Relative bioavailability of enteric coated pellets, stearate and ethylsuccinate formulations of erythromycin.

abstract：:The calcium channel antagonist, nifedipine (0.1 microM), only slightly inhibited the response to the full alpha 1-adrenoceptor agonist, (-)-norepinephrine, in rat aorta, but nearly completely inhibited the response to the partial alpha 1-adrenoceptor agonist, (-)-dobutamine, indicating that (-)-norepinephrine primaril...

journal_title：Pharmacology

authors： Oriowo MA,Ruffolo RR Jr

更新日期：1992-01-01 00:00:00

abstract：:Bilateral stopping of plantar perspiration in the mouse was obtained by application of a cotton-wool swab soaked in a 3% solution of BRL 556 in 60% ethanol for 1--2 min to the plantar surface of its right hind paw. For humans, aerosols which are at present on the market produce a sensible reduction in palmar sweating....

journal_title：Pharmacology

authors： Sivadjian J

更新日期：1978-01-01 00:00:00

abstract：:The effects of dietary taurine on lipid secretion and ketone body production were examined in the livers of Wistar and Sprague-Dawley rats fed high-cholesterol diets. The weight gain of the Sprague-Dawley rats tended to be higher than that of the Wistar rats, although food intake was comparable between the strains. Th...

journal_title：Pharmacology

authors： Yamamoto K,Yoshitama A,Sakono M,Nasu T,Murakami S,Fukuda N

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to assess the population pharmacokinetics of phenytoin in Saudi patients and identify factors affecting therapeutic parameters. METHOD:A retrospective chart review was performed at King Saud University Medical City on patients treated with oral phenytoin. We used Monolix 4.4. for population ...

journal_title：Pharmacology

authors： Alqahtani S,Alzaidi T,Alotaibi M,Alsultan A

更新日期：2019-01-01 00:00:00

abstract：:Atherosclerosis (AS) is a chronical pathological process of the arterial narrows due to the AS plaque formation. The aim of this study was to explore the therapeutic effect and the underlying mechanism of Floralozone on experimental atherosclerotic model rats. Experimental atherosclerotic model rats were induced by th...

journal_title：Pharmacology

authors： Yang YP,Zhu ML,Zhang HY,Song P,Xu J,Li P,Yin YL

更新日期：2020-01-01 00:00:00

abstract：:This study was designed to determine whether pyrazinoylguanidine (PZG) can attenuate diabetic nephropathy in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced within 1 week after a single intraperitoneal dose of STZ (45 mg/kg in 0.05 mol/l sodium citrate buffer). Diabetic rats were divided into five gro...

journal_title：Pharmacology

authors： Follansbee MH,Beyer KH Jr,Griffith JW,Vesell ES

更新日期：1997-05-01 00:00:00

abstract：:34 experienced marijuana users were divided into four equated groups of eight subjects each based on recognition memory test performance. One week later each group was retested following administration of marijuana containing 0, 5, 10 or 15 mg delta9-tetrahydrocannabinol. A dose-related effect of marijuana on pulse ra...

journal_title：Pharmacology

authors： Miller L,Cornett T,Drew W,McFarland D,Brightwell D,Wikler A

更新日期：1977-01-01 00:00:00

abstract：:Supplementation of antioxidants such as vitamin E and vitamin C as health promotion food is popular recently. Epidemiological studies supported the beneficial effect of these antioxidants because oxygen free radicals have been linked to the process of diseases and aging. The present study evaluated the effect of alpha...

journal_title：Pharmacology

authors： Huang W,Chan P,Chen Y,Chen C,Liao S,Chin W,Cheng J

更新日期：1999-11-01 00:00:00

abstract：:Altered vascular reactivity due to endothelial dysfunction, consequent to vascular damage, is observed in rheumatoid arthritis. We investigated the effect of angiotensin (Ang)-(1-7) on vasculature changes in arthritis induced by complete Freund's adjuvant in male Wistar rats. Arthritis decreased soluble receptor for a...

journal_title：Pharmacology

authors： Açikalin Ö,Bölükbaşi Hatip FF,Tan RF,Hatip-Al-Khatib I

更新日期：2016-01-01 00:00:00

abstract：:The duration of action of melatonin may be important for improvements in sleep efficiency in insomniacs. Ramelteon, a selective melatonin agonist, is primarily metabolized to the active metabolite M-II, which has a longer half-life and greater systemic exposure than ramelteon. Hence, M-II may contribute significantly ...

