Modulation of urokinase-type plasminogen activator by transforming growth factor beta1 in acetaldehyde-activated hepatic stellate cells.

abstract：:In the present study, chronic treatment of atorvastatin was evaluated on isoproterenol-induced myocardial infarction. Male Sprague-Dawley rats (200 +/- 25 g) were randomized into the following four groups: (1) control group, (2) isoproterenol-treated group, (3) atorvastatin-treated group, and (4) isoproterenol- and at...

journal_title：Pharmacology

authors： Trivedi CJ,Balaraman R,Majithiya JB,Bothara SB

更新日期：2006-01-01 00:00:00

abstract：:N-Tosyl-L-phenylalanyl-chloromethyl ketone (TPCK) is neuroprotective in rat pups. We measured bcl-2, Bax and caspase-3 to determine the mechanisms. Seven-day-old rats had the right carotid artery ligated and were subjected to 2.5 h of 8% oxygen. Ten mg/kg of PTCK or vehicle was given intraperitoneally 15 min prior to ...

journal_title：Pharmacology

authors： Feng Y,LeBlanc MH

更新日期：2002-11-01 00:00:00

abstract：:Honokiol and magnolol have been identified as modulators of the GABAA receptors in vitro. Our previous study suggested a possible selectivity of honokiol and magnolol on GABAA receptor subtypes. This possibility was examined in the current study by 3H-muscimol and 3H-flunitrazepam binding assays on various rat brain m...

journal_title：Pharmacology

authors： Ai J,Wang X,Nielsen M

更新日期：2001-07-01 00:00:00

abstract：:Esculentoside A, a kind of saponin isolated from the root of the Chinese herb Phytolaca esculenta, is reported to possess potent anti-inflammatory effects in acute and chronic experimental models. In the present study, we investigated the effects of esculentoside A on the production of tumor necrosis factor (TNF), int...

journal_title：Pharmacology

authors： Ju DW,Zheng QY,Cao X,Fang J,Wang HB

更新日期：1998-04-01 00:00:00

abstract：:The function of melatonin (MLT) in promoting fracture healing has been demonstrated in previous studies. However, the molecular mechanism underlying therapeutic effects of MLT is not entirely clear. In this study, mesenchymal stem cells (MSCs) were isolated from rat bone marrow and identified by flow cytometry. We fou...

journal_title：Pharmacology

authors： Dong P,Gu X,Zhu G,Li M,Ma B,Zi Y

更新日期：2018-01-01 00:00:00

abstract：:The vasodepressor responses to intravenous injections of arachidonic acid, and the formation of its metabolites, were studied in rats made diabetic 1 or 2 weeks after a 1-dose alloxan treatment. Arachidonic acid dose-dependently decreased the diastolic blood pressure in normal animals, but this hypotensive effect was ...

journal_title：Pharmacology

authors： Hui SC,Ogle CW,Wang Z,An Y,Hu YH

更新日期：1989-01-01 00:00:00

abstract：:Mast cells from different locations are shown to vary in their histochemical, ultrastructural, cytochemical and functional properties. The clinical consequences of this heterogeneity and possible reasons for its origin are discussed. ...

journal_title：Pharmacology

authors： Pearce FL

更新日期：1986-01-01 00:00:00

abstract：:In the present study, the effects of ghrelin against the gastric damage induced by intragastric administration of 0.6 N HCl and the involvement of histamine H₃ receptors (H₃Rs) were investigated in conscious rats with selective H₃R ligands. Intraperitoneal (i.p.) injection of ghrelin (40 μg/kg) significantly reduced (...

journal_title：Pharmacology

authors： Adami M,Pozzoli C,Leurs R,Stark H,Coruzzi G

更新日期：2010-01-01 00:00:00

abstract：:Feeding a thiamin-deficient diet to male and female rats for 3 weeks alters the mixed function oxidases responsible for metabolizing benzo(a)pyrene and enhances the response of these enzymes to induction by phenobarbital or 3-methylcholanthrene. The caloric restriction observed in thiamin deprivation may be partially ...

journal_title：Pharmacology

authors： Wade AE,Bunce OR,Harley W,Baker MT,Holmes D

更新日期：1984-01-01 00:00:00

abstract：:When rat mast cells were cultured for a short period in plastic dishes and adhering cells were permeabilized with beta-escin and exposed to Ca2+ at concentrations higher than 10(-7) mol/l, histamine release was induced dose-dependently. Protein kinase C (PKC) activity in the crude extracts obtained from adhering mast ...

