Abstract:
:Two diazepam derivatives, the N-desmethyl and the 2'-chlor-N-desmethyldiazepam, were compared in rats using behavioral and EEG techniques. Both drugs had depressant effects upon locomotor activity, facilitated behavior suppressed by punishment, increased the number of shocks received by rats in a Sidman avoidance procedure and caused a synchronization of EEG pattern lasting more than 7 h at the highest doses. The 2'-chlor-substituted compound was much more active than desmethyldiazepam potency ratio ranking between 3.67 and 20.78 according to the test employed.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Babbini M,Gaiardi M,Bartoletti Mdoi
10.1159/000136845subject
Has Abstractpub_date
1978-01-01 00:00:00pages
121-7issue
3eissn
0031-7012issn
1423-0313journal_volume
17pub_type
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