Abstract:
:The M1-selective antimuscarinic drugs pirenzepine and telenzepine moderately reduce gastric acid secretion without inhibiting smooth-muscle activity as much as nonselective antimuscarinics, e.g. atropine and 1-hyoscyamine. They hasten peptic ulcer healing and improve the symptoms of reflux oesophagitis. In combination with H2 receptor antagonists they abolish gastric acid secretion almost completely and can therefore be used in high-risk peptic conditions. Long-term trials have to show whether they can form a medical alternative to parietal cell vagotomy. The effect of M1-selective antimuscarinics on 'nonulcer dyspepsia' is equivocal, but they may possibly be useful in the treatment of spastic constipation.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Stockbrügger RWdoi
10.1159/000138507subject
Has Abstractpub_date
1988-01-01 00:00:00pages
54-63eissn
0031-7012issn
1423-0313journal_volume
37 Suppl 1pub_type
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