Effect of repeated administration of U-50,488H, a kappa opioid receptor agonist, on central 5-HT1 and 5-HT2 receptors in the rat.

abstract：:Feeding a thiamin-deficient diet to male and female rats for 3 weeks alters the mixed function oxidases responsible for metabolizing benzo(a)pyrene and enhances the response of these enzymes to induction by phenobarbital or 3-methylcholanthrene. The caloric restriction observed in thiamin deprivation may be partially ...

journal_title：Pharmacology

authors： Wade AE,Bunce OR,Harley W,Baker MT,Holmes D

更新日期：1984-01-01 00:00:00

abstract：:In gross behavioral observation the minimum effective dose of zopiclone was intravenously 0.06-0.25 mg/kg and intragastrically 1-4 mg/kg in rhesus monkeys. Zopiclone suppressed barbital withdrawal signs of rhesus monkeys at a single dose of 16 mg/kg or more. The suppressing effect of zopiclone 32 mg/kg i.g. was compar...

journal_title：Pharmacology

authors： Yanagita T

更新日期：1983-01-01 00:00:00

abstract：:Nabumetone is a nonsteroidal anti-inflammatory (NSAI) drug which is known to cause less gastrointestinal damage than other NSAI drugs. This study was performed to evaluate whether nabumetone treatment might alter the vascular aberrations related to inflammation in a rat model of adjuvant-induced arthritis. Nabumetone ...

journal_title：Pharmacology

authors： Ulker S,Onal A,Hatip FB,Sürücü A,Alkanat M,Koşay S,Evinç A

更新日期：2000-04-01 00:00:00

abstract：:Cimetidine infused intravenously into 6 healthy volunteers did not induce significant changes in plasma levels of prolactin (hPRL), thyreotropin (hTSH), gonadotropin (hLH and hFSH) and growth hormone (hGH). Conversely it caused a significant increase in prolactin response to TRH without modifying the hTSH response to ...

journal_title：Pharmacology

authors： Scarpignato C,Valenti G,Ceda GP,Bertaccini G

更新日期：1979-01-01 00:00:00

abstract：:A double-blind crossover trial was conducted in 42 outpatients of either sex in order to obtain information on the properties of 7.5 mg of zopiclone in a general practice setting compared with 2 mg of flunitrazepam. Each patient went through two periods of treatment, each period lasting 10 days. A comparison of the ef...

journal_title：Pharmacology

authors： Wickstrøm E,Barbo SE,Dreyfus JF,Jerkø D,Kleiven R,Slåttbrekk R,Stray Tønnesen JN

更新日期：1983-01-01 00:00:00

abstract：:In the rabbit, intracerebroventricular administration of dibutyryl cyclic AMP (DBC) produces fever which is selectively antagonised by phenoxybenzamine. This indicates the involvement of central alpha-adrenoceptors in DBC-induced fever. The decrease in DBC hyperthermia after 6-hydroxydopamine (6-OH-DA) supports the vi...

journal_title：Pharmacology

authors： Kandasamy SB

更新日期：1980-01-01 00:00:00

abstract：:The activity of myocardial adenylate cyclase from two age groups (10-11 and 18-19 weeks old, respectively) of male spontaneously hypertensive rats (SHR) and their age-matched normotensive Wistar-Kyoto rats (WKY) was examined. Stimulation of the enzyme by isoproterenol and 5'-guanylyl-imidodiphosphate (GMP-PNP) was dec...

journal_title：Pharmacology

authors： Chiu TH

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Centhaquin is a centrally acting hypotensive drug like clonidine. Clonidine also produces analgesia and hypothermia in mice and potentiates morphine analgesia. Clonidine analgesia is blocked by idazoxan and naloxone while it is potentiated by BQ123 and sulfisoxazole. This study was conducted to determine the...

journal_title：Pharmacology

authors： Andurkar SV,Gulati A

更新日期：2011-01-01 00:00:00

abstract：:The influence of repeated administration of histamine on lithium-induced state dependency has been investigated. A single-trial step-down inhibitory avoidance task was used to assess memory in adult male NMRI mice. Intraperitoneal (i.p.) administration of lithium (10 mg/kg), immediately after training (post-training),...

journal_title：Pharmacology

authors： Zarrindast MR,Parsaei L,Ahmadi S

更新日期：2008-01-01 00:00:00

abstract：:Nitric oxide has been shown to decrease myocardial contractility and O2 consumption. This study was designed to evaluate the hypothesis that nitric oxide-mediated increases in cyclic GMP require elevated cyclic AMP to produce cardiac depression. Using isolated, Langendorff-perfused rat hearts, we determined the effect...

