Extracellular ATP increases L-carnitine transport and content in C2C12 cells.

abstract：:To investigate the effects of beraprost sodium on the proliferation and oxidative stress of glomerular mesangial cells under high glucose conditions, a rat mesangial cell line (rat mesangial cells; RMCs) was treated with beraprost sodium in the presence of high glucose concentrations. Proliferation rates of mesangial ...

journal_title：Pharmacology

authors： Zhang LY,Zou JJ,Liu ZM

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Advanced glycation end products (AGEs) play a pivotal role in the initiation and progression of osteoarthritis (OA). Peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to exhibit anti-inflammatory and anticatabolic properties and to be protective in animal models of OA. This study was aimed t...

journal_title：Pharmacology

authors： Chen C,Ma C,Zhang Y,Zeng Y,Li Y,Wang W

更新日期：2014-01-01 00:00:00

abstract：:The effect of 4-[3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101), one of the synthetic retinoids, on collagen-induced arthritis (CIA) in mice and experimental autoimmune encephalomyelitis (EAE) in rats was studied. TAC-101 at doses of 5 and 20 mg/kg clearly inhibited the development of CIA in terms of the swe...

journal_title：Pharmacology

authors： Miyagawa N,Homma T,Kagechika H,Shudo K,Nagai H

更新日期：2003-01-01 00:00:00

abstract：:The intracerebroventricular injection of the cholecystokinin-A receptor antagonist L-364,718, at the doses of 0.5, 5, 10 or 20 micrograms/mouse, while having no effect on pain threshold (hot plate, 51 degrees C), antagonized the analgesic activity of morphine (10 mg/kg i.p.). This effect was obtained with a dose of 10...

journal_title：Pharmacology

authors： Poggioli R,Vergoni AV,Sandrini M,Barbafiera L,Marrama D,Bertolini A

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND/AIMS:Morphine causes state-dependent learning that its mechanism and brain-related structures are not fully understood. This study aimed to determine whether lidocaine reversible inactivation of the central nucleus of the amygdala (CeA) could affect acquisition, consolidation, and retrieval of morphine state...

journal_title：Pharmacology

authors： Noorbakhshnia M,Rahmani-Samani P,Eivani M

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to assess the population pharmacokinetics of phenytoin in Saudi patients and identify factors affecting therapeutic parameters. METHOD:A retrospective chart review was performed at King Saud University Medical City on patients treated with oral phenytoin. We used Monolix 4.4. for population ...

journal_title：Pharmacology

authors： Alqahtani S,Alzaidi T,Alotaibi M,Alsultan A

更新日期：2019-01-01 00:00:00

abstract：:Various new butyridenyl-2-hydroxybenzylidenyl-1,3-thiazolidinones were synthesized and characterized by elemental analyses, IR and PMR spectral data. The compounds were evaluated for their ability to afford protection against inflammation by carrageenin-induced oedema and cotton pellet implantation in albino rats of e...

journal_title：Pharmacology

authors： Tandon M,Kumar P,Pande K,Bhalla TN,Barthwal JP

更新日期：1985-01-01 00:00:00

abstract：:Altered vascular reactivity due to endothelial dysfunction, consequent to vascular damage, is observed in rheumatoid arthritis. We investigated the effect of angiotensin (Ang)-(1-7) on vasculature changes in arthritis induced by complete Freund's adjuvant in male Wistar rats. Arthritis decreased soluble receptor for a...

journal_title：Pharmacology

authors： Açikalin Ö,Bölükbaşi Hatip FF,Tan RF,Hatip-Al-Khatib I

更新日期：2016-01-01 00:00:00

abstract：:Several compounds with the backbone of 1,4-naphthoquinone chemical structure have been reported to display antiplatelet and antithrombotic activities, indicating that this congener compound may be a new source in the antithrombotic drug development. In the present study, the possible antiplatelet activity and antithro...

journal_title：Pharmacology

authors： Jin YR,Ryu CK,Moon CK,Cho MR,Yun YP

更新日期：2004-04-01 00:00:00

abstract：:Artemether, highly effective in multi-drug-resistant malaria is not routinely available for use in pregnancy due to the lack of adequate research data in animals and man. This study was therefore aimed at investigating some pregnancy-related effects of artemether. Artemether (1.5, 7.5 and 15 mg/kg i.p. daily for 7 day...

