Beneficial effect of rutin on oxonate-induced hyperuricemia and renal dysfunction in mice.


AIMS:The aim of the present study was to investigate the effects of rutin on potassium oxonate-induced hyperuricemia and renal dysfunction in mice. METHODS:Rutin was administered orally 1 h after oxonate at doses of 25, 50 and 100 mg·kg(-1). Serum uric acid levels and kidney function parameters were assayed. Mouse uromodulin levels in serum, urine and kidney were determined by the ELISA method. Simultaneously, the expression levels of renal organic ion transporters were detected. RESULTS:Rutin significantly decreased serum urate, creatinine and blood urea nitrogen, serum and kidney uromodulin levels, and increased urine uromodulin, urate and creatinine excretion in hyperuricemic mice. Rutin at 50 and 100 mg·kg(-1) significantly downregulated mRNA and protein levels of mouse glucose transporter 9 and urate transporter 1, and upregulated mRNA and protein levels of organic anion transporter 1 and organic cation/carnitine transporters in the kidney of hyperuricemic mice. CONCLUSIONS:Rutin exerted its hypouricemic action and renal function improvement by the regulation of renal organic ion transporters.






Chen YS,Hu QH,Zhang X,Zhu Q,Kong LD




Has Abstract


2013-01-01 00:00:00














  • Attitudes and opinion about adverse drug events of women living in a city of south Italy.

    abstract:BACKGROUND/AIM:Perception of risk of adverse drug events (ADEs) is different between health and nonhealth professionals, but these differences have not been investigated sufficiently in the general population. Women are more affected by ADEs. With the aim to investigate ADE risk perception in a sample of nonhealth prof...


    pub_type: 杂志文章


    authors: Salvo F,Miroddi M,Alibrandi A,Calapai F,Cafeo V,Mancari F,Gangemi S,Caputi AP,Calapai G

    更新日期:2013-01-01 00:00:00

  • Effects of sammarium on the contractile response of the isolated guinea pig ileum to acetylcholine, histamine, potassium and barium.

    abstract::The effects of sammarium (Sm3+) on drug responsiveness of the isolated guinea pig ileum were studied. The lanthanid at the concentration of 2x10(-4) M reduced responsiveness to acetylcholine, histamine and submaximal concentrations of potassium. The maximum response to potassium and the responsiveness to barium remain...


    pub_type: 杂志文章


    authors: Turrin MA,De Moraes S

    更新日期:1977-01-01 00:00:00

  • The Alcohol Intolerance Produced by Isoniazid Is Not Due to a Disulfiram-Like Reaction Despite Aldehyde Dehydrogenase Inhibition.

    abstract:BACKGROUND/AIMS:Isoniazid (ISO) has been reported to inhibit the hepatic aldehyde dehydrogenase (ALDH) and to cause a disulfiram (DIS)-like reaction, albeit there are no reports demonstrating increased blood acetaldehyde levels after co-administration of ISO with alcohol. The aim of our study was to clarify whether the...


    pub_type: 杂志文章


    authors: Karamanakos PN,Pappas P,Boumba V,Vougiouklakis T,Marselos M

    更新日期:2016-01-01 00:00:00

  • Effect of carvedilol on renal hemodynamics and renal excretory function in spontaneously hypertensive rats.

    abstract::The effects of the novel antihypertensive agent, carvedilol, on renal hemodynamics and excretory function have been investigated and compared with the effects of labetalol in conscious, spontaneously hypertensive rats. Sustained intravenous infusion of carvedilol or labetalol at a rate of 10 micrograms/kg/min resulted...


    pub_type: 杂志文章


    authors: Gellai M,DeWolf R,Ruffolo RR Jr

    更新日期:1990-01-01 00:00:00

  • Prevention of galactosamine-induced hepatotoxicity in rats with fructose-1,6-diphosphate.

    abstract::Galactosamine (GalN) administration produces hepatitis-like liver injury in animals. The hepatotoxicity of GalN is attenuated by several interventions, including activation of the reticuloendothelial system (RES). Fructose-1,6-diphosphate (FDP) administration significantly increases the phagocytic activity of the RES ...


    pub_type: 杂志文章


    authors: Markov AK,Farias LA,Bennett WS,Subramony C,Mihas AA

    更新日期:1991-01-01 00:00:00

  • Suppression of intestinal smooth muscle contraction by 4-ethylguaiacol, a constituent of wood creosote.

    abstract::Wood creosote, a mixture of phenolic compounds, suppresses in vitro contractions of rat intestine. To identify a compound in wood creosote able to inhibit intestinal motility, we screened its constituent phenolic compounds and found 4-ethylguaiacol (4-EG) as an active compound. It suppressed the spontaneous phasic (IC...


