Abstract:
:In the rabbit, intracerebroventricular administration of dibutyryl cyclic AMP (DBC) produces fever which is selectively antagonised by phenoxybenzamine. This indicates the involvement of central alpha-adrenoceptors in DBC-induced fever. The decrease in DBC hyperthermia after 6-hydroxydopamine (6-OH-DA) supports the viewpoint that DBC-induced fever is dependent on the presence of noradrenaline (NA) in the central nervous system. The accentuation of NA hyperthermia by theophylline suggests that NA fever may be mediated by cAMP. It is unlikely that DBC-induced hyperthermia in the rabbit is mediated via prostaglandins since indomethacin does not inhibit this response to DBC.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Kandasamy SBdoi
10.1159/000137385subject
Has Abstractpub_date
1980-01-01 00:00:00pages
304-9issue
6eissn
0031-7012issn
1423-0313journal_volume
20pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::Previous investigations demonstrated that CYP2D16 was expressed at high levels in guinea pig adrenal microsomes. The studies presented here were done to determine whether adrenal metabolism of bufuralol (BUF), a model CYP2D substrate, was similar to that in the liver. Guinea pig adrenal microsomes converted BUF to 1'-...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056100
更新日期:2001-05-01 00:00:00
abstract::The effects of hypothermia (4 degrees C) on the components of the cholinergic system of the ileal longitudinal muscle and the adherent Auerbach's plexus of the guinea pig ileum have been investigated. Acetylcholine (ACh) content of the muscle was determined by pyrolysis-gas chromatography. It decreased from 119 to a f...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136756
更新日期:1978-01-01 00:00:00
abstract::The haemodynamic changes during epidural anaesthesia and following the administration of dihydroergotamine (DHE; 10 micrograms/kg i.v.) were studied in 7 dogs (epidural group). Epidural anaesthesia was associated with reductions in mean arterial, mean pulmonary arterial and mean right atrial pressures. Femoral flow wa...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137566
更新日期:1981-01-01 00:00:00
abstract::The vascular relaxant effect of salbutamol and its dependence on the endothelium were studied in the isolated dog coronary artery, precontracted with prostaglandin F2 alpha. Salbutamol induced a concentration-dependent relaxation which was partially inhibited by removal of endothelial cells. Atenolol 10(-6) mol/l, a b...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138804
更新日期:1991-01-01 00:00:00
abstract::We previously reported that adenovirus-mediated gene transfer of heme oxygenase-1 (HO-1) inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. This finding implies that HO-1 induction is beneficial for protecting blood vessels. We also found that quercetin, a common polyphenolic compound in f...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000076947
更新日期:2004-06-01 00:00:00
abstract::Galactosamine (GalN) administration produces hepatitis-like liver injury in animals. The hepatotoxicity of GalN is attenuated by several interventions, including activation of the reticuloendothelial system (RES). Fructose-1,6-diphosphate (FDP) administration significantly increases the phagocytic activity of the RES ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138861
更新日期:1991-01-01 00:00:00
abstract::Acute ethanol administration to rats fasted overnight resulted in a significant decrease in the content of glutathione (GSH) of the liver concomitantly with a partial increase in oxidized glutathione levels, representing a net 38% decrease in total GSH equivalents. In these conditions, liver lipoperoxidation is signif...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137514
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVE:Advanced glycation end products (AGEs) play a pivotal role in the initiation and progression of osteoarthritis (OA). Peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to exhibit anti-inflammatory and anticatabolic properties and to be protective in animal models of OA. This study was aimed t...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000369074
更新日期:2014-01-01 00:00:00
abstract::Angiotensin II (ANG II) is a potent vasoconstrictor in most vascular beds. We studied the role of cyclooxygenase products and/or endothelium-derived relaxing factor (EDRF) in modulating the pressor response to ANG II in the isolated, blood perfused dog lung. ANG II was given as a bolus dose of 2, 4 and 8 micrograms be...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138709
更新日期:1990-01-01 00:00:00
abstract::Zinc acexamate (NAS-501), an anti-ulcer agent, has been reported to prevent various acute experimental gastric mucosal lesions and duodenal ulcers in rats. In order to clarify the mechanisms by which NAS-501 exhibits the anti-ulcer effects, we investigated the anti-oxidative effects of NAS-501 in vitro and in vivo. NA...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028283
更新日期:1999-04-01 00:00:00
abstract:AIMS:The present study evaluated the effects of sitagliptin-insulin against type 2 diabetes mellitus with neuropathy in rats and possible neuroprotective mechanisms. METHODS:Diabetes was induced in 32 adult male albino rats by 6-week high-fat high-sugar diet followed by streptozotocin 30 mg/kg intraperitoneal injectio...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000448043
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Multidrug resistance (MDR) presents a problem in cancer chemotherapy, and developing new agents to overcome MDR is important. This study intends to investigate the reversal effect of -elemene on MDR in human breast carcinoma MCF-7 and doxorubicin-resistant MCF-7 cells. METHODS:MTT cytotoxicity assays, flow ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000337178
更新日期:2012-01-01 00:00:00
abstract::The aim of this study was to determine whether transforming growth factor-beta1 (TGF-beta1) induces the synthesis, release and gene expression of urokinase-type plasminogen activator (uPA) in hepatic stellate cells. In addition to stimulating collagen production, TGF-beta1 induced the morphological and phenotypical ch...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000081071
更新日期:2005-01-01 00:00:00
abstract::There is an ongoing debate about possible advantages of the coadministration of caffeine with cyclooxygenase (COX) inhibitors in the treatment of pain. There are results suggesting interference by caffeine with COX expression and activity in rat immune cells. In the present study, we have used, therefore, human endoto...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000067742
