Characterization of Ascaris-induced biphasic skin allergic reaction model in mice: possible roles of mast cells in early-phase and CD4-positive T cells in late-phase reactions.

abstract：:In this study, we used a novel conscious dog model to evaluate the uroselectivity of selected alpha 1-antagonists either approved for human use or in clinical development for the treatment of symptomatic benign prostatic hyperplasia (BPH) and compared those results to their in vitro binding and functional affinities a...

journal_title：Pharmacology

authors： Brune ME,Katwala SP,Milicic I,Buckner SA,Ireland LM,Kerwin JF Jr,Hancock AA

更新日期：1996-12-01 00:00:00

abstract：:We investigated the total urinary kallikrein levels, left-ventricular wall thickness and mean arterial blood pressure of nontreated and captopril-treated diabetic and nondiabetic spontaneously hypertensive rats. The mean arterial blood pressure was significantly elevated in diabetic spontaneously hypertensive rats as ...

journal_title：Pharmacology

authors： Sharma JN,Kesavarao U

更新日期：2002-04-01 00:00:00

abstract：:Lesopitron acts as a ligand for central serotonin 5-HT1A receptors. Ki obtained from [3H]8-OH-DPAT competition studies was 104.8 +/- 10.6 nmol/l. As lesopitron did not affect the binding of [3H]paroxetine, involvement of the serotonin reuptake system in the effects of lesopitron is rejected. Lesopitron inhibits halope...

journal_title：Pharmacology

authors： Fisas MA,Farré A,Camarasa J,Escubedo E

更新日期：2004-10-01 00:00:00

abstract：:Tetraethylammonium chloride (TEA) at concentrations over 10(-3) mol/l produced a concentration-dependent contraction in the isolated canine coronary artery. We investigated mechanisms of the contractile response and the effects of various vasodilators on the contraction. While phentolamine, propranolol, guanethidine, ...

journal_title：Pharmacology

authors： Nishio M,Kigoshi S,Muramatsu I

更新日期：1986-01-01 00:00:00

abstract：:The present study aims at investigating the effects of mannitol and dimethylthiourea, known hydroxyl radical scavengers, on lipid peroxidation as an indicative of oxidative damage, NF-kappa B activation and IL-8 production by Helicobacter pylori in gastric epithelial cells. A human gastric epithelial cell line, AGS, t...

journal_title：Pharmacology

authors： Kim H,Seo JY,Kim KH

更新日期：1999-10-01 00:00:00

abstract：:The effects of a purine precursor, AICAriboside (5-aminoimidazole-4-carboxamide riboside), on postischemic recovery of myocardial function and adenine nucleotides have been studied in the isolated blood-perfused cat heart. The isolated hearts received either AICAriboside or saline prior to 60 min of global ischemia an...

journal_title：Pharmacology

authors： Mitsos SE,Jolly SR,Lucchesi BR

更新日期：1985-01-01 00:00:00

abstract：:It has previously been demonstrated in several species that the secretory granules of pancreatic beta-cells have the ability to store substantial amounts of calcium and bioactive amines, such as dopamine and serotonin. Furthermore, evidence for a similar topographical localization for amine and calcium within the peri...

journal_title：Pharmacology

authors： Ahrén B,Lundquist I

更新日期：1985-01-01 00:00:00

abstract：:Glutathione S-transferases (GSTs) detoxify diverse electrophilic chemicals, including anticancer drugs. Containing at least 100 microM total GST, the adult rat liver has abundant alpha and mu class GST isoenzymes. We utilized primary cultured rat hepatocytes, maintained in chemically defined medium, to examine direct ...

journal_title：Pharmacology

authors： Grgurevich S,Greene FE

更新日期：1995-06-01 00:00:00

abstract：:Imatinib and AMN107 are protein tyrosine kinase inhibitors which reduce KIT autophosphorylation with similar potency. This report describes the cellular uptake of these compounds in two human gastrointestinal stromal tumor (GIST)-derived cell lines (GIST882 and GIST GDG1), which both express constitutively activated K...

journal_title：Pharmacology

authors： Prenen H,Guetens G,de Boeck G,Debiec-Rychter M,Manley P,Schoffski P,van Oosterom AT,de Bruijn E

更新日期：2006-01-01 00:00:00

abstract：:We evaluated the effects of sodium alginate (AL-Na) on dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. DSS was added to the drinking water for 7 days. In another experiment, DSS was added to the drinking water for 5 days and DSS-free water was provided thereafter. ...

