Pentose phosphate pathway inhibition in blood cells during anticonceptive hormone therapy.

abstract：:A double-blind crossover trial was conducted in 42 outpatients of either sex in order to obtain information on the properties of 7.5 mg of zopiclone in a general practice setting compared with 2 mg of flunitrazepam. Each patient went through two periods of treatment, each period lasting 10 days. A comparison of the ef...

journal_title：Pharmacology

authors： Wickstrøm E,Barbo SE,Dreyfus JF,Jerkø D,Kleiven R,Slåttbrekk R,Stray Tønnesen JN

更新日期：1983-01-01 00:00:00

abstract：:The aim of this study was to assess whether moderate hypoxia affects the disposition of diltiazem. Six male beagle dogs received diltiazem (0.6 mg/kg) on three occasions: (1) while breathing air, i.e. during normoxia; (2) 1 h after initiating exposure to a FiO2 of 0.08, a FiCO2 of 0.035 and a FiN2 of 0.885, i.e. durin...

journal_title：Pharmacology

authors： du Souich P,Hartemann D,Saunier C

更新日期：1993-12-01 00:00:00

abstract：:Supplementation of antioxidants such as vitamin E and vitamin C as health promotion food is popular recently. Epidemiological studies supported the beneficial effect of these antioxidants because oxygen free radicals have been linked to the process of diseases and aging. The present study evaluated the effect of alpha...

journal_title：Pharmacology

authors： Huang W,Chan P,Chen Y,Chen C,Liao S,Chin W,Cheng J

更新日期：1999-11-01 00:00:00

abstract：:Although proton pump inhibitors (PPI) are generally well tolerated, with most adverse effects being minor and self-limiting, there are singular reports on hypersensitivity immune reactions triggered by a PPI or its metabolites. Here we report a case of acute drug-induced fever with leukocytosis and a transient increas...

journal_title：Pharmacology

authors： Schiller D,Maieron A,Schöfl R,Donnerer J

更新日期：2014-01-01 00:00:00

abstract：:Double-stranded, RNA-dependent protein kinase R (PKR) is a serine/threonine protein kinase activated by various stress signals. It plays an important role in inflammation, insulin sensitivity and glucose homeostasis. Increased PKR activity has been observed in obese humans as well as in obese diabetic mice. Indirubin-...

journal_title：Pharmacology

authors： Udumula MP,Medapi B,Dhar I,Bhat A,Desai K,Sriram D,Dhar A

更新日期：2016-01-01 00:00:00

abstract：:The mechanisms underlying the fade of the tetanic contraction induced by pancuronium were studied in vitro by means of myographical and electrophysiological techniques in the extensor digitorum longus muscle of the rat. Pancuronium (0.5 mumol/l) induced a complete fade of the tetanic contraction while leaving the twit...

journal_title：Pharmacology

authors： Gallacci M,Oliveira AC

更新日期：1994-10-01 00:00:00

abstract：:Chronic administration of epinephrine to adult male rats resulted in a significant increase in the rate of ethanol elimination, when given alone or together with the beta-adrenergic blocker alprenolol. This effect was observed concomitantly with an increased hepatic oxygen utilization and no changes in mitochondrial r...

journal_title：Pharmacology

authors： Petermann M,Bravo M,Videla L,Ugarte G

更新日期：1979-01-01 00:00:00

abstract：:Two groups of rats were used to examine the effect of pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, on rat hearts using an in vivo model of ischemia-reperfusion (I/R) to elucidate potential mechanisms. One group was the 30-min reperfusion group, which was further subdivided into...

journal_title：Pharmacology

authors： Cao Z,Ye P,Long C,Chen K,Li X,Wang H

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Historical evidence has verified the multifaceted antiviral efficacy of polyoxometalates (PMs). METHODS:We carried out a study to investigate the antimicrobial effects of each of the 5 substances comprising virus block (VB): 3 PMs that have antibacterial and antiviral activity, an antibiotic agent, and an a...

journal_title：Pharmacology

authors： Dan K,Katoh N,Matsuoka T,Fujinami K

更新日期：2019-06-06 00:00:00

abstract：:We studied the effects of triamterene (TA) on its phase I and phase II metabolites, p-hydroxytriamterene (OH-TA) and p-hydroxytriamterene sulfuric acid ester (OH-TA ester), on sodium transport in the isolated frog skin. While TA applied to the inside (corial side) surface had no effects on potential difference (PD) an...

journal_title：Pharmacology

authors： Kramer HJ,Rörig M,Völger KD

更新日期：1981-01-01 00:00:00

abstract：:Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and function. Reported prevalence of this geriatric syndrome, differs depending on the definition, the population and the method used to identify sarcopenia. The causes of sarcopenia are multifactorial, and can...

