Effect of (+)-cyanidanol-3 on the changes in liver glutathione content and lipoperoxidation induced by acute ethanol administration in the rat.

abstract：:We investigated the vascular effects of glucagon-like peptide-1 (GLP-1) and Exendin-4 in type 2 diabetic rat aortae. Studies were performed in a normal control group (NC) (0.2 ml i.p. saline, n = 10), streptozotocin (STZ)/nicotinamide diabetic control group (DC) (a single dose of 80 mg/kg STZ i.p. injection 15 min aft...

journal_title：Pharmacology

authors： Ozyazgan S,Kutluata N,Afşar S,Ozdaş SB,Akkan AG

更新日期：2005-06-01 00:00:00

abstract：:We investigated the total urinary kallikrein levels, left-ventricular wall thickness and mean arterial blood pressure of nontreated and captopril-treated diabetic and nondiabetic spontaneously hypertensive rats. The mean arterial blood pressure was significantly elevated in diabetic spontaneously hypertensive rats as ...

journal_title：Pharmacology

authors： Sharma JN,Kesavarao U

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND/AIMS:Bronchial asthma continues to be a big challenge to therapy. Mast cells play an important role in allergic asthma. Histamine and leukotrienes are established mast cell mediators, but antihistamines currently play no role in asthma therapy. METHODS:Human bronchial strips were exposed to the mast cell ac...

journal_title：Pharmacology

authors： Benko R,Molnar TF,Szombati V,Benkö I,Bartho L

更新日期：2015-01-01 00:00:00

abstract：:Acetylsalicylic acid (ASA; 0.1-10 mg/kg), indomethacin (IND; 0.1-1.0 mg/kg), and tartrazine (TZ; 0.1-2.0 mg/kg), given intravenously induced dose-dependent increases in carotid-sinus nerve (CSN) activity, accompanied by increases in mean arterial blood pressure (MABP), but only the IND-induced MABP increases were dose...

journal_title：Pharmacology

authors： D'Souza SJ,Biggs DF

更新日期：1987-01-01 00:00:00

abstract：:The effect of sodium rhein on contractile activity and fluid flow in the rat complete large intestine was studied in vitro. Contractile activity was recorded using serosal strain gauges and volume transducers recorded distal fluid flow from the segment. Luminal sodium rhein (1 mM) produced a protracted increase in cae...

journal_title：Pharmacology

authors： Rumsey RD,Squires PE,Read NW

更新日期：1993-10-01 00:00:00

abstract：:The present study was aimed at investigating the effects of diabetes on the cavernosal smooth muscle relaxations mediated by adenosine and adenosine triphosphate (ATP) in tissues obtained from men and rats. Adenosine- and ATP-induced relaxant responses showed an enhanced sensitivity with an unaltered effectiveness in ...

journal_title：Pharmacology

authors： Gür S,Oztürk B

更新日期：2000-02-01 00:00:00

abstract：:The present study was designed to examine the reaction pathway of colloidal bismuth subcitrate (CBS) with thiols. Studies were performed using the monothiol glutathione (GSH), the dithiol dithiothreitol (DTT) and the thiol enzymes papain and H+/K(+)-ATPase. UV-vis spectra showed that CBS forms complexes with GSH and D...

journal_title：Pharmacology

authors： Beil W,Bierbaum S,Sewing KF

更新日期：1993-08-01 00:00:00

abstract：:Three doses (0.31, 3.1 and 31 mg/kg) of methotrexate (MTX) were given intravenously to rats. The resulting concentration-time curves in plasma (normalized by dividing the plasma concentration by a multiple of the dose) were not superimposable, indicating nonlinear plasma pharmacokinetics. In liver, kidney, bone marrow...

journal_title：Pharmacology

authors： Scheufler E

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:Advanced glycation end products (AGEs) play a pivotal role in the initiation and progression of osteoarthritis (OA). Peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to exhibit anti-inflammatory and anticatabolic properties and to be protective in animal models of OA. This study was aimed t...

journal_title：Pharmacology

authors： Chen C,Ma C,Zhang Y,Zeng Y,Li Y,Wang W

更新日期：2014-01-01 00:00:00

abstract：:Pain and mental status were assessed in a series of 35 consecutive hospitalized patients with metastatic cancer receiving narcotics for pain that was difficult to control. Forty-five episodes of mental status impairment were detected in 27 of these patients. Fifteen patients had dose-related oversedation or organic br...

journal_title：Pharmacology

authors： Leipzig RM,Goodman H,Gray G,Erle H,Reidenberg MM

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:To investigate the efficacy, safety, and clinical benefit of prolonged-release trazodone (Trittico) in the treatment of major depressive disorder (MDD). METHODS:In this study, 363 Chinese patients with MDD were randomized 1:1 to receive either prolonged-release trazodone (150-450 mg) or placebo treatment for...

