Single nucleotide polymorphisms of the pregnane x receptor gene in Han Chinese and a comparison with other ethnic populations.

abstract：:The effect of cimetidine and two new histamine H2-receptor antagonists, oxmetidine and SKF 93479, on histamine-stimulated adenylate cyclase activity was studied in guinea pig gastric mucosal cells. Histamine stimulated the enzyme activity in concentration-dependent fashion. The concentration-response curve of histamin...

journal_title：Pharmacology

authors： Cheret AM,Scarpignato C,Lewin MJ,Bertaccini G

更新日期：1984-01-01 00:00:00

abstract：:Five healthy subjects performed submaximal physical exercise approximately 20 h after a single oral dose of phenytoin (5 mg/kg of the sodium salt). The plasma levels of free fatty acids (FFA) increased 2- to 3-fold in the post-exercise period. In spite of this, the degree of plasma binding of phenytoin and its total c...

journal_title：Pharmacology

authors： Borgå O,Juhlin-Dannfeldt A,Dahlqvist R

更新日期：1978-01-01 00:00:00

abstract：:Effects of choleresis produced by atropine (4-10(-4)M) on the biliary elimination of 3H-ouabain and on the biliary clearance rate of 14C-erythritol were studied in the isolated perfused rat liver. The increased bile flow produced by atropine was associated with decreased level of 3H-ouabain in the bile. The cumulative...

journal_title：Pharmacology

authors： Nevasaari K,Alakare B,Kärki NT

更新日期：1977-01-01 00:00:00

abstract：:The mechanisms by which captopril inhibits vasopressin-stimulated osmotic water flow in the toad bladder have been investigated in vitro. Captopril has two possible mechanisms for the inhibitory action on the water flow, one is its stimulative effect on prostaglandin E2 (PGE2) biosynthesis by inhibition of kininase II...

journal_title：Pharmacology

authors： Marumo F,Nara Y

更新日期：1987-01-01 00:00:00

abstract：:We compared detailed efficacy of efonidipine and nifedipine, dihydropyridine analogues, and mibefradil using recombinant T- and L-type Ca2+ channels expressed separately in mammalian cells. All these Ca2+ channel antagonists blocked T-type Ca2+ channel currents (I(Ca(T))) with distinct blocking manners: I(Ca(T)) was b...

journal_title：Pharmacology

authors： Lee TS,Kaku T,Takebayashi S,Uchino T,Miyamoto S,Hadama T,Perez-Reyes E,Ono K

更新日期：2006-01-01 00:00:00

abstract：:Three highly reproducible experiments on drug interaction in normal human volunteers provided anomalous results: chronic halofenate administration shortened plasma antipyrine and bishydroxycoumarin half-lives but prolonged plasma warfarin half-lives. This dissociation in the effect produced by a chronically administer...

journal_title：Pharmacology

authors： Vesell ES,Passananti GT

更新日期：1975-01-01 00:00:00

abstract：:Several compounds with the backbone of 1,4-naphthoquinone chemical structure have been reported to display antiplatelet and antithrombotic activities, indicating that this congener compound may be a new source in the antithrombotic drug development. In the present study, the possible antiplatelet activity and antithro...

journal_title：Pharmacology

authors： Jin YR,Ryu CK,Moon CK,Cho MR,Yun YP

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. METHODS:ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0. Then the mice were orally given GAA (25, 50 mg/kg) or dexamethasone (2 mg/kg). After treatment for 21 days,...

journal_title：Pharmacology

authors： Wen G,Li T,He H,Zhou X,Zhu J

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Angiogenesis is usually driven by inflammation. Matrix metalloproteinases MMP-3 and MMP-9 and tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 are implicated in vascular remodeling. TIMP-2 exhibits antiangiogenic properties. Statins show benefits that are additional to lipid lowering including pro- ...

journal_title：Pharmacology

authors： Siddiqui AJ,Gustafsson T,Sylven C,Crisby M

更新日期：2014-01-01 00:00:00

abstract：:This study was performed to investigate the effect of muscimol on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice. A single administration of morphine induced hyperactivity as measured in mice, and the morphine-induced hyperactivity was inhibited dose-depen...

journal_title：Pharmacology

authors： Yoon IS,Kim HS,Hong JT,Lee MK,Oh KW

更新日期：2002-08-01 00:00:00

abstract：:The use of angiotensin converting enzyme (ACE) inhibitors in combination with diuretics is a common strategy used for the treatment of patients affected by heart failure. An infant affected by initial congestive cardiac failure, after starting the treatment with enalapril in association with furosemide, developed acut...

