Abstract:
AIMS:The aim of the present study was to investigate the effects of rutin on potassium oxonate-induced hyperuricemia and renal dysfunction in mice. METHODS:Rutin was administered orally 1 h after oxonate at doses of 25, 50 and 100 mg·kg(-1). Serum uric acid levels and kidney function parameters were assayed. Mouse uromodulin levels in serum, urine and kidney were determined by the ELISA method. Simultaneously, the expression levels of renal organic ion transporters were detected. RESULTS:Rutin significantly decreased serum urate, creatinine and blood urea nitrogen, serum and kidney uromodulin levels, and increased urine uromodulin, urate and creatinine excretion in hyperuricemic mice. Rutin at 50 and 100 mg·kg(-1) significantly downregulated mRNA and protein levels of mouse glucose transporter 9 and urate transporter 1, and upregulated mRNA and protein levels of organic anion transporter 1 and organic cation/carnitine transporters in the kidney of hyperuricemic mice. CONCLUSIONS:Rutin exerted its hypouricemic action and renal function improvement by the regulation of renal organic ion transporters.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Chen YS,Hu QH,Zhang X,Zhu Q,Kong LDdoi
10.1159/000351703subject
Has Abstractpub_date
2013-01-01 00:00:00pages
75-83issue
1-2eissn
0031-7012issn
1423-0313pii
000351703journal_volume
92pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::The cardiovascular effects of SKP-450, a newly synthesized potassium channel activator, and its two major metabolites SKP-818 and SKP-310 were evaluated on isolated rat aorta and in freely moving rats and anesthetized beagle dogs. The rank order of potency in relaxing rat aorta precontracted with norepinephrine was SK...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028188
更新日期:1998-03-01 00:00:00
abstract::A dose-dependent contractile effect of substance P (SP) on the isolated, everted rat portal vein was competitively inhibited by two selective SP antagonists (pro2, phe7, trp9)-SP and (pro4, trp7,9)-SP 4-11. Phentolamine, atropine, methysergide, mepyramine, cimetidine, Sar1, Ile8-angiotensin II, Leu8, des-Arg9-bradykin...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137885
更新日期:1983-01-01 00:00:00
abstract::Hypothyroidism is a common disorder that is associated with psychological disturbances such as dementia, depression, and psychomotor disorders. We recently found that chronic treatment with the T-type calcium channel enhancer SAK3 prevents the cholinergic neurodegeneration induced by a single intraperitoneal (i.p.) in...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000488083
更新日期:2018-01-01 00:00:00
abstract::The use of angiotensin converting enzyme (ACE) inhibitors in combination with diuretics is a common strategy used for the treatment of patients affected by heart failure. An infant affected by initial congestive cardiac failure, after starting the treatment with enalapril in association with furosemide, developed acut...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000441950
更新日期:2016-01-01 00:00:00
abstract:AIMS:Basal insulin administered to type-2 diabetic patients with poor glycaemic control when managed with oral anti-diabetics (OADs) alone can lead to an increased risk of weight gain and hypoglycaemia. In the absence of head-to-head trials, an indirect comparison of the once-daily insulin detemir with insulin glargine...