    pub_type: 杂志文章


    authors: Toyoda M,Ogata N,Shibata T

    更新日期:1993-11-01 00:00:00

  • Sucralfate and gastric bicarbonate.

    abstract::The effect of sucralfate treatment (3 g daily for 6 weeks) on gastric HCO3- secretion was investigated in 15 duodenal ulcer patients. After treatment a highly significant (p less than 0.01) increase in gastric bicarbonate output was found. It is suggested that the mode of action of sucralfate includes stimulation of g...


    pub_type: 杂志文章


    authors: Guslandi M

    更新日期:1985-01-01 00:00:00

  • Stimulation of glucose release of the rat kidney in vivo by epinephrine and isoprenaline.

    abstract::In anesthetized rats the glucose release of the kidneys was estimated from the glucose concentrations in the arterial and renal venous plasma, urinary glucose excretion and the total renal plasma flow. Net renal glucose release was found in control experiments. The glucose release of the kidneys decreased with rising ...


    pub_type: 杂志文章


    authors: Greven J,van Eys B,Jacobs W

    更新日期:1975-01-01 00:00:00

  • Once-a-Day Trazodone in the Treatment of Depression in Routine Clinical Practice.

    abstract:OBJECTIVE:The aim of the study was to evaluate the efficacy, tolerability, and safety of once-a day trazodone tablets (Trittico Prolong® 300 mg) in patients with moderate to severe depression in routine clinical practice. METHODS:Men and women ≥18 years old with Montgomery-Åsberg Depression Rating Scale (MADRS) scores...


    pub_type: 杂志文章,多中心研究


    authors: Češková E,Šedová M,Kellnerová R,Starobová O

    更新日期:2018-01-01 00:00:00

  • Effect of epinephrine and alprenolol on ethanol metabolism, liver cell respiration and mitochondrial function.

    abstract::Chronic administration of epinephrine to adult male rats resulted in a significant increase in the rate of ethanol elimination, when given alone or together with the beta-adrenergic blocker alprenolol. This effect was observed concomitantly with an increased hepatic oxygen utilization and no changes in mitochondrial r...


    pub_type: 杂志文章


    authors: Petermann M,Bravo M,Videla L,Ugarte G

    更新日期:1979-01-01 00:00:00

  • Differential contractile impairment of fast- and slow-twitch skeletal muscles in a rat model of doxorubicin-induced congestive heart failure.

    abstract::Congestive heart failure (CHF) is associated with exercise intolerance that cannot be entirely explained by hypoperfusion of the skeletal muscles. We studied the contractile properties of fast-twitch (extensor digitorum longus; EDL) and slow-twitch (soleus; SOL) skeletal muscles in doxorubicin-induced CHF in rats, and...


    pub_type: 杂志文章


    authors: Ertunc M,Sara Y,Korkusuz P,Onur R

    更新日期:2009-01-01 00:00:00

  • Relative bioavailability of enteric coated pellets, stearate and ethylsuccinate formulations of erythromycin.

    abstract::In a randomized three-phase crossover study, 12 healthy male volunteers were given three 12-hourly 500-mg doses of erythromycin base, as enteric coated pellets in capsules (2 X 250 mg), erythromycin stearate tablet (1 X 500 mg), or erythromycin ethylsuccinate sachet (1 X 500 mg). The reaction time after administration...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tjandramaga TB,Van Hecken A,Mullie A,Verbesselt R,De Schepper PJ,Verbist L,Josefsson K

    更新日期:1984-01-01 00:00:00

  • Effect of atorvastatin treatment on isoproterenol-induced myocardial infarction in rats.

    abstract::In the present study, chronic treatment of atorvastatin was evaluated on isoproterenol-induced myocardial infarction. Male Sprague-Dawley rats (200 +/- 25 g) were randomized into the following four groups: (1) control group, (2) isoproterenol-treated group, (3) atorvastatin-treated group, and (4) isoproterenol- and at...


    pub_type: 杂志文章


    authors: Trivedi CJ,Balaraman R,Majithiya JB,Bothara SB

    更新日期:2006-01-01 00:00:00

  • Effect of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on ischemia-reperfusion injury in rats.

    abstract::Two groups of rats were used to examine the effect of pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, on rat hearts using an in vivo model of ischemia-reperfusion (I/R) to elucidate potential mechanisms. One group was the 30-min reperfusion group, which was further subdivided into...


    pub_type: 杂志文章


    authors: Cao Z,Ye P,Long C,Chen K,Li X,Wang H

    更新日期:2007-01-01 00:00:00

  • Metabolism of sennosides--an overview.