journal_title：Pharmacology

authors： Izushi K,Tasaka K

更新日期：1992-01-01 00:00:00

abstract：:Cathinone, the active principle of Catha edulis (khat), shows long-lasting analgesic effects when the tail-flick test is used in rats. The involvement of monoamines, endogenous opioids and stress in this analgesic effect was tested. Both early (30 min) and late (24 h) analgesic effects of cathinone were prevented by r...

journal_title：Pharmacology

authors： Nencini P,Ahmed AM,Anania MC,Moscucci M,Paroli E

更新日期：1984-01-01 00:00:00

abstract：:The aim of this study was to compare the effects of a new thromboxane synthase inhibitor, camonagrel, on platelet aggregation and platelet-subendothelium interaction under flow conditions, in comparison with a standard thromboxane synthase inhibitor (dazoxiben) and a cyclooxygenase inhibitor (acetylsalicylic acid). Wi...

journal_title：Pharmacology

authors： Villalobos MA,De La Cruz JP,Escalante R,Arrebola MM,Guerrero A,Sánchez de la Cuesta F

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this study was to evaluate the effect and mechanisms of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on immune responses in murine colitis. METHODS:Mice with dextran sulfate sodium (DSS)-induced colitis were injected intraperitoneally with hUC-MSCs or human bone marrow-deri...

journal_title：Pharmacology

authors： Li L,Liu S,Xu Y,Zhang A,Jiang J,Tan W,Xing J,Feng G,Liu H,Huo F,Tang Q,Gu Z

更新日期：2013-01-01 00:00:00

abstract：:We investigated the effects of calcium ions (Ca2+) on the adenylyl cyclase activity in purified turkey erythrocyte membranes. Results showed the following: (i) Ca2+ inhibits cAMP accumulation stimulated by isoproterenol (1 micromol/l), NaF + AlCl3 (10 mmol/l + 20 micromol/l) or forskolin (10 micromol/l) in EGTA-washed...

journal_title：Pharmacology

authors： Demirel E,Ugur O,Onaran HO

更新日期：1998-10-01 00:00:00

abstract：:The effects of the novel antihypertensive agent, carvedilol, on renal hemodynamics and excretory function have been investigated and compared with the effects of labetalol in conscious, spontaneously hypertensive rats. Sustained intravenous infusion of carvedilol or labetalol at a rate of 10 micrograms/kg/min resulted...

journal_title：Pharmacology

authors： Gellai M,DeWolf R,Ruffolo RR Jr

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Periplaneta americana is one of the ancient insect groups with the strongest vitality. Periplaneta americana extract (PAE) has been explored as an alternative remedy for many diseases. Although much progress has been made in the study about PAE, the role of the drug in renal disease is rarely reported, espec...

journal_title：Pharmacology

authors： Liu J,Zhou L,He L,Zhong Y,Zhang X,Xiao B,Liu G

更新日期：2018-01-01 00:00:00

abstract：:delta9-Tetrahydrocannabinol (THC) inhibited ulcer formation in the pylorus-ligated rat (Shay rat test). However, this antiulcer activity of THC was substantially less than for the anticholinergic substance tridihexethyl chloride both in terms of degree of activity and potency. In addition, the results of the present s...

journal_title：Pharmacology

authors： Sofia RD,Diamantis W,Harrison JE,Melton J

更新日期：1978-01-01 00:00:00

abstract：:We examined the properties of the drug interaction between morphine and 5-HT(3) receptor antagonist at the spinal level. The nociceptive state was induced by subcutaneously injecting formalin solution (5%, 50 microl) into the hindpaw of the rats. Intrathecal morphine and m-CPBG (5-HT(3) receptor agonist) dose-dependen...

journal_title：Pharmacology

authors： Yoon MH,Bae HB,Choi JI,Kim SJ,Chung ST,Kim CM

更新日期：2006-01-01 00:00:00

abstract：:The effects of two structurally dissimilar aldose reductase inhibitors, Zopolrestat and Sorbinil, were investigated on the sodium-dependent, myo-inositol (MI) cotransporter in rat lenses maintained in either normal (5.5 mmol/l) or high sugar medium (35.5 mmol/l glucose or 30 mmol/l galactose). MI influx was compared t...

journal_title：Pharmacology

authors： Beyer-Mears A,Diecke FP,Mistry K,Cruz E

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:This study aimed to assess the population pharmacokinetics of phenytoin in Saudi patients and identify factors affecting therapeutic parameters. METHOD:A retrospective chart review was performed at King Saud University Medical City on patients treated with oral phenytoin. We used Monolix 4.4. for population ...

