Protection by zinc sulphate against reserpine-induced ulceration and other gastric effects in the rat.

abstract：BACKGROUND/AIMS:morphine is known to inhibit cholinergic contractions of the guinea pig small intestine. This has been compared to the human small intestinal innervated longitudinal muscle in the current study. METHODS:cholinergic primary contractions of human small intestinal longitudinal strips were evoked by electr...

journal_title：Pharmacology

authors： Benko R,Molnár Z,Nemes D,Dékány A,Kelemen D,Illényi L,Cseke L,Papp A,Varga G,Bartho L

更新日期：2010-01-01 00:00:00

abstract：:Zopiclone (ZPC; RP 27,267), which is chemically unrelated to benzodiazepines (BZD), was found to have a similar pharmacological profile and to possess in man hypnotic activity similar to that of some BZD such as nitrazepam. It was, therefore, interesting to study the interaction of ZPC with rat brain receptors and spe...

journal_title：Pharmacology

authors： Blanchard JC,Boireau A,Julou L

更新日期：1983-01-01 00:00:00

abstract：:L-Carnitine (oral route) significantly corrects the muscle hypocontractility and hypoexcitability induced in the rat after 5 consecutive days of fasting. This effect is interpreted on the basis of the dual role of L-carnitine as cofactor in the transport of long-chain fatty acids into the mitochondria and as a detoxif...

journal_title：Pharmacology

authors： Pierrefiche G,Reynier M,Laborit H

更新日期：1993-01-01 00:00:00

abstract：:The effects of several paired analogs of angiotensin II and angiotensin III, designed as antagonists, have been compared in isolated smooth muscle (rat uterus) and by in vivo rat blood pressure assay. These analogs were (1) the angiotensin II series: (1-sarcosine, 7-X, 8-isoleucine-) angiotensin II, and (2) the angiot...

journal_title：Pharmacology

authors： Moore GJ,Ko EM

更新日期：1980-01-01 00:00:00

abstract：:It can be readily shown in vitro that various compounds inhibit platelet aggregation but it has been difficult to demonstrate in vivo. A method is suggested here to enable in vivo testing of these compounds; the method utilizes relatively low doses of sodium arachidonate, made possible by the ligation of the pterygopa...

journal_title：Pharmacology

authors： Schwartzmiller D

更新日期：1980-01-01 00:00:00

abstract：:Protein phosphatase inhibitors, e.g. cantharidin, exert positive inotropic effects in mammalian heart preparations. Endothall, a synthetic herbicide which is chemically related to cantharidin, inhibits protein phosphatase activities in mouse liver preparations. However, the cardiac effects of endothall have hitherto n...

journal_title：Pharmacology

authors： Bokník P,Vahlensieck U,Huke S,Knapp J,Linck B,Lüss H,Müller FU,Neumann J,Schmitz W

更新日期：2000-07-01 00:00:00

abstract：:The diabetogenic effects of alloxan (50 mg/kg i.v.) were recorded for 6 weeks in normotensive (WKY) and spontaneously hypertensive (SHR) rats. While systolic blood pressure increased in diabetic WKY, SHR exhibited a reduction in systolic blood pressure over the 6-week period. Heart rate of treated SHR, but not WKY, wa...

journal_title：Pharmacology

authors： Cavaliere TA,Taylor DG,Kerwin LJ,Antonaccio MJ

更新日期：1980-01-01 00:00:00

abstract：:Serum protein binding and serum levels of antipyrine, phenytoin and phenylbutazone were measured in rabbits with acute renal failure induced by uranyl nitrate. The kinetics of antipyrine are not altered in the uraemic rabbit. Serum protein binding of phenytoin and phenylbutazone is decreased and the volume of distribu...

journal_title：Pharmacology

authors： Van Peer A,Belpaire F,Bogaert M

更新日期：1978-01-01 00:00:00

abstract：:Fructose-1,6-diphosphate (FDP) was found to cause significant stimulation of nitric oxide synthase (NOS) in rat liver homogenates in vitro. This effect was more pronounced for the inducible isoform than its constitutive counterpart. Furthermore, FDP restored rat liver inducible NOS levels following their depletion by ...

journal_title：Pharmacology

authors： Mihas AA,Maliakkal RJ,Mihas TA,Kanji VK,Markov AK

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Poncirus fructus (PF), also known as the dried immature fruit of Poncirus trifoliata (L.) Raf., has long been used as a cure for the treatment of various gastrointestinal disorders in eastern Asia. Recently, it was reported that naringin, a flavonoid constituent of the PF extract, causes the acti...