更新日期:2003-02-01 00:00:00
abstract::The present study aims at investigating the effects of mannitol and dimethylthiourea, known hydroxyl radical scavengers, on lipid peroxidation as an indicative of oxidative damage, NF-kappa B activation and IL-8 production by Helicobacter pylori in gastric epithelial cells. A human gastric epithelial cell line, AGS, t...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028321
更新日期:1999-10-01 00:00:00
abstract::The histamine levels in rat plasma treated with various new trypanocidal diamidines and diimidazolines were evaluated by HPLC and fluorometric detection. Equimolar doses (10 mumol/kg) of the new compounds raised the plasma histamine level to a much smaller degree than pentamidine or diminazene. ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138385
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Lipopolysaccharide (LPS) induces intestinal dysmotility by alteration of smooth muscle and enteric neuronal activities. However, there is no report on the modulatory effects of LPS on the interstitial cells of Cajal (ICCs). We investigated the effect of LPS and its signal transduction in ICCs. M...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000340018
更新日期:2012-01-01 00:00:00
abstract::Combination therapy with antiretroviral drugs is used for the treatment of patients infected with the human immunodeficiency virus. To achieve optimal drug concentrations for viral suppression and avoidance of drug toxicity, monitoring of drug levels has been considered essential. We set up an analytical procedure for...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000073664
更新日期:2003-12-01 00:00:00
abstract::The effect of sodium rhein on contractile activity and fluid flow in the rat complete large intestine was studied in vitro. Contractile activity was recorded using serosal strain gauges and volume transducers recorded distal fluid flow from the segment. Luminal sodium rhein (1 mM) produced a protracted increase in cae...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139840
更新日期:1993-10-01 00:00:00
abstract::The aim of this study was to compare the effects of a new thromboxane synthase inhibitor, camonagrel, on platelet aggregation and platelet-subendothelium interaction under flow conditions, in comparison with a standard thromboxane synthase inhibitor (dazoxiben) and a cyclooxygenase inhibitor (acetylsalicylic acid). Wi...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000071266
更新日期:2003-09-01 00:00:00
abstract::The type-1 cannabinoid receptor (CB1R) was initially identified as the neuronal target of Δ(9)-tetrahydrocannabinol (THC), the major psychoactive substance of marijuana. This receptor is one of the most abundant G-protein-coupled receptors in the adult brain, the target of endocannabinoid ligands and a well-characteri...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000339075
更新日期:2012-01-01 00:00:00
abstract::The effect of morphine, fentanyl, pethidine and pentazocine was studied in gerbils against air blast-induced seizures. Major, generalized seizures were suppressed by morphine (ED50 = 4.0 mg/kg s.c.), fentanyl (ED50 = 64 micrograms/kg s.c.), and pethidine (ED50 = 2.4 mg/kg s.c.), but not by pentazocine. The anticonvuls...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138189
更新日期:1986-01-01 00:00:00
abstract::The influence of changes in the sodium balance on angiotensin II-induced pressor responses were studied in the pithed rat preparation, which is characterized by a highly activated renin-angiotensin-aldosterone system (RAAS) with high plasma renin and angiotensin II concentrations. The pressor response to angiotensin I...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138460
更新日期:1988-01-01 00:00:00
abstract::We studied the effects of triamterene (TA) on its phase I and phase II metabolites, p-hydroxytriamterene (OH-TA) and p-hydroxytriamterene sulfuric acid ester (OH-TA ester), on sodium transport in the isolated frog skin. While TA applied to the inside (corial side) surface had no effects on potential difference (PD) an...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137543
更新日期:1981-01-01 00:00:00
abstract::Two diazepam derivatives, the N-desmethyl and the 2'-chlor-N-desmethyldiazepam, were compared in rats using behavioral and EEG techniques. Both drugs had depressant effects upon locomotor activity, facilitated behavior suppressed by punishment, increased the number of shocks received by rats in a Sidman avoidance proc...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136845
更新日期:1978-01-01 00:00:00
abstract::This study examined effects of intracerebroventricularly (i.c.v.) administered somatostatin (SRIH-14 and SRIH-28) on growth and function of pituitary somatotropes (GH cells) and lactotropes (PRL cells). Male rats received three i.c.v. injections (1 microgram/5 microliters) of SRIH-14 or SRIH-28 every second day. Blood...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028223
更新日期:1998-07-01 00:00:00
abstract::The distribution of primaquine was measured in seven rat tissues at 15-180 min after the intraperitoneal injection of the antimalarial 8-aminoquinoline. The half-life of unmetabolized primaquine was 4.0 h in lung, 1.7-1.9 h in blood, spleen, kidney and heart, and 1.2 h in liver. At each interval, the concentrations of...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137508
更新日期:1981-01-01 00:00:00
abstract::The distribution pattern of (-)-3H-dihydroalprenolol (3H-DHA) binding sites within the thoracic and abdominal aorta was studied using a histoautoradiographic technique. Frozen sections of rabbit aorta were incubated with 3H-DHA in the presence or absence of 1 mumol/l (-)-propranolol and of increasing concentrations of...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138065
更新日期:1985-01-01 00:00:00
abstract::We evaluated the effects of sodium alginate (AL-Na) on dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. DSS was added to the drinking water for 7 days. In another experiment, DSS was added to the drinking water for 5 days and DSS-free water was provided thereafter. ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000353192
更新日期:2013-01-01 00:00:00
abstract::The effects of the calcium channel antagonist nifedipine and the protein kinase C (PKC) inhibitor, staurosporine were examined on the pressor actions of a full, cirazoline, and a partial, St587, alpha 1-adrenoceptor agonist as well as the alpha 2-adrenoceptor agonist B-HT 920 in the pithed rat preparation. Administrat...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138838
更新日期:1991-01-01 00:00:00