Abstract:
:The use of angiotensin converting enzyme (ACE) inhibitors in combination with diuretics is a common strategy used for the treatment of patients affected by heart failure. An infant affected by initial congestive cardiac failure, after starting the treatment with enalapril in association with furosemide, developed acute kidney injury (AKI). No underlying renal disease or renal artery stenosis was found. He recovered from kidney injury after the therapy was suspended, thus suggesting that the drug combination is responsible for the onset of the adverse reaction. The present case report, the appraisal of the current knowledge on the onset of AKI and the analysis of available pharmacovigilance databases indicate that particular caution should be exercised when infants affected by heart failure are treated with the enalapril and furosemide combination therapy. Moreover, we strongly suggest an up-to-date revision of the ACE-inhibitor dosing guidelines in pediatric patients to define unambiguously the safe upper limits of this class of drugs.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Fabiano V,Carnovale C,Gentili M,Radice S,Zuccotti GV,Clementi E,Perrotta C,Mameli Cdoi
10.1159/000441950subject
Has Abstractpub_date
2016-01-01 00:00:00pages
38-42issue
1-2eissn
0031-7012issn
1423-0313pii
000441950journal_volume
97pub_type
杂志文章相关文献
PHARMACOLOGY文献大全abstract::This study was performed to investigate the effect of muscimol on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice. A single administration of morphine induced hyperactivity as measured in mice, and the morphine-induced hyperactivity was inhibited dose-depen...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000064345
更新日期:2002-08-01 00:00:00
abstract::Several experiments suggested that vaccines might inhibit liver drug-metabolizing enzymes, an assumption in agreement with other findings obtained with most immuno-enhancing agents. A direct, non-specific activation of macrophages with subsequent release of interleukin 1 may account for this inhibition. The purpose of...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138370
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Surgery plays a significant role in the comprehensive treatment of breast cancer, and opioids are often the first-choice analgesics in the perioperative period. However, recent studies showed that opioids may enhance the angiogenesis of breast cancer and the recurrence and metastasis of tumor cells. OBJECTI...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000502107
更新日期:2019-01-01 00:00:00
abstract::We investigated the effects of S-777469 (1-[[6-Ethyl-1-[4-fluorobenzyl]-5-methyl-2-oxo-1, 2-dihydropyridine-3-carbonyl]amino]-cyclohexanecarboxylic acid), a novel cannabinoid type 2 receptor (CB2) agonist, on 1-fluoro-2,4-dinitrobenzene (DNFB)-induced ear inflammation and mite antigen-induced dermatitis in mice. The o...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000455916
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Since beta-adrenoceptors have been shown to affect cardiac gap junction channels, we wanted to elucidate the possible effect of metoprolol on the gap junction protein connexin-43, using racemic RS-metoprolol or the isomer R-metoprolol (no beta-adrenoceptor blockade) or S-metoprolol (beta(1)-adrenoceptor...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000276982
更新日期:2010-01-01 00:00:00
abstract::Various attempts to developing antagonists for substance P (SP) and related peptides, based on our past experience with angiotensin, kinins, and neurotensin, were unsuccessful. The particular features of SP, namely the high activity of C-terminal partial sequences in some pharmacological tests were used to develop one...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000137979
更新日期:1984-01-01 00:00:00
abstract::The effects of two synthetic heme analogues, zinc mesoporphyrin (ZnMP) and tin mesoporphyrin (SnMP), on in vivo hematopoietic progenitor cell mobilization and in vitro hematopoiesis were examined in rabbit bone marrow. Rabbits received granulocyte colony-stimulating factor (rhG-CSF) for 7 days in order to mobilize inc...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028267
更新日期:1999-01-01 00:00:00
abstract::We investigated the effects of calcium ions (Ca2+) on the adenylyl cyclase activity in purified turkey erythrocyte membranes. Results showed the following: (i) Ca2+ inhibits cAMP accumulation stimulated by isoproterenol (1 micromol/l), NaF + AlCl3 (10 mmol/l + 20 micromol/l) or forskolin (10 micromol/l) in EGTA-washed...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000028245