journal_title：Pharmacology

authors： Campins L,Camps M,Riera A,Pleguezuelos E,Yebenes JC,Serra-Prat M

更新日期：2017-01-01 00:00:00

abstract：:Elastase, a serine proteinase released by activated human neutrophils, can degrade a wide variety of biomacromolecules including elastin, and is considered a marker of inflammatory diseases. As the logical strategy to protect tissue is to inhibit excessive elastase activity, experimental and clinical researches have c...

journal_title：Pharmacology

authors： Braga PC,Dal Sasso M,Culici M,Bianchi T,Bordoni L,Marabini L

更新日期：2006-01-01 00:00:00

abstract：:Several compounds with the backbone of 1,4-naphthoquinone chemical structure have been reported to display antiplatelet and antithrombotic activities, indicating that this congener compound may be a new source in the antithrombotic drug development. In the present study, the possible antiplatelet activity and antithro...

journal_title：Pharmacology

authors： Jin YR,Ryu CK,Moon CK,Cho MR,Yun YP

更新日期：2004-04-01 00:00:00

abstract：:Various attempts to developing antagonists for substance P (SP) and related peptides, based on our past experience with angiotensin, kinins, and neurotensin, were unsuccessful. The particular features of SP, namely the high activity of C-terminal partial sequences in some pharmacological tests were used to develop one...

journal_title：Pharmacology

authors： Regoli D,Escher E,Mizrahi J

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:The purpose of this study is to examine the effectiveness of introducing both rituximab (RTX) and 131I for active Graves' ophthalmopathy (GO) with hyperthyroidism. METHODS:In total, 217 patients suffering from active GO with hyperthyroidism were included in this research. All subjects were randomly assigned to...

journal_title：Pharmacology

authors： Li J,Xiao Z,Hu X,Li Y,Zhang X,Zhang S,Gong W,Zhao J,Ye X

更新日期：2017-01-01 00:00:00

abstract：:The distribution of primaquine was measured in seven rat tissues at 15-180 min after the intraperitoneal injection of the antimalarial 8-aminoquinoline. The half-life of unmetabolized primaquine was 4.0 h in lung, 1.7-1.9 h in blood, spleen, kidney and heart, and 1.2 h in liver. At each interval, the concentrations of...

journal_title：Pharmacology

authors： Holbrook DJ Jr,Griffin JB,Fowler L,Gibson BR

更新日期：1981-01-01 00:00:00

abstract：AIMS:To compare the bioavailability of a new oromucosal formulation of flurbiprofen 8.75-mg lozenges, developed by Alfa Wassermann S.p.A. (test drug) to that of marketed flurbiprofen 8.75-mg lozenges (Benactiv Gola®, reference drug). METHODS:This was an open, randomised, two-period, crossover, pharmacokinetic (PK) stu...

journal_title：Pharmacology

authors： Matzneller P,Burian A,Martin W,Annoni O,Lauro V,Tacchi R,Brunner M,Zeitlinger M

更新日期：2012-01-01 00:00:00

abstract：:In this study, we used a novel conscious dog model to evaluate the uroselectivity of selected alpha 1-antagonists either approved for human use or in clinical development for the treatment of symptomatic benign prostatic hyperplasia (BPH) and compared those results to their in vitro binding and functional affinities a...

journal_title：Pharmacology

authors： Brune ME,Katwala SP,Milicic I,Buckner SA,Ireland LM,Kerwin JF Jr,Hancock AA

更新日期：1996-12-01 00:00:00

abstract：:The regulatory action exerted on receptors by acebutolol, a cardioselective beta-blocker containing intrinsic sympathomimetic activity, has been investigated. beta-Adrenoceptor affinity and density of human mononuclear leukocytes were assayed in hypertensive patients before and after treatment with 400 mg/day acebutol...

journal_title：Pharmacology

authors： Basso A,Piantanelli L,Cognini G,Giunta S,Andreoni A,Paciaroni E

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND/AIM:Perception of risk of adverse drug events (ADEs) is different between health and nonhealth professionals, but these differences have not been investigated sufficiently in the general population. Women are more affected by ADEs. With the aim to investigate ADE risk perception in a sample of nonhealth prof...

journal_title：Pharmacology

authors： Salvo F,Miroddi M,Alibrandi A,Calapai F,Cafeo V,Mancari F,Gangemi S,Caputi AP,Calapai G

更新日期：2013-01-01 00:00:00

abstract：:The present study was designed to investigate the involvement of the nitric oxide (NO)/cyclic guanylate monophosphate pathway in pilocarpine-induced seizures in mice. Male Swiss mice (26-32 g) were used as the in vivo model. The following pharmacological tools were utilized: the non-selective NO synthase (NOS) inhibit...