journal_title：Pharmacology

authors： Alqahtani S,Alzaidi T,Alotaibi M,Alsultan A

更新日期：2019-01-01 00:00:00

abstract：:Particulate fractions of myocardium taken from spontaneously hypertensive rats (SHR) contained an adenylate cyclase system that was less responsive than normotensive Wistar Kyoto rats to norepinephrine, isoproterenol (mixed beta-agonist), salbutamol (beta 2-agonist), dobutamine (beta 1-agonist), dopamine, histamine, a...

journal_title：Pharmacology

authors： Palmer GC,Greenberg S

更新日期：1979-01-01 00:00:00

abstract：:Ulcerative colitis is characterized by dysfunctional motility. Our main objective in this investigation was to study the effect of an acetic acid-induced ulcerative colitis on the expression and function of beta(3)-adrenoceptors in the rat colon. Inflammation was induced by administering acetic acid intrarectally into...

journal_title：Pharmacology

authors： Khan I,Hussein SM,Oriowo M

更新日期：2002-02-01 00:00:00

abstract：:Binding of cefpiramide (CPM) and other beta-lactam antimicrobial agents to 2(3)-tert-butyl-4-hydroxyanisole (BHA)-induced liver glutathione (GSH) S-transferases (EC 2.5.1.18) from CD-1 mice was studied. A marked induction of hepatic GSH S-transferase from mice fed BHA was observed. Gel chromatography of liver cytosol ...

journal_title：Pharmacology

authors： Nishiya H,Haga T,Nozue N,Komatsu T,Baba M,Ueda Y,Ono Y,Kunii O

更新日期：1989-01-01 00:00:00

abstract：:The agent, 6-(N,N-diethylamino)-hexyl- 3, 4, 5,-Trimethoxybenzoate (TMB-6) which relaxes smooth and skeletal muscle by interfering with intracellular Ca ++ availability was tested for its electrophysiological effects on canine cardiac Purkinje fibres and feline papillary muscles. In both tissues the drug causes a decr...

journal_title：Pharmacology

authors： Posner P,Chiou CY

更新日期：1976-01-01 00:00:00

abstract：:L-Carnitine (oral route) significantly corrects the muscle hypocontractility and hypoexcitability induced in the rat after 5 consecutive days of fasting. This effect is interpreted on the basis of the dual role of L-carnitine as cofactor in the transport of long-chain fatty acids into the mitochondria and as a detoxif...

journal_title：Pharmacology

authors： Pierrefiche G,Reynier M,Laborit H

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the effects of trichostatin A (TSA) on cervical cancer and the related mechanisms. METHODS:The HeLa and Caski cervical cancer cell lines were treated with different concentrations of TSA. Cell viability was measured by MTT assays. Cell apoptosis was analysed using flo...

journal_title：Pharmacology

authors： Liu JH,Cao YM,Rong ZP,Ding J,Pan X

更新日期：2020-11-03 00:00:00

abstract：:The M1-selective antimuscarinic drugs pirenzepine and telenzepine moderately reduce gastric acid secretion without inhibiting smooth-muscle activity as much as nonselective antimuscarinics, e.g. atropine and 1-hyoscyamine. They hasten peptic ulcer healing and improve the symptoms of reflux oesophagitis. In combination...

journal_title：Pharmacology

authors： Stockbrügger RW

更新日期：1988-01-01 00:00:00

abstract：:We evaluated the effects of sodium alginate (AL-Na) on dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. DSS was added to the drinking water for 7 days. In another experiment, DSS was added to the drinking water for 5 days and DSS-free water was provided thereafter. ...

journal_title：Pharmacology

authors： Yamamoto A,Itoh T,Nasu R,Nishida R

更新日期：2013-01-01 00:00:00

abstract：:To investigate the effects of beraprost sodium on the proliferation and oxidative stress of glomerular mesangial cells under high glucose conditions, a rat mesangial cell line (rat mesangial cells; RMCs) was treated with beraprost sodium in the presence of high glucose concentrations. Proliferation rates of mesangial ...

journal_title：Pharmacology

authors： Zhang LY,Zou JJ,Liu ZM

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIM:The effect of isocaloric diets and sibutramine on dietary behaviour and TNF-alpha is poorly understood. The aim of the study was to investigate the effects of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-alpha in free-feeding rats. METHODS:Three groups of male Wista...

journal_title：Pharmacology

authors： Trapali M,Liapi C,Perelas A,Perrea D,Stroubini T,Dontas I,Couvari E,Mavri M,Galanopoulou P

更新日期：2008-01-01 00:00:00