journal_title：Pharmacology

authors： Nishiyama K,Nishikawa H,Kato K,Miyamoto M,Tsukamoto T,Hirai K

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Bronchial asthma continues to be a big challenge to therapy. Mast cells play an important role in allergic asthma. Histamine and leukotrienes are established mast cell mediators, but antihistamines currently play no role in asthma therapy. METHODS:Human bronchial strips were exposed to the mast cell ac...

journal_title：Pharmacology

authors： Benko R,Molnar TF,Szombati V,Benkö I,Bartho L

更新日期：2015-01-01 00:00:00

abstract：:The regulatory action exerted on receptors by acebutolol, a cardioselective beta-blocker containing intrinsic sympathomimetic activity, has been investigated. beta-Adrenoceptor affinity and density of human mononuclear leukocytes were assayed in hypertensive patients before and after treatment with 400 mg/day acebutol...

journal_title：Pharmacology

authors： Basso A,Piantanelli L,Cognini G,Giunta S,Andreoni A,Paciaroni E

更新日期：1985-01-01 00:00:00

abstract：:We determined the susceptibility of two ages of rat pups to become tolerant to and dependent on morphine infusions from osmotic minipumps. Neonatal rats (postnatal day 6; P6) were infused for 72 h with morphine at 0.175 or 0.7 mg/kg/h. On P9, morphine's antinociceptive efficacy was reduced in both groups. P14 infant r...

journal_title：Pharmacology

authors： Stoller DC,Thornton SR,Smith FL

更新日期：2002-09-01 00:00:00

abstract：:Exposure of rat portal veins to an N2-gassed buffer markedly increased 86Rb outflow. Moreover, glucose caused a pronounced reduction in 86Rb outflow from portal veins perfused with an N2-gassed buffer. Pinacidil, cromakalim and diazoxide provoked a sustained increase in 86Rb outflow. The stimulatory effect of pinacidi...

journal_title：Pharmacology

authors： Antoine MH,Herchuelz A,Lebrun P

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND/AIMS:Functional linkages between the cannabinoid CB(1) and the dopaminergic systems have been reported although the observations and the mechanisms hypothesizing their interactions at the G protein-coupled receptor (GPCR) functionality level are conflicting. METHODS:Administration of a potent cannabinoid ag...

journal_title：Pharmacology

authors： Nguyen VH,Wang H,Verdurand M,Zavitsanou K

更新日期：2012-01-01 00:00:00

abstract：:The depression of evoked cortical potentials caused by brief periods of cerebral ischemia is attenuated by prior intracarotid injection of cytidoline (2, 4 or 8 mg/kg). Studies performed in hypercapnic cats suggest that the protection afforded by cytidoline is of metabolic rather than hemodynamic origin. The participa...

journal_title：Pharmacology

authors： Boismare F,Le Poncin M,Lefrançois J,Lecordier JC

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND/AIMS:Putative in vitro-in vivo correlations of pharmacokinetic (PK) parameters are regarded as a prerequisite to filter hits derived from high-throughput screening (HTS) approaches for subsequent murine in vivo PK studies. METHODS:In this study, we assessed stabilities in rat and human microsomes of 121 com...

journal_title：Pharmacology

authors： Schrezenmeier E,Zollmann FS,Seidel K,Böhm C,Schmerbach K,Kroh M,Kirsch S,Klare S,Bernhard S,Kappert K,Goldin-Lang P,Skuballa W,Unger T,Funke-Kaiser H

更新日期：2012-01-01 00:00:00

abstract：:The effects of intravenous administration of adrenoceptor agonists and antagonists on electrocardiographic or blood pressure (BP) functional parameters were assessed in urethane-anesthetized rats. The responses of cardiovascular functional parameters produced by these drugs included: (1) isoproterenol decreased the du...

journal_title：Pharmacology

authors： Young MS,Lin KW,Lin MT

更新日期：1992-01-01 00:00:00

abstract：AIM:To evaluate the efficacy and safety of 2 analogs of L-carnitine on rats made insulin resistant by a high-fructose diet. METHODS:Using rats made insulin resistant by a high-fructose diet, we investigated the impact of 2 analogs of L-carnitine (25 mg/kg) and L-carnitine (250 mg/kg) on glucose, triglycerides and chol...

journal_title：Pharmacology

authors： Gómez-Solís A,De la Cruz-Cordero R,Avalos-Soriano A,Duarte-Vázquez MA,Reyes-Esparza J,Rodríguez-Fragoso L

更新日期：2011-01-01 00:00:00

abstract：:The purpose of these studies was to evaluate the effects of the peptidoleukotriene (LT) receptor antagonist, ICI 198615, on the vasopressor responses produced by LTC4, LTD4 and LTE4. Conscious, normotensive rats were prepared with arterial and venous catheters for measurement of changes in arterial blood pressure and ...