    abstract::The metabolism of sennosides is discussed in view of the results obtained during the last years. Rhein anthrone is to be considered as the ultimate active form produced by microorganisms in the colon. Several contributions of this senna symposium bring complementary information of utmost interest. ...


    pub_type: 杂志文章


    authors: Lemli J

    更新日期:1988-01-01 00:00:00

  • Melatonin Induces Osteoblastic Differentiation of Mesenchymal Stem Cells and Promotes Fracture Healing in a Rat Model of Femoral Fracture via Neuropeptide Y/Neuropeptide Y Receptor Y1 Signaling.

    abstract::The function of melatonin (MLT) in promoting fracture healing has been demonstrated in previous studies. However, the molecular mechanism underlying therapeutic effects of MLT is not entirely clear. In this study, mesenchymal stem cells (MSCs) were isolated from rat bone marrow and identified by flow cytometry. We fou...


    pub_type: 杂志文章


    authors: Dong P,Gu X,Zhu G,Li M,Ma B,Zi Y

    更新日期:2018-01-01 00:00:00

  • Inhibitory effect of the new orally active CCR4 antagonist K327 on CCR4+CD4+ T cell migration into the lung of mice with ovalbumin-induced lung allergic inflammation.

    abstract::CC chemokine receptor 4 (CCR4) is expressed on Th2 cells, found in inflamed tissues of allergic diseases, and is therefore suspected to be involved in the pathogenesis of allergic diseases by controlling Th2 cell migration into inflamed tissues. The aim of the present study was to investigate the inhibitory effect of ...


    pub_type: 杂志文章


    authors: Sato T,Komai M,Iwase M,Kobayashi K,Tahara H,Ohshima E,Arai H,Miki I

    更新日期:2009-01-01 00:00:00

  • Age-dependent changes in the myocardial adenylate cyclase of normotensive and spontaneously hypertensive rat.

    abstract::The activity of myocardial adenylate cyclase from two age groups (10-11 and 18-19 weeks old, respectively) of male spontaneously hypertensive rats (SHR) and their age-matched normotensive Wistar-Kyoto rats (WKY) was examined. Stimulation of the enzyme by isoproterenol and 5'-guanylyl-imidodiphosphate (GMP-PNP) was dec...


    pub_type: 杂志文章


    authors: Chiu TH

    更新日期:1981-01-01 00:00:00

  • Effects of vinconate and pentobarbital against postischemic alterations in spirodecanone binding sites in the gerbil brain.

    abstract::We investigated the effects of vinconate and pentobarbital against the alterations in spirodecanone binding in the gerbil striatum and hippocampus 5 h and 7 days after 10 min of cerebral ischemia, using receptor autoradiography. Vinconate and pentobarbital were given intraperitoneally 10 and 30 min prior to ischemic i...


    pub_type: 杂志文章


    authors: Murakami F,Araki T,Kanai Y,Kato H,Fujiwara T,Kogure K

    更新日期:1994-11-01 00:00:00

  • The role of vasopressin suppression in phencyclidine-induced diuresis.

    abstract::Phencyclidine (PCP; 10 mg/kg, s.c.) produced a marked diuresis which occurred without significant changes in solute excretion. This diuresis occurred predominantly within 2 h of PCP injection, and was blocked by pretreatment with vasopressin. The maximum diuresis corresponded temporally to a significant fall in plasma...


    pub_type: 杂志文章


    authors: Zerbe RL,Bayorh MA,Quirion R,Kopin IJ

    更新日期:1983-01-01 00:00:00

  • Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice.

    abstract::In a model of dimethylhydrazine-induced colorectal tumors in male mice aloin- or sennoside-enriched diets (0.03%) did not promote incidence and growth of adenomas and carcinomas after 20 weeks. Furthermore, in anthranoid-fed mice no significant changes in serum electrolytes as well as parameters of hepato- and nephrot...


    pub_type: 杂志文章


    authors: Siegers CP,Siemers J,Baretton G

    更新日期:1993-10-01 00:00:00

  • Morphometric and functional changes of rat pituitary somatotropes and lactotropes after central administration of somatostatin.

    abstract::This study examined effects of intracerebroventricularly (i.c.v.) administered somatostatin (SRIH-14 and SRIH-28) on growth and function of pituitary somatotropes (GH cells) and lactotropes (PRL cells). Male rats received three i.c.v. injections (1 microgram/5 microliters) of SRIH-14 or SRIH-28 every second day. Blood...


    pub_type: 杂志文章


    authors: Milosević V,Brkić B,Velkovski SD,Sekulić M,Lovren M,Starcević V,Severs WB

    更新日期:1998-07-01 00:00:00

  • Influence of the 2'-chloro substitution on central activity of desmethyldiazepam.

