Comparative anti-ischemic effects of dihydropyridine calcium antagonists in isolated perfused rat hearts: relationship of cardiodepression and cardioprotection.

abstract：:The effect of cimetidine and two new histamine H2-receptor antagonists, oxmetidine and SKF 93479, on histamine-stimulated adenylate cyclase activity was studied in guinea pig gastric mucosal cells. Histamine stimulated the enzyme activity in concentration-dependent fashion. The concentration-response curve of histamin...

journal_title：Pharmacology

authors： Cheret AM,Scarpignato C,Lewin MJ,Bertaccini G

更新日期：1984-01-01 00:00:00

abstract：:Veratridine caused a positive inotropic action in the electrically driven left atria of rats. Quinacrine (a phospholipase A2 inhibitor), indomethacin (a cyclooxygenase inhibitor) and aspirin (a cyclooxygenase inhibitor), but not nordihydroguaiaretic acid (a lipoxygenase inhibitor), inhibited the response to veratridin...

journal_title：Pharmacology

authors： Morikawa M,Satake N,Shibata S,Shibata T

更新日期：1991-01-01 00:00:00

abstract：:Opioid antagonists have been shown to prevent the occurrence of lethal arrhythmias following coronary reperfusion. In this study, we have examined the effect of a new, long-lasting, potent opioid antagonist, nalmefene, and congeners in the prevention of reperfusion arrhythmias in dogs. Nalmefene given at a dose of 1 m...

journal_title：Pharmacology

authors： Caldwell RW,Nagarajan R,Chryssanthis A,Tuttle RR

更新日期：1990-01-01 00:00:00

abstract：:Papers published over 100 years since the beginning of the scientific study of drug metabolism in birds were reviewed. Birds were found to be able to accomplish more than 20 general biotransformation reactions in both functionalization and conjugation. Chickens were the primary subject of study but over 30 species of ...

journal_title：Pharmacology

authors： Pan HP,Fouts JR

更新日期：1979-01-01 00:00:00

abstract：:In anesthetized rats the glucose release of the kidneys was estimated from the glucose concentrations in the arterial and renal venous plasma, urinary glucose excretion and the total renal plasma flow. Net renal glucose release was found in control experiments. The glucose release of the kidneys decreased with rising ...

journal_title：Pharmacology

authors： Greven J,van Eys B,Jacobs W

更新日期：1975-01-01 00:00:00

abstract：:When rat mast cells were cultured for a short period in plastic dishes and adhering cells were permeabilized with beta-escin and exposed to Ca2+ at concentrations higher than 10(-7) mol/l, histamine release was induced dose-dependently. Protein kinase C (PKC) activity in the crude extracts obtained from adhering mast ...

journal_title：Pharmacology

authors： Izushi K,Tasaka K

更新日期：1992-01-01 00:00:00

abstract：:The hypoxia-inducible factor 1alpha (HIF-1alpha), a member of the PAS superfamily, is a global regulator of cellular and systemic O(2) homeostasis as well as embryonic development. As the activity of HIF-1alpha is increased by a lowered oxygen tension in vivo and in vitro, we established a cell line producing high amo...

journal_title：Pharmacology

authors： Meissner U,Allabauer I,Repp R,Rascher W,Dötsch J

更新日期：2003-10-01 00:00:00

abstract：:We studied the effects of triamterene (TA) on its phase I and phase II metabolites, p-hydroxytriamterene (OH-TA) and p-hydroxytriamterene sulfuric acid ester (OH-TA ester), on sodium transport in the isolated frog skin. While TA applied to the inside (corial side) surface had no effects on potential difference (PD) an...

journal_title：Pharmacology

authors： Kramer HJ,Rörig M,Völger KD

更新日期：1981-01-01 00:00:00

abstract：:The effects of alpha-adrenergic agonists on 45Ca efflux from slices of rat liver were studied and the results compared to earlier studies on the rabbit aorta. Norepinephrine and phenylephrine (PE) cause a stimulation of 45Ca efflux which was due to alpha 1-receptor activation. The mitochondrial uncoupler dinitrophenol...

journal_title：Pharmacology

authors： Lynch CJ,Deth RC

更新日期：1984-01-01 00:00:00

abstract：:Both acute and chronic oral administration (1-20 mg/kg) of FCE 22716, a new ergoline derivative, resulted in a dose-related fall of arterial blood pressure lasting for more than 6 h. Tachycardia was observed only at high dosages. Yohimbine, propranolol and indometacin did not modify its antihypertensive effect; on the...