journal_title：Pharmacology

authors： Fabiano V,Carnovale C,Gentili M,Radice S,Zuccotti GV,Clementi E,Perrotta C,Mameli C

更新日期：2016-01-01 00:00:00

abstract：:The isolated whole stomach of the mouse has been used to study the effect of atropine on gastic acid secretion stimulated by acetylcholine, bethanechol and histamine. Atropine inhibited acid secretory response to acetylcholine and bethanechol in a competitive manner. The following pA2 values for atropine were calculat...

journal_title：Pharmacology

authors： Szelenyi I,Vergin H

更新日期：1980-01-01 00:00:00

abstract：:The present experiments examined the protective effect of the nitrofuran drugs, furazolidone (FZ) and nitrofurazone (NF), on duodenal ulceration induced by cysteamine or indometacin in rats. FZ at oral doses of 25, 50 or 100 mg/kg for 2 consecutive days signficantly reduced, in a dose-dependent manner, the incidence a...

journal_title：Pharmacology

authors： Ali BH

更新日期：1991-01-01 00:00:00

abstract：:Both acute and chronic oral administration (1-20 mg/kg) of FCE 22716, a new ergoline derivative, resulted in a dose-related fall of arterial blood pressure lasting for more than 6 h. Tachycardia was observed only at high dosages. Yohimbine, propranolol and indometacin did not modify its antihypertensive effect; on the...

journal_title：Pharmacology

authors： Salvati P,Bondiolotti GP,Caccia C,Vaghi F,Bianchi G

更新日期：1989-01-01 00:00:00

abstract：:Particulate fractions of myocardium taken from spontaneously hypertensive rats (SHR) contained an adenylate cyclase system that was less responsive than normotensive Wistar Kyoto rats to norepinephrine, isoproterenol (mixed beta-agonist), salbutamol (beta 2-agonist), dobutamine (beta 1-agonist), dopamine, histamine, a...

journal_title：Pharmacology

authors： Palmer GC,Greenberg S

更新日期：1979-01-01 00:00:00

abstract：:Metformin is a widely used antidiabetic agent that is generally considered safe. However, metformin-associated lactic acidosis (MALA), though not common, occurs from time to time and results in significantly high mortality. A series of 23 MALA cases in a local major hospital in Hong Kong is reported in this article to...

journal_title：Pharmacology

authors： Yeung CW,Chung HY,Fong BM,Tsai NW,Chan WM,Siu TS,Tam S,Tsui SH

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Centhaquin is a centrally acting hypotensive drug like clonidine. Clonidine also produces analgesia and hypothermia in mice and potentiates morphine analgesia. Clonidine analgesia is blocked by idazoxan and naloxone while it is potentiated by BQ123 and sulfisoxazole. This study was conducted to determine the...

journal_title：Pharmacology

authors： Andurkar SV,Gulati A

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:Vaginismus is characterized by recurrent or persistent involuntary contraction of the perineal muscles surrounding the outer third of the vagina when penile, finger, tampon, or speculum penetration is attempted. Recent results have suggested the use of botulinum toxin for the treatment of vaginismus. He...

journal_title：Pharmacology

authors： Ferreira JR,Souza RP

更新日期：2012-01-01 00:00:00

abstract：:Opioid antagonists have been shown to prevent the occurrence of lethal arrhythmias following coronary reperfusion. In this study, we have examined the effect of a new, long-lasting, potent opioid antagonist, nalmefene, and congeners in the prevention of reperfusion arrhythmias in dogs. Nalmefene given at a dose of 1 m...

journal_title：Pharmacology

authors： Caldwell RW,Nagarajan R,Chryssanthis A,Tuttle RR

更新日期：1990-01-01 00:00:00

abstract：:GPR61 is an orphan receptor that belongs to Class A of G-protein-coupled receptors. It has been reported that GPR61 has a constitutive activity and couples to Gαs. In the present study, we characterized GPR61 function and ligand binding by experimental and molecular docking studies. We demonstrated that heterologous e...

journal_title：Pharmacology

authors： Kozielewicz P,Grafton G,Sajkowska-Kozielewicz JJ,Barnes NM

更新日期：2019-01-01 00:00:00

abstract：:The effects of aspirin and suprofen on gastrointestinal blood loss were compared in a double-blind, crossover study of 20 healthy male subjects. Fecal blood loss was measured by 51Cr-labeled red cells. Subjects treated with aspirin (2,600 mg/day) experienced a mean fecal blood loss of 4.2 ml/day, compared with subject...