journal_title：Pharmacology

authors： Zhang L,Xie WW,Li LH,Zhang HG,Wang G,Chen DC,Cao Y,Cui LJ,Zhang KR,Shi JG,Tan QR,Zheng HB,Xu XF,Cheng ZH,Zhao JP

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Morphine causes state-dependent learning that its mechanism and brain-related structures are not fully understood. This study aimed to determine whether lidocaine reversible inactivation of the central nucleus of the amygdala (CeA) could affect acquisition, consolidation, and retrieval of morphine state...

journal_title：Pharmacology

authors： Noorbakhshnia M,Rahmani-Samani P,Eivani M

更新日期：2020-01-01 00:00:00

abstract：AIM:Superfluous reactive nitrogen and oxygen species generation is implicated in the damage of tissues at sites of inflammation where activated neutrophils and macrophages are involved. This study was conducted to investigate whether the beneficial effects of carvedilol involve modulation of respiratory burst, degranul...

journal_title：Pharmacology

authors： Pecivová J,Macicková T,Lojek A,Gallova L,Cíz M,Nosál' R,Holománová D

更新日期：2007-01-01 00:00:00

abstract：:The effects of the calcium channel antagonist nifedipine and the protein kinase C (PKC) inhibitor, staurosporine were examined on the pressor actions of a full, cirazoline, and a partial, St587, alpha 1-adrenoceptor agonist as well as the alpha 2-adrenoceptor agonist B-HT 920 in the pithed rat preparation. Administrat...

journal_title：Pharmacology

authors： Tabrizchi R,Triggle CR

更新日期：1991-01-01 00:00:00

abstract：:Hepatic lipid accumulation and apoptosis is elevated in patients with non-alcoholic steatohepatitis and is closely associated with severity. Saturated fatty acid palmitate stimulates lipid accumulation and apoptosis in hepatocytes. In the present study, we examined bee-bee tree oil (BO)-mediated protective effects on ...

journal_title：Pharmacology

authors： Jung TW,Kim SY,Kim DS,Shin EC,Park YB,Lee KT

更新日期：2018-01-01 00:00:00

abstract：:Phencyclidine (PCP; 10 mg/kg, s.c.) produced a marked diuresis which occurred without significant changes in solute excretion. This diuresis occurred predominantly within 2 h of PCP injection, and was blocked by pretreatment with vasopressin. The maximum diuresis corresponded temporally to a significant fall in plasma...

journal_title：Pharmacology

authors： Zerbe RL,Bayorh MA,Quirion R,Kopin IJ

更新日期：1983-01-01 00:00:00

abstract：:Ketotifen is an antiallergic drug and may have direct inhibitory effects on eosinophils. To investigate the anti-eosinophilic effect of ketotifen, we examined the effect of ketotifen on the production of reactive oxygen species (ROS) from eotaxin-primed human eosinophils. Ketotifen at 10(-10)-10(-6) mol/l significantl...

journal_title：Pharmacology

authors： Yamada Y,Sannohe S,Saito N,Cui CH,Ueki S,Oyamada H,Kanda A,Yamaguchi K,Hamada K,Adachi T,Kayaba H,Chihara J

更新日期：2003-11-01 00:00:00

abstract：:Effects of choleresis produced by atropine (4-10(-4)M) on the biliary elimination of 3H-ouabain and on the biliary clearance rate of 14C-erythritol were studied in the isolated perfused rat liver. The increased bile flow produced by atropine was associated with decreased level of 3H-ouabain in the bile. The cumulative...

journal_title：Pharmacology

authors： Nevasaari K,Alakare B,Kärki NT

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Carvedilol is used clinically as a β-adrenoceptor antagonist for the treatment of chronic heart failure and is primarily metabolized into glucuronides by UDP-glucuronosyltransferase (UGT). In this study, the stereoselective glucuronidation of carvedilol by the human liver and intestinal microsome...

journal_title：Pharmacology

authors： Hanioka N,Tanaka S,Moriguchi Y,Narimatsu S

更新日期：2012-01-01 00:00:00

abstract：:We established an Ascaris-induced biphasic skin allergic reaction in mice. In the early-phase reaction (EPR), mast cell degranulation was observed, and tranilast inhibited ear edema. In mast-cell-deficient mice (WBB6F(1)-W/W(V) mice), ear edema in the EPR disappeared, whereas that in the late-phase reaction (LPR) rema...