journal_title：Pharmacology

authors： Salvati P,Bondiolotti GP,Caccia C,Vaghi F,Bianchi G

更新日期：1989-01-01 00:00:00

abstract：:The mechanisms by which captopril inhibits vasopressin-stimulated osmotic water flow in the toad bladder have been investigated in vitro. Captopril has two possible mechanisms for the inhibitory action on the water flow, one is its stimulative effect on prostaglandin E2 (PGE2) biosynthesis by inhibition of kininase II...

journal_title：Pharmacology

authors： Marumo F,Nara Y

更新日期：1987-01-01 00:00:00

abstract：:The involvement of AT1 and AT2 receptor subtypes in the response of the isolated rat uterus to angiotensin II (AngII) was studied throughout the estrous cycle. The AngII potency varied during the different estrous cycle phases, as indicated by significantly different pD2 values. No significant differences were observe...

journal_title：Pharmacology

authors： Accorsi-Mendonça D,Corrêa FM,Anselmo-Franci JA,Paiva TB,de Oliveira AM

更新日期：2002-07-01 00:00:00

abstract：:To investigate the effects of beraprost sodium on the proliferation and oxidative stress of glomerular mesangial cells under high glucose conditions, a rat mesangial cell line (rat mesangial cells; RMCs) was treated with beraprost sodium in the presence of high glucose concentrations. Proliferation rates of mesangial ...

journal_title：Pharmacology

authors： Zhang LY,Zou JJ,Liu ZM

更新日期：2011-01-01 00:00:00

abstract：:Galactosamine (GalN) administration produces hepatitis-like liver injury in animals. The hepatotoxicity of GalN is attenuated by several interventions, including activation of the reticuloendothelial system (RES). Fructose-1,6-diphosphate (FDP) administration significantly increases the phagocytic activity of the RES ...

journal_title：Pharmacology

authors： Markov AK,Farias LA,Bennett WS,Subramony C,Mihas AA

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Chemotherapy-induced neuropathic pain (CINP) is a serious side effect of chemotherapy. Korean Red Ginseng (KRG) is a popular herbal medicine in Asian countries. We examined the therapeutic potential of intrathecally administered KRG for CINP and clarified the mechanisms of action with regard to 5-hydroxytryp...

journal_title：Pharmacology

authors： Kim YO,Song JA,Kim WM,Yoon MH

更新日期：2020-01-01 00:00:00

abstract：:Anoxia has been shown to potentiate the constrictor effects of 5-hydroxytryptamine (5HT) in isolated vascular tissue. In the present study, canine coronary arterial rings were incubated with various treatments and exposed to 5HT (4 X 10(-7) M) and anoxia (95% N2 and 5% CO2). Developed tension was increased by 250 +/- ...

journal_title：Pharmacology

authors： Barrett JA,DePaul Lynch V,Balkon J,Smith RD,Wolf PS

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:To study the myocardial benefit effect and mechanism of paeoniflorin on myocardial ischemia reperfusion injury (MIRI) in rats. METHODS:Hundred SD rats were randomly divided into 5 groups: sham group, model group, Paeoniflorin (15 mg/kg) group, Paeoniflorin (30 mg/kg) group, and Paeoniflorin (60 mg/kg) group....

journal_title：Pharmacology

authors： Wu F,Ye B,Wu X,Lin X,Li Y,Wu Y,Tong L

更新日期：2020-01-01 00:00:00

abstract：AIM:An increase in carotid intima-media thickness (CIMT) represents an early phase of the atherosclerotic process. The aim of our study was to evaluate whether a reduction in CIMT could be seen with 1-year treatment with rosuvastatin (10 mg/day). METHODS AND RESULTS:Forty-five patients with hypercholesterolemia and as...

journal_title：Pharmacology

authors： Riccioni G,Vitulano N,Mancini B,Zanasi A,D'Orazio N

更新日期：2010-01-01 00:00:00

abstract：:The influence of changes in the sodium balance on angiotensin II-induced pressor responses were studied in the pithed rat preparation, which is characterized by a highly activated renin-angiotensin-aldosterone system (RAAS) with high plasma renin and angiotensin II concentrations. The pressor response to angiotensin I...

journal_title：Pharmacology

authors： Knape JT,van Zwieten PA

更新日期：1988-01-01 00:00:00

abstract：:The effects of nisoldipine on myocardial performance and large coronary artery diameter, resistance and cross-sectional area were studied in rabbit hearts in situ. Changes in mean internal diameter of coronary artery segments were visualized using color arteriography; changes were computer-calculated. Nisoldipine had ...

