Effect of atorvastatin treatment on isoproterenol-induced myocardial infarction in rats.

abstract：:Zinc acexamate (NAS-501), an anti-ulcer agent, has been reported to prevent various acute experimental gastric mucosal lesions and duodenal ulcers in rats. In order to clarify the mechanisms by which NAS-501 exhibits the anti-ulcer effects, we investigated the anti-oxidative effects of NAS-501 in vitro and in vivo. NA...

journal_title：Pharmacology

authors： Tsutsui Y,Nakamura Y,Yamaguchi S,Kawanaka N,Sato M

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND/AIMS:morphine is known to inhibit cholinergic contractions of the guinea pig small intestine. This has been compared to the human small intestinal innervated longitudinal muscle in the current study. METHODS:cholinergic primary contractions of human small intestinal longitudinal strips were evoked by electr...

journal_title：Pharmacology

authors： Benko R,Molnár Z,Nemes D,Dékány A,Kelemen D,Illényi L,Cseke L,Papp A,Varga G,Bartho L

更新日期：2010-01-01 00:00:00

abstract：:Zopiclone (ZPC; RP 27,267), which is chemically unrelated to benzodiazepines (BZD), was found to have a similar pharmacological profile and to possess in man hypnotic activity similar to that of some BZD such as nitrazepam. It was, therefore, interesting to study the interaction of ZPC with rat brain receptors and spe...

journal_title：Pharmacology

authors： Blanchard JC,Boireau A,Julou L

更新日期：1983-01-01 00:00:00

abstract：:The influence of changes in the sodium balance on angiotensin II-induced pressor responses were studied in the pithed rat preparation, which is characterized by a highly activated renin-angiotensin-aldosterone system (RAAS) with high plasma renin and angiotensin II concentrations. The pressor response to angiotensin I...

journal_title：Pharmacology

authors： Knape JT,van Zwieten PA

更新日期：1988-01-01 00:00:00

abstract：:The effect of 4-[3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101), one of the synthetic retinoids, on collagen-induced arthritis (CIA) in mice and experimental autoimmune encephalomyelitis (EAE) in rats was studied. TAC-101 at doses of 5 and 20 mg/kg clearly inhibited the development of CIA in terms of the swe...

journal_title：Pharmacology

authors： Miyagawa N,Homma T,Kagechika H,Shudo K,Nagai H

更新日期：2003-01-01 00:00:00

abstract：:The effect of promethazine on the metabolic responsiveness of human polymorphonuclear leukocytes to opsonized zymosan was evaluated by chemiluminescence (CL) assay under the following situations: (1) preincubation of granulocytes with promethazine; (2) simultaneous addition of zymosan and promethazine, and (3) additio...

journal_title：Pharmacology

authors： Trush MA,Van Dyke K

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND/AIMS:We studied the effect of the combined treatment with an angiotensin-converting enzyme (ACE) inhibitor (ramipril) and eplerenone compared with ramipril alone in streptozocin-induced diabetic rats. METHODS:Wistar rats were divided into 4 groups: nondiabetic controls, streptozocin-treated diabetic rats (5...

journal_title：Pharmacology

authors： Mavrakanas TA,Cheva A,Kallaras K,Karkavelas G,Mironidou-Tzouveleki M

更新日期：2010-01-01 00:00:00

abstract：:Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and function. Reported prevalence of this geriatric syndrome, differs depending on the definition, the population and the method used to identify sarcopenia. The causes of sarcopenia are multifactorial, and can...

journal_title：Pharmacology

authors： Campins L,Camps M,Riera A,Pleguezuelos E,Yebenes JC,Serra-Prat M

更新日期：2017-01-01 00:00:00

abstract：:The present study was designed to investigate the involvement of the nitric oxide (NO)/cyclic guanylate monophosphate pathway in pilocarpine-induced seizures in mice. Male Swiss mice (26-32 g) were used as the in vivo model. The following pharmacological tools were utilized: the non-selective NO synthase (NOS) inhibit...

journal_title：Pharmacology

authors： Vasconcelos Rios ER,Moura Rocha NF,Rodrigues Carvalho AM,Freire Vasconcelos L,Leite Dias M,de Carvalho Lima CN,Soares Lopes K,Cavalcante Melo FH,de França Fonteles MM

更新日期：2013-01-01 00:00:00

abstract：:We examined the properties of the drug interaction between morphine and 5-HT(3) receptor antagonist at the spinal level. The nociceptive state was induced by subcutaneously injecting formalin solution (5%, 50 microl) into the hindpaw of the rats. Intrathecal morphine and m-CPBG (5-HT(3) receptor agonist) dose-dependen...