journal_title：Pharmacology

authors： Jang Y,Kim TK,Shim WS

更新日期：2013-01-01 00:00:00

abstract：:Supplementation of antioxidants such as vitamin E and vitamin C as health promotion food is popular recently. Epidemiological studies supported the beneficial effect of these antioxidants because oxygen free radicals have been linked to the process of diseases and aging. The present study evaluated the effect of alpha...

journal_title：Pharmacology

authors： Huang W,Chan P,Chen Y,Chen C,Liao S,Chin W,Cheng J

更新日期：1999-11-01 00:00:00

abstract：:Clofibrate treatment decreased drastically the activity of serum postheparin lipoprotein lipase of rats fed with fat-free test diet but had no effect on hepatic lipase. 3 weeks' treatment was followed by a significant fall in serum cholesterol caused by a marked decrease in HDL-cholesterol. Clofibrate decreased in vit...

journal_title：Pharmacology

authors： Strandberg TE,Kuusi T,Tilvis RS,Miettinen TA

更新日期：1983-01-01 00:00:00

abstract：:In anesthetized rats intravenously infused, norepinephrine (NE) was accumulated by the heart, the spleen and the lung in a dose-related manner. With the lower dose of NE (2.5 mg/kg) the organ/blood ratios were more than unity and were generally greater than with higher doses (5 and 10 mg/kg), indicating that accumulat...

journal_title：Pharmacology

authors： Sivaramakrishna N,Gulati OD

更新日期：1975-01-01 00:00:00

abstract：:Regional cerebral metabolic rates of glucose (rCMRglu) were measured in conscious rats grouped according to three treatments: control, bicuculline (5.5 mg/kg s.c.), and intracerebroventricular arginine vasopressin (0.5 micrograms/5 microliter). Rats in the latter group were pre-exposed to the peptide 48 h earlier to r...

journal_title：Pharmacology

authors： Wurpel JN,Dundore RL,Bryan RM Jr,Keil LC,Severs WB

更新日期：1988-01-01 00:00:00

abstract：:Congestive heart failure (CHF) is associated with exercise intolerance that cannot be entirely explained by hypoperfusion of the skeletal muscles. We studied the contractile properties of fast-twitch (extensor digitorum longus; EDL) and slow-twitch (soleus; SOL) skeletal muscles in doxorubicin-induced CHF in rats, and...

journal_title：Pharmacology

authors： Ertunc M,Sara Y,Korkusuz P,Onur R

更新日期：2009-01-01 00:00:00

abstract：:Prior studies revealed an apparent bimodal distribution of adrenal xenobiotic-metabolizing activities in outbred guinea pigs. High activities were characteristic of most animals but a minority had very low rates of metabolism. The present studies were done to determine the basis for this distribution. Among the enzyma...

journal_title：Pharmacology

authors： Colby HD,Huang Y,Jiang Q,Voigt JM

更新日期：2000-08-01 00:00:00

abstract：:The haemodynamic changes during epidural anaesthesia and following the administration of dihydroergotamine (DHE; 10 micrograms/kg i.v.) were studied in 7 dogs (epidural group). Epidural anaesthesia was associated with reductions in mean arterial, mean pulmonary arterial and mean right atrial pressures. Femoral flow wa...

journal_title：Pharmacology

authors： Zimpfer M,Schwarz M,Stanek B,Raberger G

更新日期：1981-01-01 00:00:00

abstract：:Esculentoside A, a kind of saponin isolated from the root of the Chinese herb Phytolaca esculenta, is reported to possess potent anti-inflammatory effects in acute and chronic experimental models. In the present study, we investigated the effects of esculentoside A on the production of tumor necrosis factor (TNF), int...

journal_title：Pharmacology

authors： Ju DW,Zheng QY,Cao X,Fang J,Wang HB

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND/AIMS:Vaginismus is characterized by recurrent or persistent involuntary contraction of the perineal muscles surrounding the outer third of the vagina when penile, finger, tampon, or speculum penetration is attempted. Recent results have suggested the use of botulinum toxin for the treatment of vaginismus. He...

journal_title：Pharmacology

authors： Ferreira JR,Souza RP

更新日期：2012-01-01 00:00:00

abstract：:The present study examined the interaction of opioidergic systems in the hypotensive action of atenolol. Anesthetized, adult spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats were instrumented to monitor blood pressure and heart rate. Atenolol (100 micrograms/kg, i.v.) produced a decrease in blood pressure ...