    abstract::Two diazepam derivatives, the N-desmethyl and the 2'-chlor-N-desmethyldiazepam, were compared in rats using behavioral and EEG techniques. Both drugs had depressant effects upon locomotor activity, facilitated behavior suppressed by punishment, increased the number of shocks received by rats in a Sidman avoidance proc...


    pub_type: 杂志文章


    authors: Babbini M,Gaiardi M,Bartoletti M

    更新日期:1978-01-01 00:00:00

  • Gastrodin Alleviates Vascular Dementia in a 2-VO-Vascular Dementia Rat Model by Altering Amyloid and Tau Levels.

    abstract::Vascular dementia (VaD) is the second most common type of dementia and has become a major public health challenge as the global population ages. VaD is caused by cerebrovascular disease, and most patients with VaD have been reported to also have Alzheimer's pathologies, which is the formation of neurofibrillary tangle...


    pub_type: 杂志文章


    authors: Shi R,Zheng CB,Wang H,Rao Q,Du T,Bai C,Xiao C,Dai Z,Zhang C,Chen C,Li X,Tian M,Yu X,Ji B,Weng Z,Yang W

    更新日期:2020-01-01 00:00:00

  • Reversible, narcotic-associated mental status impairment in patients with metastatic cancer.

    abstract::Pain and mental status were assessed in a series of 35 consecutive hospitalized patients with metastatic cancer receiving narcotics for pain that was difficult to control. Forty-five episodes of mental status impairment were detected in 27 of these patients. Fifteen patients had dose-related oversedation or organic br...


    pub_type: 杂志文章


    authors: Leipzig RM,Goodman H,Gray G,Erle H,Reidenberg MM

    更新日期:1987-01-01 00:00:00

  • Effect of interleukin 6 on the hepatic metabolism of itraconazole and its metabolite hydroxyitraconazole using primary human hepatocytes.

    abstract::A potential cytokine-drug interaction between interleukin 6 (IL-6) and itraconazole (ITZ) was studied using human hepatocytes in primary culture. Cultures from 5 adult males (mean age 42 +/- 15 years) who had not received any medicines known to interact with CYP3A4 were studied. Cultures were exposed to ITZ 500 ng/ml,...


    pub_type: 杂志文章


    authors: Gubbins PO,Melchert RB,McConnell SA,Franks AM,Penzak SR,Gurley BJ

    更新日期:2003-04-01 00:00:00

  • Protection by zinc sulphate against reserpine-induced ulceration and other gastric effects in the rat.

    abstract::The effects of intraperitoneal pretreatment, 48 h beforehand, with zinc sulphate (22, 44 or 88 mg/kg) were studied on gastric ulceration, gastric secretion and changes in stomach wall mast cell counts induced after 4 h by reserpine (5 mg/kg) given intraperitoneally to intact (unoperated for pylorus occlusion) or pylor...


    pub_type: 杂志文章


    authors: Ogle CW,Cho CH

    更新日期:1978-01-01 00:00:00

  • Metformin-associated lactic acidosis in Chinese patients with type II diabetes.

    abstract::Metformin is a widely used antidiabetic agent that is generally considered safe. However, metformin-associated lactic acidosis (MALA), though not common, occurs from time to time and results in significantly high mortality. A series of 23 MALA cases in a local major hospital in Hong Kong is reported in this article to...


    pub_type: 杂志文章


    authors: Yeung CW,Chung HY,Fong BM,Tsai NW,Chan WM,Siu TS,Tam S,Tsui SH

    更新日期:2011-01-01 00:00:00

  • Human umbilical cord-derived mesenchymal stem cells downregulate inflammatory responses by shifting the Treg/Th17 profile in experimental colitis.

    abstract:BACKGROUND/AIMS:The aim of this study was to evaluate the effect and mechanisms of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on immune responses in murine colitis. METHODS:Mice with dextran sulfate sodium (DSS)-induced colitis were injected intraperitoneally with hUC-MSCs or human bone marrow-deri...


    pub_type: 杂志文章


    authors: Li L,Liu S,Xu Y,Zhang A,Jiang J,Tan W,Xing J,Feng G,Liu H,Huo F,Tang Q,Gu Z

    更新日期:2013-01-01 00:00:00

  • Does nitrous oxide induce release of brain opioid peptides?

    abstract::Increased concentrations of immunoreactive methionine-enkephalin but not leucine-enkephalin were measured in fractions of cerebrospinal fluid perfusate collected from ventricular-cisternally perfused, urethane-anesthetized rats exposed to a mixture of 75% nitrous oxide/25% oxygen for 60 min. These findings suggest tha...


    pub_type: 杂志文章


    authors: Quock RM,Kouchich FJ,Tseng LF

    更新日期:1985-01-01 00:00:00