Stability of chloramphenicol metabolites in human blood and liver as determined by high-performance liquid chromatography.

abstract：:A calcitonin preparation derived from porcine thyroid glands exhibited potentiating activity on the steroidogenic action not only on ACTH-(1-24) but also of ACTH-(1-18) in isolated rat adrenal cells in vitro. This activity was demonstrated in various molecular weight fractions resulting from gel filtration of the prep...

journal_title：Pharmacology

authors： Iida S,Itoh Y,Moriwaki K

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Centhaquin is a centrally acting hypotensive drug like clonidine. Clonidine also produces analgesia and hypothermia in mice and potentiates morphine analgesia. Clonidine analgesia is blocked by idazoxan and naloxone while it is potentiated by BQ123 and sulfisoxazole. This study was conducted to determine the...

journal_title：Pharmacology

authors： Andurkar SV,Gulati A

更新日期：2011-01-01 00:00:00

abstract：:The present experiments examined the protective effect of the nitrofuran drugs, furazolidone (FZ) and nitrofurazone (NF), on duodenal ulceration induced by cysteamine or indometacin in rats. FZ at oral doses of 25, 50 or 100 mg/kg for 2 consecutive days signficantly reduced, in a dose-dependent manner, the incidence a...

journal_title：Pharmacology

authors： Ali BH

更新日期：1991-01-01 00:00:00

abstract：:In the present study, the effects of ghrelin against the gastric damage induced by intragastric administration of 0.6 N HCl and the involvement of histamine H₃ receptors (H₃Rs) were investigated in conscious rats with selective H₃R ligands. Intraperitoneal (i.p.) injection of ghrelin (40 μg/kg) significantly reduced (...

journal_title：Pharmacology

authors： Adami M,Pozzoli C,Leurs R,Stark H,Coruzzi G

更新日期：2010-01-01 00:00:00

abstract：:Previously it was demonstrated that intravenously administered morphine produced greater analgesic but lower hyperthermic responses to morphine in 24-week-old rats in comparison to 8-week-old rats. The differential pharmacological responses to morphine could not solely be attributed to the pharmacokinetic parameters, ...

journal_title：Pharmacology

authors： Bhargava HN,Villar VM,Rahmani NH,Larsen AK

更新日期：1993-07-01 00:00:00

abstract：:We investigated the effects of calcium ions (Ca2+) on the adenylyl cyclase activity in purified turkey erythrocyte membranes. Results showed the following: (i) Ca2+ inhibits cAMP accumulation stimulated by isoproterenol (1 micromol/l), NaF + AlCl3 (10 mmol/l + 20 micromol/l) or forskolin (10 micromol/l) in EGTA-washed...

journal_title：Pharmacology

authors： Demirel E,Ugur O,Onaran HO

更新日期：1998-10-01 00:00:00

abstract：:The protective effect of cimetidine, ranitidine and a newer H2-receptor antagonist, mifentidine (proposed INN), on models of gastric and duodenal damage, caused by activation of H2 receptors, was studied. Gastric erosions were induced in rats by intravenous dimaprit (100 mg/kg) while duodenal damage was investigated i...

journal_title：Pharmacology

authors： Del Soldato P,Ghiorzi A,Cereda E,Donetti A

更新日期：1985-01-01 00:00:00

abstract：:Various stressful stimuli cause mast cell degranulation. Hemorrhagic shock is one such stressful stimulus which may cause mast cell degranulation and histamine release. Histamine may be involved in the pathophysiology of hemorrhage. It was reported that there are large amounts of histamine in the anterior and posterio...

journal_title：Pharmacology

authors： Tikiz H,Tunçel N,Gürer F,Baycu C

更新日期：1991-01-01 00:00:00

abstract：:Using a discrete-trial avoidance-escape schedule in rats the interactions of morphine (M), chlorpromazine (C) and Haloperidol (H) were studied. All three drugs given alone or in combination disrupted operant behavior. At low doses C and H potentiated each other's effect, while at high doses antagonism could be observe...

journal_title：Pharmacology

authors： Tarnawa I,Székely JI

更新日期：1980-01-01 00:00:00

abstract：:Mast cells from different locations are shown to vary in their histochemical, ultrastructural, cytochemical and functional properties. The clinical consequences of this heterogeneity and possible reasons for its origin are discussed. ...

journal_title：Pharmacology

authors： Pearce FL

更新日期：1986-01-01 00:00:00

abstract：:Tacrine (THA) selectively modulates binding of M1 ligands in an allosteric fashion causing positive cooperativity. The binding affinity of THA to M1 and M2 cholinoceptors is similar. It is therefore proposed that the allosteric selectivity of THA is a function of the binding site and not of THA itself. Its interaction...