journal_title：Pharmacology

authors： Smith EF 3rd,Slivjak MJ

更新日期：1990-01-01 00:00:00

abstract：:We studied the effects of triamterene (TA) on its phase I and phase II metabolites, p-hydroxytriamterene (OH-TA) and p-hydroxytriamterene sulfuric acid ester (OH-TA ester), on sodium transport in the isolated frog skin. While TA applied to the inside (corial side) surface had no effects on potential difference (PD) an...

journal_title：Pharmacology

authors： Kramer HJ,Rörig M,Völger KD

更新日期：1981-01-01 00:00:00

abstract：:The metabolism of sennosides is discussed in view of the results obtained during the last years. Rhein anthrone is to be considered as the ultimate active form produced by microorganisms in the colon. Several contributions of this senna symposium bring complementary information of utmost interest. ...

journal_title：Pharmacology

authors： Lemli J

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Cassia angustifolia L. (senna) is traditionally used as a laxative. Its major components are sennosides that are responsible for the laxative effect. Senna is recommended for the short-term treatment of acute constipation. Nevertheless people use its preparations as self-medication, often for long periods, t...

journal_title：Pharmacology

authors： Vitalone A,Di Giacomo S,Di Sotto A,Franchitto A,Mammola CL,Mariani P,Mastrangelo S,Mazzanti G

更新日期：2011-01-01 00:00:00

abstract：:The present study aims at investigating the effects of mannitol and dimethylthiourea, known hydroxyl radical scavengers, on lipid peroxidation as an indicative of oxidative damage, NF-kappa B activation and IL-8 production by Helicobacter pylori in gastric epithelial cells. A human gastric epithelial cell line, AGS, t...

journal_title：Pharmacology

authors： Kim H,Seo JY,Kim KH

更新日期：1999-10-01 00:00:00

abstract：:Human endothelial cells were cultivated on microporous membranes mimicking the luminal and basal spaces of blood vessels. When fluorescence-labeled lipid microspheres (LM) were added to the upper chambers of the model cultures, confluent monolayers of endothelial cells transported considerable levels of fluorescence t...

journal_title：Pharmacology

authors： Takahashi K,Suzuki K,Ichiki Y,Fukushima T,Nakamura H,Sawasaki Y

更新日期：1996-07-01 00:00:00

abstract：:Erythropoietin (EPO) has been used for the management of renal anemia. Recent studies suggest the pleiotropic properties of EPO in various tissues such as brain, kidney and vasculature. Diabetes mellitus is a major risk for development of vascular impairment. The aim of the present study was to investigate the hypothe...

journal_title：Pharmacology

authors： Wang J,Toba H,Morita Y,Nakashima K,Noda K,Tian W,Kobara M,Nakata T

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIMS:Serotonin (5-hydroxytryptamine, 5-HT)-induced contraction and the involvement of RhoA/Rho-kinase pathway in the 5-HT-induced contraction was investigated isometrically in vitro in both diabetic and nondiabetic human corpus cavernosum (HCC) tissues. METHODS:HCC tissues were obtained from 12 patients. Th...

journal_title：Pharmacology

authors： Murat N,Soner BC,Demir O,Esen A,Gidener S

更新日期：2009-01-01 00:00:00

abstract：:Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and function. Reported prevalence of this geriatric syndrome, differs depending on the definition, the population and the method used to identify sarcopenia. The causes of sarcopenia are multifactorial, and can...

journal_title：Pharmacology

authors： Campins L,Camps M,Riera A,Pleguezuelos E,Yebenes JC,Serra-Prat M

更新日期：2017-01-01 00:00:00

abstract：:Angiotensin had a dual action on the epididymal half of rat vas deferens. It potentiated electrical stimulated contraction and exerted a direct contractile effect on the muscle. The potentiation of electrically stimulated response may be mediated by presynaptic facilitation of neurotransmitter release. Muscular contra...

journal_title：Pharmacology

authors： Sum CS,Cheung WT

更新日期：1995-08-01 00:00:00

abstract：:When guinea pig isolated trachea is contracted with either carbachol or methacholine, relaxant concentration-response curves to isoprenaline, salmefamol and fenoterol were shifted to the right, compared with curves obtained with either spontaneous or histamine-induced tone. Carbachol and methacholine also reduced the ...

journal_title：Pharmacology

authors： Hutson PA,Carpenter JR

更新日期：1987-01-01 00:00:00