Abstract:
:This study examined the inhibitory effects of papaverine on twitches directly elicited by electrical stimulation of the mouse diaphragm. Papaverine (3-100 μM) inhibited twitches in a dose-dependent manner. Papaverine increased the cyclic adenosine monophosphate (cAMP) but not cyclic guanosine monophosphate (cGMP) content. IBMX, Db-cAMP and 8-br-cGMP did not affect twitches, whereas verapamil and NaCN inhibited twitches. Increases in extracellular Ca²+ removed the twitch inhibition caused by verapamil but not that caused by papaverine. Papaverine (30 and 100 μM) and NaCN (1 mM) decreased creatine phosphate and ATP contents. These results suggest that the relaxing effects of papaverine on mouse diaphragm are mainly due to inhibition of aerobic energy metabolism.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Kaneda T,Hayasaka R,Nagai Y,Tajima T,Urakawa N,Nakajyo S,Shimizu Kdoi
10.1159/000320769subject
Has Abstractpub_date
2010-01-01 00:00:00pages
273-80issue
5-6eissn
0031-7012issn
1423-0313pii
000320769journal_volume
86pub_type
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