Abstract:
:Sensitive radiometric assays were adapted to study the development and kinetics of meperidine and methadone N-demethylation and morphine glucuronidation by microsomes isolated from livers of fetal stump-tailed macaques (Macaca arctoides). Times in development selected for study were midterm, three-quarter term, near term and newborn (0.5 h and 14 days). With appropriate attention to keeping blanks low, hepatic drug metabolism was demonstrable as early as midterm. Vmax for the N-demethylation reactions (nmole product/10 min/mg microsomal protein) increased throughout gestation, whereas the apparent Kms remained constant. With respect to morphine glucuronidation, all kinetic parameters remained constant throughout the last half of gestation.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Dvorchik BH,Stenger VG,Hartman RDdoi
10.1159/000137259subject
Has Abstractpub_date
1979-01-01 00:00:00pages
241-50issue
5eissn
0031-7012issn
1423-0313journal_volume
18pub_type
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