journal_title：Pharmacology

authors： Weiss HR,Sadoff JD,Scholz PM,Klabunde RE

更新日期：1997-10-01 00:00:00

abstract：:The mechanisms by which captopril inhibits vasopressin-stimulated osmotic water flow in the toad bladder have been investigated in vitro. Captopril has two possible mechanisms for the inhibitory action on the water flow, one is its stimulative effect on prostaglandin E2 (PGE2) biosynthesis by inhibition of kininase II...

journal_title：Pharmacology

authors： Marumo F,Nara Y

更新日期：1987-01-01 00:00:00

abstract：:The effect of age on the clearance (CL) of therapeutic proteins has not been explored extensively in pediatric subjects. Recently, resting energy expenditure (REE) has been proposed to link age-dependent CL with developmental changes. Allometric relationship was explored to assess the impact of REE on the CL of therap...

journal_title：Pharmacology

authors： Lee SK

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Cassia angustifolia L. (senna) is traditionally used as a laxative. Its major components are sennosides that are responsible for the laxative effect. Senna is recommended for the short-term treatment of acute constipation. Nevertheless people use its preparations as self-medication, often for long periods, t...

journal_title：Pharmacology

authors： Vitalone A,Di Giacomo S,Di Sotto A,Franchitto A,Mammola CL,Mariani P,Mastrangelo S,Mazzanti G

更新日期：2011-01-01 00:00:00

abstract：:Previously it was demonstrated that intravenously administered morphine produced greater analgesic but lower hyperthermic responses to morphine in 24-week-old rats in comparison to 8-week-old rats. The differential pharmacological responses to morphine could not solely be attributed to the pharmacokinetic parameters, ...

journal_title：Pharmacology

authors： Bhargava HN,Villar VM,Rahmani NH,Larsen AK

更新日期：1993-07-01 00:00:00

abstract：:Lesopitron acts as a ligand for central serotonin 5-HT1A receptors. Ki obtained from [3H]8-OH-DPAT competition studies was 104.8 +/- 10.6 nmol/l. As lesopitron did not affect the binding of [3H]paroxetine, involvement of the serotonin reuptake system in the effects of lesopitron is rejected. Lesopitron inhibits halope...

journal_title：Pharmacology

authors： Fisas MA,Farré A,Camarasa J,Escubedo E

更新日期：2004-10-01 00:00:00

abstract：:In a model of dimethylhydrazine-induced colorectal tumors in male mice aloin- or sennoside-enriched diets (0.03%) did not promote incidence and growth of adenomas and carcinomas after 20 weeks. Furthermore, in anthranoid-fed mice no significant changes in serum electrolytes as well as parameters of hepato- and nephrot...

journal_title：Pharmacology

authors： Siegers CP,Siemers J,Baretton G

更新日期：1993-10-01 00:00:00

abstract：:We studied the action of beta-adrenergic agonists on Japanese quail erythrocyte carbonic anhydrase (CA) in vitro. Earlier we had reported that epinephrine increased CA activity by 14%; the present study focused on an attempt to increase the size of this response. Washed erythrocytes from reserpine-treated (1 mg/kg dai...

journal_title：Pharmacology

authors： Igbo IN,Reigel CE Jr,Greene IM,Kenny AD

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. METHODS:ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0. Then the mice were orally given GAA (25, 50 mg/kg) or dexamethasone (2 mg/kg). After treatment for 21 days,...

journal_title：Pharmacology

authors： Wen G,Li T,He H,Zhou X,Zhu J

更新日期：2020-01-01 00:00:00

abstract：:Effects of choleresis produced by atropine (4-10(-4)M) on the biliary elimination of 3H-ouabain and on the biliary clearance rate of 14C-erythritol were studied in the isolated perfused rat liver. The increased bile flow produced by atropine was associated with decreased level of 3H-ouabain in the bile. The cumulative...

journal_title：Pharmacology

authors： Nevasaari K,Alakare B,Kärki NT

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND/AIMS:Bronchial asthma continues to be a big challenge to therapy. Mast cells play an important role in allergic asthma. Histamine and leukotrienes are established mast cell mediators, but antihistamines currently play no role in asthma therapy. METHODS:Human bronchial strips were exposed to the mast cell ac...