journal_title：Pharmacology

authors： Vasconcelos Rios ER,Moura Rocha NF,Rodrigues Carvalho AM,Freire Vasconcelos L,Leite Dias M,de Carvalho Lima CN,Soares Lopes K,Cavalcante Melo FH,de França Fonteles MM

更新日期：2013-01-01 00:00:00

abstract：:The function of melatonin (MLT) in promoting fracture healing has been demonstrated in previous studies. However, the molecular mechanism underlying therapeutic effects of MLT is not entirely clear. In this study, mesenchymal stem cells (MSCs) were isolated from rat bone marrow and identified by flow cytometry. We fou...

journal_title：Pharmacology

authors： Dong P,Gu X,Zhu G,Li M,Ma B,Zi Y

更新日期：2018-01-01 00:00:00

abstract：:Serum protein binding and serum levels of antipyrine, phenytoin and phenylbutazone were measured in rabbits with acute renal failure induced by uranyl nitrate. The kinetics of antipyrine are not altered in the uraemic rabbit. Serum protein binding of phenytoin and phenylbutazone is decreased and the volume of distribu...

journal_title：Pharmacology

authors： Van Peer A,Belpaire F,Bogaert M

更新日期：1978-01-01 00:00:00

abstract：:TRK-530 is a novel synthetic bisphosphonate compound which exhibits inhibitory activity in the rat adjuvant arthritis (AA) model. We found that, during AA development, the concentrations of cytokine-induced neutrophil chemoattractant-1 (CINC-1) and tumor necrosis factor alpha (TNF-alpha) in the bone marrow increased, ...

journal_title：Pharmacology

authors： Tanahashi M,Koike J,Kawabe N,Nakadate-Matsushita T

更新日期：1998-05-01 00:00:00

abstract：AIM:To evaluate the efficacy and safety of 2 analogs of L-carnitine on rats made insulin resistant by a high-fructose diet. METHODS:Using rats made insulin resistant by a high-fructose diet, we investigated the impact of 2 analogs of L-carnitine (25 mg/kg) and L-carnitine (250 mg/kg) on glucose, triglycerides and chol...

journal_title：Pharmacology

authors： Gómez-Solís A,De la Cruz-Cordero R,Avalos-Soriano A,Duarte-Vázquez MA,Reyes-Esparza J,Rodríguez-Fragoso L

更新日期：2011-01-01 00:00:00

abstract：:Various new butyridenyl-2-hydroxybenzylidenyl-1,3-thiazolidinones were synthesized and characterized by elemental analyses, IR and PMR spectral data. The compounds were evaluated for their ability to afford protection against inflammation by carrageenin-induced oedema and cotton pellet implantation in albino rats of e...

journal_title：Pharmacology

authors： Tandon M,Kumar P,Pande K,Bhalla TN,Barthwal JP

更新日期：1985-01-01 00:00:00

abstract：:The dependence of intestinal absorption of xenobiotics on the blood flow rate increases from blood flow independent to blood flow limited absorption as the absorbability of the substances increases. Since the absorbed substances are mainly drained by the blood flowing through the subepithelial vessels, not only the to...

journal_title：Pharmacology

authors： Winne D

更新日期：1980-01-01 00:00:00

abstract：:Sedum telephium ssp. maximum is a medicinal plant that possesses anti-inflammatory, analgesic and keratolytic properties. We investigated the anti-inflammatory activity of its methanolic extract (STME) in rat peritoneal macrophages (MPhis) stimulated with lipopolysaccharide from Salmonella enteritidis. After stimulati...

journal_title：Pharmacology

authors： Altavilla D,Polito F,Bitto A,Minutoli L,Miraldi E,Fiumara T,Biagi M,Marini H,Giachetti D,Vaccaro M,Squadrito F

更新日期：2008-01-01 00:00:00

abstract：:The effects of 3 alpha 2-adrenergic receptor agonists on renal function in vasopressin (AVP)-deficient Brattleboro (DI) rats were evaluated. The aim of this study was to determine the relative contribution of central versus peripheral alpha 2-adrenoceptors in mediating diuresis and natriuresis, as well as the role of ...

journal_title：Pharmacology

authors： Dawson R Jr,Wallace DR

更新日期：1989-01-01 00:00:00

abstract：UNLABELLED:We have reported that intermediate conductance Ca(2+)-activated K(+) channels (ImK) showed augmented expression in angiotensin II (AII) type 1 receptor-dependent manner in post-ischemic rat heart. ImK has tyrosine phosphorylation sequence in the C-terminus and motifs for NFkappaB and AP1 in the promoter. Whi...

journal_title：Pharmacology

authors： Terata Y,Saito T,Fujiwara Y,Hasegawa H,Miura H,Watanabe H,Chiba Y,Kibira S,Miura M

更新日期：2003-08-01 00:00:00