journal_title：Pharmacology

authors： Yamamoto A,Itoh T,Nasu R,Nishida R

更新日期：2013-01-01 00:00:00

abstract：:The influence of hyperthyroidism on the functional vascular responsiveness of isolated coronary and renal resistance vessels was investigated. Hyperthyroidism was established by feeding rats for 1 and 4 weeks with 5 mg/kg L-thyroxine (T4)-containing rat chow. Preparations of either coronary or renal resistance vessels...

journal_title：Pharmacology

authors： Zwaveling J,Pfaffendorf M,van Zwieten PA

更新日期：1997-09-01 00:00:00

abstract：:The endocrine (plasma renin activity, insulin and ADH) and hemodynamic responses (heart rate and mean arterial pressure) to isoprenaline infusion were examined in conscious deoxycorticosterone-salt hypertensive rats (DS) and compared with uninephrectomized-salt control rats (US). A dose-related rise in plasma renin ac...

journal_title：Pharmacology

authors： Vargas F,Haro JM,Garcia-Torres L,Soler A,Garcia del Rio C

更新日期：1989-01-01 00:00:00

abstract：:The cardioprotective effects of (2S,3R,4S)-N'-benzyl- N"-cyano-N-(3,4-dihydro-2-dimethoxymethyl-3-hydro- xy-2-methyl-6-nitro-2H-benzopyran-4-yl)-guanidine (KR-31372) were evaluated against ischemic/reperfusion injury in isolated rat hearts in vitro and in anesthetized rats and dogs in vivo. In isolated perfused rat he...

journal_title：Pharmacology

authors： Lee BH,Seo HW,Yoo SE

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:The accumulation of amyloid-β (Aβ) plaque in the brain is a characteristic feature of Alzheimer's disease (AD) and the cause of fatal oxidative damage to neuronal cells. Korean red ginseng (RG) is used extensively in traditional medicine and is known to have anti-oxidative and anti-inflammatory properties....

journal_title：Pharmacology

authors： Choi S,Lim JW,Kim H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIMS:Putative in vitro-in vivo correlations of pharmacokinetic (PK) parameters are regarded as a prerequisite to filter hits derived from high-throughput screening (HTS) approaches for subsequent murine in vivo PK studies. METHODS:In this study, we assessed stabilities in rat and human microsomes of 121 com...

journal_title：Pharmacology

authors： Schrezenmeier E,Zollmann FS,Seidel K,Böhm C,Schmerbach K,Kroh M,Kirsch S,Klare S,Bernhard S,Kappert K,Goldin-Lang P,Skuballa W,Unger T,Funke-Kaiser H

更新日期：2012-01-01 00:00:00

abstract：:The protective effect of cimetidine, ranitidine and a newer H2-receptor antagonist, mifentidine (proposed INN), on models of gastric and duodenal damage, caused by activation of H2 receptors, was studied. Gastric erosions were induced in rats by intravenous dimaprit (100 mg/kg) while duodenal damage was investigated i...

journal_title：Pharmacology

authors： Del Soldato P,Ghiorzi A,Cereda E,Donetti A

更新日期：1985-01-01 00:00:00

abstract：:The calcium channel antagonist, nifedipine (0.1 microM), only slightly inhibited the response to the full alpha 1-adrenoceptor agonist, (-)-norepinephrine, in rat aorta, but nearly completely inhibited the response to the partial alpha 1-adrenoceptor agonist, (-)-dobutamine, indicating that (-)-norepinephrine primaril...

journal_title：Pharmacology

authors： Oriowo MA,Ruffolo RR Jr

更新日期：1992-01-01 00:00:00

abstract：:Atherosclerosis (AS) is a chronical pathological process of the arterial narrows due to the AS plaque formation. The aim of this study was to explore the therapeutic effect and the underlying mechanism of Floralozone on experimental atherosclerotic model rats. Experimental atherosclerotic model rats were induced by th...

journal_title：Pharmacology

authors： Yang YP,Zhu ML,Zhang HY,Song P,Xu J,Li P,Yin YL

更新日期：2020-01-01 00:00:00

abstract：:Sensitive radiometric assays were adapted to study the development and kinetics of meperidine and methadone N-demethylation and morphine glucuronidation by microsomes isolated from livers of fetal stump-tailed macaques (Macaca arctoides). Times in development selected for study were midterm, three-quarter term, near t...

journal_title：Pharmacology

authors： Dvorchik BH,Stenger VG,Hartman RD

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Angiogenesis is usually driven by inflammation. Matrix metalloproteinases MMP-3 and MMP-9 and tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 are implicated in vascular remodeling. TIMP-2 exhibits antiangiogenic properties. Statins show benefits that are additional to lipid lowering including pro- ...