更新日期:1998-10-01 00:00:00
abstract::The objective of this study was to determine the effects of hypercholesterolemia on basal vascular tone and vascular responses to pharmacologic agents in hindquarter resistance vessels. Blood pressure and hindquarter blood flow were measured in conscious rabbits fed a high cholesterol diet (1%) for 17 weeks (HC) compa...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000056137
更新日期:2001-01-01 00:00:00
abstract::Double-stranded, RNA-dependent protein kinase R (PKR) is a serine/threonine protein kinase activated by various stress signals. It plays an important role in inflammation, insulin sensitivity and glucose homeostasis. Increased PKR activity has been observed in obese humans as well as in obese diabetic mice. Indirubin-...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000441727
更新日期:2016-01-01 00:00:00
abstract::A potential cytokine-drug interaction between interleukin 6 (IL-6) and itraconazole (ITZ) was studied using human hepatocytes in primary culture. Cultures from 5 adult males (mean age 42 +/- 15 years) who had not received any medicines known to interact with CYP3A4 were studied. Cultures were exposed to ITZ 500 ng/ml,...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000068401
更新日期:2003-04-01 00:00:00
abstract::Rat intestinal transit was determined 30, 60, 150 and 270 min after morphine sulfate or saline given either subcutaneously (s.c.), intraduodenally (i.d.) or intracerebroventricularly (i.c.v.). In addition, two popular methods of quantifying the progression of a radioactive marker along the bowel, the intercept and geo...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137991
更新日期:1984-01-01 00:00:00
abstract::A comparison was made of the anti-ischemic effects of dihydropyridine calcium antagonists in isolated globally ischemic rat hearts. Pretreatment with amlodipine, nifedipine, nitredipine, or nisoldipine reduced reperfusion enzyme (lactate dehydrogenase) release and contracture after 25 min of global ischemia and 30 min...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138652
更新日期:1990-01-01 00:00:00
abstract::The aims of the present study were to investigate the pharmacological effects induced by Tityus serrulatus venom (TsV) and its fractions and to compare with the effects induced by pure alpha (TsTX-V) and beta (TsTX-I) toxins isolated from TsV on rat retractor penis muscle (RPM). TsV, fractions X, XI, XIIa, XIIb (0.01-...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000082804
更新日期:2005-03-01 00:00:00
abstract::A double-blind crossover trial was conducted in 42 outpatients of either sex in order to obtain information on the properties of 7.5 mg of zopiclone in a general practice setting compared with 2 mg of flunitrazepam. Each patient went through two periods of treatment, each period lasting 10 days. A comparison of the ef...
journal_title:Pharmacology
pub_type: 临床试验,杂志文章
doi:10.1159/000137923
更新日期:1983-01-01 00:00:00
abstract::The aim of the present study was to compare the cardioprotective properties of long-acting calcium channel antagonist pranidipine with amlodipine in rat model of heart failure induced by autoimmune myocarditis. Twenty-eight days after immunization the surviving rats were randomized for the oral administration of low-d...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000091746
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND/AIMS:Macitentan is a novel dual endothelin receptor antagonist with sustained receptor binding in clinical development for pulmonary arterial hypertension. The present study compared the pharmacokinetics and safety of macitentan in healthy Caucasian and Japanese subjects and explored the potential sex differ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000351704
更新日期:2013-01-01 00:00:00
abstract::The effect of sucralfate treatment (3 g daily for 6 weeks) on gastric HCO3- secretion was investigated in 15 duodenal ulcer patients. After treatment a highly significant (p less than 0.01) increase in gastric bicarbonate output was found. It is suggested that the mode of action of sucralfate includes stimulation of g...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138136
更新日期:1985-01-01 00:00:00
abstract::We compared detailed efficacy of efonidipine and nifedipine, dihydropyridine analogues, and mibefradil using recombinant T- and L-type Ca2+ channels expressed separately in mammalian cells. All these Ca2+ channel antagonists blocked T-type Ca2+ channel currents (I(Ca(T))) with distinct blocking manners: I(Ca(T)) was b...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000094900