journal_title：Pharmacology

authors： Arnold JD,Berger AE

更新日期：1983-01-01 00:00:00

abstract：:The radioligand binding profiles and in vivo pharmacological characteristics of YM-44781, YM-44778 and YM-49598, novel non-peptide tachykinin receptor antagonists, were examined and compared to those of FK-888 and GR-159897. Since no functional NK(3) receptors were found in the rat bladder, the emphasis will be on the...

journal_title：Pharmacology

authors： Choppin A,Groke G,Bringas A,Stepan G,Dillon MP

更新日期：2002-05-01 00:00:00

abstract：:Previous studies have indicated that structurally dissimilar serotonin2 (5HT2) antagonists can protect globally ischemic/reperfused reperfused rat hearts. We therefore determined if the 5HT2 antagonist cinanserin can protect the ischemic myocardium in two models of pacing-induced ischemia in anesthetized dogs. In one ...

journal_title：Pharmacology

authors： Grover GJ,Parham CS,Youssef S,Ogletree ML

更新日期：1995-05-01 00:00:00

abstract：:Distinct signal transduction pathways have been shown to regulate injury responses and regeneration in peripheral nerves. In the present investigation, the time courses of the induction of phospho-MAPK/ERK1/2 and of phospho-STAT3 were investigated in the dorsal root ganglia (DRG) and in the sciatic nerve of rats follo...

journal_title：Pharmacology

authors： Donnerer J,Liebmann I,Schicho R

更新日期：2005-11-01 00:00:00

abstract：:When rat mast cells were cultured for a short period in plastic dishes and adhering cells were permeabilized with beta-escin and exposed to Ca2+ at concentrations higher than 10(-7) mol/l, histamine release was induced dose-dependently. Protein kinase C (PKC) activity in the crude extracts obtained from adhering mast ...

journal_title：Pharmacology

authors： Izushi K,Tasaka K

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND/AIM:It has been demonstrated that dexamethasone-induced hypertension can be prevented by the NADPH oxidase inhibitor apocynin. The effect of dexamethasone on NADPH oxidase, however, is unknown. The present study was conducted to investigate the effect of dexamethasone on the gene expression of Nox1, the majo...

journal_title：Pharmacology

authors： Siuda D,Tobias S,Rus A,Xia N,Förstermann U,Li H

更新日期：2014-01-01 00:00:00

abstract：:In a randomized three-phase crossover study, 12 healthy male volunteers were given three 12-hourly 500-mg doses of erythromycin base, as enteric coated pellets in capsules (2 X 250 mg), erythromycin stearate tablet (1 X 500 mg), or erythromycin ethylsuccinate sachet (1 X 500 mg). The reaction time after administration...

journal_title：Pharmacology

authors： Tjandramaga TB,Van Hecken A,Mullie A,Verbesselt R,De Schepper PJ,Verbist L,Josefsson K

更新日期：1984-01-01 00:00:00

abstract：:Nabumetone is a nonsteroidal anti-inflammatory (NSAI) drug which is known to cause less gastrointestinal damage than other NSAI drugs. This study was performed to evaluate whether nabumetone treatment might alter the vascular aberrations related to inflammation in a rat model of adjuvant-induced arthritis. Nabumetone ...

journal_title：Pharmacology

authors： Ulker S,Onal A,Hatip FB,Sürücü A,Alkanat M,Koşay S,Evinç A

更新日期：2000-04-01 00:00:00

abstract：:The effect of sucralfate treatment (3 g daily for 6 weeks) on gastric HCO3- secretion was investigated in 15 duodenal ulcer patients. After treatment a highly significant (p less than 0.01) increase in gastric bicarbonate output was found. It is suggested that the mode of action of sucralfate includes stimulation of g...

journal_title：Pharmacology

authors： Guslandi M

更新日期：1985-01-01 00:00:00

abstract：:Previous investigations demonstrated that CYP2D16 was expressed at high levels in guinea pig adrenal microsomes. The studies presented here were done to determine whether adrenal metabolism of bufuralol (BUF), a model CYP2D substrate, was similar to that in the liver. Guinea pig adrenal microsomes converted BUF to 1'-...

journal_title：Pharmacology

authors： Colby HD,Nowak DM,Longhurst PA,Zhang X,Hayes JR,Voigt JM

更新日期：2001-05-01 00:00:00