journal_title：Pharmacology

authors： Benko R,Molnar TF,Szombati V,Benkö I,Bartho L

更新日期：2015-01-01 00:00:00

abstract：:The effects of the calcium channel antagonist nifedipine and the protein kinase C (PKC) inhibitor, staurosporine were examined on the pressor actions of a full, cirazoline, and a partial, St587, alpha 1-adrenoceptor agonist as well as the alpha 2-adrenoceptor agonist B-HT 920 in the pithed rat preparation. Administrat...

journal_title：Pharmacology

authors： Tabrizchi R,Triggle CR

更新日期：1991-01-01 00:00:00

abstract：:We report that the loop diuretic drugs bumetanide and furosemide used in the treatment of hypertension are GPR35 agonists. We utilized calcium flux, inositol phosphate accumulation, and dynamic redistribution assays to examine the pharmacology of these compounds on the human, mouse and rat GPR35. While potent on human...

journal_title：Pharmacology

authors： Yang Y,Fu A,Wu X,Reagan JD

更新日期：2012-01-01 00:00:00

abstract：:In the isolated guinea pig vas deferens, 10(-4) M cocaine shifts to the left (13.5-fold at the EC50 level) the concentration-effect curve and increases the maximum response to noradrenaline, whilst supersensitivity to phenylephrine, an amine with a low affinity for the neuronal uptake, was smaller (4.1-fold) and the m...

journal_title：Pharmacology

authors： DeMoraes S,Capaz FR

更新日期：1977-01-01 00:00:00

abstract：:Rat intestinal transit was determined 30, 60, 150 and 270 min after morphine sulfate or saline given either subcutaneously (s.c.), intraduodenally (i.d.) or intracerebroventricularly (i.c.v.). In addition, two popular methods of quantifying the progression of a radioactive marker along the bowel, the intercept and geo...

journal_title：Pharmacology

authors： Stewart JJ

更新日期：1984-01-01 00:00:00

abstract：:We previously reported that adenovirus-mediated gene transfer of heme oxygenase-1 (HO-1) inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. This finding implies that HO-1 induction is beneficial for protecting blood vessels. We also found that quercetin, a common polyphenolic compound in f...

journal_title：Pharmacology

authors： Lin HC,Cheng TH,Chen YC,Juan SH

更新日期：2004-06-01 00:00:00

abstract：:The antinociceptive effect in mice (hot-plate test) of caerulein (0.15 mg/kg s.c.) was many times more resistant to naloxone than that of morphine (2 mg/kg s.c., equipotent with the caerulein dose). The ED50 (mg/kg s.c.) of naloxone (given simultaneously with an agonist) was with morphine 0.01 and with caerulein 0.07....

journal_title：Pharmacology

authors： Zetler G

更新日期：1982-01-01 00:00:00

abstract：:High-affinity (104 +/- 18 pmol/l) and high-density (204 +/- 25 fmol/mg) angiotensin II (AII) binding sites have been identified in Xenopus laevis heart membranes. Competition binding of [125I]Sar1,Ile8 angiotensin (SIA) to these receptors by peptide analogs selective for the mammalian AII receptor subtypes AT1 and AT2...

journal_title：Pharmacology

authors： Aiyar N,Baker E,Pullen M,Nuthulaganti P,Bergsma DJ,Kumar C,Nambi P

更新日期：1994-04-01 00:00:00

abstract：AIMS:Accumulation of advanced glycation end products (AGEs) plays a pivotal role in the mechanism by which aging contributes to osteoarthritis (OA). In the present study, we examined the effect of curcumin, a pharmacologically safe phytochemical agent, on AGE-induced tumor necrosis factor-α (TNF-α) and matrix metallopr...

journal_title：Pharmacology

authors： Yang Q,Wu S,Mao X,Wang W,Tai H

更新日期：2013-01-01 00:00:00

abstract：:We investigated the total urinary kallikrein levels, left-ventricular wall thickness and mean arterial blood pressure of nontreated and captopril-treated diabetic and nondiabetic spontaneously hypertensive rats. The mean arterial blood pressure was significantly elevated in diabetic spontaneously hypertensive rats as ...

journal_title：Pharmacology

authors： Sharma JN,Kesavarao U

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:To study the myocardial benefit effect and mechanism of paeoniflorin on myocardial ischemia reperfusion injury (MIRI) in rats. METHODS:Hundred SD rats were randomly divided into 5 groups: sham group, model group, Paeoniflorin (15 mg/kg) group, Paeoniflorin (30 mg/kg) group, and Paeoniflorin (60 mg/kg) group....

journal_title：Pharmacology

authors： Wu F,Ye B,Wu X,Lin X,Li Y,Wu Y,Tong L

更新日期：2020-01-01 00:00:00