journal_title：Pharmacology

authors： Siddiqui AJ,Gustafsson T,Sylven C,Crisby M

更新日期：2014-01-01 00:00:00

abstract：:Ulcerative colitis is characterized by dysfunctional motility. Our main objective in this investigation was to study the effect of an acetic acid-induced ulcerative colitis on the expression and function of beta(3)-adrenoceptors in the rat colon. Inflammation was induced by administering acetic acid intrarectally into...

journal_title：Pharmacology

authors： Khan I,Hussein SM,Oriowo M

更新日期：2002-02-01 00:00:00

abstract：:N-Tosyl-L-phenylalanyl-chloromethyl ketone (TPCK) is neuroprotective in rat pups. We measured bcl-2, Bax and caspase-3 to determine the mechanisms. Seven-day-old rats had the right carotid artery ligated and were subjected to 2.5 h of 8% oxygen. Ten mg/kg of PTCK or vehicle was given intraperitoneally 15 min prior to ...

journal_title：Pharmacology

authors： Feng Y,LeBlanc MH

更新日期：2002-11-01 00:00:00

abstract：:Metabotropic G protein-coupled receptors have recently been recognized as targets for anesthetics and analgesics. In particular, G(q)-coupled receptors such as muscarinic M(1) receptors (M(1)R) and 5-hydroxytryptamine (5-HT) type 2A receptors have been reported to be targets for anesthetics. Much less is known, howeve...

journal_title：Pharmacology

authors： Minami K,Uezono Y,Shiraishi M,Okamoto T,Ogata J,Horishita T,Taniyama K,Shigematsu A

更新日期：2004-11-01 00:00:00

abstract：:Five healthy subjects performed submaximal physical exercise approximately 20 h after a single oral dose of phenytoin (5 mg/kg of the sodium salt). The plasma levels of free fatty acids (FFA) increased 2- to 3-fold in the post-exercise period. In spite of this, the degree of plasma binding of phenytoin and its total c...

journal_title：Pharmacology

authors： Borgå O,Juhlin-Dannfeldt A,Dahlqvist R

更新日期：1978-01-01 00:00:00

abstract：:The aim of this study was to compare the effects of a new thromboxane synthase inhibitor, camonagrel, on platelet aggregation and platelet-subendothelium interaction under flow conditions, in comparison with a standard thromboxane synthase inhibitor (dazoxiben) and a cyclooxygenase inhibitor (acetylsalicylic acid). Wi...

journal_title：Pharmacology

authors： Villalobos MA,De La Cruz JP,Escalante R,Arrebola MM,Guerrero A,Sánchez de la Cuesta F

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:The purpose of this study is to examine the effectiveness of introducing both rituximab (RTX) and 131I for active Graves' ophthalmopathy (GO) with hyperthyroidism. METHODS:In total, 217 patients suffering from active GO with hyperthyroidism were included in this research. All subjects were randomly assigned to...

journal_title：Pharmacology

authors： Li J,Xiao Z,Hu X,Li Y,Zhang X,Zhang S,Gong W,Zhao J,Ye X

更新日期：2017-01-01 00:00:00

abstract：:The frequent resistance of malignant tumors to chemotherapy documents the fact that numerous patients are uselessly traumatized by highly toxic drugs. Investigations into this resistance have shown that many different mechanisms exist which can abolish the antitumor action of chemotherapeutics. So far, no safe method ...

journal_title：Pharmacology

authors： Lippert TH,Ruoff HJ,Volm M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:Stent thrombosis is a serious complication after percutaneous coronary intervention and femoropopliteal endovascular intervention. The aim of this study was to determine the antithrombotic effects of a direct factor Xa inhibitor edoxaban alone or in combination with antiplatelet agents in a rat model of...

journal_title：Pharmacology

authors： Morishima Y,Honda Y,Kamisato C

更新日期：2019-01-01 00:00:00

abstract：:A controlled, double-blind study was made of the efficacy and safety of a new hypnotic, zopiclone, on the preoperative night's sleep by a Joint Study Unit Group of the anesthesiology departments in 6 national hospitals. The following results were found: (1) zopiclone 7.5 and 10 mg and nitrazepam 10 mg were significant...

journal_title：Pharmacology

authors： Momose T

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND/AIM:The effect of isocaloric diets and sibutramine on dietary behaviour and TNF-alpha is poorly understood. The aim of the study was to investigate the effects of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-alpha in free-feeding rats. METHODS:Three groups of male Wista...

journal_title：Pharmacology

authors： Trapali M,Liapi C,Perelas A,Perrea D,Stroubini T,Dontas I,Couvari E,Mavri M,Galanopoulou P

更新日期：2008-01-01 00:00:00