journal_title：Pharmacology

authors： Szilagyi M,Lau WM

更新日期：1993-10-01 00:00:00

abstract：:Various attempts to developing antagonists for substance P (SP) and related peptides, based on our past experience with angiotensin, kinins, and neurotensin, were unsuccessful. The particular features of SP, namely the high activity of C-terminal partial sequences in some pharmacological tests were used to develop one...

journal_title：Pharmacology

authors： Regoli D,Escher E,Mizrahi J

更新日期：1984-01-01 00:00:00

abstract：AIMS:Basal insulin administered to type-2 diabetic patients with poor glycaemic control when managed with oral anti-diabetics (OADs) alone can lead to an increased risk of weight gain and hypoglycaemia. In the absence of head-to-head trials, an indirect comparison of the once-daily insulin detemir with insulin glargine...

journal_title：Pharmacology

authors： Fakhoury W,Lockhart I,Kotchie RW,Aagren M,LeReun C

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carvedilol is used clinically as a β-adrenoceptor antagonist for the treatment of chronic heart failure and is primarily metabolized into glucuronides by UDP-glucuronosyltransferase (UGT). In this study, the stereoselective glucuronidation of carvedilol by the human liver and intestinal microsome...

journal_title：Pharmacology

authors： Hanioka N,Tanaka S,Moriguchi Y,Narimatsu S

更新日期：2012-01-01 00:00:00

abstract：:The effects of two synthetic heme analogues, zinc mesoporphyrin (ZnMP) and tin mesoporphyrin (SnMP), on in vivo hematopoietic progenitor cell mobilization and in vitro hematopoiesis were examined in rabbit bone marrow. Rabbits received granulocyte colony-stimulating factor (rhG-CSF) for 7 days in order to mobilize inc...

journal_title：Pharmacology

authors： Lutton JD,Jiang S,Drummond GS,Abraham NG,Kappas A

更新日期：1999-01-01 00:00:00

abstract：:Induction of endogenous superoxide anion stress by the use of the superoxide dismutase inhibitor diethylthiocarbamate (DETCA; 10 mmol/l) produced a potent inhibition of the ATP (0.3-10 mmol/l) and diadenosine tetraphosphate (AP(4)A) contractile activity in the isolated vas deferens by 29-92 and 24-90%, respectively. P...

journal_title：Pharmacology

authors： Al-Rawi MB,Aleisa AM,Khattab MM

更新日期：2008-01-01 00:00:00

abstract：:The effects of intraperitoneal pretreatment, 48 h beforehand, with zinc sulphate (22, 44 or 88 mg/kg) were studied on gastric ulceration, gastric secretion and changes in stomach wall mast cell counts induced after 4 h by reserpine (5 mg/kg) given intraperitoneally to intact (unoperated for pylorus occlusion) or pylor...

journal_title：Pharmacology

authors： Ogle CW,Cho CH

更新日期：1978-01-01 00:00:00

abstract：:This study examined effects of intracerebroventricularly (i.c.v.) administered somatostatin (SRIH-14 and SRIH-28) on growth and function of pituitary somatotropes (GH cells) and lactotropes (PRL cells). Male rats received three i.c.v. injections (1 microgram/5 microliters) of SRIH-14 or SRIH-28 every second day. Blood...

journal_title：Pharmacology

authors： Milosević V,Brkić B,Velkovski SD,Sekulić M,Lovren M,Starcević V,Severs WB

更新日期：1998-07-01 00:00:00

abstract：:We evaluated the contribution of neuropeptides to antigen-induced contractions of isolated bronchi and tracheae of passively sensitized guinea pigs using CP-96345 and SR 48968, specific antagonists of NK(1) and NK(2) receptors, respectively, in combination with treatment by an antihistaminic and a cysteinyl leukotrien...

journal_title：Pharmacology

authors： Tanpo T,Nabe T,Yasui K,Kamiki T,Kohno S

更新日期：2000-05-01 00:00:00

abstract：:This study was designed to determine whether pyrazinoylguanidine (PZG) can attenuate diabetic nephropathy in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced within 1 week after a single intraperitoneal dose of STZ (45 mg/kg in 0.05 mol/l sodium citrate buffer). Diabetic rats were divided into five gro...

journal_title：Pharmacology

authors： Follansbee MH,Beyer KH Jr,Griffith JW,Vesell ES

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Cassia angustifolia L. (senna) is traditionally used as a laxative. Its major components are sennosides that are responsible for the laxative effect. Senna is recommended for the short-term treatment of acute constipation. Nevertheless people use its preparations as self-medication, often for long periods, t...