journal_title:Pharmacology
pub_type: 杂志文章,meta分析
doi:10.1159/000149569
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. METHODS:ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0. Then the mice were orally given GAA (25, 50 mg/kg) or dexamethasone (2 mg/kg). After treatment for 21 days,...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000505297
更新日期:2020-01-01 00:00:00
abstract::The type-1 cannabinoid receptor (CB1R) was initially identified as the neuronal target of Δ(9)-tetrahydrocannabinol (THC), the major psychoactive substance of marijuana. This receptor is one of the most abundant G-protein-coupled receptors in the adult brain, the target of endocannabinoid ligands and a well-characteri...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000339075
更新日期:2012-01-01 00:00:00
abstract::The effects of nisoldipine on myocardial performance and large coronary artery diameter, resistance and cross-sectional area were studied in rabbit hearts in situ. Changes in mean internal diameter of coronary artery segments were visualized using color arteriography; changes were computer-calculated. Nisoldipine had ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138451
更新日期:1988-01-01 00:00:00
abstract::Both in vivo and in vitro exposure to morphine have been reported to produce a number of immunomodulatory effects in both laboratory animals and humans. The current study was performed to assess the direct in vitro effect of exposure to morphine or morphine metabolites on immune response parameters. Murine B6C3F1 sple...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139266
更新日期:1995-01-01 00:00:00
abstract::The vasodepressor responses to intravenous injections of arachidonic acid, and the formation of its metabolites, were studied in rats made diabetic 1 or 2 weeks after a 1-dose alloxan treatment. Arachidonic acid dose-dependently decreased the diastolic blood pressure in normal animals, but this hypotensive effect was ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138612
更新日期:1989-01-01 00:00:00
abstract::Cathinone, the active principle of Catha edulis (khat), shows long-lasting analgesic effects when the tail-flick test is used in rats. The involvement of monoamines, endogenous opioids and stress in this analgesic effect was tested. Both early (30 min) and late (24 h) analgesic effects of cathinone were prevented by r...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138023
更新日期:1984-01-01 00:00:00
abstract::The objective of this study was to determine the effects of hypercholesterolemia on basal vascular tone and vascular responses to pharmacologic agents in hindquarter resistance vessels. Blood pressure and hindquarter blood flow were measured in conscious rabbits fed a high cholesterol diet (1%) for 17 weeks (HC) compa...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056137
更新日期:2001-01-01 00:00:00
abstract::Two groups of rats were used to examine the effect of pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, on rat hearts using an in vivo model of ischemia-reperfusion (I/R) to elucidate potential mechanisms. One group was the 30-min reperfusion group, which was further subdivided into...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000100870
更新日期:2007-01-01 00:00:00
abstract::The marijuana plant Cannabis sp. and its derivatives and analogues, known as cannabinoids (CBs), induce many effects throughout the whole body. Herein we briefly review the gastrointestinal (GI) pharmacology of CBs, with special focus on motor function. Some drugs are available to treat nausea and emesis, and evidence...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000339072
更新日期:2012-01-01 00:00:00
abstract::Sensitive radiometric assays were adapted to study the development and kinetics of meperidine and methadone N-demethylation and morphine glucuronidation by microsomes isolated from livers of fetal stump-tailed macaques (Macaca arctoides). Times in development selected for study were midterm, three-quarter term, near t...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137259
更新日期:1979-01-01 00:00:00
abstract::The present study was designed to investigate the effects of fluid administration on survival in endotoxemic or septicemic male Sprague-Dawley rats. Endotoxemia was induced by intravenous injection of Escherichia coli lipopolysaccharide (LPS), and septicemia produced by cecal ligation and puncture (CLP). In endotoxemi...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139053
更新日期:1993-05-01 00:00:00
abstract:PURPOSE:The purpose of this study is to examine the effectiveness of introducing both rituximab (RTX) and 131I for active Graves' ophthalmopathy (GO) with hyperthyroidism. METHODS:In total, 217 patients suffering from active GO with hyperthyroidism were included in this research. All subjects were randomly assigned to...
