Abstract:
BACKGROUND/AIMS:The neurotransmitters participating in the nerve-mediated contraction of the guinea pig seminal vesicle (GPSV) have not been firmly established. There is debate as to the mediating role of norepinephrine and acetylcholine. METHODS:We have used longitudinally and circularly oriented strips of GPSV and activated their intramural nerves by electrical field stimulation (5 and 10 Hz for 30 s). RESULTS:Contractile responses to stimulation were enhanced by a cholinesterase inhibitor and reduced by the adrenergic α-receptor antagonist phentolamine (2.5 μmol/l). Atropine (1 μmol/l) significantly reduced responses in longitudinal preparations; a less consistent inhibition was found in circular preparations. The sensory neuron stimulant and blocker capsaicin was without effect. CONCLUSIONS:It is concluded that adrenergic nerves and also acetylcholine mediate the contractile response of the GPSV.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Benko R,Szombati V,Bartho Ldoi
10.1159/000351847subject
Has Abstractpub_date
2013-01-01 00:00:00pages
39-42issue
1-2eissn
0031-7012issn
1423-0313pii
000351847journal_volume
92pub_type
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