journal_title：Pharmacology

authors： Laskey RE,Jones LF,Tackett RL

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Chemotherapy-induced neuropathic pain (CINP) is a serious side effect of chemotherapy. Korean Red Ginseng (KRG) is a popular herbal medicine in Asian countries. We examined the therapeutic potential of intrathecally administered KRG for CINP and clarified the mechanisms of action with regard to 5-hydroxytryp...

journal_title：Pharmacology

authors： Kim YO,Song JA,Kim WM,Yoon MH

更新日期：2020-01-01 00:00:00

abstract：:Particulate fractions of myocardium taken from spontaneously hypertensive rats (SHR) contained an adenylate cyclase system that was less responsive than normotensive Wistar Kyoto rats to norepinephrine, isoproterenol (mixed beta-agonist), salbutamol (beta 2-agonist), dobutamine (beta 1-agonist), dopamine, histamine, a...

journal_title：Pharmacology

authors： Palmer GC,Greenberg S

更新日期：1979-01-01 00:00:00

abstract：:Topically unilaterally applied lisuride caused dose-related lowering of intraocular pressure in ipsilateral (treated) but not in contralateral eyes of normal rabbits. The ocular hypotensive response induced by lisuride was antagonized by pretreatment with metoclopramide, a dopamine receptor antagonist, and was partial...

journal_title：Pharmacology

authors： Potter DE,Ogidigben MJ,Chu TC

更新日期：1998-11-01 00:00:00

abstract：:The effects of sennosides on uterine motility were evaluated by electromyography in healthy adult ewes between day 70 and 120 of pregnancy to assess possible disturbances of the physiological pattern of contractility and eventual risks in pregnancy maintenance. At this stage of pregnancy, the ovine genital tract prese...

journal_title：Pharmacology

authors： Garcia-Villar R

更新日期：1988-01-01 00:00:00

abstract：:GPR61 is an orphan receptor that belongs to Class A of G-protein-coupled receptors. It has been reported that GPR61 has a constitutive activity and couples to Gαs. In the present study, we characterized GPR61 function and ligand binding by experimental and molecular docking studies. We demonstrated that heterologous e...

journal_title：Pharmacology

authors： Kozielewicz P,Grafton G,Sajkowska-Kozielewicz JJ,Barnes NM

更新日期：2019-01-01 00:00:00

abstract：AIM:The purpose of the present study was to examine the effects of acetaldehyde on the contractile force and membrane potentials and currents in the bullfrog heart. METHODS:Contractile force was recorded using right atrial tissues, and membrane potentials and currents were measured by using whole cell patch clamp meth...

journal_title：Pharmacology

authors： Chen FS,Satoh Y,Ide Y,Sugano T,Iimura M,Momose Y,Tsuchida K,Tagami M

更新日期：2012-01-01 00:00:00

abstract：:The effects of cyclic adenosine monophosphate-dependent protein kinase (PKA) and calcium-dependent protein kinase (PKC) modulators on secretagogue-stimulated gastric acid secretion were studied in the continuously perfused stomach of the anesthetized rat. Intravenous histamine (0.25 mg/kg/h) and pentagastrin (2 microg...

journal_title：Pharmacology

authors： Rotker JD,Strapko A,Nandi J,Bosche MC,Levine RA

更新日期：1995-10-01 00:00:00

abstract：AIMS:The present study evaluated the effects of sitagliptin-insulin against type 2 diabetes mellitus with neuropathy in rats and possible neuroprotective mechanisms. METHODS:Diabetes was induced in 32 adult male albino rats by 6-week high-fat high-sugar diet followed by streptozotocin 30 mg/kg intraperitoneal injectio...

journal_title：Pharmacology

authors： Kelany ME,Hakami TM,Omar AH,Abdallah MA

更新日期：2016-01-01 00:00:00

abstract：:Angiotensin had a dual action on the epididymal half of rat vas deferens. It potentiated electrical stimulated contraction and exerted a direct contractile effect on the muscle. The potentiation of electrically stimulated response may be mediated by presynaptic facilitation of neurotransmitter release. Muscular contra...

journal_title：Pharmacology

authors： Sum CS,Cheung WT

更新日期：1995-08-01 00:00:00

abstract：:Combination therapy with antiretroviral drugs is used for the treatment of patients infected with the human immunodeficiency virus. To achieve optimal drug concentrations for viral suppression and avoidance of drug toxicity, monitoring of drug levels has been considered essential. We set up an analytical procedure for...

journal_title：Pharmacology

authors： Donnerer J,Kronawetter M,Kapper A,Haas I,Kessler HH

更新日期：2003-12-01 00:00:00