Abstract:
:Three highly reproducible experiments on drug interaction in normal human volunteers provided anomalous results: chronic halofenate administration shortened plasma antipyrine and bishydroxycoumarin half-lives but prolonged plasma warfarin half-lives. This dissociation in the effect produced by a chronically administered drug on the metabolism of test drugs has not previously been reported in man. Chronic halofenate administration to rats, mice and dogs stimulated several hepatic microsomal drug-metabolizing systems, including those responsible for bishydroxycoumarin warfarin hydroxylation.
journal_name
Pharmacologyjournal_title
Pharmacologyauthors
Vesell ES,Passananti GTdoi
10.1159/000136892subject
Has Abstractpub_date
1975-01-01 00:00:00pages
112-27issue
2eissn
0031-7012issn
1423-0313journal_volume
13pub_type
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