependent manner; the IC50 of bepridil was 0.4 micromol/l at the holding...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000085329
更新日期:2005-07-01 00:00:00
abstract::The aim of the present study was to compare the cardioprotective properties of long-acting calcium channel antagonist pranidipine with amlodipine in rat model of heart failure induced by autoimmune myocarditis. Twenty-eight days after immunization the surviving rats were randomized for the oral administration of low-d...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000091746
更新日期:2006-01-01 00:00:00
abstract:AIM:An increase in carotid intima-media thickness (CIMT) represents an early phase of the atherosclerotic process. The aim of our study was to evaluate whether a reduction in CIMT could be seen with 1-year treatment with rosuvastatin (10 mg/day). METHODS AND RESULTS:Forty-five patients with hypercholesterolemia and as...
journal_title:Pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000276476
更新日期:2010-01-01 00:00:00
abstract::Effects of choleresis produced by atropine (4-10(-4)M) on the biliary elimination of 3H-ouabain and on the biliary clearance rate of 14C-erythritol were studied in the isolated perfused rat liver. The increased bile flow produced by atropine was associated with decreased level of 3H-ouabain in the bile. The cumulative...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000135848
更新日期:1977-01-01 00:00:00
abstract::The affinity of amitriptyline for muscarine M1 receptors was studied in the rat cerebral cortex and rabbit vas deferens utilizing binding studies as well as inhibition of carbachol-induced phosphoinositide hydrolysis in the cerebral cortex and blockade of the muscarinic prejunctional inhibition of sympathetic nerve st...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139192
更新日期:1994-05-01 00:00:00