journal_title：Pharmacology

authors： Vitalone A,Di Giacomo S,Di Sotto A,Franchitto A,Mammola CL,Mariani P,Mastrangelo S,Mazzanti G

更新日期：2011-01-01 00:00:00

abstract：:Nabumetone is a nonsteroidal anti-inflammatory (NSAI) drug which is known to cause less gastrointestinal damage than other NSAI drugs. This study was performed to evaluate whether nabumetone treatment might alter the vascular aberrations related to inflammation in a rat model of adjuvant-induced arthritis. Nabumetone ...

journal_title：Pharmacology

authors： Ulker S,Onal A,Hatip FB,Sürücü A,Alkanat M,Koşay S,Evinç A

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND/AIMS:Vaginismus is characterized by recurrent or persistent involuntary contraction of the perineal muscles surrounding the outer third of the vagina when penile, finger, tampon, or speculum penetration is attempted. Recent results have suggested the use of botulinum toxin for the treatment of vaginismus. He...

journal_title：Pharmacology

authors： Ferreira JR,Souza RP

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to assess whether moderate hypoxia affects the disposition of diltiazem. Six male beagle dogs received diltiazem (0.6 mg/kg) on three occasions: (1) while breathing air, i.e. during normoxia; (2) 1 h after initiating exposure to a FiO2 of 0.08, a FiCO2 of 0.035 and a FiN2 of 0.885, i.e. durin...

journal_title：Pharmacology

authors： du Souich P,Hartemann D,Saunier C

更新日期：1993-12-01 00:00:00

abstract：:The relationship between alpha(1)-adrenoceptor binding in rat tissues and pharmacodynamic effects of continuous infusion of KMD-3213 was examined. In vivo specific binding of [(3)H]KMD-3213 after continuous intravenous infusion of the ligand (100 pmol/kg/min for 10 min, followed by 30 pmol/kg/min for 60 or 90 min) dif...

journal_title：Pharmacology

authors： Akiyama K,Tatemichi S,Katayama S,Nakajima M,Oki T,Okura T,Yamada S,Kimura R

更新日期：2002-01-01 00:00:00

abstract：:We report that the loop diuretic drugs bumetanide and furosemide used in the treatment of hypertension are GPR35 agonists. We utilized calcium flux, inositol phosphate accumulation, and dynamic redistribution assays to examine the pharmacology of these compounds on the human, mouse and rat GPR35. While potent on human...

journal_title：Pharmacology

authors： Yang Y,Fu A,Wu X,Reagan JD

更新日期：2012-01-01 00:00:00

abstract：:The effects of the calcium channel antagonist nifedipine and the protein kinase C (PKC) inhibitor, staurosporine were examined on the pressor actions of a full, cirazoline, and a partial, St587, alpha 1-adrenoceptor agonist as well as the alpha 2-adrenoceptor agonist B-HT 920 in the pithed rat preparation. Administrat...

journal_title：Pharmacology

authors： Tabrizchi R,Triggle CR

更新日期：1991-01-01 00:00:00

abstract：:The temporal effects of vitamin A deficiency on hepatic cytochrome P-450-dependent and conjugation reactions were studied in the rat. Cytochrome P-450 levels and N-methyl-p-chloroaniline N-demethylase activity were significantly reduced in the deficient animals. No other changes in parameters dependent on cytochrome P...

journal_title：Pharmacology

authors： Siddik ZH,Drew R,Litterst CL,Mimnaugh EG,Sikic BI,Gram TE

更新日期：1980-01-01 00:00:00

abstract：:Galactosamine (GalN) administration produces hepatitis-like liver injury in animals. The hepatotoxicity of GalN is attenuated by several interventions, including activation of the reticuloendothelial system (RES). Fructose-1,6-diphosphate (FDP) administration significantly increases the phagocytic activity of the RES ...

journal_title：Pharmacology

authors： Markov AK,Farias LA,Bennett WS,Subramony C,Mihas AA

更新日期：1991-01-01 00:00:00

abstract：:The effects of nisoldipine on myocardial performance and large coronary artery diameter, resistance and cross-sectional area were studied in rabbit hearts in situ. Changes in mean internal diameter of coronary artery segments were visualized using color arteriography; changes were computer-calculated. Nisoldipine had ...

journal_title：Pharmacology

authors： Saito T,Saeed M,Bing RJ

更新日期：1988-01-01 00:00:00