journal_title：Pharmacology

authors： Sengoku T,Sato S,Sakuma S,Ogawa T,Ohkubo Y,Goto T

更新日期：2001-01-01 00:00:00

abstract：:The intracerebroventricular injection of the cholecystokinin-A receptor antagonist L-364,718, at the doses of 0.5, 5, 10 or 20 micrograms/mouse, while having no effect on pain threshold (hot plate, 51 degrees C), antagonized the analgesic activity of morphine (10 mg/kg i.p.). This effect was obtained with a dose of 10...

journal_title：Pharmacology

authors： Poggioli R,Vergoni AV,Sandrini M,Barbafiera L,Marrama D,Bertolini A

更新日期：1991-01-01 00:00:00

abstract：:The effect of sucralfate treatment (3 g daily for 6 weeks) on gastric HCO3- secretion was investigated in 15 duodenal ulcer patients. After treatment a highly significant (p less than 0.01) increase in gastric bicarbonate output was found. It is suggested that the mode of action of sucralfate includes stimulation of g...

journal_title：Pharmacology

authors： Guslandi M

更新日期：1985-01-01 00:00:00

abstract：:Fructose-1,6-diphosphate (FDP) was found to cause significant stimulation of nitric oxide synthase (NOS) in rat liver homogenates in vitro. This effect was more pronounced for the inducible isoform than its constitutive counterpart. Furthermore, FDP restored rat liver inducible NOS levels following their depletion by ...

journal_title：Pharmacology

authors： Mihas AA,Maliakkal RJ,Mihas TA,Kanji VK,Markov AK

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIMS:We studied the effect of the combined treatment with an angiotensin-converting enzyme (ACE) inhibitor (ramipril) and eplerenone compared with ramipril alone in streptozocin-induced diabetic rats. METHODS:Wistar rats were divided into 4 groups: nondiabetic controls, streptozocin-treated diabetic rats (5...

journal_title：Pharmacology

authors： Mavrakanas TA,Cheva A,Kallaras K,Karkavelas G,Mironidou-Tzouveleki M

更新日期：2010-01-01 00:00:00

abstract：:The radioligand binding profiles and in vivo pharmacological characteristics of YM-44781, YM-44778 and YM-49598, novel non-peptide tachykinin receptor antagonists, were examined and compared to those of FK-888 and GR-159897. Since no functional NK(3) receptors were found in the rat bladder, the emphasis will be on the...

journal_title：Pharmacology

authors： Choppin A,Groke G,Bringas A,Stepan G,Dillon MP

更新日期：2002-05-01 00:00:00

abstract：:Both in vivo and in vitro exposure to morphine have been reported to produce a number of immunomodulatory effects in both laboratory animals and humans. The current study was performed to assess the direct in vitro effect of exposure to morphine or morphine metabolites on immune response parameters. Murine B6C3F1 sple...

journal_title：Pharmacology

authors： Thomas PT,Bhargava HN,House RV

更新日期：1995-01-01 00:00:00

abstract：:Two groups of rats were used to examine the effect of pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, on rat hearts using an in vivo model of ischemia-reperfusion (I/R) to elucidate potential mechanisms. One group was the 30-min reperfusion group, which was further subdivided into...

journal_title：Pharmacology

authors： Cao Z,Ye P,Long C,Chen K,Li X,Wang H

更新日期：2007-01-01 00:00:00

abstract：:Stimulants (histamine, acetylcholine and substance P) and relaxants (isoprenaline and bradykinin) of the guinea pig trachea were tested in the absence and presence of mepacrine, eicosatetraynoic acid, BW 755C and indomethacin in order to evaluate the involvement of prostaglandins and congeners in the effects of amines...

journal_title：Pharmacology

authors： Mizrahi J,D'Orléans-Juste P,Caranikas S,Regoli D

更新日期：1982-01-01 00:00:00

abstract：:Particulate fractions of myocardium taken from spontaneously hypertensive rats (SHR) contained an adenylate cyclase system that was less responsive than normotensive Wistar Kyoto rats to norepinephrine, isoproterenol (mixed beta-agonist), salbutamol (beta 2-agonist), dobutamine (beta 1-agonist), dopamine, histamine, a...

journal_title：Pharmacology

authors： Palmer GC,Greenberg S

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND/AIM:It has been demonstrated that dexamethasone-induced hypertension can be prevented by the NADPH oxidase inhibitor apocynin. The effect of dexamethasone on NADPH oxidase, however, is unknown. The present study was conducted to investigate the effect of dexamethasone on the gene expression of Nox1, the majo...

journal_title：Pharmacology

authors： Siuda D,Tobias S,Rus A,Xia N,Förstermann U,Li H

更新日期：2014-01-01 00:00:00