journal_title：Pharmacology

authors： Ejiofor JI,Kwanashie HO,Anuka JA

更新日期：2006-01-01 00:00:00

abstract：:Both acute and chronic oral administration (1-20 mg/kg) of FCE 22716, a new ergoline derivative, resulted in a dose-related fall of arterial blood pressure lasting for more than 6 h. Tachycardia was observed only at high dosages. Yohimbine, propranolol and indometacin did not modify its antihypertensive effect; on the...

journal_title：Pharmacology

authors： Salvati P,Bondiolotti GP,Caccia C,Vaghi F,Bianchi G

更新日期：1989-01-01 00:00:00

abstract：AIMS:Basal insulin administered to type-2 diabetic patients with poor glycaemic control when managed with oral anti-diabetics (OADs) alone can lead to an increased risk of weight gain and hypoglycaemia. In the absence of head-to-head trials, an indirect comparison of the once-daily insulin detemir with insulin glargine...

journal_title：Pharmacology

authors： Fakhoury W,Lockhart I,Kotchie RW,Aagren M,LeReun C

更新日期：2008-01-01 00:00:00

abstract：:This study was designed to determine whether pyrazinoylguanidine (PZG) can attenuate diabetic nephropathy in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced within 1 week after a single intraperitoneal dose of STZ (45 mg/kg in 0.05 mol/l sodium citrate buffer). Diabetic rats were divided into five gro...

journal_title：Pharmacology

authors： Follansbee MH,Beyer KH Jr,Griffith JW,Vesell ES

更新日期：1997-05-01 00:00:00

abstract：:Black Swiss (BS) mice were shown to be an advantageous strain to model behavioral domains of mania, but to date only male mice were tested, whereas bipolar disorder (BPD) is equally prevalent in women and men. This study was therefore designed to examine the possibility of using both male and female BS mice in future ...

journal_title：Pharmacology

authors： Ene HM,Kara NZ,Einat H

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Aspirin and ibuprofen are the most frequently prescribed non-steroidal anti-inflammatory drugs in the world. However, both are associated with a variety of toxicities. We applied serum metabonomics and Fisher discrimination for the early diagnosis of its toxic reaction in order to help diagnose these toxicit...

journal_title：Pharmacology

authors： Zhang J,Song H,Jiang S,Chen Z,Tong S,Lin F,Wen C,Zhang X,Hu L

更新日期：2017-01-01 00:00:00

abstract：:The present study aims at investigating the effects of mannitol and dimethylthiourea, known hydroxyl radical scavengers, on lipid peroxidation as an indicative of oxidative damage, NF-kappa B activation and IL-8 production by Helicobacter pylori in gastric epithelial cells. A human gastric epithelial cell line, AGS, t...

journal_title：Pharmacology

authors： Kim H,Seo JY,Kim KH

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Centhaquin is a centrally acting hypotensive drug like clonidine. Clonidine also produces analgesia and hypothermia in mice and potentiates morphine analgesia. Clonidine analgesia is blocked by idazoxan and naloxone while it is potentiated by BQ123 and sulfisoxazole. This study was conducted to determine the...

journal_title：Pharmacology

authors： Andurkar SV,Gulati A

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:In this study, we evaluated the functional impact of facilitatory presynaptic adenosine A2A and muscarinic M1 receptors in the recovery of neuromuscular tetanic depression caused by the blockage of high-affinity choline transporter (HChT) by hemicholinium-3 (HC-3), a condition that mimics a myasthenia-l...

journal_title：Pharmacology

authors： Castellão-Santana LM,Yumi Abiko P,Ambiel CR,Peixoto AR,Noronha-Matos JB,Correia-de-Sá P,Alves-Do-Prado W

更新日期：2019-01-01 00:00:00

abstract：:The dependence of intestinal absorption of xenobiotics on the blood flow rate increases from blood flow independent to blood flow limited absorption as the absorbability of the substances increases. Since the absorbed substances are mainly drained by the blood flowing through the subepithelial vessels, not only the to...

journal_title：Pharmacology

authors： Winne D

更新日期：1980-01-01 00:00:00

abstract：:The effects of some ergot derivatives on the electroencephalogram and behavior of laboratory animals (mice, rats, rabbits) have been surveyed. The interference of bromocriptine on the dopaminergic central systems has been studied using behavioral (interference with the effects induced by L-dopa, 5HT, TRF or neurolepti...

journal_title：Pharmacology

authors： Longo VG,Loizzo A

更新日期：1978-01-01 00:00:00

abstract：:The present study examined the interaction of opioidergic systems in the hypotensive action of atenolol. Anesthetized, adult spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats were instrumented to monitor blood pressure and heart rate. Atenolol (100 micrograms/kg, i.v.) produced a decrease in blood pressure ...

