Abstract:
:Cimetidine infused intravenously into 6 healthy volunteers did not induce significant changes in plasma levels of prolactin (hPRL), thyreotropin (hTSH), gonadotropin (hLH and hFSH) and growth hormone (hGH). Conversely it caused a significant increase in prolactin response to TRH without modifying the hTSH response to thyreotropin-releasing hormone (TRH) and gonadotropin response to gonadotropin-releasing hormone (GnRH). Data obtained in these experiments, together with data reported in the literature, suggest that the amplified prolactin response to TRH observed during cimetidine infusion, is likely to be connected with a blockade of H2-receptors rather than to unspecific actions of cimetidine.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Scarpignato C,Valenti G,Ceda GP,Bertaccini Gdoi
10.1159/000137297subject
Has Abstractpub_date
1979-01-01 00:00:00pages
111-5issue
3eissn
0031-7012issn
1423-0313journal_volume
19pub_type
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