journal_title:Pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000453618
更新日期:2017-01-01 00:00:00
abstract::The present study examined the interaction of opioidergic systems in the hypotensive action of atenolol. Anesthetized, adult spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats were instrumented to monitor blood pressure and heart rate. Atenolol (100 micrograms/kg, i.v.) produced a decrease in blood pressure ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138585
更新日期:1989-01-01 00:00:00
abstract::The M1-selective antimuscarinic drugs pirenzepine and telenzepine moderately reduce gastric acid secretion without inhibiting smooth-muscle activity as much as nonselective antimuscarinics, e.g. atropine and 1-hyoscyamine. They hasten peptic ulcer healing and improve the symptoms of reflux oesophagitis. In combination...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000138507
更新日期:1988-01-01 00:00:00
abstract:AIMS:Accumulation of advanced glycation end products (AGEs) plays a pivotal role in the mechanism by which aging contributes to osteoarthritis (OA). In the present study, we examined the effect of curcumin, a pharmacologically safe phytochemical agent, on AGE-induced tumor necrosis factor-α (TNF-α) and matrix metallopr...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000345345
更新日期:2013-01-01 00:00:00
abstract::The effect of sucralfate treatment (3 g daily for 6 weeks) on gastric HCO3- secretion was investigated in 15 duodenal ulcer patients. After treatment a highly significant (p less than 0.01) increase in gastric bicarbonate output was found. It is suggested that the mode of action of sucralfate includes stimulation of g...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138136
更新日期:1985-01-01 00:00:00
abstract::This study was designed to evaluate the antidepressant activity of various antidepressants using the learned helplessness test (LH) or the forced swimming test (FS) in rats. Repeated treatment of the tricyclic antidepressants imipramine (10 mg/kg, p.o.), clomipramine (0.625 mg/kg, p.o.), amitriptyline (10 mg/kg, p.o.)...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056126
更新日期:2001-01-01 00:00:00
abstract::Fenofibrate is widely used in clinical practice, but its influence on chronic endoplasmic reticulum (ER) stress induced by feeding a high-calorie and high-cholesterol diet (HCD) has still not been studied. We thus investigated its effects on the liver of the nonalcoholic fatty liver disease (NAFLD) mouse model. Male C...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000380952
更新日期:2015-01-01 00:00:00
abstract::Mast cells from different locations are shown to vary in their histochemical, ultrastructural, cytochemical and functional properties. The clinical consequences of this heterogeneity and possible reasons for its origin are discussed. ...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000138153
更新日期:1986-01-01 00:00:00
abstract::To elucidate potential stereoselective effects of single barbiturate isomers, we compared the inhibitory potency of single thiopentone enantiomers, two isomer-enriched mixtures of methohexitone and racemic mixtures of both barbiturates on the fMLP-induced neutrophil oxidative response. A suppression of the response to...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000078627
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND/AIMS:Functional linkages between the cannabinoid CB(1) and the dopaminergic systems have been reported although the observations and the mechanisms hypothesizing their interactions at the G protein-coupled receptor (GPCR) functionality level are conflicting. METHODS:Administration of a potent cannabinoid ag...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000335368
更新日期:2012-01-01 00:00:00
abstract::Sedum telephium ssp. maximum is a medicinal plant that possesses anti-inflammatory, analgesic and keratolytic properties. We investigated the anti-inflammatory activity of its methanolic extract (STME) in rat peritoneal macrophages (MPhis) stimulated with lipopolysaccharide from Salmonella enteritidis. After stimulati...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000157626
更新日期:2008-01-01 00:00:00
abstract::In the present study, chronic treatment of atorvastatin was evaluated on isoproterenol-induced myocardial infarction. Male Sprague-Dawley rats (200 +/- 25 g) were randomized into the following four groups: (1) control group, (2) isoproterenol-treated group, (3) atorvastatin-treated group, and (4) isoproterenol- and at...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000092308
更新日期:2006-01-01 00:00:00
abstract:AIM:The purpose of the present study was to examine the effects of acetaldehyde on the contractile force and membrane potentials and currents in the bullfrog heart. METHODS:Contractile force was recorded using right atrial tissues, and membrane potentials and currents were measured by using whole cell patch clamp meth...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000342388
更新日期:2012-01-01 00:00:00
abstract::The effects of several paired analogs of angiotensin II and angiotensin III, designed as antagonists, have been compared in isolated smooth muscle (rat uterus) and by in vivo rat blood pressure assay. These analogs were (1) the angiotensin II series: (1-sarcosine, 7-X, 8-isoleucine-) angiotensin II, and (2) the angiot...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137342
更新日期:1980-01-01 00:00:00