更新日期:2006-01-01 00:00:00
abstract::Four monoclonal antibodies (MAbs) to phenobarbital-induced cytochrome P-450 (PB-P-450) show different patterns of inhibition of PB-P-450 catalyzed aryl hydrocarbon hydroxylase (AHH), 7-ethoxycoumarin deethylase, benzphetamine demethylase and ethylmorphine demethylase. The inhibition constants vary depending on the ind...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138677
更新日期:1990-01-01 00:00:00
abstract::Desferrioxamine (DFO) metabolism and its pharmacokinetics were studied in a swine model using high-performance liquid chromatography. DFO and three iron-binding metabolites occurred in plasma. Interindividual differences in pharmacokinetics and metabolism were observed. Urine analysis in 4 pigs showed three iron-bindi...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000138730
更新日期:1990-01-01 00:00:00
abstract::In this study, we used a novel conscious dog model to evaluate the uroselectivity of selected alpha 1-antagonists either approved for human use or in clinical development for the treatment of symptomatic benign prostatic hyperplasia (BPH) and compared those results to their in vitro binding and functional affinities a...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139451
更新日期:1996-12-01 00:00:00
abstract::We previously reported that adenovirus-mediated gene transfer of heme oxygenase-1 (HO-1) inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. This finding implies that HO-1 induction is beneficial for protecting blood vessels. We also found that quercetin, a common polyphenolic compound in f...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000076947
更新日期:2004-06-01 00:00:00
abstract::The function of melatonin (MLT) in promoting fracture healing has been demonstrated in previous studies. However, the molecular mechanism underlying therapeutic effects of MLT is not entirely clear. In this study, mesenchymal stem cells (MSCs) were isolated from rat bone marrow and identified by flow cytometry. We fou...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000492576
更新日期:2018-01-01 00:00:00
abstract::The observations that people infected with HIV suffer not only from an inflammatory stress but also from depleted glutathione levels have led to a general hypothesis that these two are causally related, and that treatment of AIDS should include thiol-replenishment therapy. In particular, inflammatory stimulations are ...
journal_title:Pharmacology
pub_type: 杂志文章,评审
doi:10.1159/000139037
更新日期:1993-01-01 00:00:00
abstract::Three highly reproducible experiments on drug interaction in normal human volunteers provided anomalous results: chronic halofenate administration shortened plasma antipyrine and bishydroxycoumarin half-lives but prolonged plasma warfarin half-lives. This dissociation in the effect produced by a chronically administer...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000136892
更新日期:1975-01-01 00:00:00
abstract::Particulate fractions of myocardium taken from spontaneously hypertensive rats (SHR) contained an adenylate cyclase system that was less responsive than normotensive Wistar Kyoto rats to norepinephrine, isoproterenol (mixed beta-agonist), salbutamol (beta 2-agonist), dobutamine (beta 1-agonist), dopamine, histamine, a...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137303
更新日期:1979-01-01 00:00:00
abstract::The temporal effects of vitamin A deficiency on hepatic cytochrome P-450-dependent and conjugation reactions were studied in the rat. Cytochrome P-450 levels and N-methyl-p-chloroaniline N-demethylase activity were significantly reduced in the deficient animals. No other changes in parameters dependent on cytochrome P...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000137457
更新日期:1980-01-01 00:00:00
abstract::We investigated the contribution of the sympathetic nervous system (SNS) in maintaining the blood pressure and in regulating the cardiac function during and after carvedilol administration in rats with heart failure (group F). Left ventricular end-diastolic pressure, percent functional shortening, and rates of intrave...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000080375
更新日期:2004-12-01 00:00:00
abstract::Previous studies have demonstrated that calcium storage and release from IP3-dependent sites in the sarcoplasmic reticulum play an important role in the contractile response of the rabbit urinary bladder to both field stimulation (mediated via neurotransmitter release) and bethanechol (direct muscarinic stimulation). ...
journal_title:Pharmacology
pub_type: 杂志文章
doi:10.1159/000139543
更新日期:1997-12-01 00:00:00