journal_title：Pharmacology

authors： Yoon MH,Bae HB,Choi JI,Kim SJ,Chung ST,Kim CM

更新日期：2006-01-01 00:00:00

abstract：:Effects of choleresis produced by atropine (4-10(-4)M) on the biliary elimination of 3H-ouabain and on the biliary clearance rate of 14C-erythritol were studied in the isolated perfused rat liver. The increased bile flow produced by atropine was associated with decreased level of 3H-ouabain in the bile. The cumulative...

journal_title：Pharmacology

authors： Nevasaari K,Alakare B,Kärki NT

更新日期：1977-01-01 00:00:00

abstract：:The isolated whole stomach of the mouse has been used to study the effect of atropine on gastic acid secretion stimulated by acetylcholine, bethanechol and histamine. Atropine inhibited acid secretory response to acetylcholine and bethanechol in a competitive manner. The following pA2 values for atropine were calculat...

journal_title：Pharmacology

authors： Szelenyi I,Vergin H

更新日期：1980-01-01 00:00:00

abstract：:In the isolated guinea pig vas deferens, 10(-4) M cocaine shifts to the left (13.5-fold at the EC50 level) the concentration-effect curve and increases the maximum response to noradrenaline, whilst supersensitivity to phenylephrine, an amine with a low affinity for the neuronal uptake, was smaller (4.1-fold) and the m...

journal_title：Pharmacology

authors： DeMoraes S,Capaz FR

更新日期：1977-01-01 00:00:00

abstract：:Various new butyridenyl-2-hydroxybenzylidenyl-1,3-thiazolidinones were synthesized and characterized by elemental analyses, IR and PMR spectral data. The compounds were evaluated for their ability to afford protection against inflammation by carrageenin-induced oedema and cotton pellet implantation in albino rats of e...

journal_title：Pharmacology

authors： Tandon M,Kumar P,Pande K,Bhalla TN,Barthwal JP

更新日期：1985-01-01 00:00:00

abstract：:The isolated longitudinal muscle preparation (with attached Auerbach plexus) of the guinea pig ileum was used to investigate the structure activity relationship and kinetics of some naloxone and naltrexone derivatives and that of cyclazocine. The agonist used for the investigation of the antagonistic effect of these c...

journal_title：Pharmacology

authors： Vizi ES,Foldes FF,Rich J,Knoll J

更新日期：1976-01-01 00:00:00

abstract：:The metabolism of sennosides is discussed in view of the results obtained during the last years. Rhein anthrone is to be considered as the ultimate active form produced by microorganisms in the colon. Several contributions of this senna symposium bring complementary information of utmost interest. ...

journal_title：Pharmacology

authors： Lemli J

更新日期：1988-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor that regulates lipid metabolism. Recently, PPARgamma was reported to be a negative regulator in the immune system. Eosinophils also express PPARgamma, however, the role of PPARgamma in eosinophil functions is not well understood. Surfac...

journal_title：Pharmacology

authors： Matsuwaki Y,Ueki S,Adachi T,Oyamada H,Kamada Y,Yamaguchi K,Kanda A,Hamada K,Kayaba H,Chihara J

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stepwise propofol target-controlled infusion (TCI) can achieve a less disturbed condition of hemodynamics and respiration. Its combination with dexmedetomidine may have some advantages for patients. We studied the effects of different loading doses of dexmedetomidine on the bispectral index (BIS)...

journal_title：Pharmacology

authors： Wang T,Ge S,Xiong W,Zhou P,Cang J,Xue Z

更新日期：2013-01-01 00:00:00

abstract：:The systemic and coronary hemodynamic effects of the nitrovasodilator, pirsidomine, were compared with SIN-1, nitroprusside, and nitroglycerin. Four groups consisting of 32 experiments were performed in 17 conscious dogs chronically instrumented for measurement of aortic and left ventricular pressure, left ventricular...

journal_title：Pharmacology

authors： Arkonac BM,Kersten JR,Wynsen JC,Nijhawan N,Warltier DC

更新日期：1996-02-01 00:00:00

abstract：:The transketolase activity (TKA) of the white and red blood cells of oral contraceptive users was studied in an unselected sample population. Compared with healthy controls of corresponding age, the white cell TKA in the oral contraceptive groups was lowered in about 30%. The red cell TKA was lowered in about 15% of...

journal_title：Pharmacology

authors： Markkanen T,Himanen P,Peltola O

更新日期：1974-01-01 00:00:00

abstract：BACKGROUND/AIMS:Fluorofenidone [1-(3-fluorophenyl)-5-methyl-2-(1H)-pyridone, AKF-PD], a novel pyridone agent, showed potent antifibrotic properties. The aim of the present study was to investigate the effects of AKF-PD on diabetic nephropathy and kidney fibrosis, and to obtain an insight into its mechanisms of action. ...