journal_title：Pharmacology

authors： Laskey RE,Jones LF,Tackett RL

更新日期：1989-01-01 00:00:00

abstract：:We established an Ascaris-induced biphasic skin allergic reaction in mice. In the early-phase reaction (EPR), mast cell degranulation was observed, and tranilast inhibited ear edema. In mast-cell-deficient mice (WBB6F(1)-W/W(V) mice), ear edema in the EPR disappeared, whereas that in the late-phase reaction (LPR) rema...

journal_title：Pharmacology

authors： Sengoku T,Sato S,Sakuma S,Ogawa T,Ohkubo Y,Goto T

更新日期：2001-01-01 00:00:00

abstract：:The effects of the calcium channel antagonist nifedipine and the protein kinase C (PKC) inhibitor, staurosporine were examined on the pressor actions of a full, cirazoline, and a partial, St587, alpha 1-adrenoceptor agonist as well as the alpha 2-adrenoceptor agonist B-HT 920 in the pithed rat preparation. Administrat...

journal_title：Pharmacology

authors： Tabrizchi R,Triggle CR

更新日期：1991-01-01 00:00:00

abstract：:Previous studies have demonstrated that calcium storage and release from IP3-dependent sites in the sarcoplasmic reticulum play an important role in the contractile response of the rabbit urinary bladder to both field stimulation (mediated via neurotransmitter release) and bethanechol (direct muscarinic stimulation). ...

journal_title：Pharmacology

authors： Levin RM,Nicholas TJ,Snitkoff GG,Mandell J,Russell D,Wilbur HJ,Mogavero LJ

更新日期：1997-12-01 00:00:00

abstract：:A potential cytokine-drug interaction between interleukin 6 (IL-6) and itraconazole (ITZ) was studied using human hepatocytes in primary culture. Cultures from 5 adult males (mean age 42 +/- 15 years) who had not received any medicines known to interact with CYP3A4 were studied. Cultures were exposed to ITZ 500 ng/ml,...

journal_title：Pharmacology

authors： Gubbins PO,Melchert RB,McConnell SA,Franks AM,Penzak SR,Gurley BJ

更新日期：2003-04-01 00:00:00

abstract：:Protective influence of verapamil upon ouabain-induced cardiac arrhythmias was investigated in anesthetized (alpha-chloralose 60 mg/kg and urethane 500 mg/kg) open-chest guinea pigs. Verapamil in doses between 100 and 150 micrograms/kg significantly increased (80-90%) the dose of ouabain, necessary to cause ventricula...

journal_title：Pharmacology

authors： Khatter JC,Navaratnam S,Hoeschen RJ

更新日期：1988-01-01 00:00:00

abstract：:In isolated perfused rat hearts with coronary occlusion and reperfusion, the effect of adenosine antagonists on the release of adenosine and its degradation products inosine, hypoxanthine, xanthine and uric acid was investigated. An antagonist with high selectivity for the A1 receptor, 8-phenyltheophylline, was applie...

journal_title：Pharmacology

authors： Bernauer W

更新日期：1996-11-01 00:00:00

abstract：:Double-stranded, RNA-dependent protein kinase R (PKR) is a serine/threonine protein kinase activated by various stress signals. It plays an important role in inflammation, insulin sensitivity and glucose homeostasis. Increased PKR activity has been observed in obese humans as well as in obese diabetic mice. Indirubin-...

journal_title：Pharmacology

authors： Udumula MP,Medapi B,Dhar I,Bhat A,Desai K,Sriram D,Dhar A

更新日期：2016-01-01 00:00:00

abstract：:delta9-Tetrahydrocannabinol (THC) inhibited ulcer formation in the pylorus-ligated rat (Shay rat test). However, this antiulcer activity of THC was substantially less than for the anticholinergic substance tridihexethyl chloride both in terms of degree of activity and potency. In addition, the results of the present s...

journal_title：Pharmacology

authors： Sofia RD,Diamantis W,Harrison JE,Melton J

更新日期：1978-01-01 00:00:00

abstract：:The present study was aimed at investigating the effects of diabetes on the cavernosal smooth muscle relaxations mediated by adenosine and adenosine triphosphate (ATP) in tissues obtained from men and rats. Adenosine- and ATP-induced relaxant responses showed an enhanced sensitivity with an unaltered effectiveness in ...

journal_title：Pharmacology

authors： Gür S,Oztürk B

更新日期：2000-02-01 00:00:00