Abstract:
:A dose-dependent contractile effect of substance P (SP) on the isolated, everted rat portal vein was competitively inhibited by two selective SP antagonists (pro2, phe7, trp9)-SP and (pro4, trp7,9)-SP 4-11. Phentolamine, atropine, methysergide, mepyramine, cimetidine, Sar1, Ile8-angiotensin II, Leu8, des-Arg9-bradykinin and indomethacin did not block the action of SP. However, some of these antagonists differentially reduced SP responses, but such inhibitory effects were shown to be nonspecific. The results suggest that the SP-induced contractions of the rat portal vein were directly mediated by specific receptors localized on the smooth muscle cells. In addition, the response to SP appeared to be independent of prostaglandin biosynthesis.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Mastrangelo D,Mathison R,Huggel Hdoi
10.1159/000137885subject
Has Abstractpub_date
1983-01-01 00:00:00pages
305-18issue
6eissn
0031-7012issn
1423-0313journal_volume
27pub_type
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