journal_title：Pharmacology

authors： Wang LH,Liu JS,Ning WB,Yuan QJ,Zhang FF,Peng ZZ,Lu MM,Luo RN,Fu X,Hu GY,Wang ZH,Tao LJ

更新日期：2011-01-01 00:00:00

abstract：:The distribution pattern of (-)-3H-dihydroalprenolol (3H-DHA) binding sites within the thoracic and abdominal aorta was studied using a histoautoradiographic technique. Frozen sections of rabbit aorta were incubated with 3H-DHA in the presence or absence of 1 mumol/l (-)-propranolol and of increasing concentrations of...

journal_title：Pharmacology

authors： Amenta F,Cavallotti C,De Rossi M

更新日期：1985-01-01 00:00:00

abstract：:The present experiments examined the protective effect of the nitrofuran drugs, furazolidone (FZ) and nitrofurazone (NF), on duodenal ulceration induced by cysteamine or indometacin in rats. FZ at oral doses of 25, 50 or 100 mg/kg for 2 consecutive days signficantly reduced, in a dose-dependent manner, the incidence a...

journal_title：Pharmacology

authors： Ali BH

更新日期：1991-01-01 00:00:00

abstract：:Verapamil-induced cardiovascular depression has been examined in dial-urethane-anesthetized open chest dogs. Verapamil was administered slowly intravenously until the mean arterial pressure was decreased by approximately 45 mm Hg. The dose of verapamil required to reach the hemodynamic endpoint was 1,495 +/- (SE) 165 ...

journal_title：Pharmacology

authors： Jolly SR,Kipnis JN,Lucchesi BR

更新日期：1987-01-01 00:00:00

abstract：:It can be readily shown in vitro that various compounds inhibit platelet aggregation but it has been difficult to demonstrate in vivo. A method is suggested here to enable in vivo testing of these compounds; the method utilizes relatively low doses of sodium arachidonate, made possible by the ligation of the pterygopa...

journal_title：Pharmacology

authors： Schwartzmiller D

更新日期：1980-01-01 00:00:00

abstract：:The effects of alpha-adrenergic agonists on 45Ca efflux from slices of rat liver were studied and the results compared to earlier studies on the rabbit aorta. Norepinephrine and phenylephrine (PE) cause a stimulation of 45Ca efflux which was due to alpha 1-receptor activation. The mitochondrial uncoupler dinitrophenol...

journal_title：Pharmacology

authors： Lynch CJ,Deth RC

更新日期：1984-01-01 00:00:00

abstract：:Metformin is a widely used antidiabetic agent that is generally considered safe. However, metformin-associated lactic acidosis (MALA), though not common, occurs from time to time and results in significantly high mortality. A series of 23 MALA cases in a local major hospital in Hong Kong is reported in this article to...

journal_title：Pharmacology

authors： Yeung CW,Chung HY,Fong BM,Tsai NW,Chan WM,Siu TS,Tam S,Tsui SH

更新日期：2011-01-01 00:00:00

abstract：:CC chemokine receptor 4 (CCR4) is expressed on Th2 cells, found in inflamed tissues of allergic diseases, and is therefore suspected to be involved in the pathogenesis of allergic diseases by controlling Th2 cell migration into inflamed tissues. The aim of the present study was to investigate the inhibitory effect of ...

journal_title：Pharmacology

authors： Sato T,Komai M,Iwase M,Kobayashi K,Tahara H,Ohshima E,Arai H,Miki I

更新日期：2009-01-01 00:00:00

abstract：:The calcium channel antagonist, nifedipine (0.1 microM), only slightly inhibited the response to the full alpha 1-adrenoceptor agonist, (-)-norepinephrine, in rat aorta, but nearly completely inhibited the response to the partial alpha 1-adrenoceptor agonist, (-)-dobutamine, indicating that (-)-norepinephrine primaril...

journal_title：Pharmacology

authors： Oriowo MA,Ruffolo RR Jr

更新日期：1992-01-01 00:00:00

abstract：:We studied the effects of triamterene (TA) on its phase I and phase II metabolites, p-hydroxytriamterene (OH-TA) and p-hydroxytriamterene sulfuric acid ester (OH-TA ester), on sodium transport in the isolated frog skin. While TA applied to the inside (corial side) surface had no effects on potential difference (PD) an...

journal_title：Pharmacology

authors： Kramer HJ,Rörig M,Völger KD

更新日期：1981-01-01 00:00:00