journal_title：Pharmacology

authors： Saito T,Saeed M,Bing RJ

更新日期：1988-01-01 00:00:00

abstract：:Hepatic lipid accumulation and apoptosis is elevated in patients with non-alcoholic steatohepatitis and is closely associated with severity. Saturated fatty acid palmitate stimulates lipid accumulation and apoptosis in hepatocytes. In the present study, we examined bee-bee tree oil (BO)-mediated protective effects on ...

journal_title：Pharmacology

authors： Jung TW,Kim SY,Kim DS,Shin EC,Park YB,Lee KT

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIMS:Stent thrombosis is a serious complication after percutaneous coronary intervention and femoropopliteal endovascular intervention. The aim of this study was to determine the antithrombotic effects of a direct factor Xa inhibitor edoxaban alone or in combination with antiplatelet agents in a rat model of...

journal_title：Pharmacology

authors： Morishima Y,Honda Y,Kamisato C

更新日期：2019-01-01 00:00:00

abstract：:Under the specific conditions reported for the separate tests delta9-tetrahydrocannabinol (THC) did not elicit a mutagenic response in microbial and eukaryotic in vitro test systems. THC treatment to histidine auxotrophs of Salmonella typhimurium strains TA 98 (susceptible to frame shift mutation) and TA 100 (suscepti...

journal_title：Pharmacology

authors： Zimmerman AM,Stich H,San R

更新日期：1978-01-01 00:00:00

abstract：:The oral bioavailability of two investigational formulations of bicalutamide was compared with the current clinical formulation. The first formulation was amorphous R-/S-bicalutamide in solid dispersion with a polymeric matrix of hydroxypropyl methylcellulose phthalate (HP55S) (R-/S-bicalutamide/HP55S); the second was...

journal_title：Pharmacology

authors： Cantarini M,Fuhr R,Morris T

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIMS:Morphine causes state-dependent learning that its mechanism and brain-related structures are not fully understood. This study aimed to determine whether lidocaine reversible inactivation of the central nucleus of the amygdala (CeA) could affect acquisition, consolidation, and retrieval of morphine state...

journal_title：Pharmacology

authors： Noorbakhshnia M,Rahmani-Samani P,Eivani M

更新日期：2020-01-01 00:00:00

abstract：:The effects of two synthetic heme analogues, zinc mesoporphyrin (ZnMP) and tin mesoporphyrin (SnMP), on in vivo hematopoietic progenitor cell mobilization and in vitro hematopoiesis were examined in rabbit bone marrow. Rabbits received granulocyte colony-stimulating factor (rhG-CSF) for 7 days in order to mobilize inc...

journal_title：Pharmacology

authors： Lutton JD,Jiang S,Drummond GS,Abraham NG,Kappas A

更新日期：1999-01-01 00:00:00

abstract：:We investigated the total urinary kallikrein levels, left-ventricular wall thickness and mean arterial blood pressure of nontreated and captopril-treated diabetic and nondiabetic spontaneously hypertensive rats. The mean arterial blood pressure was significantly elevated in diabetic spontaneously hypertensive rats as ...

journal_title：Pharmacology

authors： Sharma JN,Kesavarao U

更新日期：2002-04-01 00:00:00

abstract：:Previous studies have indicated that structurally dissimilar serotonin2 (5HT2) antagonists can protect globally ischemic/reperfused reperfused rat hearts. We therefore determined if the 5HT2 antagonist cinanserin can protect the ischemic myocardium in two models of pacing-induced ischemia in anesthetized dogs. In one ...

journal_title：Pharmacology

authors： Grover GJ,Parham CS,Youssef S,Ogletree ML

更新日期：1995-05-01 00:00:00

abstract：:The in vitro addition of (-)-delta9-tetrahydrocannabinol (delta9-THC) resulted in a dose-responsive inhibition of the high-affinity specific synaptosomal uptake of both 3H-tryptophan and 3H-choline in mouse forebrain crude synaptosomal preparations. The approximate concentrations of delta9-THC required to cause a 50% ...

journal_title：Pharmacology

authors： Johnson KM,Dewey WL

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Poncirus fructus (PF), also known as the dried immature fruit of Poncirus trifoliata (L.) Raf., has long been used as a cure for the treatment of various gastrointestinal disorders in eastern Asia. Recently, it was reported that naringin, a flavonoid constituent of the PF extract, causes the acti...

journal_title：Pharmacology

authors： Jang Y,Kim TK,Shim WS

更新日期：2013-01-01 00:00:00